LV10494B - A method for production of annealing proteins, of gene structures and for producing of hybrids, method for transforming of streptomycetes - Google Patents

A method for production of annealing proteins, of gene structures and for producing of hybrids, method for transforming of streptomycetes

Info

Publication number
LV10494B
LV10494B LVP-93-283A LV930283A LV10494B LV 10494 B LV10494 B LV 10494B LV 930283 A LV930283 A LV 930283A LV 10494 B LV10494 B LV 10494B
Authority
LV
Latvia
Prior art keywords
streptomycetes
hybrids
transforming
producing
production
Prior art date
Application number
LVP-93-283A
Other versions
LV10494A (en
Inventor
Koller Klaus-Peter
Riess G Günther
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of LV10494A publication Critical patent/LV10494A/en
Publication of LV10494B publication Critical patent/LV10494B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Gene structures which code for the signal sequence and approximately the first ten amino acids of tendamistat as well as a required protein are expressed in high yield in streptomyces host cells, and the fusion proteins are secreted into the medium.
LVP-93-283A 1990-04-21 1993-05-04 A method for production of annealing proteins, of gene structures and for producing of hybrids, method for transforming of streptomycetes LV10494B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4012818A DE4012818A1 (en) 1990-04-21 1990-04-21 METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES

Publications (2)

Publication Number Publication Date
LV10494A LV10494A (en) 1995-02-20
LV10494B true LV10494B (en) 1996-02-20

Family

ID=6404857

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-283A LV10494B (en) 1990-04-21 1993-05-04 A method for production of annealing proteins, of gene structures and for producing of hybrids, method for transforming of streptomycetes

Country Status (29)

Country Link
EP (1) EP0453969B1 (en)
JP (1) JP3319605B2 (en)
KR (1) KR0168669B1 (en)
CN (1) CN1049248C (en)
AT (1) ATE142263T1 (en)
AU (1) AU630287B2 (en)
BR (1) BR9101587A (en)
CA (1) CA2040810C (en)
CZ (1) CZ285440B6 (en)
DE (2) DE4012818A1 (en)
DK (1) DK0453969T3 (en)
ES (1) ES2093043T3 (en)
FI (1) FI911882A (en)
GR (1) GR3021040T3 (en)
HR (1) HRP940770A2 (en)
HU (1) HU210358B (en)
IE (1) IE911322A1 (en)
IL (1) IL97903A0 (en)
LT (1) LT3686B (en)
LV (1) LV10494B (en)
NO (1) NO911557L (en)
NZ (1) NZ237882A (en)
PL (2) PL169596B1 (en)
PT (1) PT97427B (en)
RU (1) RU2055892C1 (en)
SK (1) SK110191A3 (en)
TW (1) TW213487B (en)
YU (1) YU48435B (en)
ZA (1) ZA912937B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100188800B1 (en) * 1990-09-05 1999-06-01 이센브룩, 라피세 Enzymatic process for the conversion of preproinsulins into insulins
DE59305396D1 (en) 1992-12-02 1997-03-20 Hoechst Ag Process for obtaining proinsulin with correctly connected cystine bridges
EP0622376B1 (en) * 1993-04-27 2001-08-08 Hoechst Aktiengesellschaft Amorphous monospheric forms of insulin derivatives
DE4405179A1 (en) * 1994-02-18 1995-08-24 Hoechst Ag Method of obtaining insulin with correctly connected cystine bridges
CN1061375C (en) * 1996-07-19 2001-01-31 中国科学院上海生物工程研究中心 Using allogeneic promoter to express transparent Tremellineae haemoglobin in streptomycete
EP0821006B1 (en) 1996-07-26 2004-04-21 Aventis Pharma Deutschland GmbH Derivatives of insulin having enhanced zinc binding activity
DE19825447A1 (en) 1998-06-06 1999-12-09 Hoechst Marion Roussel De Gmbh New insulin analogues with increased zinc formation
WO2004106525A1 (en) * 2003-06-03 2004-12-09 Shanghai Centre Of Research & Development Of New Drugs A fusion protein suitable to be expressed high effectively and the production method thereof
RU2395296C1 (en) * 2009-02-19 2010-07-27 Общество С Ограниченной Ответственностью "Концерн О3" Method for making oral proinsulin preparation
CN104818291A (en) * 2015-05-08 2015-08-05 江南大学 Construction and application of streptomycete recombinant expression vector

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
DE3418274A1 (en) 1984-05-17 1985-11-21 Hoechst Ag, 6230 Frankfurt SIGNAL PEPTIDE FOR THE EXCRETION OF PEPTIDES IN STREPTOMYCETS
DE3707150A1 (en) * 1987-03-06 1988-09-15 Hoechst Ag TENDAMISTAT DERIVATIVES
DE3714866A1 (en) * 1987-05-05 1988-11-24 Hoechst Ag METHOD FOR THE PRODUCTION OF FOREIGN PROTEINS IN STREPTOMYCETES
DE3715033A1 (en) 1987-05-06 1988-11-17 Hoechst Ag METHOD FOR ISOLATING FUSION PROTEINS
DE3716722A1 (en) 1987-05-19 1988-12-01 Hoechst Ag GENE TECHNOLOGICAL METHOD FOR PRODUCING ANGIOGENINES
DE3843713A1 (en) * 1988-04-25 1989-11-02 Henkel Kgaa USE OF CALCINATED HYDROTALCITES AS CATALYSTS FOR ETHOXYLATION OR PROPOXYLATION
ES2081826T3 (en) * 1988-11-03 1996-03-16 Hoechst Ag PROCEDURE FOR THE PREPARATION OF A PREVIOUS PRODUCT OF INSULIN IN STREPTOMICETS.

Also Published As

Publication number Publication date
KR0168669B1 (en) 1999-01-15
CA2040810C (en) 2001-07-24
PL169178B1 (en) 1996-06-28
EP0453969B1 (en) 1996-09-04
PT97427B (en) 1998-08-31
FI911882A (en) 1991-10-22
YU48435B (en) 1998-07-10
YU69691A (en) 1995-12-04
DE59108128D1 (en) 1996-10-10
TW213487B (en) 1993-09-21
JPH04228086A (en) 1992-08-18
GR3021040T3 (en) 1996-12-31
JP3319605B2 (en) 2002-09-03
LV10494A (en) 1995-02-20
PT97427A (en) 1992-01-31
EP0453969A1 (en) 1991-10-30
RU2055892C1 (en) 1996-03-10
IL97903A0 (en) 1992-06-21
ZA912937B (en) 1991-12-24
FI911882A0 (en) 1991-04-18
LTIP1523A (en) 1995-06-26
HU911302D0 (en) 1991-10-28
IE911322A1 (en) 1991-10-23
ATE142263T1 (en) 1996-09-15
LT3686B (en) 1996-01-25
ES2093043T3 (en) 1996-12-16
NZ237882A (en) 1993-12-23
CN1055952A (en) 1991-11-06
NO911557L (en) 1991-10-22
AU7515491A (en) 1991-10-24
BR9101587A (en) 1991-12-10
DK0453969T3 (en) 1997-02-10
PL169596B1 (en) 1996-08-30
HRP940770A2 (en) 1997-06-30
PL289953A1 (en) 1991-11-04
CN1049248C (en) 2000-02-09
DE4012818A1 (en) 1991-10-24
HUT57268A (en) 1991-11-28
KR910018551A (en) 1991-11-30
CZ110191A3 (en) 1993-08-11
HU210358B (en) 1995-04-28
SK110191A3 (en) 1995-07-11
CZ285440B6 (en) 1999-08-11
CA2040810A1 (en) 1991-10-22
NO911557D0 (en) 1991-04-19
AU630287B2 (en) 1992-10-22

Similar Documents

Publication Publication Date Title
GR3032790T3 (en) Materials and methods for hypersecretion of amino acids
AU4710393A (en) Production of phytate degrading enzymes in (trichoderma)
HUT42523A (en) Process for preparing thrombine inhibitors
LV10494B (en) A method for production of annealing proteins, of gene structures and for producing of hybrids, method for transforming of streptomycetes
AU8258591A (en) Human mk gene and protein sequence
AU7155296A (en) Interleukin-19
AU1503797A (en) Process for production of secretory Kex2 derivatives
DE3877035D1 (en) GENE TECHNOLOGICAL METHOD FOR PRODUCING POLYPEPTIDES.
DK0776971T3 (en) Hyperthermostable protease gene
AU1720397A (en) Recombinant expression of s-layer proteins
GR3022653T3 (en) A process for refolding of (pro-)chymosin, comprising recycling of urea.
EP0327522A3 (en) Production of fused proteins or polypeptides
DE3586410D1 (en) METHOD FOR PRODUCING NEUTRAL PROTEASE.
MX9601087A (en) Gene participating in the mechanism of secretion of esterase.
AU2482988A (en) Dna sequences, recombinant dna molecules and processes for producing soluble t4 proteins