LT3464306T - Fosforodiamidato morfolino oligomerų gamybos būdas - Google Patents
Fosforodiamidato morfolino oligomerų gamybos būdasInfo
- Publication number
- LT3464306T LT3464306T LTEPPCT/US2017/034284T LTUS2017034284T LT3464306T LT 3464306 T LT3464306 T LT 3464306T LT US2017034284 T LTUS2017034284 T LT US2017034284T LT 3464306 T LT3464306 T LT 3464306T
- Authority
- LT
- Lithuania
- Prior art keywords
- processes
- morpholino oligomers
- phosphorodiamidate morpholino
- preparing
- preparing phosphorodiamidate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/062—Organo-phosphoranes without P-C bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662340953P | 2016-05-24 | 2016-05-24 | |
US201662357134P | 2016-06-30 | 2016-06-30 | |
PCT/US2017/034284 WO2017205513A1 (en) | 2016-05-24 | 2017-05-24 | Processes for preparing phosphorodiamidate morpholino oligomers |
Publications (1)
Publication Number | Publication Date |
---|---|
LT3464306T true LT3464306T (lt) | 2024-05-10 |
Family
ID=59078166
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEPPCT/US2017/034284T LT3464306T (lt) | 2016-05-24 | 2017-05-24 | Fosforodiamidato morfolino oligomerų gamybos būdas |
Country Status (22)
Country | Link |
---|---|
US (2) | US10961262B2 (lt) |
EP (2) | EP4406600A2 (lt) |
JP (1) | JP6987081B2 (lt) |
KR (1) | KR102504759B1 (lt) |
CN (1) | CN109311920B (lt) |
AU (1) | AU2017271524B2 (lt) |
BR (1) | BR112018074270B1 (lt) |
CA (1) | CA3024182A1 (lt) |
CO (1) | CO2018013827A2 (lt) |
DK (1) | DK3464306T3 (lt) |
FI (1) | FI3464306T3 (lt) |
HR (1) | HRP20240583T1 (lt) |
IL (1) | IL263033B2 (lt) |
LT (1) | LT3464306T (lt) |
MA (1) | MA45155A (lt) |
MX (1) | MX2018014162A (lt) |
PT (1) | PT3464306T (lt) |
RS (1) | RS65504B1 (lt) |
SA (1) | SA518400462B1 (lt) |
SG (1) | SG11201809499UA (lt) |
TW (1) | TWI737736B (lt) |
WO (1) | WO2017205513A1 (lt) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
AU2017270598B2 (en) * | 2016-05-24 | 2022-12-01 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
DK3464306T3 (da) * | 2016-05-24 | 2024-05-21 | Sarepta Therapeutics Inc | Fremgangsmåder til fremstilling af phosphorodiamidat-morpholino-oligomerer |
MX2021008539A (es) * | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics Inc | Procesos para preparar oligomeros. |
MA45362A (fr) * | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
CN109152775B (zh) * | 2016-06-30 | 2022-04-26 | 萨勒普塔医疗公司 | 制备磷酸二酰胺吗啉代寡聚物的方法 |
ES2963336T3 (es) * | 2017-09-25 | 2024-03-26 | Sarepta Therapeutics Inc | Procesos para preparar oligómeros de fosforodiamidato morfolino mediante síntesis de flujo rápido |
SG11202100934PA (en) | 2018-08-02 | 2021-02-25 | Dyne Therapeutics Inc | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
CN109704980B (zh) * | 2019-02-16 | 2022-05-13 | 安徽大学 | 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法 |
US20230174981A1 (en) * | 2020-03-16 | 2023-06-08 | National University Corporation Tokyo Medical And Dental University | Heteronucleic acid containing morpholino nucleic acid |
US11771776B2 (en) | 2021-07-09 | 2023-10-03 | Dyne Therapeutics, Inc. | Muscle targeting complexes and uses thereof for treating dystrophinopathies |
CN118201640A (zh) * | 2021-11-01 | 2024-06-14 | 达因疗法公司 | 用于治疗肌养蛋白病的肌肉靶向复合物 |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
JP2528107B2 (ja) | 1985-03-15 | 1996-08-28 | サマ−トン,ジエ−ムス | ポリヌクレオチド測定試薬と方法 |
US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
WO1990002749A1 (en) | 1988-09-01 | 1990-03-22 | Forskningscenter Risø | Peptide synthesis method and solid support for use in the method |
EP0737193A1 (en) * | 1993-12-29 | 1996-10-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine adenosine antagonists |
US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
EP1178999B1 (en) | 1999-05-04 | 2007-03-14 | Santaris Pharma A/S | L-ribo-lna analogues |
EP1282699B1 (en) | 2000-05-04 | 2012-11-21 | Sarepta Therapeutics, Inc. | Splice-region antisense composition and method |
WO2003020739A2 (en) | 2001-09-04 | 2003-03-13 | Exiqon A/S | Novel lna compositions and uses thereof |
US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
WO2004044140A2 (en) | 2002-11-05 | 2004-05-27 | Isis Pharmaceticals, Inc. | 2’-substituted oligomeric compounds and compositions for use in gene modulations |
US7759513B2 (en) | 2003-02-21 | 2010-07-20 | Nigu Chemie Gmbh | Photolabile protective groups for improved processes to prepare oligonucleotide arrays |
ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
US9371348B2 (en) | 2006-11-27 | 2016-06-21 | The Trustees Of The University Of Pennsylvania | Photocleavable oligonucleotide and uses thereof |
US8076476B2 (en) | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
US8299206B2 (en) | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
CN101861318A (zh) | 2007-11-15 | 2010-10-13 | Avi生物制药公司 | 合成吗啉代低聚物的方法 |
CN109576268A (zh) | 2009-04-10 | 2019-04-05 | 肌肉学研究协会 | 用于治疗疾病的三环dna反义寡核苷酸、组合物和方法 |
KR102113306B1 (ko) | 2009-11-12 | 2020-05-21 | 더 유니버시티 오브 웨스턴 오스트레일리아 | 안티센스 분자 및 이를 이용한 질환 치료방법 |
KR20200133284A (ko) * | 2010-05-28 | 2020-11-26 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
TWI463423B (zh) * | 2010-05-28 | 2014-12-01 | Poynt Corp | 用以針對基於三維形狀之廣告系統使用位置資訊的方法 |
TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
WO2012043730A1 (ja) | 2010-09-30 | 2012-04-05 | 日本新薬株式会社 | モルホリノ核酸誘導体 |
BR112013020273A2 (pt) * | 2011-02-08 | 2016-10-18 | Charlotte Mecklenburg Hospital | oligonucleotídeos antissenso |
US9920084B2 (en) | 2011-08-23 | 2018-03-20 | The Royal Institution For The Advancement Of Learning/Mcgill University | Ionic tags for synthesis of oligoribonucleotides |
EP2581448B1 (en) | 2011-10-13 | 2015-01-28 | Association Institut de Myologie | Tricyclo-phosphorothioate DNA |
KR20140097398A (ko) | 2011-11-18 | 2014-08-06 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 기능적으로-변형된 올리고뉴클레오티드 및 이의 서브유니트 |
US9944926B2 (en) | 2011-11-30 | 2018-04-17 | Sarepta Therapeutics, Inc. | Induced exon inclusion in spinal muscle atrophy |
RU2619184C2 (ru) * | 2011-12-28 | 2017-05-12 | Ниппон Синяку Ко., Лтд. | Антисмысловые нуклеиновые кислоты |
EP2820155B1 (en) | 2012-02-28 | 2017-07-26 | Population Genetics Technologies Ltd. | Method for attaching a counter sequence to a nucleic acid sample |
CN102702265A (zh) * | 2012-05-14 | 2012-10-03 | 天津特安化学科技有限公司 | 一种固相合成磷酰二胺吗啉代寡核苷酸及方法 |
EP2970964B8 (en) * | 2013-03-14 | 2019-03-06 | Sarepta Therapeutics, Inc. | Exon skipping compositions for treating muscular dystrophy |
EA035882B1 (ru) * | 2013-03-14 | 2020-08-27 | Сарепта Терапьютикс, Инк. | Антисмысловые олигонуклеотиды, обеспечивающие пропуск экзонов, для лечения мышечной дистрофии |
US8999152B2 (en) * | 2013-03-15 | 2015-04-07 | Uop Llc | Process and apparatus for recovering and blending hydroprocessed hydrocarbons and composition |
WO2014144978A2 (en) | 2013-03-15 | 2014-09-18 | Sarepta Therapeutics, Inc. | Improved compositions for treating muscular dystrophy |
EP3015467A4 (en) | 2013-05-24 | 2016-11-02 | Ajinomoto Kk | PROCESS FOR THE PRODUCTION OF MORPHOLINO-OLIGONUCLEOTIDE |
MX2021008539A (es) * | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics Inc | Procesos para preparar oligomeros. |
DK3464306T3 (da) | 2016-05-24 | 2024-05-21 | Sarepta Therapeutics Inc | Fremgangsmåder til fremstilling af phosphorodiamidat-morpholino-oligomerer |
US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
MA45183A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
MA45362A (fr) * | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
KR20230110811A (ko) | 2016-12-19 | 2023-07-25 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체 |
-
2017
- 2017-05-24 DK DK17731337.6T patent/DK3464306T3/da active
- 2017-05-24 PT PT177313376T patent/PT3464306T/pt unknown
- 2017-05-24 EP EP24161437.9A patent/EP4406600A2/en active Pending
- 2017-05-24 CA CA3024182A patent/CA3024182A1/en active Pending
- 2017-05-24 WO PCT/US2017/034284 patent/WO2017205513A1/en unknown
- 2017-05-24 AU AU2017271524A patent/AU2017271524B2/en active Active
- 2017-05-24 RS RS20240522A patent/RS65504B1/sr unknown
- 2017-05-24 MX MX2018014162A patent/MX2018014162A/es unknown
- 2017-05-24 EP EP17731337.6A patent/EP3464306B1/en active Active
- 2017-05-24 LT LTEPPCT/US2017/034284T patent/LT3464306T/lt unknown
- 2017-05-24 HR HRP20240583TT patent/HRP20240583T1/hr unknown
- 2017-05-24 TW TW106117191A patent/TWI737736B/zh active
- 2017-05-24 JP JP2018560662A patent/JP6987081B2/ja active Active
- 2017-05-24 MA MA045155A patent/MA45155A/fr unknown
- 2017-05-24 SG SG11201809499UA patent/SG11201809499UA/en unknown
- 2017-05-24 US US16/302,443 patent/US10961262B2/en active Active
- 2017-05-24 FI FIEP17731337.6T patent/FI3464306T3/fi active
- 2017-05-24 BR BR112018074270-8A patent/BR112018074270B1/pt active IP Right Grant
- 2017-05-24 KR KR1020187036634A patent/KR102504759B1/ko active IP Right Grant
- 2017-05-24 CN CN201780030642.8A patent/CN109311920B/zh active Active
-
2018
- 2018-11-15 IL IL263033A patent/IL263033B2/en unknown
- 2018-11-19 SA SA518400462A patent/SA518400462B1/ar unknown
- 2018-12-19 CO CONC2018/0013827A patent/CO2018013827A2/es unknown
-
2021
- 2021-02-08 US US17/169,611 patent/US20220340605A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
TW201825506A (zh) | 2018-07-16 |
CA3024182A1 (en) | 2017-11-30 |
DK3464306T3 (da) | 2024-05-21 |
US10961262B2 (en) | 2021-03-30 |
KR102504759B1 (ko) | 2023-02-28 |
EP3464306B1 (en) | 2024-03-27 |
CO2018013827A2 (es) | 2018-12-28 |
FI3464306T3 (fi) | 2024-05-16 |
AU2017271524B2 (en) | 2021-06-24 |
SG11201809499UA (en) | 2018-12-28 |
MA45155A (fr) | 2019-04-10 |
EP4406600A2 (en) | 2024-07-31 |
PT3464306T (pt) | 2024-05-17 |
CN109311920A (zh) | 2019-02-05 |
IL263033B (en) | 2022-10-01 |
CN109311920B (zh) | 2021-11-09 |
RS65504B1 (sr) | 2024-06-28 |
EP3464306A1 (en) | 2019-04-10 |
HRP20240583T1 (hr) | 2024-07-19 |
SA518400462B1 (ar) | 2022-06-12 |
US20190276480A1 (en) | 2019-09-12 |
BR112018074270B1 (pt) | 2021-02-02 |
BR112018074270A2 (pt) | 2019-03-12 |
US20220340605A1 (en) | 2022-10-27 |
JP2019523754A (ja) | 2019-08-29 |
KR20190013844A (ko) | 2019-02-11 |
WO2017205513A1 (en) | 2017-11-30 |
IL263033A (en) | 2018-12-31 |
JP6987081B2 (ja) | 2021-12-22 |
AU2017271524A1 (en) | 2018-11-15 |
TWI737736B (zh) | 2021-09-01 |
MX2018014162A (es) | 2019-04-01 |
IL263033B2 (en) | 2023-02-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL263033A (en) | Processes for the preparation of phosphorodiamidate morpholino oligomers | |
IL263044A (en) | Processes for the preparation of phosphorodiamidate morpholino oligomers | |
ZA201708142B (en) | Process for preparing 4-amino-pyridazines | |
PL3325443T3 (pl) | Sposób otrzymywania pridopidyny | |
IL263149A (en) | Processes for the preparation of oligomers | |
IL274439A (en) | Process for making Tapinaroff | |
HUE058257T2 (hu) | Eljárások oxatiazin-jellegû vegyületek elõállítására | |
IL263052B (en) | Processes for the preparation of phosphorodiamidate morpholino oligomers | |
PL3548473T3 (pl) | Sposób wytwarzania hmf | |
HK1247097A1 (zh) | 用於製備氟酮內酯的方法 | |
IL253877A0 (en) | Process for preparing 3-chloro-2-vinylphenylsulfonates | |
EP3463389A4 (en) | PROCESSES FOR THE PREPARATION OF MORPHOLINO PHOSPHORODIAMIDATE OLIGOMERS | |
IL272114A (en) | A process for the preparation of phosphorus-containing alpha-aminonitriles | |
ZA201908452B (en) | Improved process for preparing imetelstat | |
ZA201903463B (en) | Method for preparing hexadecahydropyrene | |
HUE064118T2 (hu) | Harmonika csatlakozószerkezethez | |
ZA201807441B (en) | Process for preparing oxathiazin-like compounds | |
IL253830B (en) | Process for the preparation of piperidine-4-carbothioamide hydrochloride |