MA29836B1 - FUSION PROTEINS WITH ALBUMIN - Google Patents
FUSION PROTEINS WITH ALBUMINInfo
- Publication number
- MA29836B1 MA29836B1 MA30727A MA30727A MA29836B1 MA 29836 B1 MA29836 B1 MA 29836B1 MA 30727 A MA30727 A MA 30727A MA 30727 A MA30727 A MA 30727A MA 29836 B1 MA29836 B1 MA 29836B1
- Authority
- MA
- Morocco
- Prior art keywords
- fusion proteins
- albumin fusion
- albumin
- vectors
- host cells
- Prior art date
Links
- 102000009027 Albumins Human genes 0.000 title abstract 6
- 108010088751 Albumins Proteins 0.000 title abstract 6
- 102000037865 fusion proteins Human genes 0.000 title abstract 6
- 108020001507 fusion proteins Proteins 0.000 title abstract 6
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 239000013598 vector Substances 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention englobe des protéines de fusion d'albumine. Les molécules d'acides nucléiques codant pour les protéines de fusion d'albumine de l'invention sont également englobées par l'invention, de même que les vecteurs contenant ces acides nucléiques, les cellules hôtes transformées avec ces vecteurs d'acides nucléiques, et les procédés de fabrication des protéines de fusion d'albumine de l'invention et utilisant ces acides nucléiques, vecteurs, et/ou cellules hôtes. De plus, la présente invention comprend des compositions pharmaceutiques comprenant les protéines de fusion d'albumine et les procédés de traitement, de prévention, ou d'amélioration de maladies, troubles pathologies utilisant les protéines de fusion d'albumine de l'invention.The present invention encompasses albumin fusion proteins. The nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acid vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and / or host cells. In addition, the present invention includes pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating disease, pathological conditions using the albumin fusion proteins of the invention.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70752105P | 2005-08-12 | 2005-08-12 | |
US71238605P | 2005-08-31 | 2005-08-31 | |
US73272405P | 2005-11-03 | 2005-11-03 | |
US77691406P | 2006-02-28 | 2006-02-28 | |
US78136106P | 2006-03-13 | 2006-03-13 | |
US81018206P | 2006-06-02 | 2006-06-02 | |
US81368206P | 2006-06-15 | 2006-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29836B1 true MA29836B1 (en) | 2008-10-03 |
Family
ID=37758042
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA30727A MA29836B1 (en) | 2005-08-12 | 2008-03-07 | FUSION PROTEINS WITH ALBUMIN |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1924596A4 (en) |
JP (1) | JP2009504157A (en) |
KR (1) | KR20080071119A (en) |
AU (1) | AU2006280312A1 (en) |
BR (1) | BRPI0614761A2 (en) |
CA (1) | CA2618476A1 (en) |
EC (1) | ECSP088262A (en) |
IL (1) | IL189246A0 (en) |
MA (1) | MA29836B1 (en) |
MX (1) | MX2008001865A (en) |
NO (1) | NO20081233L (en) |
TN (1) | TNSN08064A1 (en) |
WO (1) | WO2007021494A2 (en) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
EP2267026A1 (en) | 2000-04-12 | 2010-12-29 | Human Genome Sciences, Inc. | Albumin fusion proteins |
PT1463751E (en) | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Albumin fusion proteins |
US20080194481A1 (en) | 2001-12-21 | 2008-08-14 | Human Genome Sciences, Inc. | Albumin Fusion Proteins |
PL1729795T3 (en) | 2004-02-09 | 2016-08-31 | Human Genome Sciences Inc | Albumin fusion proteins |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
BRPI0712383A2 (en) | 2006-06-07 | 2012-07-10 | Human Genome Sciences Inc | albumin fusion proteins |
US20100254944A1 (en) * | 2006-09-14 | 2010-10-07 | Mani Subramanian | Albumin Fusion Proteins |
EP2423221B1 (en) | 2007-01-30 | 2015-04-29 | Epivax, Inc. | Regulatory t cell epitopes, compositions and uses thereof |
US20110293557A1 (en) | 2008-06-13 | 2011-12-01 | Proyecto De Biomedicina Cima, S.L. | Conjugates for the administration of biologically active compounds |
CN102378635A (en) * | 2009-01-16 | 2012-03-14 | 特瓦制药工业有限公司 | Recombinant human albumin-human granulocyte colony stimulating factor for the prevention of neutropenia |
US9493545B2 (en) | 2009-02-11 | 2016-11-15 | Albumedix A/S | Albumin variants and conjugates |
KR20100100254A (en) * | 2009-03-05 | 2010-09-15 | (주)바이오큐어팜 | Composition for preventing or treating cancer comprising human serum albumin-timp-2 fusion protein and anti-cancer agent |
WO2011028229A1 (en) | 2009-08-24 | 2011-03-10 | Amunix Operating Inc. | Coagulation factor ix compositions and methods of making and using same |
EP3421491A3 (en) | 2009-10-30 | 2019-03-27 | Albumedix Ltd | Albumin variants |
JP5969458B2 (en) | 2010-04-09 | 2016-08-17 | アルブミディクス アクティーゼルスカブ | Albumin derivatives and variants |
BR112012029611A2 (en) | 2010-05-21 | 2017-07-25 | Merrimack Pharmaceuticals Inc | bispecific fusion protein, pharmaceutical composition, method of treating tissue damage in an individual, method of promoting tissue regeneration or survival in an individual, and nucleic acid molecule |
JP5948683B2 (en) * | 2011-02-28 | 2016-07-06 | 国立研究開発法人国立循環器病研究センター | Medicament for inhibiting malignant tumor metastasis |
US8822417B2 (en) | 2011-05-05 | 2014-09-02 | Novozymes Biopharma DIC A/S | Albumin variants |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
AU2012267484B2 (en) | 2011-06-10 | 2017-03-23 | Bioverativ Therapeutics Inc. | Pro-coagulant compounds and methods of use thereof |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
CN104383541A (en) | 2011-10-21 | 2015-03-04 | 艾伯维公司 | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon |
DK2583680T1 (en) | 2011-10-21 | 2015-01-19 | Abbvie Inc | Mono (PSI-7977), or combination treatment of DAA for use in the treatment of HCV |
EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
LT2804623T (en) | 2012-01-12 | 2019-12-10 | Bioverativ Therapeutics Inc | Chimeric factor viii polypeptides and uses thereof |
HUE043537T2 (en) | 2012-02-15 | 2019-08-28 | Bioverativ Therapeutics Inc | Recombinant factor viii proteins |
RS63870B1 (en) | 2012-02-15 | 2023-01-31 | Bioverativ Therapeutics Inc | Factor viii compositions and methods of making and using same |
BR112014018679A2 (en) | 2012-03-16 | 2017-07-04 | Novozymes Biopharma Dk As | albumin variants |
JP2015525222A (en) | 2012-06-08 | 2015-09-03 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Chimeric coagulation factor |
JP2015521589A (en) | 2012-06-08 | 2015-07-30 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Procoagulant compounds |
CN103525695B (en) * | 2012-07-04 | 2015-05-20 | 长沙中生众捷生物技术有限公司 | Portable kidney function detecting system |
LT2882450T (en) | 2012-07-11 | 2020-03-25 | Bioverativ Therapeutics Inc. | Factor viii complex with xten and von willebrand factor protein, and uses thereof |
CA2888806A1 (en) | 2012-10-18 | 2014-04-24 | Biogen Idec Ma Inc. | Methods of using a fixed dose of a clotting factor |
BR112015010318A2 (en) | 2012-11-08 | 2017-08-22 | Albumedix As | ALBUMIN VARIANTS |
RS61387B1 (en) | 2013-02-15 | 2021-02-26 | Bioverativ Therapeutics Inc | Optimized factor viii gene |
AU2014217831A1 (en) | 2013-02-16 | 2015-07-16 | Albumedix Ltd. | Pharmacokinetic animal model |
EP2968498A4 (en) | 2013-03-15 | 2016-09-07 | Biogen Ma Inc | Factor ix polypeptide formulations |
EP3013358A4 (en) | 2013-06-28 | 2017-03-22 | Biogen MA Inc. | Thrombin cleavable linker with xten and its uses thereof |
US10548953B2 (en) | 2013-08-14 | 2020-02-04 | Bioverativ Therapeutics Inc. | Factor VIII-XTEN fusions and uses thereof |
US10611794B2 (en) | 2013-09-25 | 2020-04-07 | Bioverativ Therapeutics Inc. | On-column viral inactivation methods |
EP3065769A4 (en) | 2013-11-08 | 2017-05-31 | Biogen MA Inc. | Procoagulant fusion compound |
CN116731201A (en) | 2014-01-10 | 2023-09-12 | 比奥贝拉蒂治疗公司 | Factor VIII chimeric proteins and uses thereof |
US11008561B2 (en) | 2014-06-30 | 2021-05-18 | Bioverativ Therapeutics Inc. | Optimized factor IX gene |
EA201700181A1 (en) | 2014-10-14 | 2017-09-29 | Галозим, Инк. | COMPOSITIONS OF ADENOSINDEMINASE-2 (ADA-2), THEIR OPTIONS AND METHODS OF USE |
MA40835A (en) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | ANTI-GPIIB / IIIA ANTIBODIES AND THEIR USES |
MA40861A (en) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | ANTI-GLYCOPROTEIN IIB / IIIA ANTIBODIES |
EP3331608A4 (en) | 2015-08-03 | 2019-05-01 | Bioverativ Therapeutics Inc. | Factor ix fusion proteins and methods of making and using same |
CN108137674B (en) | 2015-08-20 | 2022-12-06 | 阿尔布梅迪克斯医疗有限公司 | Albumin variants and conjugates |
CN115960249A (en) | 2015-10-02 | 2023-04-14 | 银溪制药股份有限公司 | Bispecific therapeutic proteins for tissue repair |
CN105254766B (en) * | 2015-10-26 | 2018-10-16 | 中国航天员科研训练中心 | Application of the Mecano growth factor MGF E domain peptides in regulation and control memory related gene and miRNA expression |
AU2017214378B2 (en) | 2016-02-01 | 2023-05-04 | Bioverativ Therapeutics Inc. | Optimized Factor VIII genes |
CA3022119A1 (en) | 2016-04-28 | 2017-11-02 | Emory University | Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto |
US20210333279A1 (en) | 2016-11-04 | 2021-10-28 | Aarhus Universitet | Identification and treatment of tumors characterized by an overexpression of the neonatal fc receptor |
MA46968A (en) | 2016-12-02 | 2019-10-09 | Bioverativ Therapeutics Inc | METHODS FOR INDUCTION OF IMMUNE TOLERANCE TO COAGULATION FACTORS |
KR20190090827A (en) | 2016-12-02 | 2019-08-02 | 바이오버라티브 테라퓨틱스 인크. | How Chimeric Coagulation Factors Can Be Used to Treat Hemophilic Arthrosis |
WO2018112362A1 (en) | 2016-12-16 | 2018-06-21 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
MX2019009063A (en) | 2017-01-31 | 2019-10-21 | Bioverativ Therapeutics Inc | Factor ix fusion proteins and methods of making and using same. |
JP2020517657A (en) * | 2017-04-20 | 2020-06-18 | ノヴォ ノルディスク アー/エス | Purification method of albumin fusion protein |
EP3665289A1 (en) | 2017-08-09 | 2020-06-17 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof |
WO2019152692A1 (en) | 2018-02-01 | 2019-08-08 | Bioverativ Therapeutics, Inc. | Use of lentiviral vectors expressing factor viii |
US20200069817A1 (en) | 2018-08-09 | 2020-03-05 | Bioverativ Therapeutics Inc. | Nucleic acid molecules and uses thereof for non-viral gene therapy |
JP2022514465A (en) | 2018-12-06 | 2022-02-14 | バイオベラティブ セラピューティクス インコーポレイテッド | Use of lentiviral vector expressing factor IX |
TW202126284A (en) | 2019-09-30 | 2021-07-16 | 美商百歐維拉提夫治療公司 | Lentiviral vector formulations |
WO2022030580A1 (en) * | 2020-08-06 | 2022-02-10 | 国立大学法人宮崎大学 | Novel long-acting adrenomedullin derivative, method for producing same and pharmaceutical use thereof |
JP2024056667A (en) * | 2022-10-11 | 2024-04-23 | Jcrファーマ株式会社 | Fusion protein of serum albumin and a biologically active protein |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005003296A2 (en) * | 2003-01-22 | 2005-01-13 | Human Genome Sciences, Inc. | Albumin fusion proteins |
PT1463751E (en) * | 2001-12-21 | 2013-08-26 | Human Genome Sciences Inc | Albumin fusion proteins |
PL1729795T3 (en) * | 2004-02-09 | 2016-08-31 | Human Genome Sciences Inc | Albumin fusion proteins |
US20060051859A1 (en) * | 2004-09-09 | 2006-03-09 | Yan Fu | Long acting human interferon analogs |
-
2006
- 2006-07-31 MX MX2008001865A patent/MX2008001865A/en not_active Application Discontinuation
- 2006-07-31 JP JP2008526056A patent/JP2009504157A/en not_active Withdrawn
- 2006-07-31 EP EP06813242A patent/EP1924596A4/en not_active Withdrawn
- 2006-07-31 BR BRPI0614761-5A patent/BRPI0614761A2/en not_active IP Right Cessation
- 2006-07-31 CA CA002618476A patent/CA2618476A1/en not_active Abandoned
- 2006-07-31 WO PCT/US2006/029391 patent/WO2007021494A2/en active Application Filing
- 2006-07-31 AU AU2006280312A patent/AU2006280312A1/en not_active Abandoned
- 2006-07-31 KR KR1020087006077A patent/KR20080071119A/en not_active Application Discontinuation
-
2008
- 2008-02-04 IL IL189246A patent/IL189246A0/en unknown
- 2008-02-11 TN TNP2008000064A patent/TNSN08064A1/en unknown
- 2008-03-07 MA MA30727A patent/MA29836B1/en unknown
- 2008-03-10 NO NO20081233A patent/NO20081233L/en not_active Application Discontinuation
- 2008-03-12 EC EC2008008262A patent/ECSP088262A/en unknown
Also Published As
Publication number | Publication date |
---|---|
ECSP088262A (en) | 2008-05-30 |
CA2618476A1 (en) | 2007-02-22 |
KR20080071119A (en) | 2008-08-01 |
BRPI0614761A2 (en) | 2009-05-19 |
EP1924596A2 (en) | 2008-05-28 |
WO2007021494A3 (en) | 2007-07-26 |
WO2007021494A2 (en) | 2007-02-22 |
JP2009504157A (en) | 2009-02-05 |
EP1924596A4 (en) | 2009-07-29 |
NO20081233L (en) | 2008-05-09 |
TNSN08064A1 (en) | 2009-07-14 |
MX2008001865A (en) | 2008-04-15 |
IL189246A0 (en) | 2008-08-07 |
AU2006280312A1 (en) | 2007-02-22 |
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