MA40818B2 - Improved delivery of viral particles to the striatum and cortex - Google Patents

Improved delivery of viral particles to the striatum and cortex

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Publication number
MA40818B2
MA40818B2 MA40818A MA40818A MA40818B2 MA 40818 B2 MA40818 B2 MA 40818B2 MA 40818 A MA40818 A MA 40818A MA 40818 A MA40818 A MA 40818A MA 40818 B2 MA40818 B2 MA 40818B2
Authority
MA
Morocco
Prior art keywords
striatum
cortex
viral particles
improved delivery
mammal
Prior art date
Application number
MA40818A
Other languages
French (fr)
Other versions
MA40818A1 (en
Inventor
Lamya Shihabuddin
Lisa Stanek
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Priority claimed from PCT/US2016/017210 external-priority patent/WO2016130591A2/en
Publication of MA40818A1 publication Critical patent/MA40818A1/en
Publication of MA40818B2 publication Critical patent/MA40818B2/en

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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne de nouveaux procédés d'administration de particules virales adéno-associées recombinées (raav) au système nerveux central d'un mammifère (p. Ex., l'homme). Selon certains aspects, les procédés impliquent l'administration des particules raav contenant un acide nucléique hétérologue au striatum et l'induction de l'expression de l'acide nucléique hétérologue dans au moins le cortex cérébral et le striatum du mammifère.The present invention relates to novel methods of delivering recombinant adeno-associated virus (raav) particles to the central nervous system of a mammal (eg, human). In some aspects, the methods involve administering the raav particles containing heterologous nucleic acid to the striatum and inducing expression of the heterologous nucleic acid in at least the cerebral cortex and striatum of the mammal.

MA40818A 2015-02-10 2016-02-09 Improved delivery of viral particles to the striatum and cortex MA40818B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562114544P 2015-02-10 2015-02-10
PCT/US2016/017210 WO2016130591A2 (en) 2015-02-10 2016-02-09 Enhanced delivery of viral particles to the striatum and cortex

Publications (2)

Publication Number Publication Date
MA40818A1 MA40818A1 (en) 2018-01-31
MA40818B2 true MA40818B2 (en) 2022-04-29

Family

ID=61730514

Family Applications (1)

Application Number Title Priority Date Filing Date
MA40818A MA40818B2 (en) 2015-02-10 2016-02-09 Improved delivery of viral particles to the striatum and cortex

Country Status (2)

Country Link
HR (1) HRP20220042T1 (en)
MA (1) MA40818B2 (en)

Also Published As

Publication number Publication date
HRP20220042T1 (en) 2022-04-01
MA40818A1 (en) 2018-01-31

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