MA30598B1 - Composition pharmaceutique contenant un acide tetrahydrofolique. - Google Patents

Composition pharmaceutique contenant un acide tetrahydrofolique.

Info

Publication number
MA30598B1
MA30598B1 MA31584A MA31584A MA30598B1 MA 30598 B1 MA30598 B1 MA 30598B1 MA 31584 A MA31584 A MA 31584A MA 31584 A MA31584 A MA 31584A MA 30598 B1 MA30598 B1 MA 30598B1
Authority
MA
Morocco
Prior art keywords
tetrahydrofolic acid
pharmaceutical composition
composition containing
progestagen
estrogen
Prior art date
Application number
MA31584A
Other languages
English (en)
Inventor
Kristina King
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36763829&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA30598(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA30598B1 publication Critical patent/MA30598B1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention concerne des compositions pharmaceutiques solides, en particulier des contraceptifs oraux, comprenant un progestagène, telle que la drospirénone; un oestrogène, tel que l'éthinyloestradiol; un acide tétrahydrofolique ou sel pharmaceutiquement acceptable de celui-ci, tel que le 5-méthyl-(6S)- tétrahydrofolate de calcium; et au moins un excipient ou support pharmaceutiquement acceptable. Les compositions de l'invention confèrent une bonne stabilité de l'acide tétrahydrofolique au stockage tout en garantissant encore une libération rapide et fiable de l'¿strogène et du progestagène présents dans la composition.
MA31584A 2006-07-06 2009-01-23 Composition pharmaceutique contenant un acide tetrahydrofolique. MA30598B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06014002 2006-07-06

Publications (1)

Publication Number Publication Date
MA30598B1 true MA30598B1 (fr) 2009-07-01

Family

ID=36763829

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31584A MA30598B1 (fr) 2006-07-06 2009-01-23 Composition pharmaceutique contenant un acide tetrahydrofolique.

Country Status (32)

Country Link
EP (2) EP2422774B1 (fr)
JP (1) JP2009542591A (fr)
KR (2) KR20090033889A (fr)
CN (3) CN101489563A (fr)
AR (2) AR061958A1 (fr)
AU (1) AU2007271449B2 (fr)
BR (1) BRPI0713565B8 (fr)
CA (2) CA2656131C (fr)
CL (1) CL2007001962A1 (fr)
CO (1) CO6150125A2 (fr)
CR (1) CR10549A (fr)
CU (1) CU20090004A7 (fr)
EC (1) ECSP099030A (fr)
ES (1) ES2626838T5 (fr)
GT (1) GT200900001A (fr)
HK (1) HK1131917A1 (fr)
IL (3) IL196027A0 (fr)
MA (1) MA30598B1 (fr)
MX (1) MX2009000079A (fr)
MY (1) MY169516A (fr)
NO (1) NO347567B1 (fr)
NZ (1) NZ573766A (fr)
PE (3) PE20150287A1 (fr)
PH (1) PH12012501774B1 (fr)
RU (2) RU2479306C2 (fr)
SG (1) SG188869A1 (fr)
TN (1) TNSN08543A1 (fr)
TW (2) TWI508730B (fr)
UA (2) UA105078C2 (fr)
UY (1) UY30462A1 (fr)
WO (1) WO2008003432A1 (fr)
ZA (4) ZA200900868B (fr)

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US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
US20100317635A1 (en) * 2009-06-16 2010-12-16 Endorecherche, Inc. Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators
UY32836A (es) * 2009-08-12 2011-03-31 Bayer Schering Pharma Ag Partículas estabilizadas que comprenden 5-metil-(6s)-tetrahidrofolato
EA026095B1 (ru) * 2010-04-15 2017-03-31 Байер Интеллекчуал Проперти Гмбх Очень низкодозированные твердые пероральные лекарственные формы для гормонозаместительной терапии (гзт)
US11351122B1 (en) 2010-07-28 2022-06-07 Laboratorios Leon Farma Sa Synthetic progestogens and pharmaceutical compositions comprising the same
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
CN102516247A (zh) * 2010-12-15 2012-06-27 连云港金康医药科技有限公司 A型l-5-甲基四氢叶酸钙盐多晶型及其制备方法
EP2383279A1 (fr) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Procédé de préparation d'estetrol
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EP2878600B1 (fr) 2013-12-02 2018-06-27 Cerbios-Pharma S.A. Complexes stables d'un sel de métal alcalino-terreux d'acide N5-méthyl-tétrahydrofolique et un polyol
CN104490887A (zh) * 2014-09-04 2015-04-08 连云港金康和信药业有限公司 (6s)-5-甲基-四氢叶酸钙盐的稳定药物组合物
ME03728B (fr) 2015-06-18 2021-01-20 Estetra Sprl Unité galénique orodispersible contenant un composant estetrol
RS61777B1 (sr) 2015-06-18 2021-06-30 Estetra Sprl Oralno-disperzibilna tableta koja sadrži estetrol
SI3310345T1 (sl) 2015-06-18 2021-05-31 Estetra Sprl Orodisperzibilna tableta, ki vsebuje estetrol
MY195019A (en) 2015-06-18 2023-01-03 Estetra Sprl Orodispersible dosage unit containing an estetrol component
CN105030779A (zh) * 2015-07-21 2015-11-11 福格森（武汉）生物科技股份有限公司 一种(6s)-5-甲基四氢叶酸钙口服营养补充剂及其制备方法
KR20220144885A (ko) 2016-08-05 2022-10-27 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
CN106336444A (zh) * 2016-08-23 2017-01-18 国家卫生计生委科学技术研究所 一种新晶型炔雌醇
CN107446458A (zh) * 2017-08-04 2017-12-08 合众（佛山）化工有限公司 一种高耐水性的丙烯酸改性聚氨酯杂化树脂水性涂料
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
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CN114569567B (zh) * 2021-12-20 2023-03-14 南通联亚药业股份有限公司 一种稳定的双醋炔诺酮炔雌醇复方片及其制备方法

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Also Published As

Publication number Publication date
IL224484A (en) 2016-05-31
ES2626838T3 (es) 2017-07-26
WO2008003432A1 (fr) 2008-01-10
MX2009000079A (es) 2009-01-23
EP2040683A1 (fr) 2009-04-01
TNSN08543A1 (en) 2010-04-14
NZ573766A (en) 2011-05-27
TW200812593A (en) 2008-03-16
BRPI0713565B1 (pt) 2021-02-02
CN101489563A (zh) 2009-07-22
SG188869A1 (en) 2013-04-30
ZA201501673B (en) 2016-02-24
EP2040683B1 (fr) 2017-03-01
NO20090578L (no) 2009-03-09
CN102813663B (zh) 2019-03-22
PE20150287A1 (es) 2015-03-15
ES2626838T5 (es) 2024-03-14
IL245355A0 (en) 2016-06-30
KR20090033889A (ko) 2009-04-06
CL2007001962A1 (es) 2008-01-04
CA2856344A1 (fr) 2008-01-10
RU2624236C2 (ru) 2017-07-03
JP2009542591A (ja) 2009-12-03
CN101484143A (zh) 2009-07-15
CN102813663A (zh) 2012-12-12
BRPI0713565A2 (pt) 2012-03-20
CU20090004A7 (es) 2011-07-11
ZA201808084B (en) 2021-06-30
RU2479306C2 (ru) 2013-04-20
AU2007271449A1 (en) 2008-01-10
RU2009103649A (ru) 2010-08-20
NO20090578A (no) 2009-03-09
CR10549A (es) 2009-01-27
EP2422774A1 (fr) 2012-02-29
KR20130042638A (ko) 2013-04-26
NO347567B1 (no) 2024-01-15
TW201538161A (zh) 2015-10-16
ECSP099030A (es) 2009-02-27
HK1131917A1 (en) 2010-02-12
GT200900001A (es) 2009-12-08
RU2012133154A (ru) 2014-02-10
BRPI0713565B8 (pt) 2021-05-25
AR061958A1 (es) 2008-08-10
ZA200900868B (en) 2021-05-26
PE20120375A1 (es) 2012-05-23
UA105078C2 (uk) 2014-04-10
ZA201808083B (en) 2021-06-30
PE20080273A1 (es) 2008-05-16
UA100228C2 (uk) 2012-12-10
IL196027A0 (en) 2009-09-01
AU2007271449B2 (en) 2013-07-11
EP2040683B2 (fr) 2023-08-16
PH12012501774A1 (en) 2015-09-21
CA2656131C (fr) 2015-10-13
TWI508730B (zh) 2015-11-21
CU23902B1 (fr) 2013-06-28
CA2656131A1 (fr) 2008-01-10
AR106561A2 (es) 2018-01-24
IL245355B (en) 2019-05-30
CN101484143B (zh) 2012-07-04
MY169516A (en) 2019-04-22
EP2422774B1 (fr) 2015-08-12
CO6150125A2 (es) 2010-04-20
UY30462A1 (es) 2008-02-29
PH12012501774B1 (en) 2015-09-21
CA2856344C (fr) 2017-02-28

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