MC435A1 - Disubstituted 1,4-piperazines and process for their preparation - Google Patents

Disubstituted 1,4-piperazines and process for their preparation

Info

Publication number
MC435A1
MC435A1 MC453A MC453A MC435A1 MC 435 A1 MC435 A1 MC 435A1 MC 453 A MC453 A MC 453A MC 453 A MC453 A MC 453A MC 435 A1 MC435 A1 MC 435A1
Authority
MC
Monaco
Prior art keywords
piperazines
disubstituted
preparation
Prior art date
Application number
MC453A
Other languages
French (fr)
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of MC435A1 publication Critical patent/MC435A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B43/00—Preparation of azo dyes from other azo compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
MC453A 1963-04-04 1963-09-10 Disubstituted 1,4-piperazines and process for their preparation MC435A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US27053463A 1963-04-04 1963-04-04
US27053663A 1963-04-04 1963-04-04
US27053763A 1963-04-04 1963-04-04
US37971464A 1964-07-01 1964-07-01
US468142A US3331843A (en) 1963-04-04 1965-06-29 1-substituted-4-substituted aminoalkylene piperazines
US468143A US3331830A (en) 1963-04-04 1965-06-29 1-substituted-4-substituted aminoalkylene piperazines

Publications (1)

Publication Number Publication Date
MC435A1 true MC435A1 (en) 1964-07-06

Family

ID=27559486

Family Applications (1)

Application Number Title Priority Date Filing Date
MC453A MC435A1 (en) 1963-04-04 1963-09-10 Disubstituted 1,4-piperazines and process for their preparation

Country Status (13)

Country Link
US (2) US3331830A (en)
BE (1) BE637271A (en)
BR (1) BR6352303D0 (en)
CH (1) CH482691A (en)
DE (1) DE1445425A1 (en)
FI (2) FI41280C (en)
FR (1) FR3708M (en)
GB (1) GB1047935A (en)
LU (1) LU44424A1 (en)
MC (1) MC435A1 (en)
NL (1) NL297170A (en)
NO (1) NO117694B (en)
SE (2) SE320667B (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1165283A (en) * 1967-01-17 1969-09-24 Science Union & Cie New Purine Derivatives and processes for prepararing them
US3491098A (en) * 1967-05-29 1970-01-20 Sterling Drug Inc 1-((imidazolyl)-lower-alkyl)-4-substituted-piperazines
GB1279843A (en) * 1969-05-23 1972-06-28 Science Union & Cie Benzamidoethyl-piperazines and process for their preparation
US4081542A (en) * 1975-04-21 1978-03-28 Merck & Co., Inc. Piperazinylpyrazines
CH653021A5 (en) * 1981-04-24 1985-12-13 Delalande Sa PIPERIDINO, PIPERAZINO AND HOMOPIPERAZINO DERIVATIVES, N-SUBSTITUTED BY AN AROMATIC HETEROCYCLIC GROUP, THEIR PREPARATION METHOD AND THERAPEUTIC COMPOSITION CONTAINING THEM.
US4457931A (en) * 1982-09-27 1984-07-03 Selvi & C. S.P.A. Piperazine derivatives with anticholinergic and/or antihistaminic activity
HUT43600A (en) * 1985-06-22 1987-11-30 Sandoz Ag Process for production of new thiazole derivatives and medical compound containing those
US5057517A (en) * 1987-07-20 1991-10-15 Merck & Co., Inc. Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US4977156A (en) * 1988-07-26 1990-12-11 The Dow Chemical Company Amino piperazine esters showing biocidal activity
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
JP3193560B2 (en) * 1993-04-16 2001-07-30 明治製菓株式会社 New benzoxazole derivatives
JP2002538120A (en) * 1999-03-03 2002-11-12 メルク エンド カムパニー インコーポレーテッド Inhibitors of prenyl protein transferase
EP1165082A4 (en) * 1999-03-03 2002-06-12 Merck & Co Inc Inhibitors of prenyl-protein transferase
KR20010085555A (en) 1999-06-24 2001-09-07 히라이 가쯔히꼬 α1Β-ADRENERGIC RECEPTOR ANTAGONISTS
WO2001014331A2 (en) * 1999-08-24 2001-03-01 Regents Of The University Of California Non-quinoline inhibitors of malaria parasites
OA12793A (en) 2002-03-13 2006-07-10 Janssen Pharmaceutica Nv Sulfonylamino-derivatives as novel inhibitors of histone deacetylase.
KR20040090981A (en) 2002-03-13 2004-10-27 얀센 파마슈티카 엔.브이. Carbonylamino-derivatives as novel inhibitors of histone deacetylase
CA2476296C (en) * 2002-03-13 2011-02-22 Janssen Pharmaceutica N.V. Amino-derivatives as inhibitors of histone deacetylase
WO2003076438A1 (en) * 2002-03-13 2003-09-18 Janssen Pharmaceutica N.V. Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase
SG156687A1 (en) 2004-07-28 2009-11-26 Janssen Pharmaceutica Nv Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase
UY29177A1 (en) * 2004-10-25 2006-05-31 Astex Therapeutics Ltd SUBSTITUTED DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA, COMPOSITIONS THAT CONTAIN METHODS FOR THEIR PREPARATION AND ITS USES
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
EP1848428A4 (en) 2005-02-18 2012-04-18 Neurogen Corp Thiazole amides, imidazole amides and related analogues
CA2605272C (en) 2005-05-18 2013-12-10 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
RS51191B (en) * 2006-01-19 2010-10-31 Janssen Pharmaceutica N.V. Aminophenyl derivatives as novel inhibitors of histone deacetylase
US8101616B2 (en) * 2006-01-19 2012-01-24 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
WO2007082874A1 (en) * 2006-01-19 2007-07-26 Janssen Pharmaceutica N.V. Pyridine and pyrimidine derivatives as inhibitors of histone deacetylase
EP1981875B1 (en) * 2006-01-19 2014-04-16 Janssen Pharmaceutica N.V. Substituted indolyl-alkyl-amino-derivatives as inhibitors of histone deacetylase
JP5606734B2 (en) 2006-04-25 2014-10-15 アステックス、セラピューティックス、リミテッド Pharmaceutical compounds
CN101754957A (en) * 2007-07-19 2010-06-23 弗·哈夫曼-拉罗切有限公司 Novel heterocyclyl compounds and their use as chemokine antagonists
KR20150076264A (en) * 2007-08-22 2015-07-06 아스트라제네카 아베 Cyclopropyl amide derivatives
ES2522365T3 (en) 2007-10-11 2014-11-14 Astrazeneca Ab Pyrrolo [2,3-D] pyrimidine derivatives as protein kinase B inhibitors
WO2009050734A2 (en) * 2007-10-15 2009-04-23 Elder Pharmaceuticals Ltd. An industrially feasible process for the manufacture of bisquinoline derivatives by using substantially pure n-monosubstituted piperazines
TW201039825A (en) * 2009-02-20 2010-11-16 Astrazeneca Ab Cyclopropyl amide derivatives 983
FR2945289A1 (en) * 2009-05-11 2010-11-12 Sanofi Aventis 2-CYCLOAMINO-5- (PYRIDIN-4-YL) IMIDAZO-2,1-B1 DERIVATIVES 1,3,4! THIADIAZOLE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
WO2011095885A1 (en) * 2010-02-08 2011-08-11 Matrix Laboratories Ltd. An improved process for the preparation of piperaquine
TW201136898A (en) * 2010-02-18 2011-11-01 Astrazeneca Ab Solid forms comprising a cyclopropyl amide derivative
MX336333B (en) * 2010-02-18 2016-01-15 Astrazeneca Ab New crystalline form of a cyclopropyl benzamide derivative.
PL2694056T3 (en) 2011-04-01 2020-03-31 Astrazeneca Ab Therapeutic treatment
CA2835344A1 (en) 2011-06-06 2012-12-13 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A Novel process for the synthesis of 7-chloro-4-(piperazin-1-yl)-quinoline
PL2785349T5 (en) 2011-11-30 2023-01-30 Astrazeneca Ab Combination treatment of cancer
AU2013204533B2 (en) 2012-04-17 2017-02-02 Astrazeneca Ab Crystalline forms
JP2019500352A (en) 2015-12-10 2019-01-10 ピーティーシー セラピューティクス， インコーポレイテッド Treatment for Huntington's disease
BR112019025740A2 (en) 2017-06-05 2020-06-23 Ptc Therapeutics, Inc. COMPOUNDS TO TREAT HUNTINGTON'S DISEASE
CA3067592A1 (en) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Methods for treating huntington's disease
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
MX2020009957A (en) 2018-03-27 2021-01-15 Ptc Therapeutics Inc Compounds for treating huntington's disease.
CN110606830B (en) * 2018-06-14 2022-03-18 珠海润都制药股份有限公司 Method for producing piperaquine phosphate intermediate quinoline piperazine hydrochloride by applying piperazine
WO2020005882A1 (en) * 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
US11858941B2 (en) 2018-06-27 2024-01-02 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2513026A (en) * 1950-06-27 Process for preparing same
NL72956C (en) * 1947-11-12
US2861072A (en) * 1952-07-19 1958-11-18 Abbott Lab Preparation of piperazine derivatives
US2794804A (en) * 1955-03-24 1957-06-04 American Cyanamid Co Substituted piperazines and method of preparing the same
US2949431A (en) * 1957-07-17 1960-08-16 Mobay Chemical Corp Preparation of cellular polyurethanes using piperazine catalysts
US3098066A (en) * 1960-03-04 1963-07-16 Ciba Geigy Corp Diaza-heterocyclic guanidine compounds
US3015657A (en) * 1959-05-28 1962-01-02 Charles F Geschickter 1-carbalkoxy-4-(aminoalkanol) piperazines
US3030366A (en) * 1961-01-25 1962-04-17 Lakeside Lab Inc Piperazinoalkyl glycolamides
FR1525M (en) * 1961-07-25 1962-11-16 Ile De France New antiemetic drugs.
US3190883A (en) * 1962-10-05 1965-06-22 Geschickter Fund Med Res Aminoalkanol derivatives of piperazines
US3184382A (en) * 1963-08-12 1965-05-18 Pure Oil Co Method of producing tranquilization by hydroxy-loweralkyl-n-substituted carbamic acid esters

Also Published As

Publication number Publication date
SE346316B (en) 1972-07-03
BE637271A (en) 1900-01-01
FI42440C (en) 1970-08-10
CH482691A (en) 1969-12-15
FI42440B (en) 1970-04-30
NL297170A (en) 1900-01-01
GB1047935A (en) 1966-11-09
FI41280B (en) 1969-06-30
US3331830A (en) 1967-07-18
DE1445425A1 (en) 1968-10-31
FR3708M (en) 1965-11-29
FI41280C (en) 1969-10-10
US3331843A (en) 1967-07-18
LU44424A1 (en) 1963-11-11
SE320667B (en) 1970-02-16
BR6352303D0 (en) 1973-07-17
NO117694B (en) 1969-09-15

Similar Documents

Publication Publication Date Title
MC435A1 (en) Disubstituted 1,4-piperazines and process for their preparation
FR1403977A (en) Substituted polyamines and their preparation process
FR1357230A (en) New piperidines and process for their preparation
FR1528557A (en) Disubstituted piperazines-1, 4 and process for their preparation
FR1463813A (en) New amino-phenylketones and process for their preparation
FR1435787A (en) Novel 2, 1-benzisothiazoles and processes for their preparation
FR1463315A (en) Process and equipment for the preparation of purely 1, 3, 5-trioxane
FR1505838A (en) Novel carboxamido-alcoylbenzoxazines-1, 3 and process for their preparation
FR1501705A (en) 3,4-di-acyl pyridoxines and process for their preparation
FR1463834A (en) New 2, 3, 4, 5-tetrahydro-1, 4-methano-1h-3-benzazepines and process for their preparation
FR1417776A (en) Copolyether-esters and process for their preparation
FR1453061A (en) 1,3-diaryl-pyrazolines and process for their preparation
FR1541156A (en) New 3, 4-dihydro-quinazolines and process for their preparation
FR1432872A (en) Fluoropyridines and process for their preparation
FR1413497A (en) Polyamides and process for their preparation
FR1321323A (en) New beta-lactones and process for their preparation
FR1458701A (en) Perhydro-1, 2, 4-thiadiazine-dioxides- (1, 1) and process for their preparation
FR1344051A (en) 2, 3, 4-trichloroanthraquinone-1-carboxyalkyl esters and process for their preparation
FR1451985A (en) Process for the preparation of 7,16-dialkoyl-pregnans
FR1474703A (en) New 3, 3-difluoro-, 20, 20-difluoro- and 3, 3, 20, 20-tetra-fluoropregnans and process for their preparation
FR1327460A (en) Substituted phosphinamides and process for their preparation
FR1384989A (en) Fluorinated copolymers and process for their preparation
FR1419696A (en) Resinous composition and process for its preparation
FR1427645A (en) Organylmercaptoalkyl compounds and their preparation process
FR1417446A (en) Substituted trisulfonylmethanes and process for their preparation