MA35010B1 - Inhibiteurs de la peptide déformylase - Google Patents
Inhibiteurs de la peptide déformylaseInfo
- Publication number
- MA35010B1 MA35010B1 MA36280A MA36280A MA35010B1 MA 35010 B1 MA35010 B1 MA 35010B1 MA 36280 A MA36280 A MA 36280A MA 36280 A MA36280 A MA 36280A MA 35010 B1 MA35010 B1 MA 35010B1
- Authority
- MA
- Morocco
- Prior art keywords
- inhibitors
- peptide deformylase
- compound
- bacterial
- deformylase
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
- C12Y305/01088—Peptide deformylase (3.5.1.88)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Cette invention concerne un composé de formule (I), ou son sel pharmaceutiquement acceptable, des compositions pharmaceutiques correspondantes, la préparation du composé et des méthodes de traitement concernant les infections bactériennes et l'inhibition de l'activité de la peptide déformylase (PDF) bactérienne.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161450784P | 2011-03-09 | 2011-03-09 | |
PCT/US2012/028424 WO2012122450A2 (fr) | 2011-03-09 | 2012-03-09 | Inhibiteurs de la peptide déformylase |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35010B1 true MA35010B1 (fr) | 2014-04-03 |
Family
ID=46798826
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36280A MA35010B1 (fr) | 2011-03-09 | 2012-03-09 | Inhibiteurs de la peptide déformylase |
Country Status (22)
Country | Link |
---|---|
US (1) | US8901119B2 (fr) |
EP (1) | EP2684039A4 (fr) |
JP (1) | JP2014516917A (fr) |
KR (1) | KR20140011362A (fr) |
CN (1) | CN103827665A (fr) |
AR (1) | AR085698A1 (fr) |
AU (1) | AU2012225365A1 (fr) |
BR (1) | BR112013023057A2 (fr) |
CA (1) | CA2829361A1 (fr) |
CL (1) | CL2013002584A1 (fr) |
CO (1) | CO6761343A2 (fr) |
CR (1) | CR20130522A (fr) |
DO (1) | DOP2013000206A (fr) |
EA (1) | EA201391299A1 (fr) |
MA (1) | MA35010B1 (fr) |
MX (1) | MX2013010339A (fr) |
PE (1) | PE20140439A1 (fr) |
SG (1) | SG192948A1 (fr) |
TW (1) | TW201249824A (fr) |
UY (1) | UY33939A (fr) |
WO (1) | WO2012122450A2 (fr) |
ZA (1) | ZA201306415B (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101383565B1 (ko) | 2013-03-21 | 2014-04-09 | 박용희 | 고효율 해수 증발 장치 및 증발로프 모듈 |
GB201409536D0 (en) | 2014-05-29 | 2014-07-16 | Univ The Durham | Chemically modifying peptides |
CN109851614B (zh) * | 2019-03-29 | 2023-01-13 | 中山大学 | 一类杂环类肽脱甲酰基酶抑制剂及其制备方法和应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5250700A (en) | 1991-05-01 | 1993-10-05 | American Home Products Corporation | Phenyl pyrazolidinones as bronchodilators and anti-inflammatory agents |
US5399708A (en) | 1993-11-12 | 1995-03-21 | Eli Lilly And Company | Pyrazolidin-3-one derivatives |
UY27813A1 (es) | 2002-05-31 | 2003-12-31 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
ATE361296T1 (de) * | 2003-04-03 | 2007-05-15 | Merck Patent Gmbh | Pyrazolidin-1,2-dicarbonsäure-1-((phenyl)-amid) 2-((phenyl)-amid) derivate als koagulationsfaktor xa inhibitoren zur behandlung von thrombosen |
EP1902065A2 (fr) | 2005-06-08 | 2008-03-26 | Novartis AG | Derives d'amides cycliques inhibiteurs des proteines inhibitrices de l'apoptose, leur preparation et leur utilisation |
RU2008139192A (ru) * | 2006-03-03 | 2010-04-10 | Новартис АГ (CH) | N-формилгидроксиламины |
UA108596C2 (xx) | 2007-11-09 | 2015-05-25 | Інгібітори пептиддеформілази | |
CN101584694B (zh) * | 2009-06-15 | 2011-01-12 | 华东师范大学 | 含2,5-二氢吡咯的肽脱甲酰基酶抑制剂及合成方法 |
NZ597858A (en) | 2009-06-29 | 2014-01-31 | Genocea Biosciences Inc | Vaccines and compositions against streptococcus pneumoniae |
-
2012
- 2012-03-07 UY UY0001033939A patent/UY33939A/es unknown
- 2012-03-07 TW TW101107593A patent/TW201249824A/zh unknown
- 2012-03-07 AR ARP120100735A patent/AR085698A1/es unknown
- 2012-03-09 JP JP2013557892A patent/JP2014516917A/ja active Pending
- 2012-03-09 US US14/004,105 patent/US8901119B2/en not_active Expired - Fee Related
- 2012-03-09 BR BR112013023057A patent/BR112013023057A2/pt not_active IP Right Cessation
- 2012-03-09 MA MA36280A patent/MA35010B1/fr unknown
- 2012-03-09 CA CA2829361A patent/CA2829361A1/fr not_active Abandoned
- 2012-03-09 KR KR1020137026256A patent/KR20140011362A/ko not_active Application Discontinuation
- 2012-03-09 PE PE2013002014A patent/PE20140439A1/es not_active Application Discontinuation
- 2012-03-09 CN CN201280022371.9A patent/CN103827665A/zh active Pending
- 2012-03-09 EP EP12754317.1A patent/EP2684039A4/fr not_active Withdrawn
- 2012-03-09 SG SG2013064381A patent/SG192948A1/en unknown
- 2012-03-09 MX MX2013010339A patent/MX2013010339A/es not_active Application Discontinuation
- 2012-03-09 AU AU2012225365A patent/AU2012225365A1/en not_active Abandoned
- 2012-03-09 WO PCT/US2012/028424 patent/WO2012122450A2/fr active Application Filing
- 2012-03-09 EA EA201391299A patent/EA201391299A1/ru unknown
-
2013
- 2013-08-26 ZA ZA2013/06415A patent/ZA201306415B/en unknown
- 2013-09-09 CL CL2013002584A patent/CL2013002584A1/es unknown
- 2013-09-09 CO CO13213499A patent/CO6761343A2/es unknown
- 2013-09-11 DO DO2013000206A patent/DOP2013000206A/es unknown
- 2013-10-09 CR CR20130522A patent/CR20130522A/es unknown
Also Published As
Publication number | Publication date |
---|---|
UY33939A (es) | 2012-09-28 |
KR20140011362A (ko) | 2014-01-28 |
AU2012225365A1 (en) | 2013-09-12 |
WO2012122450A2 (fr) | 2012-09-13 |
TW201249824A (en) | 2012-12-16 |
AR085698A1 (es) | 2013-10-23 |
US20130345120A1 (en) | 2013-12-26 |
EP2684039A2 (fr) | 2014-01-15 |
ZA201306415B (en) | 2014-04-30 |
EP2684039A4 (fr) | 2015-03-11 |
CO6761343A2 (es) | 2013-09-30 |
BR112013023057A2 (pt) | 2016-08-02 |
CA2829361A1 (fr) | 2012-09-13 |
SG192948A1 (en) | 2013-09-30 |
MX2013010339A (es) | 2013-10-03 |
CN103827665A (zh) | 2014-05-28 |
US8901119B2 (en) | 2014-12-02 |
DOP2013000206A (es) | 2014-01-31 |
EA201391299A1 (ru) | 2014-02-28 |
AU2012225365A8 (en) | 2013-09-19 |
WO2012122450A3 (fr) | 2014-04-03 |
PE20140439A1 (es) | 2014-05-04 |
CL2013002584A1 (es) | 2014-02-21 |
CR20130522A (es) | 2014-05-02 |
JP2014516917A (ja) | 2014-07-17 |
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