MD20150037A2 - Compuşi heteroaromatici şi utilizarea lor ca liganzi de dopamină D1 - Google Patents

Compuşi heteroaromatici şi utilizarea lor ca liganzi de dopamină D1

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Publication number
MD20150037A2
MD20150037A2 MDA20150037A MD20150037A MD20150037A2 MD 20150037 A2 MD20150037 A2 MD 20150037A2 MD A20150037 A MDA20150037 A MD A20150037A MD 20150037 A MD20150037 A MD 20150037A MD 20150037 A2 MD20150037 A2 MD 20150037A2
Authority
MD
Moldova
Prior art keywords
cognitive
schizophrenia
oxides
preparation
dopamine
Prior art date
Application number
MDA20150037A
Other languages
English (en)
Russian (ru)
Inventor
Е. Даворен Дженнифер
Бет Дунай Эми
В. Ефремов Иван
Ф. Грэй Дэвид Л
Р. Мент Скот
Стивен В. О`Нейл
Брюс Н. Роджерс
Чакрапани Субраманиам
Лэй Чжан
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49955424&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20150037(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20150037A2 publication Critical patent/MD20150037A2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Prezenta invenţie se referă la compuşii cu formula (I):(I)şi sărurile farmaceutic acceptabile ale acestora şi N-oxizii celor menţionaţi mai sus; procedeele de preparare; compuşii intermediari folosiţi la preparare; compoziţiile ce conţin aceşti compuşi, săruri sau N-oxizi, şi utilizarea lor pentru tratamentul tulburărilor mediate de receptorii D1 sau al tulburărilor asociate cu medierea receptorilor D1, de exemplu, schizofrenie (simptomele sale cognitive şi negative), disfuncţia cognitivă (de exemplu, disfuncţia cognitivă asociată cu schizofrenia, AD, PD, sau terapie farmacoterapeutică), ADHD, impulsivitate, dependenţă compulsivă de jocuri de noroc, supraalimentare, tulburare din spectrul autismului, MCI, declin cognitiv legat de vârstă, demenţă, RLS, boala Parkinson, coree Huntington, anxietate, depresie, MDD, TRD, şi tulburare bipolară.
MDA20150037A 2012-11-08 2013-10-30 Compuşi heteroaromatici şi utilizarea lor ca liganzi de dopamină D1 MD20150037A2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261723995P 2012-11-08 2012-11-08
PCT/IB2013/059768 WO2014072882A1 (en) 2012-11-08 2013-10-30 Heteroaromatic compounds as dopamine d1 ligands

Publications (1)

Publication Number Publication Date
MD20150037A2 true MD20150037A2 (ro) 2015-11-30

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ID=49955424

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MDA20150037A MD20150037A2 (ro) 2012-11-08 2013-10-30 Compuşi heteroaromatici şi utilizarea lor ca liganzi de dopamină D1

Country Status (30)

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US (3) US8822494B2 (ro)
EP (1) EP2917216B1 (ro)
JP (1) JP5823657B1 (ro)
KR (1) KR101660664B1 (ro)
CN (1) CN104837839A (ro)
AP (1) AP3861A (ro)
AR (1) AR095359A1 (ro)
AU (1) AU2013343105B2 (ro)
BR (1) BR112015010412A2 (ro)
CA (1) CA2889572C (ro)
CL (1) CL2015001233A1 (ro)
CO (1) CO7350619A2 (ro)
CR (1) CR20150237A (ro)
EA (1) EA201500402A1 (ro)
ES (1) ES2652514T3 (ro)
GE (1) GEP201606598B (ro)
HK (1) HK1213256A1 (ro)
IL (1) IL238712A0 (ro)
MA (1) MA38069A1 (ro)
MD (1) MD20150037A2 (ro)
MX (1) MX2015005506A (ro)
NI (1) NI201500066A (ro)
PE (1) PE20150966A1 (ro)
PH (1) PH12015500883A1 (ro)
SG (1) SG11201502884TA (ro)
TN (1) TN2015000167A1 (ro)
TW (1) TWI577678B (ro)
UA (1) UA111687C2 (ro)
UY (1) UY35129A (ro)
WO (1) WO2014072882A1 (ro)

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