MA46359A - Protéines de liaison à l'antigène à viscosité faible et leurs procédés de préparation - Google Patents

Protéines de liaison à l'antigène à viscosité faible et leurs procédés de préparation

Info

Publication number
MA46359A
MA46359A MA046359A MA46359A MA46359A MA 46359 A MA46359 A MA 46359A MA 046359 A MA046359 A MA 046359A MA 46359 A MA46359 A MA 46359A MA 46359 A MA46359 A MA 46359A
Authority
MA
Morocco
Prior art keywords
antigen binding
low viscosity
binding proteins
preparation processes
processes
Prior art date
Application number
MA046359A
Other languages
English (en)
Inventor
Neeraj Jagdish Agrawal
Pavel Bondarenko
Joon Huh
Andrew Nichols
Da Ren
Richard Smith
Riki Stevenson
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of MA46359A publication Critical patent/MA46359A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N11/00—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties
    • G01N11/10—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material
    • G01N11/14—Investigating flow properties of materials, e.g. viscosity, plasticity; Analysing materials by determining flow properties by moving a body within the material by using rotary bodies, e.g. vane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA046359A 2016-09-29 2017-09-28 Protéines de liaison à l'antigène à viscosité faible et leurs procédés de préparation MA46359A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662401770P 2016-09-29 2016-09-29
US201662430773P 2016-12-06 2016-12-06
US201762546469P 2017-08-16 2017-08-16

Publications (1)

Publication Number Publication Date
MA46359A true MA46359A (fr) 2019-08-07

Family

ID=60245172

Family Applications (1)

Application Number Title Priority Date Filing Date
MA046359A MA46359A (fr) 2016-09-29 2017-09-28 Protéines de liaison à l'antigène à viscosité faible et leurs procédés de préparation

Country Status (14)

Country Link
US (2) US11059908B2 (fr)
EP (1) EP3519439A2 (fr)
JP (3) JP2019532063A (fr)
KR (2) KR20230107696A (fr)
CN (1) CN110036031A (fr)
AU (1) AU2017336673A1 (fr)
CA (1) CA3038909A1 (fr)
CL (2) CL2019000835A1 (fr)
IL (2) IL307684A (fr)
MA (1) MA46359A (fr)
MX (1) MX2019003727A (fr)
SG (1) SG10201912565QA (fr)
WO (1) WO2018064307A2 (fr)
ZA (1) ZA201902297B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6454547B2 (ja) * 2011-07-06 2019-01-16 ゲンマブ エー／エス 抗体重鎖のｃ末端の修飾による補体依存性細胞傷害の調節
EP2953634B1 (fr) 2013-02-07 2021-05-26 The General Hospital Corporation Procédés d'expansion ou de déplétion de lymphocytes t régulateurs
WO2016010927A1 (fr) * 2014-07-14 2016-01-21 Amgen Inc. Formulations d'anticorps cristallins
KR102534017B1 (ko) 2014-10-23 2023-05-19 암젠 인크 약제학적 제형의 점도 감소
WO2017197331A2 (fr) 2016-05-13 2017-11-16 The General Hospital Corporation Anticorps antagonistes de la superfamille du récepteur du facteur de nécrose contre les tumeurs
JP7377596B2 (ja) 2017-02-22 2023-11-10 アムジエン・インコーポレーテツド 低粘度、高濃度エボロクマブ製剤及びそれらの製造方法
KR20190132215A (ko) 2018-05-18 2019-11-27 서울반도체 주식회사 발광 다이오드, 발광 다이오드 모듈 및 그것을 갖는 표시 장치
US20210340268A1 (en) * 2018-08-20 2021-11-04 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily polypeptides
US20220177581A1 (en) * 2019-03-11 2022-06-09 Memorial Sloan Kettering Cancer Center Cd22 antibodies and methods of using the same
GB2590642B (en) * 2019-12-20 2024-02-14 Kymab Ltd Improved lambda antibodies
KR20220038356A (ko) * 2019-06-26 2022-03-28 아뮤닉스 파마슈티컬스, 인크. Egfr 항원 결합 단편 및 이를 포함하는 조성물
AU2021246922A1 (en) * 2020-03-30 2022-10-20 Crystal Bioscience Inc. Anti-GIPR antibody and methods of use thereof
CN113512116B (zh) * 2020-04-10 2022-09-20 苏州普乐康医药科技有限公司 一种抗igf-1r抗体及其应用
US20230340082A1 (en) * 2020-07-10 2023-10-26 The Wistar Institute Of Anatomy And Biology Dna antibody constructs for use against rotavirus

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (fr) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Récepteurs chimériques par liaison et expression de l'ADN
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
DE69133566T2 (de) 1990-01-12 2007-12-06 Amgen Fremont Inc. Bildung von xenogenen Antikörpern
UY33679A (es) 2010-10-22 2012-03-30 Esbatech Anticuerpos estables y solubles
MX2013010172A (es) 2011-03-11 2013-10-25 Amgen Inc Metodo de analisis mutacional correlacionado para mejorar anticuerpos terapeuticos.
JOP20200043A1 (ar) * 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
HRP20211641T1 (hr) * 2012-07-13 2022-02-04 Roche Glycart Ag Bispecifična protutijela anti-vegf/anti-ang-2 i njihova primjena u liječenju vaskularnih očnih bolesti
CA2904805A1 (fr) 2013-04-29 2014-11-06 F. Hoffmann-La Roche Ag Anticorps asymetriques modifies liant a la recepteur fc et procedes d'utilisation
EP3026061A1 (fr) * 2014-11-26 2016-06-01 Novo Nordisk A/S Mutagenèse dirigée sur site d'anticorps trem-1 pour diminuer la viscosite
MX2018007859A (es) 2015-12-23 2018-11-09 Amgen Inc Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1.

Also Published As

Publication number Publication date
EP3519439A2 (fr) 2019-08-07
JP2023178409A (ja) 2023-12-14
US11993663B2 (en) 2024-05-28
JP2022081654A (ja) 2022-05-31
WO2018064307A3 (fr) 2018-07-05
US20210371544A1 (en) 2021-12-02
KR102551269B1 (ko) 2023-07-05
US11059908B2 (en) 2021-07-13
IL265692A (en) 2019-05-30
JP2019532063A (ja) 2019-11-07
IL307684A (en) 2023-12-01
CA3038909A1 (fr) 2018-04-05
ZA201902297B (en) 2019-12-18
IL265692B1 (en) 2023-11-01
IL265692B2 (en) 2024-03-01
WO2018064307A4 (fr) 2018-09-27
CL2021003596A1 (es) 2022-08-19
MX2019003727A (es) 2019-08-05
KR20190053271A (ko) 2019-05-17
CN110036031A (zh) 2019-07-19
US20190233543A1 (en) 2019-08-01
AU2017336673A1 (en) 2019-04-18
SG10201912565QA (en) 2020-02-27
WO2018064307A2 (fr) 2018-04-05
KR20230107696A (ko) 2023-07-17
CL2019000835A1 (es) 2019-05-31

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