MA32561B1 - Anticorps neutralisant le cytomegalovirus humain et leurs utilisations - Google Patents
Anticorps neutralisant le cytomegalovirus humain et leurs utilisationsInfo
- Publication number
- MA32561B1 MA32561B1 MA33614A MA33614A MA32561B1 MA 32561 B1 MA32561 B1 MA 32561B1 MA 33614 A MA33614 A MA 33614A MA 33614 A MA33614 A MA 33614A MA 32561 B1 MA32561 B1 MA 32561B1
- Authority
- MA
- Morocco
- Prior art keywords
- antibodies
- antibody fragments
- human cytomegalovirus
- neutralize human
- relates
- Prior art date
Links
- 241000701024 Human betaherpesvirus 5 Species 0.000 title 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 4
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/088—Varicella-zoster virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01D—HARVESTING; MOWING
- A01D34/00—Mowers; Mowing apparatus of harvesters
- A01D34/01—Mowers; Mowing apparatus of harvesters characterised by features relating to the type of cutting apparatus
- A01D34/412—Mowers; Mowing apparatus of harvesters characterised by features relating to the type of cutting apparatus having rotating cutters
- A01D34/63—Mowers; Mowing apparatus of harvesters characterised by features relating to the type of cutting apparatus having rotating cutters having cutters rotating about a vertical axis
- A01D34/71—Mowers; Mowing apparatus of harvesters characterised by features relating to the type of cutting apparatus having rotating cutters having cutters rotating about a vertical axis with means for discharging mown material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/089—Cytomegalovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01D—HARVESTING; MOWING
- A01D2101/00—Lawn-mowers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01D—HARVESTING; MOWING
- A01D34/00—Mowers; Mowing apparatus of harvesters
- A01D34/01—Mowers; Mowing apparatus of harvesters characterised by features relating to the type of cutting apparatus
- A01D34/412—Mowers; Mowing apparatus of harvesters characterised by features relating to the type of cutting apparatus having rotating cutters
- A01D34/63—Mowers; Mowing apparatus of harvesters characterised by features relating to the type of cutting apparatus having rotating cutters having cutters rotating about a vertical axis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La présente invention concerne des anticorps neutralisants, et des fragments d'anticorps de ceux-ci, ayant un pouvoir élevé de neutralisation de hcmv, où lesdits anticorps et fragments d'anticorps sont spécifiques d'un, ou d'une combinaison de deux ou plus, produit(s) de gène ul de hcmv. L'invention concerne en outre des lymphocytes b immortalisés qui produisent, et des épitopes qui se lient à, de tels anticorps et fragments d'anticorps. De plus, l'invention concerne l'utilisation des anticorps, fragments d'anticorps et épitopes dans des procédés de criblage ainsi que dans le diagnostic, la prévention et la thérapie de maladies.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8133408P | 2008-07-16 | 2008-07-16 | |
PCT/IB2009/006641 WO2010007533A2 (fr) | 2008-07-16 | 2009-07-15 | Anticorps neutralisant le cytomégalovirus humain et utilisation de ceux-ci |
Publications (1)
Publication Number | Publication Date |
---|---|
MA32561B1 true MA32561B1 (fr) | 2011-08-01 |
Family
ID=41550776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA33614A MA32561B1 (fr) | 2008-07-16 | 2011-02-11 | Anticorps neutralisant le cytomegalovirus humain et leurs utilisations |
Country Status (31)
Country | Link |
---|---|
US (21) | US8603480B2 (fr) |
EP (3) | EP3178845A1 (fr) |
JP (5) | JP5422649B2 (fr) |
KR (1) | KR101356350B1 (fr) |
CN (3) | CN103980363B (fr) |
AU (1) | AU2009272284C1 (fr) |
BR (1) | BRPI0916443A2 (fr) |
CA (2) | CA2730776C (fr) |
CL (3) | CL2011000084A1 (fr) |
CO (1) | CO6351801A2 (fr) |
CR (2) | CR20160355A (fr) |
CU (1) | CU23953B1 (fr) |
DK (2) | DK3009449T3 (fr) |
EA (1) | EA031177B1 (fr) |
EC (2) | ECSP11010827A (fr) |
ES (2) | ES2654543T3 (fr) |
GT (4) | GT201100011BA (fr) |
HK (1) | HK1220981A1 (fr) |
HN (1) | HN2011000161A (fr) |
IL (7) | IL210356A (fr) |
MA (1) | MA32561B1 (fr) |
MX (5) | MX2011000543A (fr) |
NZ (5) | NZ707788A (fr) |
PE (7) | PE20141435A1 (fr) |
PH (1) | PH12015500782A1 (fr) |
PL (2) | PL3009449T3 (fr) |
PT (2) | PT2352759T (fr) |
SG (3) | SG191699A1 (fr) |
UA (1) | UA106354C2 (fr) |
WO (1) | WO2010007533A2 (fr) |
ZA (1) | ZA201600335B (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0700133D0 (en) * | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
US7947274B2 (en) * | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
DK3009449T3 (en) | 2008-07-16 | 2018-08-06 | Inst Res Biomedicine | Human cytomegalovirus neutralizing antibodies and their use |
SG181901A1 (en) | 2009-12-23 | 2012-08-30 | 4Antibody Ag | Binding members for human cytomegalovirus |
EP2582389B1 (fr) * | 2010-06-16 | 2018-02-21 | Trellis Bioscience, LLC | Anticorps humains à affinité élevée contre la protéine gb du cytomégalovirus (cmv) humain |
JP5940064B2 (ja) | 2010-07-06 | 2016-06-29 | ノバルティス アーゲー | 低用量のrnaを用いた大型哺乳動物の免疫化 |
LT3243526T (lt) | 2010-07-06 | 2020-02-10 | Glaxosmithkline Biologicals S.A. | Rnr pristatymas, skirtas keleto imuninio atsako paleidimui |
WO2012006378A1 (fr) | 2010-07-06 | 2012-01-12 | Novartis Ag | Liposomes à lipides ayant une valeur de pka avantageuse pour la délivrance d'arn |
RS63983B1 (sr) | 2010-08-31 | 2023-03-31 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
CN104945505A (zh) * | 2010-09-29 | 2015-09-30 | 弗·哈夫曼-拉罗切有限公司 | 抗体组合物及使用方法 |
JP2013544504A (ja) * | 2010-10-11 | 2013-12-19 | ノバルティス アーゲー | 抗原送達プラットフォーム |
EP3332802A1 (fr) | 2011-07-06 | 2018-06-13 | GlaxoSmithKline Biologicals SA | Compositions de combinaisons immunogènes et utilisations de celles-ci |
US9139659B2 (en) * | 2012-03-28 | 2015-09-22 | Genentech, Inc. | Idiotypic antibodies and uses thereof |
DK2877580T3 (en) | 2012-07-27 | 2019-04-23 | Hope City | VAT VACCINE TO DELIVER A UL128 COMPLEX AND PREVENT CMV INFECTION |
US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
PL2888283T3 (pl) | 2012-08-24 | 2019-03-29 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
WO2016055950A1 (fr) | 2014-10-08 | 2016-04-14 | Novartis Ag | Combinaison d'anticorps de neutralistion du cytomégalovirus humain |
EP3048114A1 (fr) * | 2015-01-22 | 2016-07-27 | Novartis AG | Antigènes du cytomégalovirus et leurs utilisations |
IL254887B2 (en) | 2015-04-07 | 2023-11-01 | Alector Llc | Anti-sortilin antibodies and methods of using them |
EP3347045A4 (fr) | 2015-09-10 | 2019-08-28 | City of Hope | Anticorps générés par le vaccin mva-gh/gl-pc neutralisant le pouvoir infectieux du cytomégalovirus humain et procédés associés |
CN105296588A (zh) * | 2015-10-16 | 2016-02-03 | 常州市第一人民医院 | 一种检测肾移植患者在术后感染巨细胞病毒危害程度的方法 |
US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
WO2017153954A1 (fr) | 2016-03-11 | 2017-09-14 | Pfizer Inc. | Polypeptide gb de cytomégalovirus humain |
CN109071665B (zh) | 2016-04-18 | 2022-11-01 | 塞德斯医疗公司 | 结合人cd40的激动性抗体及其用途 |
US11230591B2 (en) | 2016-04-20 | 2022-01-25 | Merck Sharp & Dohme Corp. | CMV neutralizing antigen binding proteins |
WO2017196819A2 (fr) * | 2016-05-09 | 2017-11-16 | Icahn School Of Medicine At Mount Sinai | Anticorps anti-cytomégalovirus humain (hcmv) largement neutralisant et leurs procédé d'utilisation |
US10688181B2 (en) | 2016-06-27 | 2020-06-23 | The Regents Of The University Of California | Cancer treatment combinations |
WO2018031903A1 (fr) | 2016-08-12 | 2018-02-15 | Streck, Inc. | Contrôles de référence moléculaires |
CN106519027B (zh) * | 2016-11-11 | 2019-09-17 | 深圳先进技术研究院 | 抗h7n9全人源单克隆抗体5j13及其制法与应用 |
US11484570B2 (en) | 2017-04-14 | 2022-11-01 | University Of Massachusetts | Targeting cell tropism receptors to inhibit cytomegalovirus infection |
EP3612550A1 (fr) | 2017-04-19 | 2020-02-26 | GlaxoSmithKline Biologicals S.A. | Protéines de cytomégalovirus modifiées et complexes stabilisés |
CN107325178A (zh) * | 2017-06-29 | 2017-11-07 | 佛山市南海区普罗圣塔生物科技有限公司 | 一种抗人巨细胞病毒卵黄抗体及其制备方法和应用 |
WO2019183375A1 (fr) * | 2018-03-22 | 2019-09-26 | Eureka Therapeutics, Inc. | Agents d'anticorps reconnaissant spécifiquement le transporteur monocarboxylate 4 et leurs utilisations |
KR20210011919A (ko) | 2018-04-17 | 2021-02-02 | 셀덱스 쎄라퓨틱스, 인크. | 항-cd27 항체 및 항-pd-l1 항체 및 이중특이적 작제물 |
LT3618928T (lt) | 2018-07-13 | 2023-04-11 | Alector Llc | Anti-sortilino antikūnai ir jų panaudojimo būdai |
JP2022505094A (ja) | 2018-10-17 | 2022-01-14 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 改変されたサイトメガロウイルスタンパク質及び安定化された複合体 |
CN109580944A (zh) * | 2018-12-07 | 2019-04-05 | 潍坊医学院 | 一种人巨细胞病毒检测试纸及其制造方法 |
US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
CN109738631A (zh) * | 2019-01-21 | 2019-05-10 | 潍坊医学院 | 一种人巨细胞病毒IgM抗体检测试纸的制备方法 |
WO2020176871A1 (fr) * | 2019-02-28 | 2020-09-03 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Anticorps contre la maladie de kawasaki identifiant des peptides d'hépacivirus |
WO2020208082A1 (fr) * | 2019-04-09 | 2020-10-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Méthode de traitement des maladies liées au cytomégalovirus |
CN112898414B (zh) * | 2019-12-04 | 2024-05-10 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
EP4126931A1 (fr) * | 2020-03-27 | 2023-02-08 | GlaxoSmithKline Biologicals S.A. | Anticorps de liaison à pentamère de hcvm |
TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白B(gB)多肽 |
CA3230585A1 (fr) * | 2021-09-03 | 2023-03-09 | Domenico Tortorella | Anticorps anti-hcmv et leurs fragments de liaison a l'antigene |
CN116162154B (zh) * | 2022-10-21 | 2024-06-11 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
CN115947869B (zh) * | 2022-11-28 | 2023-12-12 | 广州佰芮慷生物科技有限公司 | 一种靶向人巨细胞病毒的嵌合抗原受体、car-nk细胞及用途 |
Family Cites Families (106)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4294817A (en) | 1977-11-25 | 1981-10-13 | International Diagnostic Technology, Inc. | Method of fluoro immunoassay |
US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
US4313927A (en) | 1979-10-19 | 1982-02-02 | Ames-Yissum Ltd. | Immunoassay method for detecting viral antibodies in whole blood samples |
US4334016A (en) | 1980-06-19 | 1982-06-08 | The Wistar Institute Of Anatomy And Biology | Human osteogenic sarcoma cell line and use thereof for immunofluorescent antibody test |
JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
DE3380726D1 (en) | 1982-06-24 | 1989-11-23 | Japan Chem Res | Long-acting composition |
FR2543570B1 (fr) | 1983-03-31 | 1985-08-09 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus humains, hybridomes secreteurs de ces anticorps et polypeptides porteurs d'un determinant antigenique sequentiel de cytomegalovirus humains |
US4617379A (en) | 1983-06-14 | 1986-10-14 | Miles Laboratories, Inc. | High titer cytomegalovirus immune serum globulin |
GB8404368D0 (en) | 1984-02-20 | 1984-03-28 | Cogent Ltd | Monoclonal antibodies to human cytomegalovirus |
US6100064A (en) | 1984-04-06 | 2000-08-08 | Chiron Corporation | Secreted viral proteins useful for vaccines and diagnostics |
FR2563630B1 (fr) | 1984-04-27 | 1988-02-19 | Pasteur Institut | Anticorps monoclonaux anticytomegalovirus et procedes pour le diagnostic in vitro des infections par les cytomegalovirus humains et d'une proteine-kinase inductible par les cytomegalovirus et susceptible d'etre reconnue par les susdits anticorps monoclonaux |
US4783399A (en) | 1984-05-04 | 1988-11-08 | Scripps Clinic And Research Foundation | Diagnostic system for the detection of cytomegalovirus |
US4743562A (en) | 1984-08-21 | 1988-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Purified human cytomegalovirus protein |
US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
WO1986002092A1 (fr) | 1984-09-28 | 1986-04-10 | Teijin Limited | Hybridome homme-souris produisant un anticorps humain antiviral, procede de preparation et anticorps monoclonal humain antiviral |
US4808518A (en) | 1985-02-11 | 1989-02-28 | University Of Tennessee Research Corporation | Recovery of cytomegalovirus antigen and use thereof in an assay |
US4804627A (en) | 1985-05-09 | 1989-02-14 | Sloan-Kettering Institute For Cancer Research | Method for cloning lymphoblastoid cells |
US4766106A (en) | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
EP0248909B1 (fr) | 1985-12-06 | 1994-08-17 | Teijin Limited | Anticorps monoclonal humain contre le virus megalocytique et procede de preparation dudit anticorps |
US6162620A (en) | 1986-03-07 | 2000-12-19 | Cogent Limited | Processes for the production of HCMV glycoproteins, antibodies thereto and HCMV vaccines, and recombinant vectors therefor |
US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
US5153311A (en) | 1986-11-24 | 1992-10-06 | The Children's Hospital, Incorporated | Immunogenic glycoproteins of human cytomegalovirus gCII |
US5126130A (en) | 1986-11-24 | 1992-06-30 | The Childrens Hospital Incorporated | Monoclonal antibodies reactive with specific antigenic sites on human cytomegalovirus glycoprotein a |
LU86752A1 (fr) | 1987-01-30 | 1988-08-23 | Univ Bruxelles | Procede de production d'anticorps monoclonaux humains(igg)anticytomegalovirus et anticorps monoclonaux ainsi obtenus |
FI884924A (fi) | 1987-10-28 | 1989-04-29 | Oncogen | Humanimmuglobulin som producerats med hybrid-dna-teknik. |
US5180813A (en) | 1989-03-24 | 1993-01-19 | University Of Iowa Research Foundation | Early envelope glycoprotein of human cytomegalovirus (hmcv) and monoclonal antibodies to the glycoproteins |
US5194654A (en) | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
WO1991004277A1 (fr) | 1989-09-14 | 1991-04-04 | Children's Biomedical Research Institute | Anticorps monoclonaux specifiques contre une glycoproteine de cytomegalovirus |
WO1991005876A1 (fr) | 1989-10-20 | 1991-05-02 | Children's Biomedical Research Institute | Cocktail d'anticorps monoclonaux specifiques du cytomegalovirus humain |
GB9008223D0 (en) | 1990-04-11 | 1990-06-13 | Royal Free Hosp School Med | Improvements relating to the detection of viruses |
DE4035174A1 (de) | 1990-11-06 | 1992-05-07 | Biotest Ag | Verfahren zur bestimmung von proteinen in koerperfluessigkeiten und mittel zur durchfuehrung des verfahrens |
US5997878A (en) | 1991-03-07 | 1999-12-07 | Connaught Laboratories | Recombinant poxvirus-cytomegalovirus, compositions and uses |
JPH053794A (ja) | 1991-06-26 | 1993-01-14 | Green Cross Corp:The | 抗サイトメガロウイルスヒトモノクローナル抗体およびその産生細胞 |
DE4128684A1 (de) | 1991-08-29 | 1993-03-04 | Behringwerke Ag | Hcmv-spezifische peptide, mittel dazu und ihre verwendung |
DE69227623T2 (de) | 1992-04-10 | 1999-05-20 | Erland Uppsala Hanas | Verfahren zum Nachweis einer CMV-Infektion |
SE9201281L (sv) | 1992-04-23 | 1993-10-24 | Bioinvent Int Ab | Nya humana monoklonala antikroppar och förfarande för framställning därav |
JPH05260961A (ja) | 1992-05-21 | 1993-10-12 | Teijin Ltd | サイトメガロウイルスに対するヒト・モノクローナル抗体を産生するハイブリドーマ |
GB9221654D0 (en) | 1992-10-15 | 1992-11-25 | Scotgen Ltd | Recombinant human anti-cytomegalovirus antibodies |
ES2131188T3 (es) | 1993-01-21 | 1999-07-16 | Erna Moller | Prevencion y tratamiento de citomegalovirus utilizando aminopeptidasa. |
EP0683675A4 (fr) | 1993-01-28 | 1997-05-21 | Sandoz Pharmaceuticals Corp | Anticorps monoclonaux humains contre le cytomegalovirus. |
US5750106A (en) | 1993-01-28 | 1998-05-12 | Novartis Ag | Human monoclonal antibodies to cytomegalovirus |
AU6777594A (en) | 1993-04-30 | 1994-11-21 | Scripps Research Institute, The | Human monoclonal antibodies to human cytomegalovirus, and methods therefor |
US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
EP0702083A3 (fr) | 1994-07-26 | 1997-01-15 | Biotest Ag | Polypeptides et protéines fusionnées contenant la structure à lecture ouverte UL57 ou la séquence C-terminal de la protéine pp150 de tégument de HCMV, oligonucléotides et trousses diagnostiques correspondantes |
US5502652A (en) | 1994-08-24 | 1996-03-26 | Hoggatt; Austin C. | Method and apparatus for measuring heat transfer in small diameter pipes using acoustic signals |
US5783383A (en) | 1995-05-23 | 1998-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of detecting cytomegalovirus (CMV) |
US6019980A (en) | 1995-06-07 | 2000-02-01 | Connaught Laboratories Limited | Nucleic acid respiratory syncytial virus vaccines |
US5800981A (en) | 1996-02-22 | 1998-09-01 | University Of Limburg | Human cytomegalovirus antigen and its use |
JP4218985B2 (ja) | 1996-07-12 | 2009-02-04 | アクゾ・ノベル・エヌ・ベー | ヒトサイトメガロウイルス(cmv)を検出するためのペプチド試薬 |
JP2000516617A (ja) | 1996-08-14 | 2000-12-12 | ザ・ウイスター・インステイテユート・オブ・アナトミー・アンド・バイオロジー | アテローム性動脈硬化病変の出現を予防するか又は遅らせるための方法及び組成物 |
US7504493B2 (en) * | 1997-01-23 | 2009-03-17 | The John Hopkins University | Characterization of the yeast transcriptome |
JP2001509676A (ja) | 1997-01-30 | 2001-07-24 | シーダーズ−サイナイ メディカル センター | Hhv−8▲上+▼リンパ腫細胞の確立,産生されるウイルス,抗体,診断方法およびhhv−8感染の検出のためのキット |
US6183752B1 (en) | 1997-02-05 | 2001-02-06 | Pasteur Merieux Serums Et Vaccins | Restenosis/atherosclerosis diagnosis, prophylaxis and therapy |
AU8063798A (en) | 1997-06-19 | 1999-01-04 | Regents Of The University Of California, The | Secretory immunoglobulin produced by single cells and methods for making and using same |
CA2296089A1 (fr) | 1997-07-18 | 1999-01-28 | Connaught Laboratories Limited | Vaccins d'acide nucleique codant une proteine g du virus respiratoire syncytial |
AU749345B2 (en) | 1997-11-14 | 2002-06-27 | Connaught Laboratories Limited | Alphavirus vectors for paramyxovirus vaccines |
DE19756214C1 (de) | 1997-12-17 | 1999-02-25 | Biotest Ag | Polypeptide mit Aminosäuresequenzen aus dem N-terminalen Bereich von gp116 und deren Verwendung bei der Diagnostik, Prophylaxe und Therapie |
AU754380B2 (en) | 1998-03-12 | 2002-11-14 | Genentech Inc. | Method of preventing the death of retinal neurons and treating ocular diseases |
DE59907027D1 (de) | 1998-06-29 | 2003-10-23 | Wolfgang Bergter | Antivirale und antiretrovirale radioimmunpharmaka auf der basis von alpha- und beta-strahlern |
RU2133472C1 (ru) | 1998-09-16 | 1999-07-20 | Унитарное государственное Московское предприятие по производству бактерийных препаратов | Способ диагностики активной стадии цитомегаловирусной инфекции человека |
MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
US7220840B2 (en) | 2000-06-16 | 2007-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to B lymphocyte stimulator protein |
WO2002066629A2 (fr) | 2001-02-21 | 2002-08-29 | Gabriele Hahn | Vecteur de recombinaison contenant le genome infectieux du cytomegalovirus humain, conservant les caracteristiques de type sauvage d'isolats cliniques |
ITMI20012160A1 (it) | 2001-10-18 | 2003-04-18 | Edoardo Marchisio | Sistema immunoenzimatico per la caratterizzazione antigenica dell'infezione attiva da cytomegalovirus e cmv confirmation test |
CN1188427C (zh) * | 2001-12-07 | 2005-02-09 | 暨南大学 | 检测hcmv抗体的重组嵌合肽抗原及其产生方法 |
US6828113B2 (en) | 2002-03-21 | 2004-12-07 | Cornell Research Foundation, Inc. | IgM antibodies to the 70 kDa heat shock protein as a marker for cytomegalovirus infection |
US8420353B2 (en) | 2002-03-22 | 2013-04-16 | Aprogen, Inc. | Humanized antibody and process for preparing same |
EP1578980A4 (fr) | 2002-04-01 | 2013-01-02 | Agensys Inc | Acide nucleique et proteine correspondante 213p1f11 que l'on utilise dans le traitement et la detection du cancer |
DE10228103A1 (de) | 2002-06-24 | 2004-01-15 | Bayer Cropscience Ag | Fungizide Wirkstoffkombinationen |
DE10232322A1 (de) | 2002-07-16 | 2004-07-29 | Hahn, Gabriele, Dr. | Viral kodierte CxC determinieren den Gewebetropismus von HCMV |
TWI270088B (en) | 2002-11-29 | 2007-01-01 | Furukawa Electric Co Ltd | Insulated wire and resin dispersion |
RU2239453C2 (ru) | 2002-12-03 | 2004-11-10 | Федеральное государственное унитарное предприятие " Научно-производственное объединение по медицинским иммунобиологическим препаратам " Микроген" | Препарат иммуноглобулина человека против цитомегаловируса и способ его получения |
CN1445243A (zh) * | 2002-12-13 | 2003-10-01 | 中国疾病控制中心病毒病预防控制所 | 抗人巨细胞病毒人源中和性基因工程Fab抗体 |
AU2004215125B2 (en) | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
US20040228842A1 (en) | 2003-02-27 | 2004-11-18 | Shan Lu | Compositions and methods for cytomegalovirus treatment |
WO2004078926A2 (fr) | 2003-02-28 | 2004-09-16 | Board Of Trustees Operating Michigan State University | Marqueurs immunologiques |
EP2662390B1 (fr) | 2004-06-21 | 2017-08-02 | E. R. Squibb & Sons, L.L.C. | Anticorps du récepteur 1 de l'interféron alpha et leurs utilisations |
CA2573090A1 (fr) | 2004-07-09 | 2006-01-19 | Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. | Differences dans les profils d'expression de genes intestinaux |
BE1016287A6 (nl) | 2004-07-14 | 2006-07-04 | Picanol Nv | Gaapvormingsonderdeel voor een weefmachine en weefmachine. |
US7976845B2 (en) | 2004-11-29 | 2011-07-12 | The Council Of The Queensland Institute Of Medical Research | Human cytomegalovirus immunotherapy |
US7973140B2 (en) | 2004-12-21 | 2011-07-05 | Medimmune Limited | Antibodies directed to angiopoietin-2 and uses thereof |
ATE503770T1 (de) | 2005-03-14 | 2011-04-15 | Us Gov Health & Human Serv | Humane monoklonale antikörper gegen hendra- und nipah-viren |
EP1895898B1 (fr) | 2005-06-29 | 2011-02-16 | Compumedics Limited | Ensemble capteur a pont conducteur |
JP5142458B2 (ja) * | 2005-06-30 | 2013-02-13 | キヤノン株式会社 | 標的物質捕捉分子、標的物質捕捉用の素子、これらを用いた標的物質検出用の装置及びキット、並びに、標的物質の検出方法 |
ES2367322T3 (es) | 2005-12-16 | 2011-11-02 | Ribovax Biotechnologies Sa | Métodos para obtener células inmortalizadas que secretan anticuerpos. |
JPWO2007094423A1 (ja) | 2006-02-15 | 2009-07-09 | 株式会社イーベック | ヒトサイトメガロウイルスに結合するヒトのモノクローナル抗体並びにその抗原結合部分 |
KR101442209B1 (ko) | 2006-05-19 | 2014-11-18 | 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. | 융합 단백질, 이의 용도 및 이의 제조방법 |
EP3031469B1 (fr) * | 2006-06-07 | 2023-08-23 | The Trustees Of Princeton University | Complexe de protéine de surface du cytomégalovirus destiné à être utilisé dans des vaccins et en tant que cible de médicament |
TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
RU2448979C2 (ru) * | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
AU2007331463B2 (en) | 2006-12-15 | 2014-03-27 | Ribovax Biotechnologies Sa | Antibodies against human cytomegalovirus (hCMV) |
GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
WO2008120203A2 (fr) | 2007-03-29 | 2008-10-09 | Technion Research & Development Foundation Ltd. | Procédés de diagnostic et de traitement de maladies provoquées par le cytomégalovirus |
US20080248042A1 (en) | 2007-04-05 | 2008-10-09 | Irccs Centro Di Riferimento Oncologico Di Aviano, | Monoclonal antibody cross-reactive against infective agent causing a B-cell expansion and IgG-Fc |
EP2190876A1 (fr) | 2007-08-22 | 2010-06-02 | Ribovax Biotechnologies SA | Anticorps dirigés contre le cytomégalovirus humain (hcmv) |
WO2009085383A1 (fr) | 2007-12-19 | 2009-07-09 | Dcb-Usa Llc | Anticorps anti-cytomégalovirus humain |
WO2010000020A1 (fr) | 2008-06-30 | 2010-01-07 | Cathrx Ltd | Cathéter |
CN102143974B (zh) | 2008-07-16 | 2015-03-25 | 生命医学研究学会 | 人巨细胞病毒中和抗体及其用途 |
DK3009449T3 (en) | 2008-07-16 | 2018-08-06 | Inst Res Biomedicine | Human cytomegalovirus neutralizing antibodies and their use |
-
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