KR970705635A - 사람 케모킨 베타-9(Human chemokine beta-9) - Google Patents
사람 케모킨 베타-9(Human chemokine beta-9) Download PDFInfo
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- 102000019034 Chemokines Human genes 0.000 title abstract 2
- 108010012236 Chemokines Proteins 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 25
- 229920001184 polypeptide Polymers 0.000 claims abstract 24
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 24
- 108020004414 DNA Proteins 0.000 claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 7
- 201000010099 disease Diseases 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 2
- 230000035772 mutation Effects 0.000 claims abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 5
- 239000002299 complementary DNA Substances 0.000 claims description 2
- 108091033319 polynucleotide Proteins 0.000 claims 16
- 102000040430 polynucleotide Human genes 0.000 claims 16
- 239000002157 polynucleotide Substances 0.000 claims 16
- 150000001413 amino acids Chemical class 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 230000009452 underexpressoin Effects 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 108091026890 Coding region Proteins 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000037581 Persistent Infection Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 208000037976 chronic inflammation Diseases 0.000 abstract 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000010188 recombinant method Methods 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
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Abstract
사람 Ckβ-9 폴리펩타이드 및 이러한 케모킨 폴리펩타이드를 암호화하는 DNA(RNA) 및 재조합 기술에 의해 이러한 폴리펩타이드를 제조하는 방법이 기술되어 있다. 또한 백혈병, 종양, 만성 감염, 자가면적 질환, 섬유중 질환, 상처 치유 및 건선 치료시 이러한 Ckβ-9 폴리펩타이드를 이용하는 방법이 또한 기술되어 있다. 이러한 폴리펩타이드에 대한 길항제 및 류마치스 관절염, 자가면역 질환, 만성 염증성 질환 및 감염성 질환을 치료하기 위한 치료제로서의 이의 용도가 또한 기술되어 있다. Ckβ-9 암호화 서열중 돌연변이의 존재 및 Ckβ-9 단백질의 과-발현을 검출하는 진단 방법이 또한 기술되어 있다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 cDNA 서열을 도시한 것이며 이는 Ckβ-9의 유추된 아미노산 서열에 상응한다. 제2도는 Ckβ-9 과 에토탁신의 성숙한 펩타이드(하단)간의 아미노산 서열 상동성을 나타낸다.
Claims (20)
- (a) 서열 2에 설정된 바와 같은 -23번 아미노산에서 111번 아미노산까지를 포함하는 폴리펩타이드를 암호화하는 폴리뉴클레오타이드; (b) 서열2에 설정된 바와 같은 1번 아미노산에서 111번 아미노산까지를 포함하는 폴리펩타이드를 암호화하는 폴리뉴클레오타이드; (c) 상기 (a) 또는 (b)의 폴리뉴클레오타이드와 70% 이상의 동일하며 이에 하이브리드화할 수 있는 폴리뉴클레오타이드; 및 (d) 상기 (a), (b) 또는 (c)의 폴리뉴클레오타이드의 폴리뉴클레오타이드 단편으로 이루어진 그룹중에서 선택된 구성원을 포함하는 분리된 폴리뉴클레오타이드.
- 제1항에 있어서, DNA인 폴리뉴클레오타이드.
- 제2항에 있어서, 서열 2의 1번 아미노산에서 111번 아미노산까지를 포함하는 폴리펩타이드를 암호화하는 폴리뉴클레오타이드.
- (a) ATCC 기탁 번호 제75803호중에 포함된 DNA에의해 발현된 아미노산 서열을 갖는 성숙한 폴리펩타이드를 암호화하는 폴리뉴클레오타이드; (b) ATCC 기탁 번호 제75803호중에 포함된 DNA에 의해 발현된 아미노산 서열을 갖는 폴리펩타이드를 암호화하는 폴리뉴클레오타이드; (c) 상기 (a)의 폴리뉴클레오타이드; 및 (d) 상기 (a), (b) 또는 (c)의 폴리뉴클레오타이드의 폴리뉴클레오타이드 단편으로 이루어진 그룹중에서 선택된 구성원을 포함하는 분리된 폴리뉴클레오타이드.
- 제1항에 있어서, 서열 1에 설정된 바와 같은 1번 뉴클레오타이드에서 405번 뉴클레오타이드까지의 서열을 포함하는 폴리뉴클레오타이드.
- 제1항에 있어서, 서열 1에 설정된 바와 같은 70번 뉴클레오타이드에서 405번 뉴클레오타이드까지의 서열을 포함하는 폴리뉴클레오타이드.
- 제2항에 따른 DNA를 포함하는 벡터.
- 제7항에 따른 벡터를 사용하여 유전적으로 조작된 숙주 세포.
- 제8항에 따른 숙주 세포로부터 상기 DNA가 암호화한 폴리펩타이드를 발현시킴을 포함하는, 폴리펩타이드의 제조 방법.
- 제7항에 따른 벡터로 세포를 유전적으로 조작함을 포함하여, 폴리펩타이드를 발현시킬 수 있는 세포를 생산하는 방법.
- (i) 서열 2의 유추된 아미노산 서열을 갖는 성숙한 폴리펩타이드, 및 이의 단편, 동족체 및 유도체; 및 (ⅱ) ATCC 기탁번호 제75803호의 cDNA에 의해 암호화된 성숙한 폴리펩타이드, 및 이의 단편, 동족체 및 유도체로 이루어진 그룹중에서 선택된 구성원을 포함하는, 제1항에 따른 폴리뉴클레오타이드에 의해 암호화된 폴리펩타이드.
- 제11항에 있어서, 서열 2의 1번 아미노산에서 111번 아미노산까지를 포함하는 폴리펩타이드.
- 제11항에 따른 폴리펩타이드에 대한 수용체의 활성화를 억제하는 화합물.
- 제11항에 따른 폴리펩타이드에 대한 수용체의 활성화시키는 화합물.
- 제11항에 따른 폴리펩타이드의 치료학적 유효량을, Ckβ-9를필요로 하는 환자에게 투여함을 포함하여, 상기 환자를 치료하는 방법.
- 제15항에 있어서, 치료학적 유효량의 상기 폴리펩타이드가, 상기 폴리펩타이드를 암호화하는 DNA를 환자에게 제공하고 생체내에서 이러한 폴리펩타이드를 발현시킴에 의해 투여되는 방법.
- 제13항에 따른 화합물의 치료학적 유효량을, Ckβ-9 폴리펩타이드를 억제할 필요가 있는 환자에게 투여함을 포함하여, 상기 환자를 치료하는 방법.
- 제11항에 따른 폴리펩타이드를 암호화하는 핵산 서열중의 돌연변이를 결정함을 포함하여, 상기 폴리펩타이드의 저-발현(under-expression)과 관련된 질병 자체 또는 이러한 빌병에 걸리기 쉬운지의 여부를 진단하는 방법.
- 숙주로부터 기원한 샘플중에서 제11항에 따른 폴리펩타이드의 존재를 분석함을 포함하는 진단 방법.
- 수용체에 대한 결합을 허용하는 조건하에서, 분석적으로 검출가능한 화합물을, 이 화합물과의 결합에 반응하여 검출가능한 시그날을 제공할 수 있는 제2성분과 얀합된, 폴리펩타이드에 대한 수용체를 자체의 표면상에서 발현하는 세포와 접촉시키는 단계; 및 상기 화합물과 수용체의 상호작용으로부터 생성되는 시그날의 부재 또는 존재 여부를 검정하는 단계를 포함하는, 제11항의 폴리펩타이드에 대한 효능제 화합물 또는 길항제 화합물을 동정하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
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US29425194A | 1994-08-23 | 1994-08-23 | |
US08/294,251 | 1994-08-23 | ||
PCT/US1995/006260 WO1996006169A1 (en) | 1994-08-23 | 1995-06-06 | Human chemokine beta-9 |
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KR970705635A true KR970705635A (ko) | 1997-10-09 |
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KR1019970701144A KR970705635A (ko) | 1994-08-23 | 1995-06-06 | 사람 케모킨 베타-9(Human chemokine beta-9) |
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US (3) | US6518046B1 (ko) |
EP (1) | EP0799311B1 (ko) |
JP (2) | JPH10505493A (ko) |
KR (1) | KR970705635A (ko) |
AT (1) | ATE290080T1 (ko) |
AU (1) | AU708558B2 (ko) |
CA (1) | CA2198206A1 (ko) |
DE (1) | DE69534044T2 (ko) |
DK (1) | DK0799311T3 (ko) |
ES (1) | ES2235172T3 (ko) |
MX (1) | MX9701330A (ko) |
NZ (1) | NZ288799A (ko) |
PT (1) | PT799311E (ko) |
WO (1) | WO1996006169A1 (ko) |
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US6174995B1 (en) | 1994-08-23 | 2001-01-16 | Haodong Li | Human chemokines, CKβ4 and CKβ10/MCP-4 |
US6391589B1 (en) | 1994-08-23 | 2002-05-21 | Human Genome Sciences, Inc. | Human chemokine beta-10 mutant polypeptides |
US6458349B1 (en) | 1995-06-02 | 2002-10-01 | Human Genome Sciences, Inc. | Chemokine β-4 polypeptides |
US7005509B1 (en) | 1995-02-17 | 2006-02-28 | Incyte Corporation | Chemokine PANEC-1 polynucleotides and compositions and methods related thereto |
US6290948B1 (en) * | 1996-05-14 | 2001-09-18 | Smithkline Beecham Corporation | Method of treating sepsis and ARDS using chamohine beta-10 |
CA2267092A1 (en) * | 1996-10-02 | 1998-04-09 | Schering Corporation | Mammalian chemokines |
AU5496798A (en) * | 1997-01-20 | 1998-08-07 | Shionogi & Co., Ltd. | Human cc chemokine slc |
JP2002504823A (ja) * | 1997-06-11 | 2002-02-12 | ジェネティックス・インスチチュート・インコーポレーテッド | ヒトl105蛋白およびそれをコードするポリヌクレオチド |
US6084071A (en) * | 1997-06-11 | 2000-07-04 | Genetics Institute | Human L105 polypeptides and polynucleotides encoding same |
US6153441A (en) * | 1998-02-17 | 2000-11-28 | Smithkline Beecham Corporation | Methods of screening for agonists and antagonists for human CCR7 receptor and CKβ-9 ligand and interaction thereof |
EP1140141A2 (en) * | 1998-12-31 | 2001-10-10 | Chiron Corporation | Methods for treating cancer and for mediating chemotaxis of dendritic cells |
US6949243B1 (en) | 1999-11-24 | 2005-09-27 | Schering Corporation | Methods of inhibiting metastasis |
MXPA02005199A (es) * | 1999-11-24 | 2002-11-07 | Schering Corp | Metodos para inhibir metastasis. |
US20030175801A1 (en) * | 2001-04-18 | 2003-09-18 | Dubinett Steven M. | Methods of using secondary lymphoid organ chemokine to modulate physiological processes in mammals |
US20020168358A1 (en) * | 2001-04-30 | 2002-11-14 | Gladue Ronald P. | Treatment of T-cell mediated diseases |
EP1534752B1 (en) | 2002-05-01 | 2011-08-03 | Human Genome Sciences, Inc. | Antibodies that specifically bind to chemokine beta-4 |
US8795668B2 (en) * | 2005-12-23 | 2014-08-05 | The Regents Of The University Of Michigan | Methods for treating pulmonary fibrosis |
WO2007136707A2 (en) * | 2006-05-17 | 2007-11-29 | University Of Utah Research Foundation | Methods and compositions related to eosinophil regulation |
MX361929B (es) | 2010-11-19 | 2018-12-19 | Eisai R&D Man Co Ltd Star | Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes. |
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DE69130981D1 (de) | 1990-09-14 | 1999-04-15 | Chiron Corp | Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen |
US7005509B1 (en) | 1995-02-17 | 2006-02-28 | Incyte Corporation | Chemokine PANEC-1 polynucleotides and compositions and methods related thereto |
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- 1995-06-06 EP EP95923661A patent/EP0799311B1/en not_active Expired - Lifetime
- 1995-06-06 CA CA002198206A patent/CA2198206A1/en not_active Abandoned
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EP0799311A4 (en) | 1998-09-30 |
DK0799311T3 (da) | 2005-07-11 |
US7097985B2 (en) | 2006-08-29 |
US6518046B1 (en) | 2003-02-11 |
JPH10505493A (ja) | 1998-06-02 |
US7198944B2 (en) | 2007-04-03 |
JP2003047492A (ja) | 2003-02-18 |
US20050244888A1 (en) | 2005-11-03 |
PT799311E (pt) | 2005-05-31 |
AU708558B2 (en) | 1999-08-05 |
AU2814195A (en) | 1996-03-14 |
CA2198206A1 (en) | 1996-02-29 |
WO1996006169A1 (en) | 1996-02-29 |
NZ288799A (en) | 1999-06-29 |
MX9701330A (es) | 1998-02-28 |
ES2235172T3 (es) | 2005-07-01 |
EP0799311B1 (en) | 2005-03-02 |
US20060040313A1 (en) | 2006-02-23 |
EP0799311A1 (en) | 1997-10-08 |
DE69534044D1 (de) | 2005-04-07 |
ATE290080T1 (de) | 2005-03-15 |
DE69534044T2 (de) | 2005-12-29 |
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