MA38071A1 - Formes cristallines d'un inhibiteur de facteur xia - Google Patents

Formes cristallines d'un inhibiteur de facteur xia

Info

Publication number
MA38071A1
MA38071A1 MA38071A MA38071A MA38071A1 MA 38071 A1 MA38071 A1 MA 38071A1 MA 38071 A MA38071 A MA 38071A MA 38071 A MA38071 A MA 38071A MA 38071 A1 MA38071 A1 MA 38071A1
Authority
MA
Morocco
Prior art keywords
crystalline forms
factor xia
xia inhibitor
inhibitor
compositions
Prior art date
Application number
MA38071A
Other languages
English (en)
Other versions
MA38071B1 (fr
Inventor
Marta Dabros
Chenkou Wei
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of MA38071A1 publication Critical patent/MA38071A1/fr
Publication of MA38071B1 publication Critical patent/MA38071B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne des formes cristallines de l'acide(s,e)-4-(2-(3-(3-chloro-2-fluoro-6-(1h-tétrazol-1-yl)phényl)acryloyl)-5-(4-méthyl-2-oxopipérazin-1-yl)-1,2,3,4-tétrahydroisoquinoline-1-carboxamido)benzoïque et ses solvates ; des procédés pour la production de telles formes cristallines ; des compositions comportant de telles formes cristallines ; et des procédé de traitement de troubles thromboemboliques avec lesdites formes cristallines ou lesdites compositions pharmaceutiques.
MA38071A 2012-10-12 2015-05-07 Formes cristallines d'un inhibiteur de facteur xia MA38071B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261712850P 2012-10-12 2012-10-12
PCT/US2013/064423 WO2014059203A1 (fr) 2012-10-12 2013-10-11 Formes cristallines d'un inhibiteur de facteur xia

Publications (2)

Publication Number Publication Date
MA38071A1 true MA38071A1 (fr) 2016-06-30
MA38071B1 MA38071B1 (fr) 2017-01-31

Family

ID=49474724

Family Applications (1)

Application Number Title Priority Date Filing Date
MA38071A MA38071B1 (fr) 2012-10-12 2015-05-07 Formes cristallines d'un inhibiteur de facteur xia

Country Status (34)

Country Link
US (1) US9920034B2 (fr)
EP (1) EP2906551B1 (fr)
JP (1) JP6154473B2 (fr)
KR (1) KR102143257B1 (fr)
CN (1) CN104837833B (fr)
AU (1) AU2013329125B2 (fr)
BR (1) BR112015007937A2 (fr)
CA (1) CA2888100A1 (fr)
CL (1) CL2015000916A1 (fr)
CO (1) CO7350621A2 (fr)
CY (1) CY1120238T1 (fr)
DK (1) DK2906551T3 (fr)
EA (1) EA032092B1 (fr)
ES (1) ES2668318T3 (fr)
HK (1) HK1212333A1 (fr)
HR (1) HRP20180465T1 (fr)
HU (1) HUE038272T2 (fr)
IL (1) IL238089B (fr)
LT (1) LT2906551T (fr)
MA (1) MA38071B1 (fr)
MX (1) MX351848B (fr)
MY (1) MY173058A (fr)
NO (1) NO2819265T3 (fr)
NZ (1) NZ707990A (fr)
PE (1) PE20150639A1 (fr)
PH (1) PH12015500678A1 (fr)
PL (1) PL2906551T3 (fr)
PT (1) PT2906551T (fr)
RS (1) RS57039B1 (fr)
SG (1) SG11201502605PA (fr)
SI (1) SI2906551T1 (fr)
TR (1) TR201807316T4 (fr)
WO (1) WO2014059203A1 (fr)
ZA (1) ZA201503238B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201319068A (zh) 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
CA2851810C (fr) 2011-10-14 2020-01-07 Bristol-Myers Squibb Company Composes de tetrahydroisoquinoleine substitues comme inhibiteurs du facteur xia
EP2906552B1 (fr) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Composés de tetrahydroisoquinoline substitués par guanidine en tant qu'inhibiteurs de factor xia
US9403774B2 (en) 2012-10-12 2016-08-02 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
JP6479763B2 (ja) 2013-03-25 2019-03-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン
WO2015116886A1 (fr) 2014-01-31 2015-08-06 Bristol-Myers Squibb Company Macrocycles à groupes hétérocycliques p2' servant d'inhibiteurs du facteur xia
NO2760821T3 (fr) 2014-01-31 2018-03-10
WO2016036893A1 (fr) 2014-09-04 2016-03-10 Bristol-Myers Squibb Company Diamides macrocycliques qui sont des inhibiteurs de fxia
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors
WO2016205482A1 (fr) 2015-06-19 2016-12-22 Bristol-Myers Squibb Company Macrocycles diamides utilisés en tant qu'inhibiteurs du facteur xia
EP3328852B1 (fr) 2015-07-29 2021-04-28 Bristol-Myers Squibb Company Composés macrocycliques portant un groupe p2' non aromatique en tant qu'inhibiteurs de facteur xia
ES2803659T3 (es) 2015-07-29 2021-01-28 Bristol Myers Squibb Co Inhibidores macrocíclicos del factor xia que contienen restos alquilo o cicloalquilo p2’
CN106496249B (zh) * 2015-09-07 2019-12-13 江苏恒瑞医药股份有限公司 噁唑并吲哚类衍生物、其制备方法及其在医药上的应用
EP3371162B1 (fr) 2015-10-29 2022-01-26 Merck Sharp & Dohme Corp. Dérivé spirocarbamate macrocyclique comme inhibiteurs du facteur xia, compositions pharmaceutiquement acceptables et leur utilisation
EP3500556B1 (fr) 2016-08-22 2023-08-02 Merck Sharp & Dohme LLC Dérivés pyridine-1-oxyde et leur utilisation en tant qu'inhbiteurs du facteur xia
CN109867660A (zh) * 2017-12-01 2019-06-11 四川科伦博泰生物医药股份有限公司 含季铵离子的四氢异喹啉酰胺化合物及其药物用途
WO2019184744A1 (fr) 2018-03-28 2019-10-03 四川科伦博泰生物医药股份有限公司 Dérivé de tétrahydro-isoquinoline, son procédé de préparation et ses applications

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7155E (fr) 1906-03-16 1907-05-23 Rene Gabriel Poncet Séchoir rotatif
FR1525186A (fr) 1967-03-29 1968-05-17 Roussel Uclaf Nouvelles pénicillines et procédé de préparation
ATA937274A (de) 1973-12-17 1978-02-15 Thomae Gmbh Dr K Verfahren zur herstellung neuer araliphatischer ketone
DE4034829A1 (de) 1990-11-02 1992-05-07 Merck Patent Gmbh Cyclopeptide
JP3190431B2 (ja) 1991-07-01 2001-07-23 三菱化学株式会社 ケトン誘導体
GB9206757D0 (en) 1992-03-27 1992-05-13 Ferring Bv Novel peptide receptor ligands
US5624936A (en) 1995-03-29 1997-04-29 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
WO1996034010A2 (fr) 1995-03-29 1996-10-31 Merck & Co., Inc. Inhibiteurs de la farnesyle transferase
JP2000507597A (ja) 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシルタンパク質トランスフェラーゼ阻害剤
US5869682A (en) 1996-04-03 1999-02-09 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
TW557297B (en) 1997-09-26 2003-10-11 Abbott Lab Rapamycin analogs having immunomodulatory activity, and pharmaceutical compositions containing same
KR100898094B1 (ko) 1998-03-19 2009-05-18 버텍스 파마슈티칼스 인코포레이티드 카스파제의 억제제
IL139599A0 (en) 1998-05-26 2002-02-10 Warner Lambert Co Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
US6307049B1 (en) 1998-09-30 2001-10-23 The Procter & Gamble Co. Heterocyclic 2-substituted ketoamides
BR9916732A (pt) 1999-01-02 2001-09-25 Aventis Pharma Gmbh Derivados de ácido malÈnico, processo para a sua preparação, seu uso e composições farmacêuticas contendo-os (inibição da atividade do fator xa)
EP1016663A1 (fr) 1999-01-02 2000-07-05 Aventis Pharma Deutschland GmbH Dérivés de l'acide malonique, procédé pour leur préparation, leur utilisation comme médicaments et compositions les contenant (inhibiteurs du facteur Xa )
DE50008510D1 (de) 1999-04-09 2004-12-09 Abbott Gmbh & Co Kg Niedermolekulare inhibitoren von komplementproteasen
EP1125925A1 (fr) 2000-02-15 2001-08-22 Applied Research Systems ARS Holding N.V. Dérivés amines pour le traitement de l'apoptose
AU5959201A (en) 2000-05-11 2001-11-20 Bristol Myers Squibb Co Tetrahydroisoquinoline analogs useful as growth hormone secretagogues
SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
AU2002322802A1 (en) 2001-07-27 2003-02-17 Merck And Co., Inc. Thrombin inhibitors
US6649606B1 (en) 2001-11-09 2003-11-18 Bristol-Myers Squibb Co. Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity
US7138412B2 (en) 2003-03-11 2006-11-21 Bristol-Myers Squibb Company Tetrahydroquinoline derivatives useful as serine protease inhibitors
US7129264B2 (en) 2003-04-16 2006-10-31 Bristol-Myers Squibb Company Biarylmethyl indolines and indoles as antithromboembolic agents
AU2004263508A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7417063B2 (en) 2004-04-13 2008-08-26 Bristol-Myers Squibb Company Bicyclic heterocycles useful as serine protease inhibitors
US7429604B2 (en) 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
JP2008505976A (ja) 2004-07-12 2008-02-28 アイディーユーエヌ・ファーマスーティカルズ・インコーポレーテッド テトラペプチド類似体
WO2006076575A2 (fr) 2005-01-13 2006-07-20 Bristol-Myers Squibb Company Composes de biaryle substitue en tant qu'inhibiteurs du facteur xia
WO2006089005A2 (fr) 2005-02-17 2006-08-24 Bristol-Myers Squibb Company Nouvelle combinaison d'inhibiteurs selectifs du facteur viia et/ou du facteur xia et d'inhibiteurs selectifs de kallicreine plasmatique
KR20080067697A (ko) * 2005-11-11 2008-07-21 에프. 호프만-라 로슈 아게 응고 인자 ｘａ의 억제제로서 카보사이클릭 융합된사이클릭 아민
WO2007070816A2 (fr) 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Derives de thiophene en tant qu'inhibiteurs du facteur xia
WO2007070818A1 (fr) 2005-12-14 2007-06-21 Bristol-Myers Squibb Company Heterocycles a six elements utiles en tant qu’inhibiteurs de serine protease
AR058379A1 (es) 2005-12-14 2008-01-30 Bristol Myers Squibb Co Derivados de arilpropionamida arilacrilamida arilpropinamida o arilmetilurea como inhibidores del factor xia. proceso de obtencion y composiciones farmaceuticas.
AR058380A1 (es) 2005-12-23 2008-01-30 Bristol Myers Squibb Co Inhibidores del factor viia macrociclicos utiles como anticoagulantes
JP5342450B2 (ja) 2006-12-15 2013-11-13 ブリストル−マイヤーズ スクイブ カンパニー 第ＸＩａ因子インヒビターとしてのアリールプロピオンアミド、アリールアクリルアミド、アリールプロピンアミド、またはアリールメチルウレアアナログ
PE20081775A1 (es) 2006-12-20 2008-12-18 Bristol Myers Squibb Co Compuestos macrociclicos como inhibidores del factor viia
AU2008266228A1 (en) 2007-06-13 2008-12-24 Bristol-Myers Squibb Company Dipeptide analogs as coagulation factor inhibitors
US8324199B2 (en) 2008-03-13 2012-12-04 Bristol-Myers Squibb Company Pyridazine derivatives as factor xia inhibitors
US8624040B2 (en) 2009-06-22 2014-01-07 Millennium Pharmaceuticals, Inc. Substituted hydroxamic acids and uses thereof
US8513433B2 (en) 2009-07-02 2013-08-20 Angion Biomedica Corp. Small molecule inhibitors of PARP activity
US8609676B2 (en) 2009-08-04 2013-12-17 Merck Sharp & Dohme, Corp. 4, 5, 6-trisubstituted pyrimidine derivatives as factor IXa inhibitors
JP5844287B2 (ja) 2010-02-11 2016-01-13 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 第ｘｉａ因子阻害剤としてのマクロ環
US9161924B2 (en) 2011-07-08 2015-10-20 Merck Sharp & Dohme Corp. Factor IXa inhibitors
TW201319068A (zh) 2011-08-05 2013-05-16 必治妥美雅史谷比公司 作為ｘｉａ因子抑制劑之環狀ｐ１接合劑
TW201311689A (zh) 2011-08-05 2013-03-16 必治妥美雅史谷比公司 作為因子ｘｉａ抑制劑之新穎巨環化合物
US9079929B2 (en) 2011-10-14 2015-07-14 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
EP2899183B1 (fr) 2011-10-14 2018-09-19 Bristol-Myers Squibb Company Composés de tétrahydroisiquinoline substitués en tant qu'inhibiteurs du facteur Xia
CA2851810C (fr) * 2011-10-14 2020-01-07 Bristol-Myers Squibb Company Composes de tetrahydroisoquinoleine substitues comme inhibiteurs du facteur xia
BR112014015669B1 (pt) 2011-12-21 2021-10-13 Ono Pharmaceutical Co., Ltd Compostos derivados de piridinona e pirimidinona, composição farmacêutica que compreende os ditos compostos e uso dos mesmos para o tratamento ou prevenção de uma doença tromboembólica
EP2807156A1 (fr) 2012-01-27 2014-12-03 Novartis AG Dérivés d'aminopyridine utilisés en tant qu'inhibiteurs de la kallicréine plasmatique
EP2807157A1 (fr) 2012-01-27 2014-12-03 Novartis AG Dérivés hétéroarylcarboxamide à 5 chaînons comme inhibiteurs de la kallikréine plasmatique
JP2015083542A (ja) 2012-02-08 2015-04-30 大日本住友製薬株式会社 ３位置換プロリン誘導体
JP6348900B2 (ja) 2012-05-10 2018-06-27 バイエル ファーマ アクチエンゲゼルシャフト 凝固因子ｘｉおよび／またはその活性化形態である因子ｘｉａに結合しうる抗体ならびにその用途
GB201209138D0 (en) 2012-05-24 2012-07-04 Ono Pharmaceutical Co Compounds
AU2013291098A1 (en) 2012-07-19 2015-02-05 Sumitomo Dainippon Pharma Co., Ltd. 1-(cycloalkyl-carbonyl)proline derivative
KR20150038369A (ko) 2012-08-03 2015-04-08 브리스톨-마이어스 스큅 컴퍼니 인자 XIa 억제제로서의 디히드로피리돈 P1
CN104507924B (zh) 2012-08-03 2018-01-23 百时美施贵宝公司 二氢吡啶酮p1作为凝血因子xia抑制剂
US9403774B2 (en) 2012-10-12 2016-08-02 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
EP2906552B1 (fr) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Composés de tetrahydroisoquinoline substitués par guanidine en tant qu'inhibiteurs de factor xia
US9708308B2 (en) 2012-12-19 2017-07-18 Merck Sharp Dohme Corp. Factor IXa inhibitors
GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
GB2510407A (en) 2013-02-04 2014-08-06 Kalvista Pharmaceuticals Ltd Aqueous suspensions of kallikrein inhibitors for parenteral administration
JP6479763B2 (ja) 2013-03-25 2019-03-06 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 第ｘｉａ因子阻害剤としての置換アゾール含有のテトラヒドロイソキノリン

Also Published As

Publication number Publication date
CN104837833B (zh) 2017-07-14
ZA201503238B (en) 2017-11-29
CA2888100A1 (fr) 2014-04-17
DK2906551T3 (en) 2018-05-22
KR20150065189A (ko) 2015-06-12
EA201590548A1 (ru) 2015-07-30
KR102143257B1 (ko) 2020-08-10
PL2906551T3 (pl) 2018-07-31
EP2906551A1 (fr) 2015-08-19
MX2015004328A (es) 2015-06-10
JP6154473B2 (ja) 2017-06-28
US9920034B2 (en) 2018-03-20
CL2015000916A1 (es) 2015-08-14
CO7350621A2 (es) 2015-08-10
IL238089B (en) 2019-03-31
US20150266855A1 (en) 2015-09-24
NO2819265T3 (fr) 2018-07-28
SG11201502605PA (en) 2015-05-28
HRP20180465T1 (hr) 2018-05-04
SI2906551T1 (en) 2018-05-31
CY1120238T1 (el) 2019-07-10
EA032092B1 (ru) 2019-04-30
ES2668318T3 (es) 2018-05-17
CN104837833A (zh) 2015-08-12
BR112015007937A2 (pt) 2017-07-04
EP2906551B1 (fr) 2018-02-28
PE20150639A1 (es) 2015-05-11
LT2906551T (lt) 2018-04-25
AU2013329125A1 (en) 2015-05-28
MA38071B1 (fr) 2017-01-31
HK1212333A1 (en) 2016-06-10
HUE038272T2 (hu) 2018-10-29
PT2906551T (pt) 2018-05-10
MX351848B (es) 2017-10-31
TR201807316T4 (tr) 2018-06-21
AU2013329125B2 (en) 2017-03-30
RS57039B1 (sr) 2018-05-31
MY173058A (en) 2019-12-23
PH12015500678A1 (en) 2015-05-18
JP2015533168A (ja) 2015-11-19
NZ707990A (en) 2018-07-27
WO2014059203A1 (fr) 2014-04-17

Similar Documents

Publication Publication Date Title
MA38071B1 (fr) Formes cristallines d'un inhibiteur de facteur xia
MA35365B1 (fr) Pyrimidines annelées substituées et leur utilisation
MA42376B1 (fr) Dérivés d'oxopyridine substitués
MA33419B1 (fr) Composés et compositions pour le traitement de maladies parasitaires
MA35661B1 (fr) Inhibiteurs de pak pour le traitement de troubles de prolifération cellulaire
MA41010A (fr) Compositions comprenant des souches bactériennes
MA41977B1 (fr) Imidazopyrazinones utilisées comme inhibiteurs de pde1
MA34797B1 (fr) Hétéroaryles et leurs utilisations
MA41238A (fr) Dérivés 5-[(pipérazin-1-yl)-3-oxo-propyl]-imidazolidine-2,4-dione en tant qu'inhibiteurs d'adamts pour le traitement de l'ostéoarthrit
TW200738688A (en) Compounds for the treatment of inflammatory disorders
NO20076371L (no) Fremgangsmate for fremstilling av fenoliske 4-bifenylylazetidin-2-oner
MA39259A1 (fr) Sel de camsylate
MA39170A1 (fr) Composes inhibiteurs de sérine/thréonine kinase pour leurs utilisations dans le traitement du cancer
MA38349A1 (fr) Œstra-1,3,5(10),16-tétraéno-3-carboxamide pour inhiber la 17-bêta-hydroxystéroïde déshydrogénase (akr1c3)
MA38253B1 (fr) Compositions comprenant de la vortioxétine et du donépézil
MA34512B1 (fr) Formes solides amorphes du chlorhydrate de la 4-[-2-[[5-méthyl-1-(2-naphtalényl)-1h-pyrazol-3-yl]oxy]éthyl]morpholine
MA39163A1 (fr) Forme cristalline de (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone et utilisation de celle-ci en tant qu'antagonistes des recepteurs de l'orexine
MA33417B1 (fr) Compositions pharmaceutiques et formes solides
MA37700B1 (fr) N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments
MA39837B1 (fr) Quinazoline-thf-amines halogénées en tant qu'inhibiteurs de la pde1
FR2928153B1 (fr) Nouvel additif pour le traitement des aciers resulfures
MA44660B1 (fr) (+) -azasetron pour son utilisation dans le traitement des troubles de l'oreille
FR2930727B1 (fr) Composition pour le traitement des etats seborrheiques.
MA39533B1 (fr) Composés, composition pharmaceutique et leur utilisation dans le traitement de maladies neurodégénératives
MA39019A1 (fr) Acétate de 4-{4-[(1e)-4-(2,9-diazaspiro[5.5]undéc-2-yl)but-1-én-1-yl]-2-méthylbenzyl}-5-(propan-2-yl)-1h-pyrazol-3-yl-bêta-d-glucopyranoside