LT2494039T - Ląstelių perprogramavimo būdai ir jų panaudojimas - Google Patents

Ląstelių perprogramavimo būdai ir jų panaudojimas

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Publication number
LT2494039T
LT2494039T LTEP10825907.8T LT10825907T LT2494039T LT 2494039 T LT2494039 T LT 2494039T LT 10825907 T LT10825907 T LT 10825907T LT 2494039 T LT2494039 T LT 2494039T
Authority
LT
Lithuania
Prior art keywords
methods
reprogramming cells
reprogramming
cells
Prior art date
Application number
LTEP10825907.8T
Other languages
English (en)
Inventor
Jan-Eric Ahlfors
Rouwayda Elayoubi
Original Assignee
Genesis Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genesis Technologies Limited filed Critical Genesis Technologies Limited
Publication of LT2494039T publication Critical patent/LT2494039T/lt

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Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642091B2 (en) 2005-02-24 2010-01-05 Jau-Nan Lee Human trophoblast stem cells and use thereof
US9453205B2 (en) 2009-10-31 2016-09-27 Genesis Technologies Limited Methods for reprogramming cells and uses thereof
ES2739672T3 (es) * 2009-10-31 2020-02-03 Genesis Tech Limited Procedimientos de reprogramación de células y usos de los mismos
US9228170B2 (en) * 2010-02-05 2016-01-05 Auckland Uniservices Limited Cell programming
CN110016463A (zh) * 2010-11-15 2019-07-16 艾克塞利瑞提德生物技术公司 由人类滋养层干细胞生成神经干细胞
KR102482184B1 (ko) * 2010-12-22 2022-12-28 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
US20140024119A1 (en) * 2011-01-14 2014-01-23 Korea Research Institute Of Bioscience And Biotechnology Cell reprogramming composition comprising rex1 and an induced pluripotent stem cell production method using the same
US20140289882A1 (en) * 2011-07-19 2014-09-25 Oregon Health And Science University Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage
US20130224782A1 (en) * 2012-02-29 2013-08-29 Chenzhong Kuang Neurogenesis screening method and system using adipose tissue derived stem cells
US9428730B2 (en) 2012-02-29 2016-08-30 Mead Johnson Nutrition Company Coatings and culture media for promoting neurogenesis in adipose tissue derived stem cells
GB201118964D0 (en) * 2011-11-03 2011-12-14 Ucl Business Plc Method
AU2012350353B2 (en) * 2011-12-13 2018-01-04 Unisa Ventures Pty Ltd Method of producing multipotent stem cells
CN102604894B (zh) * 2012-02-29 2014-07-30 中国科学院广州生物医药与健康研究院 用于制备神经干细胞的培养基及其用途
WO2013138368A1 (en) * 2012-03-12 2013-09-19 Loma Linda University Medical Center Substances and methods for the treatment of cerebral amyloid angiopathy related conditions or diseases
US10561742B2 (en) 2012-07-19 2020-02-18 The Penn State Research Foundation Methods and compositions for treatment of disease or injury of the nervous system
US20140134139A1 (en) * 2012-11-07 2014-05-15 Northwestern University Cd34+ cells and methods of use
US10294457B2 (en) 2012-11-29 2019-05-21 Takara Bio Europe Ab Maturation of hepatocyte-like cells derived from human pluripotent stem cells
CN113712997A (zh) 2012-11-30 2021-11-30 艾克塞利瑞提德生物技术公司 通过调节mir-124分化干细胞的方法
CA2895106C (en) * 2012-12-14 2023-01-24 Anthrogenesis Corporation Anoikis resistant placental stem cells and uses thereof
US9982232B2 (en) * 2012-12-17 2018-05-29 John PIMANDA Methods of generating cells with multilineage potential
ES2908026T3 (es) 2013-03-14 2022-04-27 Brigham & Womens Hospital Inc Composiciones y procedimientos para la expansión y el cultivo de células madre epiteliales
AU2014236285A1 (en) * 2013-03-14 2015-11-05 Children's Medical Center Corporation Compositions and methods for reprogramming hematopoietic stem cell lineages
WO2014170488A1 (en) * 2013-04-19 2014-10-23 Universita' Degli Studi Di Milano Methods for the conversion of somatic cells into pancreatic-hormone secreting cells
KR101655383B1 (ko) 2013-07-27 2016-09-08 고려대학교 산학협력단 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물
CA2926372C (en) * 2013-10-10 2023-09-26 Mcmaster University Diagnosis and monitoring of endometriosis through bdnf and full-length ntrk2 levels
US20160298080A1 (en) 2013-12-03 2016-10-13 The Johns Hopkins University Method for highly efficient conversion of human stem cells to lineage-specific neurons
US9512406B2 (en) 2013-12-20 2016-12-06 The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone Generating hepatocytes
FR3016372B1 (fr) * 2014-01-13 2018-01-19 Centre Leon Berard Procede de preparation de cellules pluripotentes induites
JP2017509322A (ja) * 2014-01-29 2017-04-06 ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト (ゲーエムベーハー) 分化細胞の分化転換
US11268069B2 (en) 2014-03-04 2022-03-08 Fate Therapeutics, Inc. Reprogramming methods and cell culture platforms
US20150353623A1 (en) * 2014-04-03 2015-12-10 Loma Linda University Substances and methods for the treatment of cerebral amyloid angiopathy related conditions or diseases
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
KR101731624B1 (ko) * 2014-07-01 2017-05-04 광주과학기술원 세포 리프로그래밍 유도용 조성물
EP3189134A1 (en) 2014-09-03 2017-07-12 The Brigham and Women's Hospital, Inc. Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss
US9730975B2 (en) 2014-11-25 2017-08-15 The Penn State Research Foundation Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair
JP6836990B2 (ja) 2014-11-26 2021-03-03 アクセラレイテッド・バイオサイエンシズ・コーポレーション 誘導肝細胞およびそれらの使用
MA41296A (fr) * 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
US10839509B2 (en) 2015-07-10 2020-11-17 3Scan Inc. Spatial multiplexing of histological stains
CN105062953A (zh) * 2015-08-06 2015-11-18 深圳爱生再生医学科技有限公司 三维诱导间充质干细胞转化为胰岛细胞的方法
SG11201802957PA (en) 2015-10-16 2018-05-30 Fate Therapeutics Inc Platform for the induction & maintenance of ground state pluripotency
AU2017205194A1 (en) 2016-01-08 2018-07-19 Massachusetts Institute Of Technology Production of differentiated enteroendocrine cells and insulin producing cells
CN109069544B (zh) 2016-02-18 2023-05-09 宾州研究基金会 脑内生成gaba能神经元
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
CN113151157B (zh) * 2016-06-03 2022-06-28 中国人民解放军军事医学科学院野战输血研究所 由消化道来源上皮细胞重编程获得的内胚层干/祖细胞的传代方法及应用
CN105861447B (zh) * 2016-06-13 2017-12-19 广州市搏克生物技术有限公司 一种非病毒iPSCs诱导组合物及其试剂盒
KR102373674B1 (ko) 2016-06-20 2022-03-11 제네시스 테크놀로지스 리미티드 자동화된 세포 처리 시스템 및 방법
SG10201910821XA (en) 2016-12-30 2020-01-30 Frequency Therapeutics Inc 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
EP3587563A4 (en) * 2017-02-24 2021-01-06 Koji Tanabe NERVOUS CELL PRODUCTION PROCESS
CN111471653B (zh) * 2017-03-01 2022-11-25 中国科学院动物研究所 一种将非神经元细胞转化为神经元细胞的方法
CN110093309B (zh) * 2018-01-29 2021-07-02 中国科学院动物研究所 一种诱导成纤维细胞转分化为脂肪细胞的方法
CN113881624A (zh) * 2018-01-29 2022-01-04 中国科学院动物研究所 一种细胞诱导的方法
CN110093310B (zh) * 2018-01-29 2021-07-02 中国科学院动物研究所 一种将成纤维细胞转化为永生化细胞的方法及其应用
CN110093305B (zh) * 2018-01-29 2021-07-02 中国科学院动物研究所 一种诱导肝细胞体外扩增的方法
EP3746109A4 (en) * 2018-02-02 2021-11-03 The Penn State Research Foundation METHODS AND MATERIALS FOR TREATING BRAIN INJURY
CN110305846A (zh) * 2018-03-20 2019-10-08 中山大学中山眼科中心 视网膜节细胞的制备方法
WO2019241846A1 (en) * 2018-06-22 2019-12-26 The University Of Sydney Expansion and differentiation of neuronal precursor cells
US11617745B2 (en) 2018-08-17 2023-04-04 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating FOXO
AU2019321641A1 (en) 2018-08-17 2021-04-15 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating Jag-1
WO2020061366A1 (en) * 2018-09-19 2020-03-26 Regeneration Biomedical, Inc. Wnt-activated adipose-derived stem cell apparatuses, methods and systems
US11518971B2 (en) 2018-11-27 2022-12-06 Research Triangle Institute Method and apparatus for spatial control of cellular growth
KR20220000913A (ko) * 2019-01-02 2022-01-04 주식회사 셀라퓨틱스바이오 체세포로부터 분화된 신규한 유사신경교세포 및 이를 포함하는 신경 질환 치료용 세포 치료제
JP2022517784A (ja) * 2019-01-11 2022-03-10 フィジーン、エルエルシー 線維芽細胞再生細胞
KR102183208B1 (ko) * 2019-07-25 2020-11-25 한국과학기술연구원 Ngn2(neurogenin-2)를 이용하여 척수 손상 모델에서 반응성 성상세포를 신경세포로 리프로그래밍하는 방법
WO2021119061A1 (en) * 2019-12-09 2021-06-17 The Brigham And Women's Hospital, Inc. Methods for generating hematopoietic stem cells
CN111471651A (zh) * 2020-04-24 2020-07-31 中国人民解放军第四军医大学 一种人脂肪干细胞无血清培养基及其制备方法
CN113862218A (zh) * 2021-10-12 2021-12-31 广州医科大学附属第一医院(广州呼吸中心) 一种肿瘤相关性血管周细胞亚群及制备方法与应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087168A (en) * 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US7621606B2 (en) 2001-08-27 2009-11-24 Advanced Cell Technology, Inc. Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
US20020136709A1 (en) 2000-12-12 2002-09-26 Nucleus Remodeling, Inc. In vitro-derived adult pluripotent stem cells and uses therefor
US20030217378A1 (en) 2002-04-05 2003-11-20 The University Of Georgia Research Foundation, Inc Cloning using rapidly matured oocytes
KR100519227B1 (ko) * 2002-08-17 2005-10-07 서해영 간엽 줄기세포를 신경세포로 분화시키는 방법
EP1856248A4 (en) 2005-02-09 2010-01-20 Burnham Inst Medical Research HOMOGENEOUS NEURALE CURRENT CELLS
US8440460B2 (en) 2005-07-27 2013-05-14 The Board Of Regents Of The University Of Texas System Methods for transdifferentiating cells
CN101389761A (zh) 2006-02-27 2009-03-18 银怎株式会社 使用bmi-1使星形胶质细胞去分化成为神经干细胞
US20080152630A1 (en) * 2006-12-07 2008-06-26 Irene Ginis Method of generation and expansion of tissue-progenitor cells and mature tissue cells from intact bone marrow or intact umbilical cord tissue
WO2009018832A1 (en) * 2007-08-09 2009-02-12 Rigshospitalet Method for increasing the plasticity level of a cell
EP3078738B1 (en) 2007-08-31 2020-05-20 Whitehead Institute for Biomedical Research Wnt pathway stimulation in reprogramming somatic cells
KR101564044B1 (ko) * 2007-10-31 2015-10-28 고쿠리츠 다이가쿠 호진 교토 다이가쿠 핵초기화 방법
US20090136461A1 (en) * 2007-11-28 2009-05-28 Moon Suk Kim Neuronal differentiation method of adult stem cells using small molecules
AU2008333972A1 (en) * 2007-11-30 2009-06-11 New York Medical College Compositions comprising HDAC inhibitors and methods of their use in restoring stem cell function and preventing heart failure
CA2709566A1 (en) 2007-12-17 2009-06-25 Gliamed, Inc. Stem-like cells and method for reprogramming adult mammalian somatic cells
BRPI0908708A2 (pt) * 2008-03-17 2019-09-24 Scripps Research Inst métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desdiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de células tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de célula tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, composição, e, kit
EP2276838A4 (en) * 2008-04-07 2012-02-01 Nupotential Inc RE-PROGRAMMING A CELL BY INDUCING A PLURIPOTENTIC GENE THROUGH RNA INTERFERENCE
US9399759B2 (en) 2008-11-05 2016-07-26 Keio University Method for producing neurospheres
US20120121546A1 (en) 2009-02-05 2012-05-17 Vishal Bhasin Method of Producing Progenitor Cells from Differentiated Cells
WO2010124143A1 (en) * 2009-04-23 2010-10-28 Nevada Cancer Institute Reprogramming of somatic cells with purified proteins
BRPI1010684A2 (pt) * 2009-05-20 2017-07-18 Cardio3 Biosciences Sa método para determinar o potencial cardiorregenerativo de células mamíferas
ES2739672T3 (es) * 2009-10-31 2020-02-03 Genesis Tech Limited Procedimientos de reprogramación de células y usos de los mismos
US9453205B2 (en) * 2009-10-31 2016-09-27 Genesis Technologies Limited Methods for reprogramming cells and uses thereof
WO2011163531A2 (en) * 2010-06-23 2011-12-29 Vivoscript, Inc. Compositions and methods for re-programming cells without genetic modification for treatment of cardiovascular diseases
US9828585B2 (en) * 2011-08-30 2017-11-28 The J. David Gladstone Instututes Methods for generating cardiomyocytes
WO2013116307A1 (en) 2012-01-30 2013-08-08 Mount Sinai School Of Medicine Method for programming differentiated cells into hematopoietic stem cells

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