MA46064B1 - Pyridin-2- (1h) -one-quinolinone derivatives as isocitrate dehydrogenase inhibitors - Google Patents

Pyridin-2- (1h) -one-quinolinone derivatives as isocitrate dehydrogenase inhibitors

Info

Publication number
MA46064B1
MA46064B1 MA46064A MA46064A MA46064B1 MA 46064 B1 MA46064 B1 MA 46064B1 MA 46064 A MA46064 A MA 46064A MA 46064 A MA46064 A MA 46064A MA 46064 B1 MA46064 B1 MA 46064B1
Authority
MA
Morocco
Prior art keywords
pyridin
isocitrate dehydrogenase
dehydrogenase inhibitors
quinolinone derivatives
quinolinone
Prior art date
Application number
MA46064A
Other languages
French (fr)
Other versions
MA46064A (en
Inventor
Susan Ashwell
Ann-Marie Campbell
Justin Andrew Caravella
R Bruce Diebold
Anna Ericsson
Gary Gustafson
Jian Lin
Wei Lu
Zhongguo Wang
David R Lancia Jr
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of MA46064A publication Critical patent/MA46064A/en
Publication of MA46064B1 publication Critical patent/MA46064B1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cette invention concerne des inhibiteurs de protéines d'isocitrate déshydrogénase mutantes (mt-idh) ayant une activité néomorphe, utiles pour traiter les troubles liés à la prolifération cellulaire et les cancers, de formule : (i) où a, u, w1, w2, w3, r1-r6, et r9 sont tels que décrits dans la présente.This invention relates to mutant isocitrate dehydrogenase (mt-idh) protein inhibitors having neomorphic activity useful for treating cell proliferation-related disorders and cancers of the formula: (i) where a, u, w1, w2 , w3, r1-r6, and r9 are as described herein.

MA46064A 2014-09-19 2015-09-18 Pyridin-2- (1h) -one-quinolinone derivatives as isocitrate dehydrogenase inhibitors MA46064B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462053006P 2014-09-19 2014-09-19
US201562128089P 2015-03-04 2015-03-04
US201562150812P 2015-04-21 2015-04-21

Publications (2)

Publication Number Publication Date
MA46064A MA46064A (en) 2019-07-03
MA46064B1 true MA46064B1 (en) 2020-04-30

Family

ID=58698665

Family Applications (1)

Application Number Title Priority Date Filing Date
MA46064A MA46064B1 (en) 2014-09-19 2015-09-18 Pyridin-2- (1h) -one-quinolinone derivatives as isocitrate dehydrogenase inhibitors

Country Status (3)

Country Link
AR (1) AR101976A1 (en)
HR (1) HRP20182176T1 (en)
MA (1) MA46064B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107556366A (en) * 2016-06-30 2018-01-09 上海海和药物研究开发有限公司 Compound, preparation method and the usage with saltant type isocitric dehydrogenase inhibitory activity
BR112023024454A2 (en) * 2021-06-15 2024-02-06 Wigen Biomedicine Tech Shanghai Co Ltd COMPOUND OF GENERAL FORMULA (1) OR AN ISOMER, A CRYSTALLINE FORM, A PHARMACEUTICALLY ACCEPTABLE SALT, A HYDRATE OR A SOLVATE THEREOF; AND; USE OF THE COMPOUND OR ISOMER

Also Published As

Publication number Publication date
MA46064A (en) 2019-07-03
HRP20182176T1 (en) 2019-02-22
AR101976A1 (en) 2017-01-25

Similar Documents

Publication Publication Date Title
MA40481A (en) PYRIDIN-2- (1H) -ONE-QUINOLINONE DERIVATIVES AS MUTANT ISOCITRATE DEHYDROGENASE INHIBITORS
PH12019502264A1 (en) Fused imidazo-piperidine jak inhibitors compound
PH12018500268A1 (en) 2-amino-3-fluoro-3-(fluoromethyl)-6-methyl-6-phenyl-3,4,5,6-tetrahydropyridins as bace1 inhibitors
EA201892151A1 (en) METHOD OF SYNTHESIS 2-HYDROXY-6 - ((2- (1-IZOPROPIL-1H-PYRAZOL-5-IL) Pyridine-3-IL) METHOXY) BENZALDEHYDE
PH12017500841A1 (en) 2-amino-6-(difluoromethyl)- 5,5-difluoro-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors
MA41238B1 (en) 5 - [(piperazin-1-yl) -3-oxo-propyl] -imidazolidine-2,4-dione derivatives as adamt inhibitors for the treatment of osteoarthritis
EA201792047A1 (en) NEW CONNECTIONS
AU2015293541B2 (en) Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof
MA39172B1 (en) Heterocyclic bicyclic derivatives as bromodomaine inhibitors
EA201790806A1 (en) IMMUNOREGULATING AGENTS
MA39193A1 (en) Gpr6 modulators based on tetrahydropyridopyrazines
EA201691428A1 (en) BICYCLIC HETEROCYCLIC DERIVATIVES AS IRAK4 INHIBITORS
EA201690199A1 (en) Drug for the treatment of non-alcoholic fatty liver disease
PH12017501043A1 (en) 2-amino-5,5-difluoro-6-(fluoromethyl)-6-phenyl-3,4,5,6-tetrahydropyridines as bace1 inhibitors
MA40993A (en) 4-OXO-3,4-DIHYDRO-1,2,3-BENZOTRIAZINE DERIVATIVES AS GPR139 MODULATORS
NZ721645A (en) Compounds for use as gpr120 agonists
EA201691997A1 (en) 2,4-TIAZOLINIDON DERIVATIVES IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM
MA39335B1 (en) Tetrazolone-substituted dihydropyridinone mgat2 inhibitors
MA40875A (en) 2,4-DIAMINO-QUINOLEIN SUBSTITUTED AS NEW ANTI-CANCER AGENTS
MA34545B1 (en) CO-CRYSTALS AND SALTS OF CCR3 INHIBITORS
MA34968B1 (en) ASYMMETRIC UREA AND MEDICAL USES THEREOF
PH12016501941B1 (en) Use of heterocyclic compounds for controlling nematodes
MA39983A (en) CARBOXAMIDE DERIVATIVES
EA202190272A1 (en) ADDITIONALLY SUBSTITUTED TRIAZOLOQUINOXALINE DERIVATIVES
EA202190271A1 (en) SUBSTITUTED TRIAZOLOQUINOXALINE DERIVATIVES