MA35423B1 - Composés de cyclopropanamine - Google Patents

Composés de cyclopropanamine

Info

Publication number
MA35423B1
MA35423B1 MA36798A MA36798A MA35423B1 MA 35423 B1 MA35423 B1 MA 35423B1 MA 36798 A MA36798 A MA 36798A MA 36798 A MA36798 A MA 36798A MA 35423 B1 MA35423 B1 MA 35423B1
Authority
MA
Morocco
Prior art keywords
cyclopropanamine
compounds
cyclopropanamine compounds
Prior art date
Application number
MA36798A
Other languages
English (en)
Inventor
Naoki Tomita
Shigeo Kajii
Douglas Robert Cary
Daisuk Tomita
Shinichi Imamura
Ken Tsuchida
Satoru Matsuda
Ryujiro Hara
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47668552&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35423(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MA35423B1 publication Critical patent/MA35423B1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
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    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012324803B9 (en) * 2011-10-20 2017-08-24 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
JP6046154B2 (ja) * 2011-10-20 2016-12-14 オリソン ヘノミクス エセ． アー． Ｌｓｄ１阻害剤としての（ヘテロ）アリールシクロプロピルアミン化合物
JP6325449B2 (ja) * 2012-10-12 2018-05-16 武田薬品工業株式会社 シクロプロパンアミン化合物およびその用途
WO2014194280A2 (fr) * 2013-05-30 2014-12-04 The Board of Regents of the Nevada System of Higher Education on behalf of the University of Nouveaux inhibiteurs suicides de la lsd1 ciblant les cellules cancéreuses exprimant le sox2
MX2016001587A (es) 2013-08-06 2016-08-05 Imago Biosciences Inc Inhibidores de kdm1a para el tratamiento de enfermedades.
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
EP3105226B1 (fr) * 2014-02-13 2019-09-04 Incyte Corporation Cyclopropylamines en tant qu'inhibiteurs de lsd1
CR20200199A (es) 2014-02-13 2020-06-19 Incyte Corp CICLOPROPILAMINA COMO INHIBIDOR DE LA LSD1 (Divisional 2016-0396)
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
CN104042616B (zh) * 2014-02-20 2016-08-24 复旦大学附属眼耳鼻喉科医院 赖氨酸特异性去甲基化酶1抑制剂的应用
US10053456B2 (en) 2014-04-11 2018-08-21 Takeda Pharmaceutical Company Limited Cyclopropanamine compound and use thereof
KR101628707B1 (ko) * 2014-05-29 2016-06-10 한남대학교 산학협력단 난청 치료용 약물 전달 시스템 및 이의 제조방법
EP2949648A1 (fr) 2014-05-30 2015-12-02 IEO - Istituto Europeo di Oncologia Srl Dérivés de cyclopropylamine en tant qu'inhibiteurs de l'histone déméthylase
US10233165B2 (en) * 2014-05-30 2019-03-19 Istituto Europeo Di Oncologia S.R.L. Cyclopropylamine compounds as histone demethylase inhibitors
WO2016007731A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines et imidazopyrazines à utiliser en tant qu'inhibiteurs de lsd1
WO2016007722A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1
WO2016007736A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines en tant qu'inhibiteurs de lsd1
WO2016007727A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1
WO2016028971A1 (fr) * 2014-08-21 2016-02-25 Bristol-Myers Squibb Company Dérivés rattachés de benzamide utilisés comme puissants inhibiteurs de rock
CA2958704A1 (fr) 2014-08-25 2016-03-03 University Of Canberra Compositions pour moduler les cellules souches cancereuses et leurs utilisations
EP2993175A1 (fr) 2014-09-05 2016-03-09 IEO - Istituto Europeo di Oncologia Srl Thiénopyrroles en tant qu'inhibiteurs de l'histone déméthylase
EA039196B1 (ru) * 2014-10-08 2021-12-16 Инсайт Корпорейшн Циклопропиламины в качестве ингибиторов lsd1
EP3224352B1 (fr) * 2014-11-26 2024-01-03 Istituto Europeo di Oncologia S.r.l. Modèles de troubles neurologiques du développement basés sur la reprogrammation et utilisations associées
CN107438593B (zh) * 2015-01-30 2020-10-30 基因泰克公司 治疗化合物及其用途
WO2016130952A1 (fr) 2015-02-12 2016-08-18 Imago Biosciences, Inc. Inhibiteurs de kdm1a pour le traitement d'une maladie
AU2016243939B2 (en) 2015-04-03 2020-09-03 Incyte Holdings Corporation Heterocyclic compounds as LSD1 inhibitors
MX2017015922A (es) 2015-06-12 2018-12-11 Oryzon Genomics Sa Biomarcadores asociados con inhibidores de lsd1 y usos de los mismos.
WO2017013061A1 (fr) 2015-07-17 2017-01-26 Oryzon Genomics, S.A. Biomarqueurs associés à des inhibiteurs de lsd1 et utilisations de ceux-ci
TWI765860B (zh) 2015-08-12 2022-06-01 美商英塞特公司 Lsd1抑制劑之鹽
US10059668B2 (en) 2015-11-05 2018-08-28 Mirati Therapeutics, Inc. LSD1 inhibitors
AU2016382463B2 (en) 2015-12-29 2021-05-27 Mirati Therapeutics, Inc. LSD1 inhibitors
IL261721B (en) 2016-03-15 2022-07-01 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
EP3430015A1 (fr) 2016-03-16 2019-01-23 Oryzon Genomics, S.A. Procédés de détermination de l'engagement d'une cible kdm1a et chimiosondes utiles correspondantes
JP6999574B2 (ja) 2016-04-22 2022-01-18 インサイト・コーポレイション Ｌｓｄ１阻害剤の製剤
EP3246330A1 (fr) 2016-05-18 2017-11-22 Istituto Europeo di Oncologia S.r.l. Imidazoles comme inhibiteurs de histone demethylase
WO2018035259A1 (fr) * 2016-08-16 2018-02-22 Imago Biosciences, Inc. Procédés et processus pour la préparation d'inhibiteurs de kdm1a
WO2018083189A1 (fr) 2016-11-03 2018-05-11 Oryzon Genomics, S.A. Biomarqueurs pour déterminer la sensibilité à des inhibiteurs de lsd1
EP3535414A1 (fr) 2016-11-03 2019-09-11 Oryzon Genomics, S.A. Biomarqueurs pharmacodynamiques pour traitement du cancer personnalisé à l'aide d'agents de modification épigénétique
EP3551178A1 (fr) 2016-12-09 2019-10-16 Constellation Pharmaceuticals, Inc. Marqueurs pour un traitement personnalisé du cancer avec des inhibiteurs de lsd1
WO2018172570A1 (fr) * 2017-03-24 2018-09-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibiteurs de gfi1 pour le traitement de l'hyperglycémie
MX2020001323A (es) 2017-08-03 2020-03-20 Oryzon Genomics Sa Metodos para tratar alteraciones del comportamiento.
WO2019034774A1 (fr) 2017-08-18 2019-02-21 Istituto Europeo Di Oncologia (Ieo) S.R.L. Dérivés d'indole utilisés en tant inhibiteurs de l'histone déméthylase
WO2019068326A1 (fr) 2017-10-05 2019-04-11 Université D'aix-Marseille Inhibiteurs de la lsd1 pour le traitement et la prévention de cardiomyopathies
WO2019217972A1 (fr) 2018-05-11 2019-11-14 Imago Biosciences, Inc. Inhibiteurs de kdm1a pour le traitement d'une maladie
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
US20220151999A1 (en) 2019-03-20 2022-05-19 Oryzon Genomics, S.A. Methods of treating attention deficit hyperactivity disorder using kdm1a inhibitors such as the compound vafidemstat
JP2022525679A (ja) 2019-03-20 2022-05-18 オリソン ヘノミクス，ソシエダ アノニマ 境界性パーソナリティ障害の処置方法
WO2021004610A1 (fr) 2019-07-05 2021-01-14 Oryzon Genomics, S.A. Biomarqueurs et procédés pour le traitement personnalisé d'un cancer du poumon à petites cellules au moyen d'inhibiteurs de kdm1a
EP3964204A1 (fr) 2020-09-08 2022-03-09 Université d'Aix-Marseille Composés destinés à être utilisés dans le traitement et la prévention de la fibrose de tissus
MX2023011779A (es) 2021-04-08 2023-11-22 Oryzon Genomics Sa Combinaciones de inhibidores de lsd1 para el tratamiento de canceres mieloides.
WO2023217784A1 (fr) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Méthodes de traitement de tumeurs mutantes nf1 à l'aide d'inhibiteurs de lsd1
WO2023217758A1 (fr) 2022-05-09 2023-11-16 Oryzon Genomics, S.A. Méthodes de traitement d'une tumeur maligne des gaines des nerfs périphériques (tmgnp) à l'aide d'inhibiteurs de lsd1
WO2024110649A1 (fr) 2022-11-24 2024-05-30 Oryzon Genomics, S.A. Combinaisons d'inhibiteurs de lsd1 et d'inhibiteurs de ménine pour le traitement du cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0316915D0 (en) * 2003-07-18 2003-08-20 Glaxo Group Ltd Compounds
WO2010043721A1 (fr) 2008-10-17 2010-04-22 Oryzon Genomics, S.A. Inhibiteurs d’oxydases et leur utilisation
EP2389362B1 (fr) 2009-01-21 2019-12-11 Oryzon Genomics, S.A. Dérivés de phénylcyclopropylamine et leur utilisation médicale
US8389580B2 (en) 2009-06-02 2013-03-05 Duke University Arylcyclopropylamines and methods of use
WO2010143582A1 (fr) 2009-06-11 2010-12-16 公立大学法人名古屋市立大学 Dérivés de phénylcyclopropylamine et inhibiteurs de la lsd1
WO2011035941A1 (fr) 2009-09-25 2011-03-31 Oryzon Genomics S.A. Inhibiteurs de déméthylase-1 spécifique de la lysine et leur utilisation
US8946296B2 (en) 2009-10-09 2015-02-03 Oryzon Genomics S.A. Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
JP4759644B1 (ja) 2010-02-25 2011-08-31 株式会社ハウゼサンエイ 換気棟
CN102985402B (zh) * 2010-04-20 2015-04-29 罗马大学 反苯环丙胺衍生物作为组蛋白去甲基酶lsd1和/或lsd2的抑制剂
WO2012043721A1 (fr) * 2010-09-29 2012-04-05 日本ゼオン株式会社 Composition de résine et résine moulée
SG193241A1 (en) * 2011-03-25 2013-10-30 Glaxosmithkline Ip No 2 Ltd Cyclopropylamines as lsd1 inhibitors

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PH12016501822A1 (en) 2018-01-29
US20140228405A1 (en) 2014-08-14
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US9682925B2 (en) 2017-06-20
AU2012293223B2 (en) 2017-03-02
CA2844525A1 (fr) 2013-02-14
PE20141202A1 (es) 2014-10-03
MX2014001568A (es) 2014-03-31
CL2014000314A1 (es) 2014-08-08
EA201490445A1 (ru) 2014-06-30
ZA201401553B (en) 2015-11-25
WO2013022047A1 (fr) 2013-02-14
AP2014007488A0 (en) 2014-03-31
AU2012293223A1 (en) 2014-03-27
KR20140052018A (ko) 2014-05-02
SG2014009161A (en) 2014-04-28
EP2743256A4 (fr) 2015-05-13
ECSP14013230A (es) 2015-04-30
DOP2014000026A (es) 2014-06-30
AU2012293223A2 (en) 2014-04-17
GEP201606559B (en) 2016-10-25
EP2743256A1 (fr) 2014-06-18
BR112014002939A2 (pt) 2017-03-01
JPWO2013022047A1 (ja) 2015-03-05
CO6900145A2 (es) 2014-03-20
CN103842332A (zh) 2014-06-04
US9278931B2 (en) 2016-03-08
UA114406C2 (uk) 2017-06-12
CR20140108A (es) 2014-05-16
IL230839A0 (en) 2014-03-31
EP2743256B1 (fr) 2018-06-27
US20160130215A1 (en) 2016-05-12
TN2014000042A1 (en) 2015-07-01
CN103842332B (zh) 2016-08-17
EA025529B1 (ru) 2017-01-30

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