KR970706492A - 광 판독 스트립(Optically readable strip for Analyte detection having on-strip standard) - Google Patents

광 판독 스트립(Optically readable strip for Analyte detection having on-strip standard)

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KR970706492A
KR970706492A KR1019970701613A KR19970701613A KR970706492A KR 970706492 A KR970706492 A KR 970706492A KR 1019970701613 A KR1019970701613 A KR 1019970701613A KR 19970701613 A KR19970701613 A KR 19970701613A KR 970706492 A KR970706492 A KR 970706492A
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데이비드 피 매트징거
조오지 엠 데펀
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제임스 리젠필드
라이프스캔 인코포레이티드
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    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/521—Single-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G01N2021/8488—Investigating reagent band the band presenting reference patches

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Abstract

본 발명에 따라 그것에 도포된 액체를 갖고, 이러한 액체 중의 애널라이트의 존재 또는 그의 양을 측정하기 위한 시험 스트립이 제공된다. 특히, 이 시험 스트립은 도포된 액체 중에 존재하는 애널라이트의 양의 함수로서 반사율이 변화하는 반응 영역을 포함한다. 이 스트립은 광학적 판독 장치로 삽입되는 것이다. 표준 영역은 스트립이 판독 장치에 삽입될 때 반응 영역을 유도하도록 스트립 상에 위치한다. 이 장치에는 스트립이 장치에 완전히 삽입된 것일 때 표준 영역의 반사율 값 및 스트립이 삽입된 후 반응 영역의 반사율 값을 순차로 측정하기 위한 광학적 수단이 제공될 수 있다. 이 장치에는 표준 영역 반사율 및 반응 영역 반사율의 함수로서 문제의 애널라이트의 존재 및(또는) 그의 양을 산출하기 위한 수단들이 추가로 제공된다.

Description

광 판독 스트립(Optically readable strip for Analyte detection having on-strip standard)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 교훈을 실시하는 스트립 및 장치의 전개 사시도이고, 제2도는 장치에 완전히 삽입된 스트립을 설명하는 제1도의 직선 2-2를 따라 취한 부분 종단면도이며, 제3도는 장치에 완전히 삽입된 스트립을 설명하는, 제1도의 직선 3-3을 따라 취한 부분 횡단면도이고, 제6도는 장치에 삽입된 제4도의 스트립 및 스트립을 판독하기 위한 수단들의 개략적 종단면도이다.

Claims (13)

  1. 선도 에지 및 후속 에지; 반응 영역을 한정하는 표면을 갖고, 이 반응 영역은 도포된 액체 내에 존재하는 애널라이트의 양의 함수로서 반사율에서 변화하는, 그곳에 액체를 도포시키기 위한 부분 및 추가로 상기 반응 영역에 대해 상대적으로 큰 반사율을 갖고, 상기 스트립이 상기 장치에 삽입될 때 상기 반응 영역을 선도하도록 상기 스트립 상에 위치하고, 상기 반응 영역으로부터 상기 선도 에지를 향하여 약 0.3인치의 거리 만큼 신장하는 표준 영역을 포함하는 상기 시험 스트립을 광학적 판독 장치에 삽입함으로써 상기 장치에는 스트립이 장치에 삽입될 때 표준 영역의 반사율 및 스트립이 삽입된 후 반응 영역의 반사율을 순차로 측정하기 위한 광학적 수단 및 이들 반사율의 함수로서 액체 중의 애널라이트의 존재 또는 그의 양을 측정하기 위한 마이크로프로세싱 수단이 제공될 수 있는, 액체 중의 애널라이트의 존재 또는 그의 양을 측정하기 위한 시험 스트립.
  2. 제1항에 있어서, 상기 표준 영역은 반응 영역이 글루코스 100㎎/㎗를 함유하는 완전형의 도포 후 색체-전개될 때의 반응 영역의 반사율의 적어도 약 4배인 660㎚ 파장의 빛의 반사율을 나타내는 시험 스트립.
  3. 제1항에 있어서, 상기 표준 영역은 이것이 초당 3.5 인치의 속도로 장치에 삽입될 때 그의 반사율이 장치에 의해 적어도 3배 판독되기에 충분한 길이를 갖는 스트립.
  4. 제1항에 있어서, 표준 영역이 적어도 약 0.4 인치의 길이를 갖는 스트립.
  5. 제1항에 있어서, 표준 영역이 광학적으로 볼 수 있는 반응 영역의 폭을 갖는 시험 스트립.
  6. 제1항에 있어서, 상기 표준 영역이 적어도 약 0.13인치 폭을 갖는 시험 스트립.
  7. 제1항에 있어서, 표준 영역이 스트립의 선도 에지로부터 반응 영역의 선도 에지로 신장하도록 위치하는 스트립.
  8. 제1항에 있어서, 표준 영역이 스트립의 선도 에지의 내부 지점으로부터 반응 영역의 선도 에지로 신장하도록 위치하는 스트립.
  9. 상기 장치로의 수직 삽입부와 관련하여 선도 횡단 에지 및 후속 횡단 에지를 갖고, 제1 및 제2주 표면을 갖는, 수직으로 신장하는 지지체; 제1 및 제2주표면을 갖는 시험 패드를 함유하고, 상기 지지체의 제1주표면과 직면관계인 상기 시험 패드의 제2주표면을 갖는 상기 지지체에 부착된 것인 다공성 반응물; 반응 영역을 한정하고, 상기 구멍을 통해 시험 패드의 제2표면의 일부를 광학적으로 노출시키도록 위치하는 지지체 내의 지지체 구멍을 포함하고; 상기 지지체의 상기 제2표면은 상기 반응 영역에 대해 상대적으로 큰 반사율의 표준 영역을 추가로 포함하고, 상기 스트립이 상기 장치에 삽입될 때 상기 반응 영역을 선도하도록 상기 지지체의 제2표면상에 위치하고, 상기 표준 영역은 상기 반응 영역으로부터 상기 선도 에지를 향하여 적어도 0.3인치의 거리만큼 신장하는, 시험 스트립을 광학적 판독 장치에 삽입함으로써, 상기 장치에는 스트립이 장치에 삽입될 때 표준 영역의 반사율 및 스트립이 삽입된 후 반응영역의 반사율을 순차로 측정하기 위한 광학적 수단 및 이들 반사율의 함수로서 액체 중의 애널라이트의 존재 또는 그의 양을 측정하기 위한 마이크로프로세싱 수단이 제공될 수 있는, 액체 중의 애널라이트의 존재 또는 그의 양을 측정하기 위한 시험 스트립.
  10. 스트립의 선도 에지를 장치에 삽입하기 위한 개수; 상기 개구로부터 신장하고, 스트립이 완전히 삽입된 후 스트립을 임페딩하기 위한 스트립 임페딩 수단에서 종료되는 스트립 통로; 구멍과 중첩하는 스트립의 표면의 일부를 볼 수 있고, 구멍이 통로를 따라 위치함으로써 상기 스트립이 상기 스트립의 상기 반응 영역에 완전히 삽입될 때 상기 스트립을 그를 통해 볼수 있는 상기 통로를 통한 광학적 구멍; 상기 광학적 구멍과 광학적으로 소통하고, 상기 스트립의 상기 일부 상으로 빛을 향하게 하기 위한 적어도 하나의 광원 및 상기 스트립의 상기 부분으로부터 반사된 빛을 검출하기 위한 적어도 하나의 반사율 검출기를 포함하는 광학적 수단; 스트립이 통로에 삽입되는 것일 때 및 스트립이 스트립 임페딩 수단에 다다른 후 광학적 수단을 제어하기 위한 마이크로프로세서; 및 얻어진 양을 보고하기 위한 수단들을 포함하고, 상기 마이크로프로세서는 상기 광원 및 검출기가 반응 영역을 선도하는 스트립의 표면 상에 제공되고, 스트립이 삽입될 때 광학적 구멍을 통해 볼 수 있는 표준 영역의 복수개의 판독 값을 얻을 수 있게 함으로써 검정된 표준 반사율을 제공하도록 프로그램된 것이고; 상기 마이크로프로세서는 스트립이 삽입된 후 반응 영역의 반사율을 상기 광원 및 상기 검출기가 판독할 수 있도록 프로그램된 것이고; 상기 마이크로프로세서는 상기 검정된 표준 영역 반사율 및 상기 반응 영역의 반사율의 함수로서 시료 중의 애널라이트의 양을 측정하도록 프로그램된 것인, 반사 영역이 도포된 액체 중에 존재하는 애널라이트의 양의 함수로서 반사율에서 변화하는 반응 영역을 한정하는 광학적으로 볼 수 있는 표면을 갖는 수직으로 신장하는 시험 스트립의 일부에 도포된 애널라이트의 존재 또는 그의 양을 측정하는 장치.
  11. 도포된 액체 중에 존재한 애널라이트의 양의 함수로설 반사율에서 변화하는 반응 영역을 한정하는 표면을 갖는 부분을 포함하고, 실질적으로 일정한 반사율의 표준 영역을 추가로 포함하는 시험 스트립에 액체를 도포하는 단계; 상기 스트립이삽입될 때 상기 반응 영역을 선도하는 상기 표준 영역을 갖는 상기 장치에 상기 스트립을 삽입하는 단계; 상기 스트립이 삽입될 때 상기 표준 영역의 반사율을 판독하는 단계; 상기 스트립이 삽입된 후 상기 반응 영역의 반사율을 판독하는 단계; 및 이들 반사율 판독 값의 함수로서 액체 중의 애널라이트의 존재 또는 그의 양을 측정하는 단계를 포함하는, 광학적 판독 장치에 삽입된 시험 스트립에 도포된 액체 중의 애널라이트의 준재 또는 그의 양을 측정하기 위한 방법.
  12. 제11항에 있어서, 상기 표준 영역의 상기 반사율이 복수 개의 판독 값을 취하고, 애널라이트의 존재 또는 그의 양을 측정하기 위해 사용된 판독 값으로서 이러한 판독 값 중 가장 큰 값만을 사용함으로서 판독되는 방법.
  13. 제12항에 있어서, 적어도 3개의 판독 값이 표준 영역으로부터 취해지는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970701613A 1994-09-08 1995-09-08 광판독스트립 KR100354581B1 (ko)

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US30216094A 1994-09-08 1994-09-08
US302160 1994-09-08
PCT/US1995/012156 WO1996007908A1 (en) 1994-09-08 1995-09-08 Optically readable strip for analyte detection having on-strip standard

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KR100354581B1 KR100354581B1 (ko) 2003-02-11

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AU (1) AU709992B2 (ko)
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CN1109895C (zh) 2003-05-28
EP0779984B1 (en) 2001-11-21
CN1162358A (zh) 1997-10-15
NO971008D0 (no) 1997-03-05
CA2199494A1 (en) 1996-03-14
DK0779984T3 (da) 2002-05-21
DE69524108T2 (de) 2002-06-06
NO971008L (no) 1997-04-25
WO1996007908A1 (en) 1996-03-14
JPH10505676A (ja) 1998-06-02
CA2199494C (en) 2007-11-06
DE69524108D1 (de) 2002-01-03
PT779984E (pt) 2002-03-28
EP0779984A1 (en) 1997-06-25
US5780304A (en) 1998-07-14
AU3723595A (en) 1996-03-27
KR100354581B1 (ko) 2003-02-11
ES2168389T3 (es) 2002-06-16
NO319708B1 (no) 2005-09-05
MX9701792A (es) 1997-06-28
ATE209355T1 (de) 2001-12-15
AU709992B2 (en) 1999-09-09
JP3488925B2 (ja) 2004-01-19

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