MA26949A1 - Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives. - Google Patents

Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives.

Info

Publication number
MA26949A1
MA26949A1 MA27069A MA27069A MA26949A1 MA 26949 A1 MA26949 A1 MA 26949A1 MA 27069 A MA27069 A MA 27069A MA 27069 A MA27069 A MA 27069A MA 26949 A1 MA26949 A1 MA 26949A1
Authority
MA
Morocco
Prior art keywords
preparation
derivatives
arylanthranilic
arylanthranilic acids
acids
Prior art date
Application number
MA27069A
Other languages
English (en)
Inventor
Michael Huai Gu Chen
Edward Mark Davis
Javier Magano
Thomas Norman Nanninga
Derick Dale Winkle
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MA26949A1 publication Critical patent/MA26949A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

Abstract

DEPOSANT Société dite : WARNER-LAMBERT COMPANY LLC REVENDICATION DE PRIORITES US 25 Août 2000 60/228,206 Voir en annexe le titre de l'invention et le texte de l'abrégé Procédé pour la préparation d'acides N-arylanthraniliques et de leurs dérivés La présente invention concerne un procédé pour la préparation d'acides N-arylanthraniliques et un procédé pour la préparation d'esters, amides et esters hydroxamiques N-arylanthraniliques.
MA27069A 2000-08-25 2003-03-14 Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives. MA26949A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22820600P 2000-08-25 2000-08-25

Publications (1)

Publication Number Publication Date
MA26949A1 true MA26949A1 (fr) 2004-12-20

Family

ID=22856235

Family Applications (1)

Application Number Title Priority Date Filing Date
MA27069A MA26949A1 (fr) 2000-08-25 2003-03-14 Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives.

Country Status (31)

Country Link
EP (1) EP1313694A1 (fr)
JP (1) JP2004507518A (fr)
KR (1) KR20030059115A (fr)
CN (1) CN1458921A (fr)
AP (1) AP2001002249A0 (fr)
AR (1) AR032175A1 (fr)
AU (1) AU2001277044A1 (fr)
BG (1) BG107635A (fr)
BR (1) BR0113520A (fr)
CA (1) CA2420003A1 (fr)
CZ (1) CZ2003477A3 (fr)
DO (1) DOP2001000238A (fr)
EA (1) EA200300187A1 (fr)
GT (1) GT200100174A (fr)
HN (1) HN2001000216A (fr)
HU (1) HUP0300828A2 (fr)
IL (1) IL154507A0 (fr)
IS (1) IS6724A (fr)
MA (1) MA26949A1 (fr)
MX (1) MXPA03001654A (fr)
NO (1) NO20030844L (fr)
PA (1) PA8526501A1 (fr)
PE (1) PE20020393A1 (fr)
PL (1) PL360699A1 (fr)
SK (1) SK2072003A3 (fr)
SV (1) SV2002000601A (fr)
TN (1) TNSN01127A1 (fr)
UY (1) UY26908A1 (fr)
WO (1) WO2002018319A1 (fr)
YU (1) YU14303A (fr)
ZA (1) ZA200301182B (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI350285B (en) 2002-03-13 2011-10-11 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
US7235537B2 (en) 2002-03-13 2007-06-26 Array Biopharma, Inc. N3 alkylated benzimidazole derivatives as MEK inhibitors
US7144907B2 (en) 2003-09-03 2006-12-05 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en) 2003-09-03 2009-05-26 Array Biopharma Inc. Method of treating inflammatory diseases
BRPI0415710A (pt) 2003-10-21 2006-12-19 Warner Lambert Co formas polimórficas de n-[(r)-2,3-dihidróxi-propóxi]-3,4-diflúor-2-(2-flúor-4-io dofenilamino)-benzamida
US7732616B2 (en) 2003-11-19 2010-06-08 Array Biopharma Inc. Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
US7517994B2 (en) 2003-11-19 2009-04-14 Array Biopharma Inc. Heterocyclic inhibitors of MEK and methods of use thereof
PL1689387T3 (pl) 2003-11-19 2012-02-29 Array Biopharma Inc Bicykliczne inhibitory MEK i sposoby ich otrzymywania
RU2006121990A (ru) 2003-11-21 2007-12-27 Эррэй Биофарма Инк. (Us) Ингибиторы протеинкиназ акт
UA89035C2 (ru) * 2003-12-03 2009-12-25 Лео Фарма А/С Эфиры гидроксамовых кислот и их фармацевтическое применение
EP2332909B1 (fr) 2005-04-13 2014-10-15 Astex Therapeutics Limited Dérivés d'hydroxybenzamide et leur utilisation comme inhibiteurs de hsp90
EP2361905B1 (fr) 2005-05-18 2013-03-06 Array Biopharma Inc. Inhibiteurs hétérocycliques de MEK et leurs utilisation
US7754725B2 (en) 2006-03-01 2010-07-13 Astex Therapeutics Ltd. Dihydroxyphenyl isoindolymethanones
CN101516891B (zh) 2006-07-06 2013-06-05 阵列生物制药公司 作为akt蛋白激酶抑制剂的二氢噻吩并嘧啶
SI2049500T1 (sl) 2006-07-06 2012-01-31 Array Biopharma Inc Ciklopenta (d) pirimidini kot AKT protein kinazni inhibitorji
CA2656566C (fr) 2006-07-06 2014-06-17 Array Biopharma Inc. Dihydrofuro pyrimidines comme inhibiteurs de la proteine kinase akt
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073804B1 (fr) 2006-10-12 2017-09-13 Astex Therapeutics Limited Composes amides d'acide benzoique substitues par un groupe hydroxyle pour son utilisation dans le traitement de la douleur
WO2008044027A2 (fr) 2006-10-12 2008-04-17 Astex Therapeutics Limited Composés pharmaceutiques
GB0620259D0 (en) 2006-10-12 2006-11-22 Astex Therapeutics Ltd Pharmaceutical compounds
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2073802A1 (fr) 2006-10-12 2009-07-01 Astex Therapeutics Limited Combinaisons pharmaceutiques
WO2009006569A1 (fr) 2007-07-05 2009-01-08 Array Biopharma Inc. Pyrimidyl cyclopentanes utilsés comme inhibiteurs de la protéine kinase akt
KR20150089099A (ko) 2007-07-05 2015-08-04 어레이 바이오파마 인크. Ａｋｔ 단백질 키나제 억제제로서의 피리미딜 시클로펜탄
US8846683B2 (en) 2007-07-05 2014-09-30 Array Biopharma, Inc. Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en) 2007-07-05 2016-08-09 Array Biopharma Inc. Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CN101932564B (zh) 2008-01-09 2012-12-26 阵列生物制药公司 作为akt蛋白激酶抑制剂的羟基化嘧啶基环戊烷类
ES2401685T3 (es) 2008-01-09 2013-04-23 Array Biopharma, Inc. Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT
GB0806527D0 (en) 2008-04-11 2008-05-14 Astex Therapeutics Ltd Pharmaceutical compounds
CN101985428B (zh) * 2009-07-29 2014-02-12 杭州民生药业有限公司 邻苯胺基苯甲酸衍生物或其药学上可接受的盐、其制备方法及其用途
CA2789373A1 (fr) * 2010-02-19 2011-08-25 Centre National De La Recherche Scientifique Processus de preparation de composes chimiques d'interet par substitution nucleophile aromatique de derives d'acides carboxyliques aromatiques soutenant au moins un groupe attirant les electrons
CA2789361A1 (fr) * 2010-02-19 2011-08-25 Jacques Mortier Procede de preparation de composes chimiques d'interet par substitution nucleophile aromatique
EP2694073B1 (fr) 2011-04-01 2018-08-08 Genentech, Inc. Combinaisons de inhibiteurs d'akt et mek pour le traitement du cancer
KR102021157B1 (ko) 2011-04-01 2019-09-11 제넨테크, 인크. Ａｋｔ 억제제 화합물 및 아비라테론의 조합물, 및 사용 방법
MX2015004660A (es) * 2012-10-12 2015-08-07 Exelixis Inc Proceso novedoso para la elaboración de compuestos para su uso en el tratamiento del cáncer.
CN112745237B (zh) * 2019-10-29 2023-06-20 中国科学院上海药物研究所 2-芳基胺类化合物及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138636A (en) * 1960-06-23 1964-06-23 Parke Davis & Co Anthranilic acid derivatives
US6251943B1 (en) * 1997-02-28 2001-06-26 Warner-Lambert Company Method of treating or preventing septic shock by administering a MEK inhibitor
DE69836378T2 (de) * 1997-07-01 2007-10-11 Warner-Lambert Co. Llc Benzoesäure- und Benzamid-Derivate von Anthranilsäure und ihre Anwendung als MEK-Inhibitoren
ES2229515T3 (es) * 1997-07-01 2005-04-16 Warner-Lambert Company Llc Derivados 4-bromo o 4-yodo del acido fenilamino benzhidroxamico y su uso como inhibidores de la mek.
CA2348236A1 (fr) * 1999-01-13 2000-07-20 Stephen Douglas Barrett 4-arylamino, 4-aryloxy, et 4-arylthio diarylamines et leurs derives comme inhibiteurs selectifs de mek
CN1213997C (zh) * 1999-04-21 2005-08-10 沃尼尔·朗伯公司 制备－2－(n－苯基氨基)苯甲酸衍生物的方法

Also Published As

Publication number Publication date
BG107635A (bg) 2004-09-30
PE20020393A1 (es) 2002-05-09
KR20030059115A (ko) 2003-07-07
CZ2003477A3 (cs) 2003-10-15
SV2002000601A (es) 2002-04-03
DOP2001000238A (es) 2003-01-31
MXPA03001654A (es) 2004-09-10
CN1458921A (zh) 2003-11-26
PA8526501A1 (es) 2002-07-30
PL360699A1 (en) 2004-09-20
IL154507A0 (en) 2003-09-17
TNSN01127A1 (en) 2005-11-10
NO20030844L (no) 2003-02-25
NO20030844D0 (no) 2003-02-24
UY26908A1 (es) 2001-11-30
IS6724A (is) 2003-02-20
YU14303A (sh) 2006-08-17
AP2001002249A0 (en) 2001-09-30
AU2001277044A1 (en) 2002-03-13
JP2004507518A (ja) 2004-03-11
CA2420003A1 (fr) 2002-03-07
HUP0300828A2 (hu) 2003-09-29
EP1313694A1 (fr) 2003-05-28
AR032175A1 (es) 2003-10-29
SK2072003A3 (en) 2004-01-08
GT200100174A (es) 2002-07-18
ZA200301182B (en) 2004-05-12
BR0113520A (pt) 2003-06-24
EA200300187A1 (ru) 2003-08-28
WO2002018319A1 (fr) 2002-03-07
HN2001000216A (es) 2002-05-22

Similar Documents

Publication Publication Date Title
MA26949A1 (fr) Procede pour la preparation d'acides n-arylanthraniliques et de leurs derives.
BR9904998A (pt) Derivados de hidroxamida do ácido 5-oxo-pirrolidina-2-carboxìlico
HUP0302230A3 (en) Polyarylcarboxamides useful as lipid lowering agents, process for producing them and pharmaceutical compositions containing them
TNSN01108A1 (en) Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
GR3036305T3 (en) Chiral methyl phenyl oxazolidinones
MA27182A1 (fr) Derives de thiazole et d'oxazole qui modulent l'activite de ppar.
FR2814174B1 (fr) Lubrifiants contenant des esters d'acides gras substitues par un groupe 5-tert-butyl-4-hydroxy-3-methylphenyle
EP1219596A4 (fr) Derives de salicylamide
MA27169A1 (fr) Metabolites de l'acide (3-{ [(4-tertiobutylbenzyl)-(pyridine-3-sulfonyl)-amino]-methyl}-phenoxy)-acetique
GB2383041B (en) Process for the preparation of gabapentin
MXPA02012889A (es) Esteres de acidos 4-alcoxi-ciclohexano-1-amino-carboxilicos y procedimiento para su obtencion.
YU78302A (sh) Derivat piridin-1-oksida i postupak za njegovu transformaciju u farmaceutski efikasna jedinjenja
DZ3041A1 (fr) Composition pharmaceutique nouvelle comprenant un inhibiteur de nos, et procédé pour sa préparation.
DZ2607A1 (fr) Procédé pour la synthése de dérivés de quinoléine pharmaceutiquement actifs.
ES2076838T3 (es) Nuevo derivado de la isoindolinona, su preparacion y las composiciones farmaceuticas que le contienen.
YU15002A (sh) Upotreba alfa-lipoinske kiseline ili njenih derivata
MXPA02012112A (es) Composiciones que contienen policarbonato.
MXPA03008837A (es) Una composicion farmaceutica estable de pravastatina.
BR0016400A (pt) Processo para a preparação de sais de sódio de estatinas
WO2001054647A3 (fr) Composition pharmaceutique comprenant des transporteurs de produits a base de vitamine e, de papaine et d'hyaluronidase
DZ2932A1 (fr) Dérivés d'hygromycine a nouveaux, procédé pour le ur préparation et compositions pharmaceutiques lescontenant.
ATE248158T1 (de) Synthese von optisch reinen verbindungen als garft-inhibitoren und deren zwischenprodukte
WO2002039965A3 (fr) Composition pour l'ondulation permanente de la chevelure comprenant au moins un derive de l'acide formamidinesulfinique
HK1038768A1 (zh) 制備旋光的3-羥基吡咯烷衍生物的微生物法
ITMI20001660A0 (it) Processo per la sintesi del metil estere dell'acido l-metil-5-(4-metilbenzoli)-pirrol-2-acetico