LT2018534A - Monoclonal antibodies against a peptide regulating the synthesis of psen 1 protein associated with alzheimer's disease - Google Patents
Monoclonal antibodies against a peptide regulating the synthesis of psen 1 protein associated with alzheimer's diseaseInfo
- Publication number
- LT2018534A LT2018534A LT2018534A LT2018534A LT2018534A LT 2018534 A LT2018534 A LT 2018534A LT 2018534 A LT2018534 A LT 2018534A LT 2018534 A LT2018534 A LT 2018534A LT 2018534 A LT2018534 A LT 2018534A
- Authority
- LT
- Lithuania
- Prior art keywords
- monoclonal antibodies
- psen1
- peptide
- antibodies against
- psen
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 241001323319 Psen Species 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 101100192145 Homo sapiens PSEN1 gene Proteins 0.000 abstract 1
- 101000617536 Homo sapiens Presenilin-1 Proteins 0.000 abstract 1
- 101150035190 PSEN1 gene Proteins 0.000 abstract 1
- 102100022033 Presenilin-1 Human genes 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000003149 assay kit Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
The present invention provides novel monoclonal antibodies specific for the PSEN1-49 peptide encoded by the human PSEN1 gene. The developed monoclonal antibodies can be used for diagnostic purposes. The present invention provides novel hybridomas 11D1 and 2C1 that produce monoclonal antibodies against the 49 amino acid peptide PSEN1-49 encoded by the 5'-NCS of the PSEN1 gene. Detailed analysis of the recognition sequences showed that 11D1 and 2C1 monoclonal antibodies recognize different fragments of the PSEN1 sequence. Monoclonal antibodies can be used to test the PSEN1-49 peptide and to develop assay kits.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LT2018534A LT6721B (en) | 2018-07-04 | 2018-07-04 | Monoclonal antibodies against a peptide regulating the synthesis of psen 1 protein associated with alzheimer's disease |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LT2018534A LT6721B (en) | 2018-07-04 | 2018-07-04 | Monoclonal antibodies against a peptide regulating the synthesis of psen 1 protein associated with alzheimer's disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LT2018534A true LT2018534A (en) | 2020-01-27 |
| LT6721B LT6721B (en) | 2020-03-25 |
Family
ID=69174630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LT2018534A LT6721B (en) | 2018-07-04 | 2018-07-04 | Monoclonal antibodies against a peptide regulating the synthesis of psen 1 protein associated with alzheimer's disease |
Country Status (1)
| Country | Link |
|---|---|
| LT (1) | LT6721B (en) |
-
2018
- 2018-07-04 LT LT2018534A patent/LT6721B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| LT6721B (en) | 2020-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Patent application published |
Effective date: 20200127 |
|
| FG9A | Patent granted |
Effective date: 20200325 |
|
| MM9A | Lapsed patents |
Effective date: 20230704 |