KR960703405A - TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY - Google Patents

TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY

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Publication number
KR960703405A
KR960703405A KR1019950705952A KR19950705952A KR960703405A KR 960703405 A KR960703405 A KR 960703405A KR 1019950705952 A KR1019950705952 A KR 1019950705952A KR 19950705952 A KR19950705952 A KR 19950705952A KR 960703405 A KR960703405 A KR 960703405A
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KR
South Korea
Prior art keywords
atom
bond
methine
integer
represent
Prior art date
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KR1019950705952A
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Korean (ko)
Inventor
마사토시 하야시
마사야 가토
유스께 사까이
가즈히꼬 미쯔이
Original Assignee
나까무라 다메아끼
스미토모 긴조꾸 고우교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 나까무라 다메아끼, 스미토모 긴조꾸 고우교 가부시끼가이샤 filed Critical 나까무라 다메아끼
Publication of KR960703405A publication Critical patent/KR960703405A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

본 발명은 하기 일반식(I)의 테트라졸 유도체 또는 이것의 약리학적으로 허용될 수 있는 염, 및 이것을 함유하는 항-히스타민제, 항-알레르기제 및 천식 치료제에 관한 것이다:The present invention relates to tetrazole derivatives of the general formula (I) or pharmacologically acceptable salts thereof, and to anti-histamines, anti-allergic agents and therapeutic agents for asthma containing them:

상기식에서, A는 -CH=CH, -CH2-CH2-, -CH20-, 및 산소 원자 또는 황 원자를 나타내거나, 또는 A가 인접 방향족 고리와 상호 결합되지않는 경우, 이것은 인접 방향족 고리에 각각 결합된 2개의 수소 원자를 나타내고; V는 -CH=CH- 또는 황 원자를 나타내고; X 및 Y는 각각 알콕시기, 할로겐 원자 또는 수소 원자를 나타내고; (a) W는 하나의 결합을 나타내고, Z는 탄소 원자 또는 메틴을 나타내고, B는 Z와 함께 결합을 형성하거나 또는 히드록실기를 나타내거나, 또는 (b) W, Z 및 B는 각각 하나의 결합, 질소 원자 및 수소 원자를 나타내거나, 또는 (c) W, Z 및 B는 각각 산소 원자, 메틴 및 수소 원자를 나타내고; P는 2 또는 3의 정수를 타나내고; n은 1 내지 6의 정수를 나타낸다.Wherein A represents —CH═CH, —CH 2 —CH 2 —, —CH 2 0—, and an oxygen atom or a sulfur atom, or if A is not mutually bonded to an adjacent aromatic ring, it is an adjacent aromatic Two hydrogen atoms each bonded to the ring; V represents —CH═CH— or a sulfur atom; X and Y each represent an alkoxy group, a halogen atom or a hydrogen atom; (a) W represents one bond, Z represents a carbon atom or methine, B represents a bond with Z or represents a hydroxyl group, or (b) W, Z and B each represents one Or a bond, a nitrogen atom and a hydrogen atom, or (c) W, Z and B each represent an oxygen atom, a methine and a hydrogen atom; P represents an integer of 2 or 3; n represents the integer of 1-6.

Description

항-히스타민 및 항-알레르기 활성을 갖는 테트라졸 유도체(TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY)TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음As this is a public information case, the full text was not included.

Claims (2)

하기 일반식(I)의 테트라졸 유도체 또는 이것의 약리학적으로 허용될 수 있는 염 :Tetrazole derivatives of formula (I) or pharmacologically acceptable salts thereof: 상기식에서, A는 -CH=CH, -CH2-CH2, -CH2O-, 및 산소 원자 또는 황 원자를 나타내거나, 또는 A가 인접 방향족 고리와 상호 결합되지 않는 경우, 이것은 인접 방향족 고리에 각각 결합된 2개의 수소 원자를 나타내고; V는 -CH=CH- 또는 황 원자를 나타내고; X 및 Y는 각각 알콕시기, 할로겐 원자 또는 수소 원자를 나타내고; (a) W는 하나의 결합을 나타내고, Z는 탄소 원자 또는 메틴을 나타내고, B는 Z와 함께 결합을 형성하거나 또는 히드록실기를 나타내거나, 또는 (b) W, Z 및 B는 각각 하나의 결합, 질소 원자 및 수소 원자를 나타내거나, 또는 (c) W, Z 및 B는 각각 산소 원자, 메틴 및 수소 원자를 나타내고; p는 2 또는 3의 정수를 나타내고; n은 1 내지 6의 정수를 나타낸다.Wherein A represents —CH═CH, —CH 2 —CH 2 , —CH 2 O—, and an oxygen atom or a sulfur atom, or when A is not mutually bonded to an adjacent aromatic ring, it is an adjacent aromatic ring Two hydrogen atoms each bonded to; V represents —CH═CH— or a sulfur atom; X and Y each represent an alkoxy group, a halogen atom or a hydrogen atom; (a) W represents one bond, Z represents a carbon atom or methine, B represents a bond with Z or represents a hydroxyl group, or (b) W, Z and B each represents one Or a bond, a nitrogen atom and a hydrogen atom, or (c) W, Z and B each represent an oxygen atom, a methine and a hydrogen atom; p represents an integer of 2 or 3; n represents the integer of 1-6. 활성 성분으로서 하기 일반식(I)의 테트라졸 유도체 또는 이것의 약리학적으로 허용될 수 있는 염을 함유하는 항-히스타민제, 항-알레르기제 및 천식 치료제 :Anti-histamines, anti-allergic agents and asthma therapies containing as an active ingredient a tetrazole derivative of the general formula (I) or a pharmacologically acceptable salt thereof: 상기식에서, A는 -CH=CH, -CH2-CH2-, -CH2O-, 및 산소 원자 또는 황 원자를 나타내거나, 또는 A가 인접 방향족 고리와 상호 결합되지 않는 경우, 이것은 인접 방향족 고리에 각각 결합된 2개의 수소 원자를 나타내고; V는 -CH=CH- 또는 황 원자를 나타내고; X 및 Y는 각각 알콕시기, 할로겐 원자 또는 수소 원자를 나타내고; (a) W는 하나의 결합을 나타내고, Z는 탄소 원자 또는 메틴을 나타내고, B는 Z와 함께 결합을 형성하거나 또는 히드록실기를 나타내거나, 또는 (b) W, Z 및 B는 각각 하나의 결합, 질소 원자 및 수소 원자를 나타내거나, 또는 (c) W, Z 및 B는 각각 산소 원자, 메틴 및 수소 원자를 나타내고; p는 2 또는 3의 정수를 나타내고; n은 1 내지 6의 정수를 나타낸다.Wherein A represents —CH═CH, —CH 2 —CH 2 —, —CH 2 O—, and an oxygen atom or a sulfur atom, or if A is not mutually bonded to an adjacent aromatic ring, it is an adjacent aromatic Two hydrogen atoms each bonded to the ring; V represents —CH═CH— or a sulfur atom; X and Y each represent an alkoxy group, a halogen atom or a hydrogen atom; (a) W represents one bond, Z represents a carbon atom or methine, B represents a bond with Z or represents a hydroxyl group, or (b) W, Z and B each represents one Or a bond, a nitrogen atom and a hydrogen atom, or (c) W, Z and B each represent an oxygen atom, a methine and a hydrogen atom; p represents an integer of 2 or 3; n represents the integer of 1-6. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950705952A 1993-06-29 1994-06-23 TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY KR960703405A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP1993-158741 1993-06-29
JP15874593 1993-06-29
JP1993-158745 1993-06-29
JP15874193 1993-06-29
JP1994-138756 1994-06-21
JP13875694A JP3338913B2 (en) 1993-06-29 1994-06-21 Tetrazole derivative
PCT/JP1994/001010 WO1995001350A1 (en) 1993-06-29 1994-06-23 Tetrazole derivatives having antihistaminic and antiallergic activity

Publications (1)

Publication Number Publication Date
KR960703405A true KR960703405A (en) 1996-08-17

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ID=27317735

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Application Number Title Priority Date Filing Date
KR1019950705952A KR960703405A (en) 1993-06-29 1994-06-23 TETRAZOLE DERIVATIVES HAVING ANTIHISTAMINIC AND ANTIALLERGIC ACTIVITY

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Country Link
EP (1) EP0706522A1 (en)
JP (1) JP3338913B2 (en)
KR (1) KR960703405A (en)
AU (1) AU673754B2 (en)
CA (1) CA2165792A1 (en)
IL (1) IL110144A0 (en)
TW (1) TW281677B (en)
WO (1) WO1995001350A1 (en)

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JP3779349B2 (en) * 1995-04-24 2006-05-24 興和株式会社 Piperidine derivatives
CA2261633A1 (en) * 1996-07-29 1998-02-05 Banyu Pharmaceutical Co., Ltd. Chemokine receptor antagonists
ES2172436B1 (en) * 2000-10-31 2004-01-16 Almirall Prodesfarma Sa INDOLILPIPERIDINE DERIVATIVES AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
US7189757B2 (en) 2001-10-16 2007-03-13 Hypnion, Inc. Treatment of sleep disorders using CNS target modulators
US7355042B2 (en) 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
WO2003032912A2 (en) 2001-10-16 2003-04-24 Hypnion, Inc. Treatment of cns disorders using cns target modulators
ES2201907B1 (en) 2002-05-29 2005-06-01 Almirall Prodesfarma, S.A. NEW DERIVATIVES OF INDOLILPIPERIDINE AS POWERFUL ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
BR0316747A (en) * 2002-12-18 2005-10-18 Fmc Corp N- (substituted arylmethyl) -4- (disubstituted methyl) piperidines and piperazines
US7482460B2 (en) 2003-12-10 2009-01-27 Hypnion, Inc. Doxepin analogs and methods of use thereof
US7411069B2 (en) 2003-12-10 2008-08-12 Hypnion, Inc. Doxepin analogs and methods of use thereof
US7326721B2 (en) 2003-12-10 2008-02-05 Hypnion, Inc. Doxepin analogs and methods of use thereof
US7524864B2 (en) 2004-04-23 2009-04-28 Hypnion, Inc. Methods of treating sleep disorders
WO2007018460A1 (en) * 2005-08-08 2007-02-15 Astrazeneca Ab Therapeutic agents
PT2319840E (en) * 2008-08-01 2016-02-10 Nippon Zoki Pharmaceutical Co Aminopropylidene derivative
EP3645257A1 (en) * 2017-06-30 2020-05-06 Nikon Corporation A method of producing an optical device and a corresponding system
WO2019203296A1 (en) 2018-04-19 2019-10-24 国立大学法人東京農工大学 Preventative and therapeutic agents for sarcopenia
CN113880808A (en) * 2020-07-03 2022-01-04 合肥医工医药股份有限公司 Triazole compounds, preparation method and medical application thereof

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NO155805C (en) * 1981-02-06 1987-06-10 Ucb Sa ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 2- (4- (DIPHENYLMETHYL) -1-PIPERAZINYL) -ACDIC ACIDS AND THEIR AMIDS AND NON-TOXIC SALTS.
JPH03246287A (en) * 1990-02-22 1991-11-01 Hokuriku Seiyaku Co Ltd Piperazine derivative
FR2665160A1 (en) * 1990-07-26 1992-01-31 Esteve Labor Dr NOVEL DERIVATIVES OF 1-DIPHENYLMETHYLPIPERAZINE, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS.
FR2665161B1 (en) * 1990-07-26 1992-11-27 Esteve Labor Dr NOVEL BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS.

Also Published As

Publication number Publication date
JPH0770112A (en) 1995-03-14
CA2165792A1 (en) 1995-01-12
JP3338913B2 (en) 2002-10-28
TW281677B (en) 1996-07-21
WO1995001350A1 (en) 1995-01-12
EP0706522A1 (en) 1996-04-17
IL110144A0 (en) 1994-10-07
AU6983094A (en) 1995-01-24
AU673754B2 (en) 1996-11-21

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