MA35034B1 - Procedes de preparation de pepsipeptides macrocycliques et nouveaux intermediaires - Google Patents

Procedes de preparation de pepsipeptides macrocycliques et nouveaux intermediaires

Info

Publication number
MA35034B1
MA35034B1 MA36321A MA36321A MA35034B1 MA 35034 B1 MA35034 B1 MA 35034B1 MA 36321 A MA36321 A MA 36321A MA 36321 A MA36321 A MA 36321A MA 35034 B1 MA35034 B1 MA 35034B1
Authority
MA
Morocco
Prior art keywords
pepsipeptides
methods
novel intermediates
preparing macrocyclic
macrocyclic
Prior art date
Application number
MA36321A
Other languages
Arabic (ar)
English (en)
Inventor
Murat Acemoglu
Heribert Hellstern
Felix Kollmer
John Lopez
Robert Schreiber
Christian Sprecher
Hans Stettler
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46317455&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA35034(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA35034B1 publication Critical patent/MA35034B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cookers (AREA)
  • Cereal-Derived Products (AREA)

Abstract

L'invention concerne une méthode ou un procédé de préparation chimique de depsipeptides de formule (I), les symboles présentant la signification définie dans la description, de nouveaux intermédiaires et leur préparation ainsi que des modes de réalisation de l'invention associés.
MA36321A 2011-04-20 2012-04-19 Procedes de preparation de pepsipeptides macrocycliques et nouveaux intermediaires MA35034B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161477319P 2011-04-20 2011-04-20
PCT/IB2012/051977 WO2012143888A1 (fr) 2011-04-20 2012-04-19 Procédés de préparation de depsipeptides macrocycliques et nouveaux intermédiaires

Publications (1)

Publication Number Publication Date
MA35034B1 true MA35034B1 (fr) 2014-04-03

Family

ID=46317455

Family Applications (1)

Application Number Title Priority Date Filing Date
MA36321A MA35034B1 (fr) 2011-04-20 2012-04-19 Procedes de preparation de pepsipeptides macrocycliques et nouveaux intermediaires

Country Status (21)

Country Link
US (2) US8614289B2 (fr)
EP (1) EP2699585A1 (fr)
JP (2) JP5951006B2 (fr)
KR (1) KR101580729B1 (fr)
CN (2) CN104804072A (fr)
AR (1) AR086168A1 (fr)
AU (1) AU2012245980B2 (fr)
BR (1) BR112013026660A2 (fr)
CA (1) CA2833109A1 (fr)
CL (2) CL2013003037A1 (fr)
CO (1) CO6801799A2 (fr)
EA (2) EA201500734A1 (fr)
GT (1) GT201300256A (fr)
IL (1) IL228727A0 (fr)
MA (1) MA35034B1 (fr)
MX (1) MX337526B (fr)
PE (1) PE20141206A1 (fr)
SG (1) SG193918A1 (fr)
TN (1) TN2013000385A1 (fr)
TW (1) TW201249863A (fr)
WO (1) WO2012143888A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5520824B2 (ja) 2007-08-17 2014-06-11 ノバルティス アーゲー 環状デプシペプチド類
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
CN106029684A (zh) 2014-04-08 2016-10-12 诺华股份有限公司 用于生产大环缩酚酸肽和新中间体的新型缩醛类方法
HUE055535T2 (hu) * 2015-05-20 2021-12-28 Boehringer Ingelheim Animal Health Usa Inc Féreghajtó depszipeptid-vegyületek
EP3350197A4 (fr) 2015-09-17 2019-04-24 Massachusetts Institute of Technology Procédés et systèmes de synthèse de peptide en phase solide
KR102031186B1 (ko) * 2017-01-11 2019-11-08 주식회사 엘지생활건강 단백질 강도 강화용 조성물
WO2020018888A1 (fr) 2018-07-20 2020-01-23 The Board Of Regents Of The University Of Oklahoma Peptides antimicrobiens et méthodes d'utilisation

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3043252C2 (de) 1980-11-15 1982-12-02 Degussa Ag, 6000 Frankfurt Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung
US5595756A (en) 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
DE4421113A1 (de) 1994-06-16 1995-12-21 Biotechnolog Forschung Gmbh Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
JP2000154198A (ja) 1998-11-20 2000-06-06 Nisshin Flour Milling Co Ltd 環状デプシペプチドの固相合成方法及びその中間体
GB0108234D0 (en) * 2001-04-02 2001-05-23 Pharma Mar Sa Process for producing trunkamide A compounds
US20040110228A1 (en) 2002-04-01 2004-06-10 Mcalpine Shelli R. Combinatorial organic synthesis of unique biologically active compounds
KR101099409B1 (ko) 2003-06-06 2011-12-27 아렉시스 악티에볼라그 피부 상태 또는 암 치료를 위한 ｓｃｃｅ 저해제로서의융합된 헤테로사이클 화합물의 용도
GB0322140D0 (en) 2003-09-22 2003-10-22 Pfizer Ltd Combinations
WO2005075667A1 (fr) 2004-02-03 2005-08-18 Bayer Healthcare Ag Methodes de diagnostic et de traitement de maladies associees a la kallikreine 7 (klk7)
EP1994181A4 (fr) 2006-02-27 2010-05-19 Univ Arizona Identification et utilisation de novopeptides pour le traitement du cancer
GB0715750D0 (en) 2007-08-13 2007-09-19 Karus Therapeutics Ltd Chemical compounds
EP2183270B1 (fr) 2007-08-17 2014-12-17 Novartis AG Utilisation de dépsipeptides cycliques pour inhiber la kallikréine 7
JP5520824B2 (ja) 2007-08-17 2014-06-11 ノバルティス アーゲー 環状デプシペプチド類
DE102007052391A1 (de) 2007-10-31 2009-05-07 Henkel Ag & Co. Kgaa Mattwachs
US20110112121A1 (en) 2009-07-06 2011-05-12 Joerg Berghausen Pharmaceutical Compositions and Solid Forms
KR101004362B1 (ko) 2010-03-19 2010-12-28 가톨릭대학교 산학협력단 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제
US20120064136A1 (en) 2010-09-10 2012-03-15 Nanobio Corporation Anti-aging and wrinkle treatment methods using nanoemulsion compositions
EP2616037A2 (fr) 2010-09-14 2013-07-24 Trima - Israel Phramaceutical Products Maabarot Ltd. Composition topique moussante
EP3689331A1 (fr) 2011-01-24 2020-08-05 Anterios, Inc. Compositions de nanoparticules, leurs formulations et utilisations
TR201905477T4 (tr) 2011-01-24 2019-05-21 Anterios Inc Nano-parçacık bileşimler.
US8680054B2 (en) 2011-04-20 2014-03-25 Novartis Ag Suspension type topical formulations comprising cyclic depsipeptide
AR086168A1 (es) 2011-04-20 2013-11-27 Novartis Ag Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios
US8987413B2 (en) 2012-10-09 2015-03-24 Novartis Ag Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates
US9067978B2 (en) 2012-10-09 2015-06-30 Novartis Ag Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates
CN106029684A (zh) 2014-04-08 2016-10-12 诺华股份有限公司 用于生产大环缩酚酸肽和新中间体的新型缩醛类方法

Also Published As

Publication number Publication date
EA201500734A1 (ru) 2015-11-30
AU2012245980B2 (en) 2015-01-29
KR101580729B1 (ko) 2015-12-28
MX337526B (es) 2016-03-09
CA2833109A1 (fr) 2012-10-26
CN103476789A (zh) 2013-12-25
WO2012143888A1 (fr) 2012-10-26
CL2013003037A1 (es) 2014-10-03
JP2016164158A (ja) 2016-09-08
IL228727A0 (en) 2013-12-31
US20140080995A1 (en) 2014-03-20
SG193918A1 (en) 2013-11-29
AR086168A1 (es) 2013-11-27
EA201391554A1 (ru) 2014-11-28
CL2015000688A1 (es) 2015-06-05
GT201300256A (es) 2015-02-19
CN103476789B (zh) 2016-11-09
MX2013012188A (es) 2013-11-04
EP2699585A1 (fr) 2014-02-26
PE20141206A1 (es) 2014-09-28
TW201249863A (en) 2012-12-16
TN2013000385A1 (en) 2015-01-20
US20120277406A1 (en) 2012-11-01
JP2014511899A (ja) 2014-05-19
CO6801799A2 (es) 2013-11-29
US9278997B2 (en) 2016-03-08
JP5951006B2 (ja) 2016-07-13
CN104804072A (zh) 2015-07-29
KR20130140204A (ko) 2013-12-23
US8614289B2 (en) 2013-12-24
AU2012245980A1 (en) 2013-10-03
BR112013026660A2 (pt) 2016-09-06
EA025546B1 (ru) 2017-01-30

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