MA27677A1 - Azoles, procedes pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation - Google Patents

Azoles, procedes pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Info

Publication number
MA27677A1
MA27677A1 MA25480A MA25480A MA27677A1 MA 27677 A1 MA27677 A1 MA 27677A1 MA 25480 A MA25480 A MA 25480A MA 25480 A MA25480 A MA 25480A MA 27677 A1 MA27677 A1 MA 27677A1
Authority
MA
Morocco
Prior art keywords
processes
preparation
pharmaceutical compositions
formula
compositions containing
Prior art date
Application number
MA25480A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA27677A1 publication Critical patent/MA27677A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Azoles, procédé pour leur préparation, compositions pharmaceutiques les contenant et leur utilisation L'invention décrit des dérivés de type azole de formule I dans laquelle R14 et R15 représentent chacun indépendamment un atome d'hydrogène ou de fluor, T est un groupe de formule ou formules dans lesquelles R9 est un groupe pyrrolidinyle ou A-NH-B- ; A est un atome d'hydrogène ou un groupe alkyle en C1-C5 à chaîne droite ou ramifiée; B est un groupe alkylène en C1-C4 à chaîne droite ou ramifiée, -CH2-CONH-CH2 ou -CH2CH2CH2-CH(NH2); et X- est un anion pharmaceutiquement acceptable ; et les sels pharmaceutiquement acceptables de tels composés et les hydrates et produits de solvatation des composés de formule I et de leurs sels, des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation dans la fabrication de médicaments destinés au traitement d'infections fongiques et de mycoses.
MA25480A 1998-03-06 1999-03-02 Azoles, procedes pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation MA27677A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98104036 1998-03-06
EP98123310 1998-12-08
EP99101360 1999-01-26

Publications (1)

Publication Number Publication Date
MA27677A1 true MA27677A1 (fr) 2006-01-02

Family

ID=27239027

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25480A MA27677A1 (fr) 1998-03-06 1999-03-02 Azoles, procedes pour leur preparation, compositions pharmaceutiques les contenant et leur utilisation

Country Status (6)

Country Link
US (1) US6300353B1 (fr)
AR (1) AR018303A1 (fr)
AU (1) AU2931399A (fr)
MA (1) MA27677A1 (fr)
PE (1) PE20000328A1 (fr)
WO (1) WO1999045008A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812238B1 (en) 1999-11-02 2004-11-02 Basilea Pharmaceutica Ag N-substituted carbamoyloxyalkyl-azolium derivatives
BRPI0015254C1 (pt) * 1999-11-02 2021-05-25 Basilea Pharmaceutica Ag compostos derivados de carbamoiloxialquil-azólio, seu uso, bem como composição farmacêutica compreendendo os mesmos.
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
CA2497195C (fr) 2001-12-14 2014-07-08 The University Of Wyoming Methodes et compositions de liberation controlee de medicaments
CN1819998B (zh) 2003-07-18 2010-09-08 株式会社钟化 光学活性卤代醇衍生物及用其的光学活性环氧醇衍生物的制法
JP4404611B2 (ja) * 2003-11-27 2010-01-27 住友化学株式会社 エポキシトリアゾール化合物の製造方法及びその中間体
DE102004059725A1 (de) 2004-12-11 2006-06-22 Bayer Cropscience Ag 2-Alkyl-cycloalk(en)yl-carboxamide
AU2006319657B2 (en) * 2005-12-01 2010-08-12 Basilea Pharmaceutica Ag Process for the manufacture of epoxybutanol intermediates
AU2008290536B2 (en) 2007-08-21 2012-02-09 Basilea Pharmaceutica Ag Antifungal composition
US8207352B2 (en) * 2009-10-08 2012-06-26 Drug Process Licensing Associates LLC Process for the manufacture of enantiomerically pure antifungal azoles as ravuconazole and isavuconazole
WO2014023623A1 (fr) 2012-08-07 2014-02-13 Basilea Pharmaceutica Ag Procédé pour la fabrication d'isavuconazole ou ravuconazole
WO2015150947A1 (fr) * 2014-03-29 2015-10-08 Wockhardt Limited Procédé de préparation de l'isavuconazole et de ses intermédiaires
WO2016055918A1 (fr) 2014-10-08 2016-04-14 Wockhardt Limited Nouveaux polymorphes stables d'isavuconazole ou de son sel
CN106565699B (zh) * 2015-10-10 2019-07-26 江苏正大丰海制药有限公司 一种艾沙康唑硫酸盐晶体及其制备方法
CN105367528A (zh) * 2015-11-10 2016-03-02 南通诺泰生物医药技术有限公司 一种***类药物中间体(d)-1-(1-环烷仲胺基)-2-(2-四氢吡喃基)氧-1-丙酮类化合物及合成方法
CN108452848B (zh) * 2016-02-24 2020-12-11 上海兰立生物科技有限公司 一种催化剂
EP3584245A4 (fr) * 2017-02-17 2020-08-26 Wuhan LL Science And Technology Development Co., Ltd. Dérivé antibactérien de triazole, composition pharmaceutique et utilisation associées
CN108558846B (zh) * 2018-05-17 2020-07-07 天津莱茵泰克生物科技有限公司 艾莎康唑中间体的合成方法及其应用
CN110498774A (zh) * 2018-05-18 2019-11-26 上海医药工业研究院 一种艾沙康唑中间体的制备方法
WO2021245590A1 (fr) * 2020-06-04 2021-12-09 Metrochem Api Private Limited Procédé amélioré pour la préparation de dérivés de triazole
JP7454905B2 (ja) * 2021-09-28 2024-03-25 旭化成ファーマ株式会社 有効成分であるイサブコナゾール又はそのプロドラッグを含有する真菌症治療及び／又は予防剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861879A (en) 1983-02-28 1989-08-29 Janssen Pharmaceutica N.V. [[4-[4-Phenyl-1-piperazinyl)phenoxymethyl]-1-3-dioxolan-2-yl]-methyl]-1H-imidazoles and 1H-1,2,4-triazoles
GB9107055D0 (en) * 1991-04-04 1991-05-22 Pfizer Ltd Triazole antifungal agents
NZ270418A (en) * 1994-02-07 1997-09-22 Eisai Co Ltd Polycyclic triazole & imidazole derivatives, antifungal compositions
NZ328607A (en) 1996-09-09 1999-08-30 Hoffmann La Roche Heterocyclically substituted n-benzyl-azolium derivatives and fungicidal compositions
AU726495B2 (en) * 1996-09-09 2000-11-09 F. Hoffmann-La Roche Ag N-benzylazolium derivatives

Also Published As

Publication number Publication date
PE20000328A1 (es) 2000-05-08
WO1999045008A1 (fr) 1999-09-10
AR018303A1 (es) 2001-11-14
AU2931399A (en) 1999-09-20
US6300353B1 (en) 2001-10-09

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