MA38556A1 - Inhibiteurs de bace1 - Google Patents
Inhibiteurs de bace1Info
- Publication number
- MA38556A1 MA38556A1 MA38556A MA38556A MA38556A1 MA 38556 A1 MA38556 A1 MA 38556A1 MA 38556 A MA38556 A MA 38556A MA 38556 A MA38556 A MA 38556A MA 38556 A1 MA38556 A1 MA 38556A1
- Authority
- MA
- Morocco
- Prior art keywords
- bace1
- inhibitors
- present
- compounds
- alzheimer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
La présente invention concerne des composés de formule (i) ayant une activité inhibitrice de bace1, leur fabrication, des compositions pharmaceutiques les contenant et leur utilisation en tant que substances thérapeutiquement actives. Les composés actifs de la présente invention sont utiles dans le traitement thérapeutique et/ou prophylactique de la maladie d'alzheimer, par exemple.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13163430 | 2013-04-11 | ||
PCT/EP2014/056985 WO2014166906A1 (fr) | 2013-04-11 | 2014-04-08 | Inhibiteurs de bace1 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38556A1 true MA38556A1 (fr) | 2017-09-29 |
Family
ID=48050604
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38556A MA38556A1 (fr) | 2013-04-11 | 2014-04-08 | Inhibiteurs de bace1 |
MA44948A MA44948A1 (fr) | 2013-04-11 | 2014-04-08 | Inhibiteurs de bace 1 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA44948A MA44948A1 (fr) | 2013-04-11 | 2014-04-08 | Inhibiteurs de bace 1 |
Country Status (20)
Country | Link |
---|---|
US (1) | US11447478B2 (fr) |
EP (1) | EP2984086A1 (fr) |
JP (2) | JP6574756B2 (fr) |
KR (1) | KR102247765B1 (fr) |
CN (1) | CN105431430B (fr) |
AU (1) | AU2014253275B2 (fr) |
BR (1) | BR112015019412A8 (fr) |
CA (1) | CA2900433C (fr) |
CL (1) | CL2015002897A1 (fr) |
EA (1) | EA027860B1 (fr) |
HK (1) | HK1216533A1 (fr) |
IL (2) | IL240263A0 (fr) |
MA (2) | MA38556A1 (fr) |
MX (1) | MX2015014083A (fr) |
MY (1) | MY174747A (fr) |
PE (1) | PE20151748A1 (fr) |
PH (1) | PH12015502365A1 (fr) |
SG (1) | SG11201508412XA (fr) |
UA (1) | UA119141C2 (fr) |
WO (1) | WO2014166906A1 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8637504B2 (en) | 2008-06-13 | 2014-01-28 | Shionogi & Co., Ltd. | Sulfur-containing heterocyclic derivative having beta secretase inhibitory activity |
BR112012013854A2 (pt) | 2009-12-11 | 2019-09-24 | Shionogi & Co | derivados de oxazina. |
WO2014065434A1 (fr) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dérivés de dihydrooxazine ou d'oxazépine ayant une activité inhibitrice de bace1 |
WO2014134341A1 (fr) * | 2013-03-01 | 2014-09-04 | Amgen Inc. | Composés perfluorés 5,6-dihydro-4h-1,3-oxazine-2-amine substitués en tant qu'inhibiteurs de la bêta-sécrétase et procédés d'utilisation correspondants |
EP2964644B1 (fr) | 2013-03-08 | 2018-12-26 | Amgen, Inc. | Composés perfluorés à base de 1,3-oxazin-2-amine condensée avec un cyclopropyle en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation |
TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有bace1抑制活性之二氫噻及二氫衍生物 |
WO2016022724A1 (fr) | 2014-08-08 | 2016-02-11 | Amgen Inc. | Composés thiazin-2-amine fusionnée à un groupement cyclopropyle utilisés en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation |
WO2017061534A1 (fr) | 2015-10-08 | 2017-04-13 | Shionogi & Co., Ltd. | Dérivés de dihydrothiazine |
JP2017071603A (ja) * | 2015-10-09 | 2017-04-13 | 塩野義製薬株式会社 | ジヒドロチアジンまたはジヒドロオキサジン誘導体を含有する医薬組成物 |
EP3423450B1 (fr) * | 2016-03-01 | 2019-11-27 | H. Hoffnabb-La Roche Ag | Inhibiteurs de bace1 |
KR20210003872A (ko) | 2018-04-27 | 2021-01-12 | 시오노기 앤드 컴파니, 리미티드 | 선택적 bace1 억제 활성을 갖는 테트라하이드로피라노옥사진 유도체 |
KR102467525B1 (ko) | 2020-11-26 | 2022-11-14 | 이대근 | 작업자 중개 장치 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI270549B (en) | 2002-12-26 | 2007-01-11 | Taisho Pharmaceutical Co Ltd | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group |
WO2008141249A1 (fr) | 2007-05-10 | 2008-11-20 | Acadia Pharmaceuticals Inc. | Imidazol (1,2-a)pyridines et composés associés à activité au niveau des récepteurs cannabinoïdes cb2 |
CA2711655C (fr) | 2008-01-18 | 2013-03-05 | Eisai R&D Management Co., Ltd. | Derive d'aminodihydrothiazine condensee |
JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
BR112012013854A2 (pt) * | 2009-12-11 | 2019-09-24 | Shionogi & Co | derivados de oxazina. |
UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
EA024059B1 (ru) | 2011-01-13 | 2016-08-31 | Новартис Аг | Гетероциклические производные и их применение в лечении неврологических расстройств |
US8754075B2 (en) | 2011-04-11 | 2014-06-17 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE1 and/or BACE2 inhibitors |
WO2012147763A1 (fr) * | 2011-04-26 | 2012-11-01 | 塩野義製薬株式会社 | Dérivé d'oxazine et inhibiteur de bace 1 le contenant |
US8785436B2 (en) | 2011-05-16 | 2014-07-22 | Hoffmann-La Roche Inc. | 1,3-oxazines as BACE 1 and/or BACE2 inhibitors |
EP2718287A1 (fr) | 2011-06-07 | 2014-04-16 | F.Hoffmann-La Roche Ag | [1,3]oxazines |
US8987255B2 (en) * | 2011-06-07 | 2015-03-24 | Hoffmann-La Roche Inc. | Halogen-alkyl-1,3 oxazines as BACE1 and/or BACE2 inhibitors |
UY34278A (es) * | 2011-08-25 | 2013-04-05 | Novartis Ag | Derivados novedosos de oxazina y su uso en el tratamiento de enfermedades |
UA113538C2 (xx) | 2012-01-26 | 2017-02-10 | Фторметил-5,6-дигідро-4h-$1,3]оксазини | |
WO2014065434A1 (fr) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dérivés de dihydrooxazine ou d'oxazépine ayant une activité inhibitrice de bace1 |
WO2014134341A1 (fr) | 2013-03-01 | 2014-09-04 | Amgen Inc. | Composés perfluorés 5,6-dihydro-4h-1,3-oxazine-2-amine substitués en tant qu'inhibiteurs de la bêta-sécrétase et procédés d'utilisation correspondants |
-
2014
- 2014-04-08 CA CA2900433A patent/CA2900433C/fr active Active
- 2014-04-08 EA EA201591541A patent/EA027860B1/ru not_active IP Right Cessation
- 2014-04-08 EP EP14715908.1A patent/EP2984086A1/fr not_active Withdrawn
- 2014-04-08 SG SG11201508412XA patent/SG11201508412XA/en unknown
- 2014-04-08 KR KR1020157031878A patent/KR102247765B1/ko active IP Right Grant
- 2014-04-08 WO PCT/EP2014/056985 patent/WO2014166906A1/fr active Application Filing
- 2014-04-08 MA MA38556A patent/MA38556A1/fr unknown
- 2014-04-08 US US14/783,478 patent/US11447478B2/en active Active
- 2014-04-08 CN CN201480019357.2A patent/CN105431430B/zh active Active
- 2014-04-08 PE PE2015002129A patent/PE20151748A1/es unknown
- 2014-04-08 BR BR112015019412A patent/BR112015019412A8/pt not_active Application Discontinuation
- 2014-04-08 AU AU2014253275A patent/AU2014253275B2/en active Active
- 2014-04-08 MX MX2015014083A patent/MX2015014083A/es unknown
- 2014-04-08 JP JP2016506890A patent/JP6574756B2/ja active Active
- 2014-04-08 MY MYPI2015002528A patent/MY174747A/en unknown
- 2014-04-08 MA MA44948A patent/MA44948A1/fr unknown
- 2014-08-04 UA UAA201510494A patent/UA119141C2/uk unknown
-
2015
- 2015-07-30 IL IL240263A patent/IL240263A0/en active IP Right Grant
- 2015-09-29 CL CL2015002897A patent/CL2015002897A1/es unknown
- 2015-10-12 PH PH12015502365A patent/PH12015502365A1/en unknown
-
2016
- 2016-04-20 HK HK16104540.9A patent/HK1216533A1/zh unknown
-
2018
- 2018-10-16 JP JP2018194983A patent/JP6681451B2/ja active Active
-
2019
- 2019-03-20 IL IL265496A patent/IL265496A/en unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA35193B1 (fr) | Halogeno-alkyl-1,3 oxazines en tant qu'inhibiteurs de bace1 et/ou bace2 | |
MA38556A1 (fr) | Inhibiteurs de bace1 | |
MA35191B1 (fr) | Spiro-[1,3]-oxazines et spiro-[1,4]-oxazepines en tant qu'inhibiteurs de baec1 et/ou bace2 | |
MA35246B1 (fr) | 1,3-oxazines en tant qu'inhibiteurs de bace1 et/ou de bace2 | |
MA35748B1 (fr) | Fluorométhyl-5,6-dihydro-4h-[1,3]oxazines | |
MA35114B1 (fr) | 1,3-oxazines à titre d'inhibiteurs de bace1 et/ou de bace2 | |
MA37763B1 (fr) | Difluoro-hexahydro-cyclopentaoxazinyles et difluoro-hexahydro-benzooxazinyles en tant qu'inhibiteurs de bace1 | |
BR112015016315A2 (pt) | fluoro-[1,3]oxazinas como inibidores de bace1 | |
MA37691B1 (fr) | 5-amino[1,4]thiazines comme inhibiteurs de bace1 | |
MX2013007558A (es) | 1,4-oxazinas como inhibidores de los genes enzima de segmentacion de la proteina precursora del sitio 1 y/o 2 (bace1 y/o bace2). | |
MA39219A1 (fr) | Nouveaux composés inhibiteurs de la kinase lrrk2 utilisés pour le traitement du parkinson, de l’alzheimer et de la sclérose latérale amyotrophique | |
MA38810A1 (fr) | Inhibiteurs de rorc2 méthodes d'utilisation associées | |
CO2017007691A2 (es) | Inhibidores de la β-secretasa derivados de la 5-amino-3-(5-(3-isoxazol-5-il)-3-(fluorometil)-6,6-dimetil-1-(metilimino)-3,6-dihidro-2h-1,4-tiazina o 5-amino-3-(5-(1h-1,2,3-triazol-4-il)-2-fluorofenil)-6,6-dimetil-1-(metilimino)-3,6-dihidro-2h-1,4-tiazina composiciones que los comprenden y métodos de elaboración | |
MX2016006906A (es) | 5-aril-1-imino-1-oxo-[1,2,4]tiadiazinas. | |
MA39533B1 (fr) | Composés, composition pharmaceutique et leur utilisation dans le traitement de maladies neurodégénératives | |
MX2016016061A (es) | 2,2,2-trifluoroetil-tiadiazinas. | |
MA38473B1 (fr) | (benzyl-cyano-méthyl)-amides substitués de l'acide 2-aza-bicyclo[2.2.1]heptane-3-carboxylique utilisés comme inhibiteurs de la cathépsine c | |
MA39260A1 (fr) | (benzyl-cyano-méthyl)-amides substitués de l'acide 2-aza-bicyclo[2.2.1]heptane-3-carboxylique utilisés comme inhibiteurs de la cathépsine c |