LT3464306T - Fosforodiamidato morfolino oligomerų gamybos būdas - Google Patents

Fosforodiamidato morfolino oligomerų gamybos būdas

Info

Publication number
LT3464306T
LT3464306T LTEPPCT/US2017/034284T LTUS2017034284T LT3464306T LT 3464306 T LT3464306 T LT 3464306T LT US2017034284 T LTUS2017034284 T LT US2017034284T LT 3464306 T LT3464306 T LT 3464306T
Authority
LT
Lithuania
Prior art keywords
processes
morpholino oligomers
phosphorodiamidate morpholino
preparing
preparing phosphorodiamidate
Prior art date
Application number
LTEPPCT/US2017/034284T
Other languages
English (en)
Inventor
Bao Cai
Mitchell MARTINI
Ross SHIMABUKU
Katie THOMAS
Original Assignee
Sarepta Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sarepta Therapeutics, Inc. filed Critical Sarepta Therapeutics, Inc.
Publication of LT3464306T publication Critical patent/LT3464306T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/062—Organo-phosphoranes without P-C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LTEPPCT/US2017/034284T 2016-05-24 2017-05-24 Fosforodiamidato morfolino oligomerų gamybos būdas LT3464306T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662340953P 2016-05-24 2016-05-24
US201662357134P 2016-06-30 2016-06-30
PCT/US2017/034284 WO2017205513A1 (en) 2016-05-24 2017-05-24 Processes for preparing phosphorodiamidate morpholino oligomers

Publications (1)

Publication Number Publication Date
LT3464306T true LT3464306T (lt) 2024-05-10

Family

ID=59078166

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2017/034284T LT3464306T (lt) 2016-05-24 2017-05-24 Fosforodiamidato morfolino oligomerų gamybos būdas

Country Status (22)

Country Link
US (2) US10961262B2 (lt)
EP (2) EP4406600A2 (lt)
JP (1) JP6987081B2 (lt)
KR (1) KR102504759B1 (lt)
CN (1) CN109311920B (lt)
AU (1) AU2017271524B2 (lt)
BR (1) BR112018074270B1 (lt)
CA (1) CA3024182A1 (lt)
CO (1) CO2018013827A2 (lt)
DK (1) DK3464306T3 (lt)
FI (1) FI3464306T3 (lt)
HR (1) HRP20240583T1 (lt)
IL (1) IL263033B2 (lt)
LT (1) LT3464306T (lt)
MA (1) MA45155A (lt)
MX (1) MX2018014162A (lt)
PT (1) PT3464306T (lt)
RS (1) RS65504B1 (lt)
SA (1) SA518400462B1 (lt)
SG (1) SG11201809499UA (lt)
TW (1) TWI737736B (lt)
WO (1) WO2017205513A1 (lt)

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TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
US11472824B2 (en) 2016-05-24 2022-10-18 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
AU2017270598B2 (en) * 2016-05-24 2022-12-01 Sarepta Therapeutics, Inc. Processes for preparing phosphorodiamidate morpholino oligomers
DK3464306T3 (da) * 2016-05-24 2024-05-21 Sarepta Therapeutics Inc Fremgangsmåder til fremstilling af phosphorodiamidat-morpholino-oligomerer
MX2021008539A (es) * 2016-05-24 2022-10-18 Sarepta Therapeutics Inc Procesos para preparar oligomeros.
MA45362A (fr) * 2016-05-24 2019-04-10 Sarepta Therapeutics Inc Procédés de préparation d'oligomères morpholino de phosphorodiamidate
CN109152775B (zh) * 2016-06-30 2022-04-26 萨勒普塔医疗公司 制备磷酸二酰胺吗啉代寡聚物的方法
ES2963336T3 (es) * 2017-09-25 2024-03-26 Sarepta Therapeutics Inc Procesos para preparar oligómeros de fosforodiamidato morfolino mediante síntesis de flujo rápido
SG11202100934PA (en) 2018-08-02 2021-02-25 Dyne Therapeutics Inc Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN109704980B (zh) * 2019-02-16 2022-05-13 安徽大学 一种(z)-3-氨基-2-(2-氟-3-甲氧基苯基)-2-丁烯酸乙酯的制备方法
US20230174981A1 (en) * 2020-03-16 2023-06-08 National University Corporation Tokyo Medical And Dental University Heteronucleic acid containing morpholino nucleic acid
US11771776B2 (en) 2021-07-09 2023-10-03 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for treating dystrophinopathies
CN118201640A (zh) * 2021-11-01 2024-06-14 达因疗法公司 用于治疗肌养蛋白病的肌肉靶向复合物

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DK3464306T3 (da) 2016-05-24 2024-05-21 Sarepta Therapeutics Inc Fremgangsmåder til fremstilling af phosphorodiamidat-morpholino-oligomerer
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MA45183A (fr) 2016-05-24 2019-04-10 Sarepta Therapeutics Inc Procédés de préparation d'oligomères morpholino de phosphorodiamidate
MA45362A (fr) * 2016-05-24 2019-04-10 Sarepta Therapeutics Inc Procédés de préparation d'oligomères morpholino de phosphorodiamidate
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Also Published As

Publication number Publication date
TW201825506A (zh) 2018-07-16
CA3024182A1 (en) 2017-11-30
DK3464306T3 (da) 2024-05-21
US10961262B2 (en) 2021-03-30
KR102504759B1 (ko) 2023-02-28
EP3464306B1 (en) 2024-03-27
CO2018013827A2 (es) 2018-12-28
FI3464306T3 (fi) 2024-05-16
AU2017271524B2 (en) 2021-06-24
SG11201809499UA (en) 2018-12-28
MA45155A (fr) 2019-04-10
EP4406600A2 (en) 2024-07-31
PT3464306T (pt) 2024-05-17
CN109311920A (zh) 2019-02-05
IL263033B (en) 2022-10-01
CN109311920B (zh) 2021-11-09
RS65504B1 (sr) 2024-06-28
EP3464306A1 (en) 2019-04-10
HRP20240583T1 (hr) 2024-07-19
SA518400462B1 (ar) 2022-06-12
US20190276480A1 (en) 2019-09-12
BR112018074270B1 (pt) 2021-02-02
BR112018074270A2 (pt) 2019-03-12
US20220340605A1 (en) 2022-10-27
JP2019523754A (ja) 2019-08-29
KR20190013844A (ko) 2019-02-11
WO2017205513A1 (en) 2017-11-30
IL263033A (en) 2018-12-31
JP6987081B2 (ja) 2021-12-22
AU2017271524A1 (en) 2018-11-15
TWI737736B (zh) 2021-09-01
MX2018014162A (es) 2019-04-01
IL263033B2 (en) 2023-02-01

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