MA22153A1 - 3'-deamino-4'-deoxy-4'-amino-8-fluoro- anthracyclines et procede pour leur preparation - Google Patents

3'-deamino-4'-deoxy-4'-amino-8-fluoro- anthracyclines et procede pour leur preparation

Info

Publication number
MA22153A1
MA22153A1 MA22423A MA22423A MA22153A1 MA 22153 A1 MA22153 A1 MA 22153A1 MA 22423 A MA22423 A MA 22423A MA 22423 A MA22423 A MA 22423A MA 22153 A1 MA22153 A1 MA 22153A1
Authority
MA
Morocco
Prior art keywords
preparation
deamino
anthracyclines
deoxy
fluoro
Prior art date
Application number
MA22423A
Other languages
English (en)
Inventor
Animati F
Lourbardi P
Arcamone F
Original Assignee
Menarini Ind Farmaceuticke Riu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ind Farmaceuticke Riu filed Critical Menarini Ind Farmaceuticke Riu
Publication of MA22153A1 publication Critical patent/MA22153A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
MA22423A 1990-05-14 1991-05-13 3'-deamino-4'-deoxy-4'-amino-8-fluoro- anthracyclines et procede pour leur preparation MA22153A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20300A IT1241927B (it) 1990-05-14 1990-05-14 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono

Publications (1)

Publication Number Publication Date
MA22153A1 true MA22153A1 (fr) 1991-12-31

Family

ID=11165542

Family Applications (1)

Application Number Title Priority Date Filing Date
MA22423A MA22153A1 (fr) 1990-05-14 1991-05-13 3'-deamino-4'-deoxy-4'-amino-8-fluoro- anthracyclines et procede pour leur preparation

Country Status (30)

Country Link
US (1) US5807835A (fr)
EP (1) EP0457215B1 (fr)
JP (1) JPH04226972A (fr)
KR (1) KR910020025A (fr)
CN (1) CN1031192C (fr)
AT (1) ATE133177T1 (fr)
AU (1) AU638574B2 (fr)
BR (1) BR9101973A (fr)
CA (1) CA2042463A1 (fr)
CS (1) CS135891A3 (fr)
DE (1) DE69116423T2 (fr)
DK (1) DK0457215T3 (fr)
ES (1) ES2084724T3 (fr)
FI (1) FI912269A (fr)
GR (1) GR3018716T3 (fr)
HU (1) HU209458B (fr)
IE (1) IE911634A1 (fr)
IL (1) IL98117A0 (fr)
IT (1) IT1241927B (fr)
MA (1) MA22153A1 (fr)
MX (1) MX25747A (fr)
NO (1) NO174963C (fr)
PL (1) PL290236A1 (fr)
PT (1) PT97663B (fr)
RO (1) RO108792B1 (fr)
RU (1) RU2095365C1 (fr)
TN (1) TNSN91036A1 (fr)
TW (1) TW228524B (fr)
YU (1) YU83691A (fr)
ZA (1) ZA913644B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262565B (it) * 1993-09-30 1996-07-04 Menarini Farma Ind Disaccaridi di antracicline, loro processi di preparazione e composizioni farmaceutiche che li contengono.
IT1271689B (it) * 1994-08-04 1997-06-04 Menarini Farma Ind 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
CN104098628B (zh) * 2014-07-31 2017-07-18 大连大学 一类n‑三氟乙酰柔红霉素的硒代衍生物，其制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663445A (en) * 1985-03-20 1987-05-05 The Ohio State Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro-2'-halo anthracycline antibiotics
GB8803076D0 (en) * 1988-02-10 1988-03-09 Erba Carlo Spa 3'-deamino-4'-deoxy-4'-amino anthracyclines
GB8902709D0 (en) * 1989-02-07 1989-03-30 Erba Carlo Spa New 4'-epi-4'-amino anthracyclines

Also Published As

Publication number Publication date
EP0457215A1 (fr) 1991-11-21
CN1056500A (zh) 1991-11-27
EP0457215B1 (fr) 1996-01-17
ES2084724T3 (es) 1996-05-16
IL98117A0 (en) 1992-06-21
NO174963B (no) 1994-05-02
FI912269A (fi) 1991-11-15
CN1031192C (zh) 1996-03-06
TNSN91036A1 (fr) 1992-10-25
RO108792B1 (ro) 1994-08-30
IT9020300A1 (it) 1991-11-14
CA2042463A1 (fr) 1991-11-15
DK0457215T3 (da) 1996-06-10
ZA913644B (en) 1992-02-26
PT97663B (pt) 1998-09-30
FI912269A0 (fi) 1991-05-10
JPH04226972A (ja) 1992-08-17
US5807835A (en) 1998-09-15
YU83691A (sh) 1994-01-20
GR3018716T3 (en) 1996-04-30
AU638574B2 (en) 1993-07-01
ATE133177T1 (de) 1996-02-15
AU7649391A (en) 1991-11-14
DE69116423D1 (de) 1996-02-29
IE911634A1 (en) 1991-11-20
DE69116423T2 (de) 1996-06-27
KR910020025A (ko) 1991-12-19
IT9020300A0 (it) 1990-05-14
NO174963C (no) 1994-08-10
CS135891A3 (en) 1992-02-19
BR9101973A (pt) 1991-12-24
IT1241927B (it) 1994-02-01
MX25747A (es) 1994-03-31
TW228524B (fr) 1994-08-21
RU2095365C1 (ru) 1997-11-10
PL290236A1 (en) 1992-07-27
HUT57227A (en) 1991-11-28
PT97663A (pt) 1992-03-31
HU209458B (en) 1994-06-28
NO911798L (no) 1991-11-15
NO911798D0 (no) 1991-05-08

Similar Documents

Publication Publication Date Title
FR2680512B1 (fr) Nouveaux derives de 2,4-thiazolidinedione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IL76454A (en) Diarylacetylene derivatives,their preparation and pharmaceutical compositions containing them
FR2680507B1 (fr) Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IL76457A (en) Tetralin derivatives,their preparation and pharmaceutical compositions containing them
FR2674524B1 (fr) Nouveaux amides alkyl heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2658823B1 (fr) Nouveaux derives d'aminomethylpiperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent .
IL78666A0 (en) Pyridine derivatives,their preparation and pharmaceutical compositions containing them
MA22495A1 (fr) Derives d'amidinophenylalanine, procede pour leur preparation et leur utilisation
FR2669029B1 (fr) Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
IL76456A0 (en) 1-substituted tetralin derivatives,their preparation and pharmaceutical compositions containing them
FR2616329B3 (fr) Nouvelles compositions laxatives et leur procede d'obtention
MA21588A1 (fr) Derives d'ether de n-pheryl pyrazole-4-yle, compositions les contenant et leur procede de preparation.
MA22153A1 (fr) 3'-deamino-4'-deoxy-4'-amino-8-fluoro- anthracyclines et procede pour leur preparation
FR2658195B1 (fr) Nouveaux derives de la 20, 21-dinoreburnamenine, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant.
FR2651227B1 (fr) Nouveaux derives de l'aminopropanol, procede pour leur preparation et compositions pharmaceutiques contenant de tels derives.
FR2563519B1 (fr) Derives d'iminothiazolidine, procede pour leur preparation et compositions pharmaceutiques les contenant
EP0301371A3 (en) Benzofuran carboxamides with basic substituents, process for their preparation and therapeutical compositions containing them
HUT54682A (en) Process for producing 13-bromine- and 13,14-dibromine-ergoline derivatives and pharmaceutical preparatives containing these compounds
FR2621820B1 (fr) Nouvelles compositions laxatives et leur procede d'obtention
FR2621314B1 (fr) Nouveaux derives de quinoleinium et d'isoquinoleinium, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2641467B2 (fr) Nouvelles compositions laxatives et leur procede d'obtention
FR2615189B1 (fr) Derives de l'amino-4 quinazolinedione-5,8, leur procede de preparation et compositions pharmaceutiques les contenant
FR2675047B1 (fr) Nouvelles compositions pharmaceutiques anti-glaucomateuses et leur procede d'obtention.