LT2934514T - Transtiretino stabilizatoriai ir jų panaudojimas transtiretino amiloidozės bei sąveikų baltymas-baltymas inhibavimui - Google Patents
Transtiretino stabilizatoriai ir jų panaudojimas transtiretino amiloidozės bei sąveikų baltymas-baltymas inhibavimuiInfo
- Publication number
- LT2934514T LT2934514T LTEP13866060.0T LT13866060T LT2934514T LT 2934514 T LT2934514 T LT 2934514T LT 13866060 T LT13866060 T LT 13866060T LT 2934514 T LT2934514 T LT 2934514T
- Authority
- LT
- Lithuania
- Prior art keywords
- transthyretin
- protein
- stabilizers
- inhibiting
- amyloidosis
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/08—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261745089P | 2012-12-21 | 2012-12-21 | |
US13/830,731 US9169214B2 (en) | 2012-12-21 | 2013-03-14 | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
PCT/US2013/076213 WO2014100227A1 (en) | 2012-12-21 | 2013-12-18 | Transthyretin stabilizers and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2934514T true LT2934514T (lt) | 2018-09-10 |
Family
ID=50975335
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LTEP13866060.0T LT2934514T (lt) | 2012-12-21 | 2013-12-18 | Transtiretino stabilizatoriai ir jų panaudojimas transtiretino amiloidozės bei sąveikų baltymas-baltymas inhibavimui |
Country Status (14)
Country | Link |
---|---|
US (7) | US9169214B2 (lt) |
EP (1) | EP2934514B1 (lt) |
JP (1) | JP6333289B2 (lt) |
CY (1) | CY1120543T1 (lt) |
DK (1) | DK2934514T3 (lt) |
ES (1) | ES2683994T3 (lt) |
HR (1) | HRP20181268T1 (lt) |
HU (1) | HUE038853T2 (lt) |
LT (1) | LT2934514T (lt) |
PL (1) | PL2934514T3 (lt) |
PT (1) | PT2934514T (lt) |
RS (1) | RS57572B1 (lt) |
SI (1) | SI2934514T1 (lt) |
WO (1) | WO2014100227A1 (lt) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US8748458B2 (en) | 2009-01-28 | 2014-06-10 | Karus Therapeutics Limited | Scriptaid isosteres and their use in therapy |
WO2011140333A1 (en) * | 2010-05-07 | 2011-11-10 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
NZ707366A (en) | 2012-11-07 | 2018-11-30 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors and their use in therapy |
US9169214B2 (en) | 2012-12-21 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
AU2014264370B2 (en) | 2013-05-10 | 2017-12-14 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
WO2016025129A1 (en) | 2014-08-14 | 2016-02-18 | Alhamadsheh Mamoun M | Conjugation of pharmaceutically active agents with transthyretin ligands through adjustable linkers to increase serum half-life |
GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
EA201991921A1 (ru) * | 2017-02-17 | 2020-02-06 | Эйдос Терапьютикс, Инк. | Способы получения ag-10, его промежуточных соединений и их солей |
JOP20180092A1 (ar) | 2017-10-13 | 2019-04-13 | Gilead Sciences Inc | مثبطات hiv بروتياز |
US11058668B2 (en) * | 2018-03-23 | 2021-07-13 | Eidos Therapeutics, Inc. | Methods of treating TTR amyloidosis using AG10 |
EA202190561A1 (ru) | 2018-08-17 | 2021-05-26 | Эйдос Терапьютикс, Инк. | Препараты ag10 |
US20220071965A1 (en) | 2018-12-20 | 2022-03-10 | Pfizer Inc. | Pharmaceutical Compositions and Methods Comprising A Combination of a Benzoxazole Transthyretin Stabilizer and an Additional Therapeutic Agent |
TW202104210A (zh) | 2019-04-17 | 2021-02-01 | 美商基利科學股份有限公司 | Hiv蛋白酶抑制劑 |
CA3141998A1 (en) * | 2019-05-31 | 2020-12-03 | Plex Pharmaceuticals, Inc. | Pharmacological agents for treating protein aggregation diseases of the eye |
CA3172824A1 (en) | 2020-05-12 | 2021-11-18 | Neurimmune Ag | Combination therapy for ttr amyloidosis |
WO2022112919A1 (en) | 2020-11-25 | 2022-06-02 | Pfizer Inc. | (aza)benzothiazolyl substituted pyrazole compounds |
WO2022187633A1 (en) * | 2021-03-04 | 2022-09-09 | The Scripps Research Institute | Protein acylation modulation by heterobifunctional molecles |
WO2023009612A1 (en) | 2021-07-28 | 2023-02-02 | Protego Biopharma, Inc. | Acoramidis (3-(3-(3,5-dimethyl-1h-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid) derivatives for stabilizing transthyretin (tts) and inhibiting tts misfolding for the treatment of e.g. peripheral ttr amyloidosis |
WO2023052652A1 (en) | 2021-10-01 | 2023-04-06 | Sandoz Ag | Crystalline form of acoramidis hydrochloride |
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US9169214B2 (en) | 2012-12-21 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Compounds and compositions that bind and stabilize transthyretin and their use for inhibiting transthyretin amyloidosis and protein-protein interactions |
-
2013
- 2013-03-14 US US13/830,731 patent/US9169214B2/en active Active
- 2013-12-18 PL PL13866060T patent/PL2934514T3/pl unknown
- 2013-12-18 RS RS20180966A patent/RS57572B1/sr unknown
- 2013-12-18 DK DK13866060.0T patent/DK2934514T3/en active
- 2013-12-18 HU HUE13866060A patent/HUE038853T2/hu unknown
- 2013-12-18 WO PCT/US2013/076213 patent/WO2014100227A1/en active Application Filing
- 2013-12-18 PT PT13866060T patent/PT2934514T/pt unknown
- 2013-12-18 ES ES13866060.0T patent/ES2683994T3/es active Active
- 2013-12-18 EP EP13866060.0A patent/EP2934514B1/en active Active
- 2013-12-18 JP JP2015549642A patent/JP6333289B2/ja active Active
- 2013-12-18 LT LTEP13866060.0T patent/LT2934514T/lt unknown
- 2013-12-18 SI SI201331131T patent/SI2934514T1/sl unknown
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2015
- 2015-10-06 US US14/876,447 patent/US9642838B2/en active Active
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2017
- 2017-04-05 US US15/480,139 patent/US9913826B2/en active Active
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2018
- 2018-01-30 US US15/883,750 patent/US10398681B2/en active Active
- 2018-08-03 HR HRP20181268TT patent/HRP20181268T1/hr unknown
- 2018-08-07 CY CY20181100823T patent/CY1120543T1/el unknown
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2019
- 2019-07-12 US US16/510,574 patent/US10842777B2/en active Active
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2020
- 2020-10-20 US US17/075,519 patent/US20210260034A1/en not_active Abandoned
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2023
- 2023-01-03 US US18/092,709 patent/US20230390246A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2014100227A1 (en) | 2014-06-26 |
US20230390246A1 (en) | 2023-12-07 |
CY1120543T1 (el) | 2019-07-10 |
RS57572B1 (sr) | 2018-11-30 |
US9913826B2 (en) | 2018-03-13 |
US10842777B2 (en) | 2020-11-24 |
US20190000805A1 (en) | 2019-01-03 |
US20210260034A1 (en) | 2021-08-26 |
EP2934514B1 (en) | 2018-05-16 |
HUE038853T2 (hu) | 2018-12-28 |
US9169214B2 (en) | 2015-10-27 |
JP2016504338A (ja) | 2016-02-12 |
US20160081984A1 (en) | 2016-03-24 |
US20140179751A1 (en) | 2014-06-26 |
US9642838B2 (en) | 2017-05-09 |
EP2934514A4 (en) | 2016-06-08 |
JP6333289B2 (ja) | 2018-05-30 |
EP2934514A1 (en) | 2015-10-28 |
ES2683994T3 (es) | 2018-10-01 |
SI2934514T1 (sl) | 2018-10-30 |
US20200093797A1 (en) | 2020-03-26 |
US20170340608A1 (en) | 2017-11-30 |
US10398681B2 (en) | 2019-09-03 |
HRP20181268T1 (hr) | 2018-10-05 |
PL2934514T3 (pl) | 2018-12-31 |
PT2934514T (pt) | 2018-10-16 |
DK2934514T3 (en) | 2018-08-20 |
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