MA46968A - Procédés d'induction de tolérance immunitaire à des facteurs de coagulation - Google Patents
Procédés d'induction de tolérance immunitaire à des facteurs de coagulationInfo
- Publication number
- MA46968A MA46968A MA046968A MA46968A MA46968A MA 46968 A MA46968 A MA 46968A MA 046968 A MA046968 A MA 046968A MA 46968 A MA46968 A MA 46968A MA 46968 A MA46968 A MA 46968A
- Authority
- MA
- Morocco
- Prior art keywords
- induction
- methods
- coagulation factors
- immune tolerance
- immune
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662429516P | 2016-12-02 | 2016-12-02 | |
US201762466937P | 2017-03-03 | 2017-03-03 | |
US201762529866P | 2017-07-07 | 2017-07-07 | |
US201762558790P | 2017-09-14 | 2017-09-14 | |
US201762582829P | 2017-11-07 | 2017-11-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA46968A true MA46968A (fr) | 2019-10-09 |
Family
ID=61006303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA046968A MA46968A (fr) | 2016-12-02 | 2017-12-01 | Procédés d'induction de tolérance immunitaire à des facteurs de coagulation |
Country Status (13)
Country | Link |
---|---|
US (1) | US20200085915A1 (fr) |
EP (1) | EP3548063A1 (fr) |
JP (2) | JP2019536794A (fr) |
KR (1) | KR20190091292A (fr) |
CN (1) | CN110520149A (fr) |
AU (1) | AU2017368328A1 (fr) |
BR (1) | BR112019011198A2 (fr) |
CA (1) | CA3044838A1 (fr) |
IL (1) | IL266970A (fr) |
MA (1) | MA46968A (fr) |
MX (1) | MX2019006446A (fr) |
TW (2) | TW201821101A (fr) |
WO (1) | WO2018102760A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10588949B2 (en) | 2013-03-15 | 2020-03-17 | Bioverativ Therapeutics Inc. | Factor IX polypeptide formulations |
AU2019270184A1 (en) | 2018-05-18 | 2020-11-26 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia A |
CN114364796B (zh) * | 2019-09-02 | 2023-07-11 | 甘李药业股份有限公司 | 嵌合蛋白 |
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CN108530543B (zh) | 2009-02-03 | 2023-06-23 | 阿穆尼克斯制药公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
JP5805634B2 (ja) | 2009-06-08 | 2015-11-04 | アムニクス オペレーティング インコーポレイテッド | 成長ホルモンポリペプチド並びにその作成及び使用方法 |
JP5839597B2 (ja) | 2009-06-08 | 2016-01-06 | アムニクス オペレーティング インコーポレイテッド | グルコース調節ポリペプチド並びにその作成及び使用方法 |
CA2772051C (fr) | 2009-08-24 | 2020-08-18 | Amunix Operating Inc. | Compositions de facteur ix de coagulation et leurs procedes de fabrication et d'utilisation |
WO2011028344A2 (fr) | 2009-08-25 | 2011-03-10 | Amunix Operating Inc. | Compositions d'antagonistes des récepteurs d'interleukine-1 et leurs procédés de préparation et d'utilisation |
EP3453402B1 (fr) | 2012-01-12 | 2021-07-21 | Bioverativ Therapeutics Inc. | Réduction de l'immunogénicité contre le facteur viii chez les individus soumis à un traitement par facteur viii |
HUE046396T2 (hu) | 2012-01-12 | 2020-02-28 | Bioverativ Therapeutics Inc | Kiméra faktor VIII polipeptidek és ezek alkalmazása |
EA201491470A1 (ru) | 2012-02-15 | 2015-01-30 | Амуникс Оперэйтинг Инк. | Композиции фактора viii и способы получения и использования подобных |
CN110054699A (zh) | 2012-07-11 | 2019-07-26 | 比奥贝拉蒂治疗公司 | 具有xten和血管性血友病因子蛋白的因子viii复合物、及其用途 |
EP4122487A1 (fr) | 2013-03-15 | 2023-01-25 | Bioverativ Therapeutics Inc. | Formulations de polypeptide de facteur viii |
EP4389139A2 (fr) | 2014-01-10 | 2024-06-26 | Bioverativ Therapeutics Inc. | Protéines chimériques du facteur viii et leurs utilisations |
-
2017
- 2017-12-01 MX MX2019006446A patent/MX2019006446A/es unknown
- 2017-12-01 BR BR112019011198A patent/BR112019011198A2/pt unknown
- 2017-12-01 CN CN201780085212.6A patent/CN110520149A/zh active Pending
- 2017-12-01 EP EP17832387.9A patent/EP3548063A1/fr active Pending
- 2017-12-01 KR KR1020197018601A patent/KR20190091292A/ko not_active IP Right Cessation
- 2017-12-01 AU AU2017368328A patent/AU2017368328A1/en active Pending
- 2017-12-01 US US16/464,105 patent/US20200085915A1/en active Pending
- 2017-12-01 MA MA046968A patent/MA46968A/fr unknown
- 2017-12-01 WO PCT/US2017/064323 patent/WO2018102760A1/fr unknown
- 2017-12-01 CA CA3044838A patent/CA3044838A1/fr active Pending
- 2017-12-01 JP JP2019529527A patent/JP2019536794A/ja active Pending
- 2017-12-04 TW TW106142381A patent/TW201821101A/zh unknown
- 2017-12-04 TW TW112115972A patent/TW202408564A/zh unknown
-
2019
- 2019-05-29 IL IL266970A patent/IL266970A/en unknown
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2022
- 2022-12-09 JP JP2022196725A patent/JP2023027231A/ja active Pending
Also Published As
Publication number | Publication date |
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CN110520149A (zh) | 2019-11-29 |
US20200085915A1 (en) | 2020-03-19 |
CA3044838A1 (fr) | 2018-06-07 |
AU2017368328A1 (en) | 2019-07-18 |
JP2019536794A (ja) | 2019-12-19 |
IL266970A (en) | 2019-07-31 |
WO2018102760A1 (fr) | 2018-06-07 |
JP2023027231A (ja) | 2023-03-01 |
EP3548063A1 (fr) | 2019-10-09 |
MX2019006446A (es) | 2019-12-11 |
KR20190091292A (ko) | 2019-08-05 |
TW202408564A (zh) | 2024-03-01 |
BR112019011198A2 (pt) | 2019-12-17 |
TW201821101A (zh) | 2018-06-16 |
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