MA42290B1 - Gel fluide ophtalmique de bimatoprost - Google Patents
Gel fluide ophtalmique de bimatoprostInfo
- Publication number
- MA42290B1 MA42290B1 MA42290A MA42290A MA42290B1 MA 42290 B1 MA42290 B1 MA 42290B1 MA 42290 A MA42290 A MA 42290A MA 42290 A MA42290 A MA 42290A MA 42290 B1 MA42290 B1 MA 42290B1
- Authority
- MA
- Morocco
- Prior art keywords
- amount
- weight
- bimatoprost
- ophthalmic
- viscosity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
L'invention concerne un gel ophtalmique administrable sous forme de gouttes, ledit gel ayant une composition comprenant du bimatoprost en une quantité comprise entre 0,003 et 0,03 % en poids, du polyacrylate en une quantité > 0,2 % en poids, de la polyvidone (pvp), du dextrane, des polyéthylène glycols (peg), de la carboxyméthyl cellulose (cmc) ou de l'alcool polyvinylique (pva) en une quantité comprise entre 0,2 et 10 % en poids, un agent d'isotonisation en une quantité permettant d'atteindre une osmolalité comprise entre 200 et 400 mosml/kg, un sel pour régler la viscosité en une quantité comprise entre 0,05 et 0,4 % en poids, une base en une quantité permettant de régler le ph compris entre 6 et 8 et des excipients normalement utilisés dans des gels ophtalmiques, à une viscosité se situant dans la plage comprise entre 200 et 2 000 mpa·s.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15171233.8A EP3103439B1 (fr) | 2015-06-09 | 2015-06-09 | Gel ophtalmique de bimatoprost applicable en gouttes |
EP16729525.2A EP3307241B8 (fr) | 2015-06-09 | 2016-06-08 | Gel fluide ophtalmique de bimatoprost |
PCT/EP2016/062990 WO2016198434A1 (fr) | 2015-06-09 | 2016-06-08 | Gel ophthalmique à base de bimatoprost administrable sous forme de gouttes |
Publications (2)
Publication Number | Publication Date |
---|---|
MA42290A MA42290A (fr) | 2016-12-15 |
MA42290B1 true MA42290B1 (fr) | 2018-11-30 |
Family
ID=53298285
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA42290A MA42290B1 (fr) | 2015-06-09 | 2016-06-08 | Gel fluide ophtalmique de bimatoprost |
Country Status (28)
Country | Link |
---|---|
US (1) | US10314780B2 (fr) |
EP (2) | EP3103439B1 (fr) |
JP (1) | JP6342087B1 (fr) |
KR (1) | KR101889878B1 (fr) |
CN (1) | CN107771074B (fr) |
AU (1) | AU2016277336B2 (fr) |
BR (1) | BR112017026552B1 (fr) |
CA (1) | CA2985897C (fr) |
CY (1) | CY1120883T1 (fr) |
DK (1) | DK3307241T3 (fr) |
ES (2) | ES2747302T3 (fr) |
HK (1) | HK1247118A1 (fr) |
HR (1) | HRP20181840T1 (fr) |
IL (1) | IL256071B (fr) |
LT (1) | LT3307241T (fr) |
MA (1) | MA42290B1 (fr) |
MX (1) | MX2017015835A (fr) |
PL (2) | PL3103439T3 (fr) |
PT (1) | PT3307241T (fr) |
RS (1) | RS57948B1 (fr) |
RU (1) | RU2698456C2 (fr) |
SA (1) | SA517390480B1 (fr) |
SG (1) | SG11201708642VA (fr) |
SI (1) | SI3307241T1 (fr) |
TN (1) | TN2017000445A1 (fr) |
TR (1) | TR201815791T4 (fr) |
UA (1) | UA121139C2 (fr) |
WO (1) | WO2016198434A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112566622A (zh) * | 2018-06-19 | 2021-03-26 | 细胞疗法有限责任公司 | 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送*** |
CN110200904B (zh) * | 2019-05-27 | 2021-07-23 | 上海昊海生物科技股份有限公司 | 一种降眼压缓释滴眼组合物及其制备方法 |
US11786538B2 (en) | 2019-12-11 | 2023-10-17 | Somerset Therapeutics, Llc | Low benzalkonium chloride bimatoprost ophthalmic compositions with effective penetration and preservation properties |
US20230293541A1 (en) | 2022-03-21 | 2023-09-21 | Somerset Therapeutics, Llc | Methods of treating ophthalmic conditions with enhanced penetration compositions of bimatoprost and timolol |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4209722C3 (de) * | 1992-03-25 | 1997-06-19 | Medproject Pharma Entwicklungs | Tropfbares Gel für die Augenheilkunde |
DE10132876A1 (de) * | 2001-07-06 | 2003-01-30 | Medproject Pharma Entwicklungs | Zweiphasige, tropfbare Hydrogele zur Anwendung am Auge |
GB0501192D0 (en) * | 2005-01-20 | 2005-03-02 | Resolution Chemicals Ltd | Stable prostaglandin-containing compositions |
US7851504B2 (en) | 2005-03-16 | 2010-12-14 | Allergan, Inc. | Enhanced bimatoprost ophthalmic solution |
FR2918891B1 (fr) * | 2007-07-20 | 2009-09-25 | Thea Sa Lab | Solution ophtalmique a base de prostaglandines sans conservateur |
EP2127638A1 (fr) | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Procédé et composition pour traiter l'hypertension oculaire et le glaucome |
FR2961694B1 (fr) * | 2010-06-29 | 2013-01-25 | Thea Lab | Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur |
EP2598117A2 (fr) | 2010-07-29 | 2013-06-05 | Allergan, Inc. | Solutions de bimatoprost sans conservateur |
EP2714007A2 (fr) * | 2011-05-27 | 2014-04-09 | Ratiopharm GmbH | Préparation ophtalmique contenant un analogue de pgf2alpha |
CA2841969A1 (fr) * | 2011-07-20 | 2013-01-24 | Allergan, Inc. | Combinaison a dose fixe de bimatoprost et brimonidine |
CN104288092A (zh) * | 2013-07-16 | 2015-01-21 | 广东东阳光药业有限公司 | 拉坦前列素滴眼剂 |
CN104622798B (zh) * | 2014-12-05 | 2017-12-22 | 广东东阳光药业有限公司 | 一种含有他氟前列素的滴眼液及其制备方法 |
-
2015
- 2015-06-09 EP EP15171233.8A patent/EP3103439B1/fr active Active
- 2015-06-09 ES ES15171233T patent/ES2747302T3/es active Active
- 2015-06-09 PL PL15171233T patent/PL3103439T3/pl unknown
-
2016
- 2016-06-08 MA MA42290A patent/MA42290B1/fr unknown
- 2016-06-08 KR KR1020177033703A patent/KR101889878B1/ko active IP Right Grant
- 2016-06-08 EP EP16729525.2A patent/EP3307241B8/fr active Active
- 2016-06-08 DK DK16729525.2T patent/DK3307241T3/en active
- 2016-06-08 PL PL16729525T patent/PL3307241T3/pl unknown
- 2016-06-08 TR TR2018/15791T patent/TR201815791T4/tr unknown
- 2016-06-08 UA UAA201800181A patent/UA121139C2/uk unknown
- 2016-06-08 SI SI201630107T patent/SI3307241T1/sl unknown
- 2016-06-08 US US15/580,770 patent/US10314780B2/en active Active
- 2016-06-08 RS RS20181341A patent/RS57948B1/sr unknown
- 2016-06-08 SG SG11201708642VA patent/SG11201708642VA/en unknown
- 2016-06-08 TN TNP/2017/000445A patent/TN2017000445A1/en unknown
- 2016-06-08 CA CA2985897A patent/CA2985897C/fr active Active
- 2016-06-08 PT PT16729525T patent/PT3307241T/pt unknown
- 2016-06-08 RU RU2017138099A patent/RU2698456C2/ru active
- 2016-06-08 WO PCT/EP2016/062990 patent/WO2016198434A1/fr active Application Filing
- 2016-06-08 CN CN201680033806.8A patent/CN107771074B/zh active Active
- 2016-06-08 AU AU2016277336A patent/AU2016277336B2/en active Active
- 2016-06-08 JP JP2017557200A patent/JP6342087B1/ja active Active
- 2016-06-08 BR BR112017026552-4A patent/BR112017026552B1/pt active IP Right Grant
- 2016-06-08 LT LTEP16729525.2T patent/LT3307241T/lt unknown
- 2016-06-08 ES ES16729525T patent/ES2703432T3/es active Active
- 2016-06-08 MX MX2017015835A patent/MX2017015835A/es active IP Right Grant
-
2017
- 2017-12-03 IL IL256071A patent/IL256071B/en active IP Right Grant
- 2017-12-05 SA SA517390480A patent/SA517390480B1/ar unknown
-
2018
- 2018-05-25 HK HK18106817.8A patent/HK1247118A1/zh unknown
- 2018-11-06 HR HRP20181840TT patent/HRP20181840T1/hr unknown
- 2018-11-20 CY CY181101224T patent/CY1120883T1/el unknown
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