MA44227A - Anticorps pour il-17c - Google Patents

Anticorps pour il-17c

Info

Publication number
MA44227A
MA44227A MA044227A MA44227A MA44227A MA 44227 A MA44227 A MA 44227A MA 044227 A MA044227 A MA 044227A MA 44227 A MA44227 A MA 44227A MA 44227 A MA44227 A MA 44227A
Authority
MA
Morocco
Prior art keywords
antibodies
fragments
relates
antibody
psoriasis
Prior art date
Application number
MA044227A
Other languages
English (en)
Other versions
MA44227B1 (fr
Inventor
Jan Dominik Haas
Jürgen Klattig
Nick Ernest René Vandeghinste
Original Assignee
Galapagos Nv
Morphosys Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galapagos Nv, Morphosys Ag filed Critical Galapagos Nv
Publication of MA44227A publication Critical patent/MA44227A/fr
Publication of MA44227B1 publication Critical patent/MA44227B1/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne des anticorps ou des fragments d'anticorps se liant à l'il-17c humaine. En particulier, l'invention concerne des anticorps ou des fragments d'anticorps qui présentent des propriétés bénéfiques combinées et sont donc utiles pour le traitement d'êtres humains présentant, par exemple, une dermatite atopique ou un psoriasis.
MA44227A 2016-02-19 2017-02-17 Anticorps pour il-17c MA44227B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16156582 2016-02-19
EP16156651 2016-02-22
PCT/EP2017/053592 WO2017140831A1 (fr) 2016-02-19 2017-02-17 Anticorps anti-il-17c

Publications (2)

Publication Number Publication Date
MA44227A true MA44227A (fr) 2018-12-26
MA44227B1 MA44227B1 (fr) 2021-06-30

Family

ID=58057136

Family Applications (2)

Application Number Title Priority Date Filing Date
MA44227A MA44227B1 (fr) 2016-02-19 2017-02-17 Anticorps pour il-17c
MA43088A MA43088B1 (fr) 2016-02-19 2017-02-17 Anticorps anti-il-17c

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA43088A MA43088B1 (fr) 2016-02-19 2017-02-17 Anticorps anti-il-17c

Country Status (32)

Country Link
US (4) US20190048071A1 (fr)
EP (1) EP3416983B1 (fr)
JP (2) JP6535139B2 (fr)
KR (1) KR20180109977A (fr)
CN (1) CN108699143B (fr)
AU (1) AU2017219837B2 (fr)
BR (1) BR112018016798A2 (fr)
CA (1) CA3014842A1 (fr)
CL (1) CL2018002340A1 (fr)
CO (1) CO2018008724A2 (fr)
CU (1) CU20180087A7 (fr)
CY (1) CY1124296T1 (fr)
DK (1) DK3416983T3 (fr)
EA (1) EA037813B1 (fr)
EC (1) ECSP18070641A (fr)
ES (1) ES2877376T3 (fr)
HR (1) HRP20211059T1 (fr)
HU (1) HUE054755T2 (fr)
IL (1) IL260733B2 (fr)
LT (1) LT3416983T (fr)
MA (2) MA44227B1 (fr)
MD (1) MD3416983T2 (fr)
MX (1) MX2018009860A (fr)
PH (1) PH12018501739A1 (fr)
PL (1) PL3416983T3 (fr)
RS (1) RS62012B1 (fr)
SG (1) SG11201806161TA (fr)
SI (1) SI3416983T1 (fr)
TN (1) TN2018000289A1 (fr)
TW (1) TW201734041A (fr)
WO (1) WO2017140831A1 (fr)
ZA (1) ZA201806249B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190048071A1 (en) 2016-02-19 2019-02-14 Morphosys Ag Antibodies for il-17c
TW201919698A (zh) 2017-09-25 2019-06-01 德商莫菲西斯公司 異位性皮炎之治療
GB201803563D0 (en) 2018-03-06 2018-04-18 Galapagos Nv Antibodies and pharmaceutical compositions thereof for the treatment of autoimmune skin diseases
TW202011995A (zh) 2018-07-03 2020-04-01 比利時商葛萊伯格有限公司 高濃度液體抗體配製物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
ES2301198T3 (es) 1997-06-12 2008-06-16 Novartis International Pharmaceutical Ltd. Polipeptidos artificiales de anticuerpos.
EP2333069A3 (fr) * 1998-05-15 2011-09-14 Genentech, Inc. Utilisations therapeutiques de polypeptides homologues de il-17
DK1144607T5 (da) 1999-07-20 2009-10-05 Morphosys Ag Fremgangsmåde til præsentation af (poly)peptider/proteiner på bakteriofage partikler via disulfidbindinger
US7771951B2 (en) 2001-12-03 2010-08-10 Amgen Fremont Inc. Antibody categorization based on binding characteristics
EA200700823A1 (ru) 2004-10-18 2008-02-28 Займодженетикс, Инк., Сша Растворимый zcytor21, анти-zcytor21 антитела и связывающие партнёры и способы применения при воспалении
US20070129302A1 (en) * 2005-10-18 2007-06-07 Zeren Gao Il-17c antagonists and methods of using the same
CA2666842A1 (fr) 2006-10-18 2008-04-24 Zymogenetics, Inc. Antagonistes de l'il-17c et leurs procedes d'utilisation
TW201307385A (zh) * 2010-10-25 2013-02-16 Genentech Inc 胃腸炎症和銀屑病以及哮喘的治療
SG10201509257VA (en) 2010-11-19 2015-12-30 Morphosys Ag A collection and methods for its use
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
ES2669984T3 (es) * 2011-10-19 2018-05-29 Morphosys Ag Antagonistas de IL17C para el tratamiento de trastornos inflamatorios
DK2858670T3 (en) 2012-06-12 2018-10-22 Orega Biotech Antagonists of IL-17 isoforms and their applications
AU2015367684A1 (en) * 2014-12-15 2017-07-06 Galapagos Nv Antibodies for IL-17C
US20190048071A1 (en) 2016-02-19 2019-02-14 Morphosys Ag Antibodies for il-17c

Also Published As

Publication number Publication date
US20180340024A1 (en) 2018-11-29
PH12018501739A1 (en) 2019-06-10
IL260733A (fr) 2018-09-20
AU2017219837B2 (en) 2023-08-17
ECSP18070641A (es) 2018-10-31
JP2019162119A (ja) 2019-09-26
KR20180109977A (ko) 2018-10-08
TN2018000289A1 (en) 2020-01-16
ZA201806249B (en) 2020-02-26
IL260733B1 (en) 2023-11-01
US10259869B2 (en) 2019-04-16
SI3416983T1 (sl) 2021-08-31
MD3416983T2 (ro) 2021-08-31
US20190048071A1 (en) 2019-02-14
EP3416983B1 (fr) 2021-04-07
US20200216529A1 (en) 2020-07-09
JP6916834B2 (ja) 2021-08-11
MA43088B1 (fr) 2020-10-28
CN108699143B (zh) 2021-11-09
HUE054755T2 (hu) 2021-09-28
EA037813B1 (ru) 2021-05-24
LT3416983T (lt) 2021-07-12
JP2019511910A (ja) 2019-05-09
EP3416983A1 (fr) 2018-12-26
ES2877376T3 (es) 2021-11-16
PL3416983T3 (pl) 2021-10-25
CN108699143A (zh) 2018-10-23
CU20180087A7 (es) 2019-03-04
RS62012B1 (sr) 2021-07-30
US10633439B2 (en) 2020-04-28
CO2018008724A2 (es) 2018-08-31
EA201891594A1 (ru) 2019-01-31
MA44227B1 (fr) 2021-06-30
SG11201806161TA (en) 2018-08-30
BR112018016798A2 (pt) 2018-12-26
IL260733B2 (en) 2024-03-01
WO2017140831A1 (fr) 2017-08-24
DK3416983T3 (en) 2021-06-21
MA43088A1 (fr) 2019-05-31
JP6535139B2 (ja) 2019-06-26
CA3014842A1 (fr) 2017-08-24
HRP20211059T1 (hr) 2021-10-01
AU2017219837A1 (en) 2018-08-09
MX2018009860A (es) 2019-03-28
CL2018002340A1 (es) 2018-11-23
TW201734041A (zh) 2017-10-01
CY1124296T1 (el) 2022-11-25
US20190202906A1 (en) 2019-07-04
US11987621B2 (en) 2024-05-21

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