MC1599A1 - Nouveaux derives de pyrimidine - Google Patents

Nouveaux derives de pyrimidine

Info

Publication number: MC1599A1
Authority: MC; Monaco
Prior art keywords: pyrimidine derivatives; agents; new pyrimidine; naphthyl; substituted
Prior art date: 1983-04-14

Application number

MC841700A

Other languages

English (en)

Inventor

Ivan Kompis

Hans Maag

Rita Locher

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-04-14

Filing date

1984-04-11

Publication date

1985-05-09

1984-04-11 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1985-05-09 Publication of MC1599A1 publication Critical patent/MC1599A1/fr

Links

229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title abstract 2
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
125000001624 naphthyl group Chemical group 0.000 abstract 2
-1 1,3-propylene Chemical group 0.000 abstract 1
208000035143 Bacterial infection Diseases 0.000 abstract 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
239000005977 Ethylene Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
239000003430 antimalarial agent Substances 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
ZZYXNRREDYWPLN-UHFFFAOYSA-N pyridine-2,3-diamine Chemical group NC1=CC=CN=C1N ZZYXNRREDYWPLN-UHFFFAOYSA-N 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
229940124530 sulfonamide Drugs 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Saccharide Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

MC841700A 1983-04-14 1984-04-11 Nouveaux derives de pyrimidine MC1599A1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CH200383		1983-04-14
CH63384		1984-02-10

Publications (1)

Publication Number	Publication Date
MC1599A1 true MC1599A1 (fr)	1985-05-09

Family

ID=25685195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MC841700A MC1599A1 (fr)	1983-04-14	1984-04-11	Nouveaux derives de pyrimidine

Country Status (19)

Country	Link
US (2)	US4590270A (fr)
EP (1)	EP0122580B1 (fr)
KR (1)	KR840008352A (fr)
AT (1)	ATE30423T1 (fr)
AU (1)	AU567731B2 (fr)
CA (1)	CA1244028A (fr)
DE (1)	DE3466988D1 (fr)
DK (1)	DK169984A (fr)
ES (3)	ES8602751A1 (fr)
FI (1)	FI841429A (fr)
GR (1)	GR81833B (fr)
HU (1)	HU193923B (fr)
IE (1)	IE57201B1 (fr)
IL (1)	IL71478A (fr)
MC (1)	MC1599A1 (fr)
NO (1)	NO158420C (fr)
NZ (1)	NZ207761A (fr)
PH (1)	PH20484A (fr)
PT (1)	PT78427B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1244028A (fr) *	1983-04-14	1988-11-01	Hans Maag	Derives de pyrimidine
US5260293A (en) *	1988-01-30	1993-11-09	Merck Sharp & Dohme Limited	Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia
NZ227684A (en) *	1988-01-30	1991-07-26	Merck Sharp & Dohme	Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
CA2095518A1 (fr) *	1990-11-14	1992-05-15	Jeffrey M. Blaney	Inhibition specifique de la dihydrofolate-reductase et composes utilises
GB9510459D0 (en)	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
EP0901490B1 (fr) *	1996-05-13	2004-04-07	Syngenta Limited	Amines bicycliques utilisees comme insecticides
GB9623944D0 (en) *	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
GB9624114D0 (en) *	1996-11-20	1997-01-08	Zeneca Ltd	Pesticidal bicyclic amine derivatives
GB9624611D0 (en) *	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
SK69299A3 (en)	1996-11-26	2000-01-18	Zeneca Ltd	8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, their preparation and their use as insecticides
ATE267199T1 (de)	1997-05-30	2004-06-15	Neurosearch As	8-azabicyclo(3,2,1)oct-2-en- und octanderivate als liganden der nicotinergen ach rezeptoren
AU2003234670B2 (en) *	2002-05-24	2010-06-10	Angiotech International Ag	Compositions and methods for coating medical implants
US8313760B2 (en) *	2002-05-24	2012-11-20	Angiotech International Ag	Compositions and methods for coating medical implants
CN102649786B (zh) *	2011-02-28	2014-08-27	郑州福源动物药业有限公司	一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
BR112018015924A2 (pt)	2016-02-05	2018-12-26	Vyera Pharmaceuticals Llc	composições e métodos para tratar infecções
AU2018312985A1 (en) *	2017-08-07	2020-02-27	Vyera Pharmaceuticals, LLC	DHFR inhibitors, compositions, and methods related thereto
US11472295B2 (en)	2018-12-27	2022-10-18	Msns, Llc	Regenerative braking energy dissipater and system and method of using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB762256A (en) *	1953-09-17	1956-11-28	Sterling Drug Inc	Tertiary-amino-substituted compounds of the tropane and granatanine series
US3133073A (en) *	1959-12-10	1964-05-12	Sterling Drug Inc	3-aryl-1, 5-iminocycloalkanes and preparation thereof
JPS4911710A (fr) *	1972-05-15	1974-02-01
US4053475A (en) *	1975-03-07	1977-10-11	Sterling Drug Inc.	N-[2-(Pyridinyl)-4-pyrimidinyl]ureas preparation
US4008235A (en) *	1975-03-07	1977-02-15	Sterling Drug Inc.	N-[2-(pyridinyl)-4-pyrimidinyl]ureas
US4109092A (en) *	1976-10-07	1978-08-22	Sterling Drug Inc.	Preparation of 2-(pyridinyl)-4-pyrimidinamines
FR2476088A2 (fr) *	1979-01-16	1981-08-21	Delalande Sa	Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2493848B2 (fr) *	1980-11-07	1986-05-16	Delalande Sa	Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
US4438267A (en) *	1980-11-11	1984-03-20	Daluge Susan M	Monoheteroring compounds and their use
CA1244028A (fr) *	1983-04-14	1988-11-01	Hans Maag	Derives de pyrimidine

1984
- 1984-03-26 CA CA000450447A patent/CA1244028A/fr not_active Expired
- 1984-03-27 DK DK169984A patent/DK169984A/da not_active IP Right Cessation
- 1984-04-06 NZ NZ207761A patent/NZ207761A/en unknown
- 1984-04-09 IL IL71478A patent/IL71478A/xx not_active IP Right Cessation
- 1984-04-09 AT AT84103964T patent/ATE30423T1/de not_active IP Right Cessation
- 1984-04-09 DE DE8484103964T patent/DE3466988D1/de not_active Expired
- 1984-04-09 EP EP84103964A patent/EP0122580B1/fr not_active Expired
- 1984-04-09 AU AU26642/84A patent/AU567731B2/en not_active Ceased
- 1984-04-09 US US06/598,119 patent/US4590270A/en not_active Expired - Fee Related
- 1984-04-11 GR GR74368A patent/GR81833B/el unknown
- 1984-04-11 HU HU841409A patent/HU193923B/hu unknown
- 1984-04-11 MC MC841700A patent/MC1599A1/fr unknown
- 1984-04-11 FI FI841429A patent/FI841429A/fi not_active Application Discontinuation
- 1984-04-13 PT PT78427A patent/PT78427B/pt unknown
- 1984-04-13 IE IE919/84A patent/IE57201B1/xx unknown
- 1984-04-13 NO NO841508A patent/NO158420C/no unknown
- 1984-04-13 ES ES531578A patent/ES8602751A1/es not_active Expired
- 1984-04-13 PH PH30545A patent/PH20484A/en unknown
- 1984-04-13 KR KR1019840001962A patent/KR840008352A/ko not_active Application Discontinuation
1985
- 1985-01-14 ES ES539536A patent/ES8601925A1/es not_active Expired
- 1985-01-14 ES ES539537A patent/ES8601184A1/es not_active Expired
1987
- 1987-10-23 US US07/112,908 patent/US4774249A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES531578A0 (es)	1985-12-01
DK169984D0 (da)	1984-03-27
HU193923B (en)	1987-12-28
FI841429A0 (fi)	1984-04-11
ES8602751A1 (es)	1985-12-01
FI841429A (fi)	1984-10-15
ATE30423T1 (de)	1987-11-15
IL71478A0 (en)	1984-07-31
ES539537A0 (es)	1985-11-01
US4590270A (en)	1986-05-20
AU567731B2 (en)	1987-12-03
NO158420C (no)	1988-09-07
NO841508L (no)	1984-10-15
ES539536A0 (es)	1985-11-16
NZ207761A (en)	1987-01-23
ES8601925A1 (es)	1985-11-16
ES8601184A1 (es)	1985-11-01
DE3466988D1 (en)	1987-12-03
HUT34017A (en)	1985-01-28
GR81833B (fr)	1984-12-12
EP0122580B1 (fr)	1987-10-28
PH20484A (en)	1987-01-16
PT78427B (en)	1986-08-22
IL71478A (en)	1987-07-31
DK169984A (da)	1984-10-15
US4774249A (en)	1988-09-27
IE57201B1 (en)	1992-06-03
CA1244028A (fr)	1988-11-01
NO158420B (no)	1988-05-30
KR840008352A (ko)	1984-12-14
IE840919L (en)	1984-10-14
PT78427A (en)	1984-05-01
EP0122580A1 (fr)	1984-10-24
AU2664284A (en)	1984-10-18

Legal Events

Date	Code	Title	Description
1988-03-03	YP	Annual fee paid
1991-08-21	YP	Annual fee paid

Publication	Publication Date	Title
MC1599A1 (fr)	1985-05-09	Nouveaux derives de pyrimidine
YU194691A (sh)	1994-01-20	Benzodiazepinoni
NO863790D0 (no)	1986-09-23	Kinolinderivater.
AU578395B2 (en)	1988-10-20	Antiallergic 5-alkyl-1-phenyl-2-piperazinoalkyl-pyrazoline- 3-one compounds
ES8403108A1 (es)	1984-03-01	Un procedimiento para preparar azetidinas.
DE59905341D1 (de)	2003-06-05	Verwendung von Oxathiazolonen als Mikrobizide
SE7609222L (sv)	1977-02-21	Alkylsulfonylaminosubstituerade heterocykler
FI842360A0 (fi)	1984-06-12	Nya 1-acetonyl-2-(fenylimino)-imidazo lidiner, deras syraadditionssalter, dessa innehaollande laekemedel och foerfarande foer deras framstaellning.
YU166291A (sh)	1994-04-05	Indenoindol jedinjenja
DE3865521D1 (de)	1991-11-21	4-methyl-4-phenyl-1-pentanale, deren herstellung und verwendung als riechstoffe.
DE59102829D1 (de)	1994-10-13	Ergolinderivate.