MA31435B1 - Inhibition de metastases tumorales par des anticoprs anti-neuropiline 2 - Google Patents

Inhibition de metastases tumorales par des anticoprs anti-neuropiline 2

Info

Publication number
MA31435B1
MA31435B1 MA32406A MA32406A MA31435B1 MA 31435 B1 MA31435 B1 MA 31435B1 MA 32406 A MA32406 A MA 32406A MA 32406 A MA32406 A MA 32406A MA 31435 B1 MA31435 B1 MA 31435B1
Authority
MA
Morocco
Prior art keywords
norobillin
antibody anti
inhibitor
malignant metastases
malignant
Prior art date
Application number
MA32406A
Other languages
Arabic (ar)
English (en)
Inventor
Yan Wu
Wei-Ching Liang
Ryan Jefferson Watts
Anil Durgadas Bagri
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MA31435B1 publication Critical patent/MA31435B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des antagonistes de la nrp2, tels que des anticorps anti-nrp2 et leur utilisation dans la prévention et le traitement de métastases tumorales.
MA32406A 2007-05-17 2009-12-07 Inhibition de metastases tumorales par des anticoprs anti-neuropiline 2 MA31435B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/069179 WO2008143665A1 (fr) 2007-05-17 2007-05-17 Inhibition de métastases tumorales par des anticorps anti-neuropiline 2

Publications (1)

Publication Number Publication Date
MA31435B1 true MA31435B1 (fr) 2010-06-01

Family

ID=39301228

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32406A MA31435B1 (fr) 2007-05-17 2009-12-07 Inhibition de metastases tumorales par des anticoprs anti-neuropiline 2

Country Status (17)

Country Link
US (2) US8648173B2 (fr)
EP (1) EP2152307B1 (fr)
JP (1) JP5745840B2 (fr)
KR (1) KR101520115B1 (fr)
CN (1) CN101754771B (fr)
AU (1) AU2007353778B9 (fr)
BR (1) BRPI0721660A2 (fr)
CA (1) CA2687247A1 (fr)
CR (1) CR11126A (fr)
ES (1) ES2469743T3 (fr)
HK (2) HK1134040A1 (fr)
IL (1) IL202005A (fr)
MA (1) MA31435B1 (fr)
MX (1) MX2009012421A (fr)
NO (1) NO20093542L (fr)
UA (1) UA99292C2 (fr)
WO (1) WO2008143665A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008141275A1 (fr) * 2007-05-11 2008-11-20 The Johns Hopkins University Biomarqueurs pour mélanomes
US20110091384A1 (en) * 2009-10-13 2011-04-21 The Johns Hopkins University Biomarker for identification of melanoma tumor cells
CN105378075B (zh) 2013-03-15 2022-04-05 Atyr 医药公司 组氨酰-trna合成酶-fc缀合物
US10174385B2 (en) * 2013-12-20 2019-01-08 Trustees Of Boston University Assays and methods relating to the treatment of melanoma
JP2020517638A (ja) 2017-04-20 2020-06-18 エータイアー ファーマ， インコーポレイテッド 肺の炎症を治療するための組成物および方法
JP2020522562A (ja) * 2017-06-06 2020-07-30 ストキューブ アンド シーオー．， インコーポレイテッド Ｂｔｎ１ａ１又はｂｔｎ１ａ１リガンドに結合する抗体及び分子を用いて癌を治療する方法
AU2019247511A1 (en) * 2018-04-06 2020-10-22 Atyr Pharma, Inc. Compositions and methods comprising anti-NRP2 antibodies
CA3156803A1 (fr) 2019-10-03 2021-04-08 Atyr Pharma, Inc. Compositions et methodes comprenant des anticorps anti-nrp2
CN114277152A (zh) * 2022-01-14 2022-04-05 张赟建 用于预测甲状腺***状癌***转移的特异性基因及制备方法
CN114262683B (zh) * 2022-03-01 2022-06-17 中国科学院动物研究所 一种表达vegfr3 d2多肽的细菌制剂及其构建方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
DE69842174D1 (de) 1997-04-07 2011-04-21 Genentech Inc Verfahren zur Herstellung humanisierter Antikörper durch randomisierte Mutagenese
ES2273415T3 (es) 1997-04-07 2007-05-01 Genentech, Inc. Anticuerpos anti-vegf.
AU1633999A (en) 1997-12-09 1999-06-28 Children's Medical Center Corporation Soluble inhibitors of vascular endothelial growth factor and use thereof
EP1037925A2 (fr) 1997-12-09 2000-09-27 Children's Medical Center Corporation Fonction et utilisation de l'antagoniste du recepteur de la neuropiline
US6417169B1 (en) * 1998-04-23 2002-07-09 Genesense Technologies Inc. Insulin-like growth factor II antisense oligonucleotide sequences and methods of using same to inhibit cell growth
US20030113324A1 (en) 2001-10-01 2003-06-19 Kari Alitalo Neuropilin/VEGF-C/VEGFR-3 materials and methods
EP1513879B1 (fr) 2002-06-03 2018-08-22 Genentech, Inc. Bibliotheques de phages et anticorps synthetiques
WO2005030240A2 (fr) 2003-09-23 2005-04-07 Ludwig Institute For Cancer Research Produits vegf-c ou vegf-d et methodes de stimulation des cellules souches neurales
EP1439192A1 (fr) * 2003-01-15 2004-07-21 Xerion Pharmaceuticals AG Inhibiteurs de neuropilin-1
UA96139C2 (uk) * 2005-11-08 2011-10-10 Дженентек, Інк. Антитіло до нейропіліну-1 (nrp1)

Also Published As

Publication number Publication date
UA99292C2 (uk) 2012-08-10
CN101754771A (zh) 2010-06-23
JP5745840B2 (ja) 2015-07-08
CN101754771B (zh) 2015-03-04
US20100172921A1 (en) 2010-07-08
HK1144556A1 (en) 2011-02-25
AU2007353778B2 (en) 2013-11-07
EP2152307A1 (fr) 2010-02-17
US20140234312A1 (en) 2014-08-21
AU2007353778A1 (en) 2008-11-27
BRPI0721660A2 (pt) 2013-01-22
JP2010527350A (ja) 2010-08-12
KR101520115B1 (ko) 2015-05-13
KR20100018567A (ko) 2010-02-17
IL202005A (en) 2014-11-30
EP2152307B1 (fr) 2014-04-16
AU2007353778B9 (en) 2014-04-03
WO2008143665A1 (fr) 2008-11-27
CA2687247A1 (fr) 2008-11-27
US8648173B2 (en) 2014-02-11
CR11126A (es) 2010-05-19
ES2469743T3 (es) 2014-06-18
NO20093542L (no) 2010-02-12
HK1134040A1 (en) 2010-04-16
US8920805B2 (en) 2014-12-30
IL202005A0 (en) 2010-06-16
MX2009012421A (es) 2009-12-01

Similar Documents

Publication Publication Date Title
MA31435B1 (fr) Inhibition de metastases tumorales par des anticoprs anti-neuropiline 2
MA33256B1 (fr) Anticorps et immunoconjugués anti-fcrh5 et procédés d'utilisation
MA34818B1 (fr) Anticorps anti-pcsk9 et procédés d'utilisation
MA30497B1 (fr) Anticorps et immunco-conjugues, et leurs utilisations.
MA30384B1 (fr) Therapies combinatoires
CY1109985T1 (el) Αναστολεις πρωτεασωματος και μεθοδοι χρησης αυτων
MA30531B1 (fr) Anticorps anti-dll4 et leurs procedes d'utilisation
NO20081636L (no) FAP - inhibitorer
TW201713640A (en) Bruton's tyrosine kinase inhibitors
MA31167B1 (fr) Inhibiteurs de l'activite de akt
MA29369B1 (fr) Dosage fixe d'anticorps anti-her
EA201070247A1 (ru) Ингибиторы протеасом
ATE530540T1 (de) Pyrimidonverbindungen als gsk-3-inhibitoren
EA201170531A1 (ru) Соединения на основе пиридина и пиримидина в качестве ингибиторов сигнального пути wnt для лечения рака
SG155163A1 (en) Pharmacokinetically improved compounds
MA30353B1 (fr) Anticorps se liant à la protéine tyrosine phosphatase bêta humaine (hptpbêta) et utilisations correspondantes.
MA34753B1 (fr) Compositions et procédés de traitement dans des applications cliniques à large spectre, indifférenciées ou mixtes
BR112013008140A2 (pt) "compostos imidazotriazinona".
CO6571886A2 (es) Antagonistas de pcsk9
MA38176A1 (fr) Nouvel anticorps anti-hemagglutinine, utile pour le traitement, l'inhibition ou la prévention de l’infection virale a grippe a
MA31977B1 (fr) Nouveaux anticorps inhibant la dimérisation de c-met et utilisations de ceux-ci
EA200870409A1 (ru) Антагонисты киназы pi3
SG10201405377XA (en) Compositions and methods for antibodies targeting complement protein c5
MY151191A (en) Novel antibodies
MX2012004258A (es) Inhibidores de la tirosina quinasa de bruton.