KR960041153A - 15-deoxyasparguanine analogues, their preparation and their therapeutic use - Google Patents
15-deoxyasparguanine analogues, their preparation and their therapeutic use Download PDFInfo
- Publication number
- KR960041153A KR960041153A KR1019960016609A KR19960016609A KR960041153A KR 960041153 A KR960041153 A KR 960041153A KR 1019960016609 A KR1019960016609 A KR 1019960016609A KR 19960016609 A KR19960016609 A KR 19960016609A KR 960041153 A KR960041153 A KR 960041153A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- group
- hydrogen atom
- compound
- amino
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 7
- 230000001225 therapeutic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 25
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 18
- 150000003839 salts Chemical class 0.000 claims abstract 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 239000002585 base Substances 0.000 claims 4
- 239000012442 inert solvent Substances 0.000 claims 3
- 239000000543 intermediate Substances 0.000 claims 3
- 231100000252 nontoxic Toxicity 0.000 claims 3
- 230000003000 nontoxic effect Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 claims 1
- -1 diphenylphosphoryl nitrite Chemical compound 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 150000002513 isocyanates Chemical class 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical compound NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/14—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to hydrocarbon groups substituted by amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/24—Y being a hetero atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Tropical Medicine & Parasitology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
Abstract
본 발명은 (ⅰ) 다음 구조식으로 표시되는 화합물과:(I) a compound represented by the following structural formula:
상기 식에서, A는 -CO-NH- 또는 NH-CO-기이고, R은 수소원자 또는 메틸기이고, *C는 R이 수소원자가 아닌 경우 (R,S) 또는 (R) 배열이다.Wherein A is -CO-NH- or NH-CO- group, R is a hydrogen atom or a methyl group, and * C is an (R, S) or (R) arrangement when R is not a hydrogen atom.
(ⅱ) 그의 첨가염으로 이루어지는 군에서 선택되는 신규한 화합물에 관한 것이다.(Ii) its addition salts.
더욱 상세하게는 이 화합물의 제조방법과 치료학적 용도에 관한 것이다.More particularly, the present invention relates to a method for producing the compound and a therapeutic use thereof.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.
Claims (10)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9505862A FR2734263B1 (en) | 1995-05-17 | 1995-05-17 | 15-DEOXYSPERGUALIN ANALOGS, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC USE |
FR9505862 | 1995-05-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR960041153A true KR960041153A (en) | 1996-12-19 |
Family
ID=9479086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960016609A KR960041153A (en) | 1995-05-17 | 1996-05-17 | 15-deoxyasparguanine analogues, their preparation and their therapeutic use |
Country Status (22)
Country | Link |
---|---|
US (1) | US5733928A (en) |
EP (1) | EP0743300B1 (en) |
JP (1) | JP2860778B2 (en) |
KR (1) | KR960041153A (en) |
CN (1) | CN1063744C (en) |
AT (1) | ATE182882T1 (en) |
AU (1) | AU694342B2 (en) |
CA (1) | CA2176670C (en) |
CZ (1) | CZ292373B6 (en) |
DE (1) | DE69603541T2 (en) |
DK (1) | DK0743300T3 (en) |
ES (1) | ES2137634T3 (en) |
FR (1) | FR2734263B1 (en) |
GR (1) | GR3031684T3 (en) |
HU (1) | HUP9601323A3 (en) |
NO (1) | NO306397B1 (en) |
NZ (1) | NZ286582A (en) |
RU (1) | RU2130015C1 (en) |
SK (1) | SK283372B6 (en) |
TW (1) | TW354782B (en) |
UA (1) | UA42798C2 (en) |
ZA (1) | ZA963775B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843995A (en) * | 1997-07-07 | 1998-12-01 | University Of Medicine And Dentistry Of New Jersey | Inhibition of HIV-1 replication using oligocarbamate derivatives |
DE19737463A1 (en) * | 1997-08-28 | 1999-03-04 | Hoechst Marion Roussel De Gmbh | Use of inhibitors of the sodium-hydrogen exchanger for the manufacture of a medicament for the treatment of diseases caused by protozoa |
DE19923961A1 (en) * | 1999-05-25 | 2000-11-30 | Euro Nippon Kayaku Gmbh | Use of 15-deoxyspergualin for the treatment of hyper-reactive inflammatory and autoimmune diseases |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5942356A (en) * | 1982-09-02 | 1984-03-08 | Microbial Chem Res Found | Spergualin-related compound and preparation thereof |
JPS61129119A (en) * | 1984-11-13 | 1986-06-17 | Microbial Chem Res Found | Novel immunosuppressive agent |
US4990536A (en) * | 1989-04-03 | 1991-02-05 | Nippon Kayaku Kabushiki Kaisha | Immunopotentiator and spergualin-related compound therefor |
FR2698628B1 (en) * | 1992-12-02 | 1995-02-17 | Fournier Ind & Sante | Analogs of 15-deoxyspergualine, their preparation process and their use in therapy. |
FR2716452B1 (en) * | 1994-02-24 | 1996-05-10 | Fournier Ind & Sante | Analogs of 15-deoxyspergualine, their preparation process and their use in therapy. |
-
1995
- 1995-05-17 FR FR9505862A patent/FR2734263B1/en not_active Expired - Fee Related
-
1996
- 1996-05-03 EP EP96400949A patent/EP0743300B1/en not_active Expired - Lifetime
- 1996-05-03 AT AT96400949T patent/ATE182882T1/en not_active IP Right Cessation
- 1996-05-03 ES ES96400949T patent/ES2137634T3/en not_active Expired - Lifetime
- 1996-05-03 DE DE69603541T patent/DE69603541T2/en not_active Expired - Fee Related
- 1996-05-03 DK DK96400949T patent/DK0743300T3/en active
- 1996-05-06 AU AU52081/96A patent/AU694342B2/en not_active Ceased
- 1996-05-07 UA UA96051800A patent/UA42798C2/en unknown
- 1996-05-10 NO NO961891A patent/NO306397B1/en not_active IP Right Cessation
- 1996-05-10 TW TW085105514A patent/TW354782B/en active
- 1996-05-13 ZA ZA963775A patent/ZA963775B/en unknown
- 1996-05-15 CA CA002176670A patent/CA2176670C/en not_active Expired - Fee Related
- 1996-05-15 US US08/647,813 patent/US5733928A/en not_active Expired - Fee Related
- 1996-05-15 NZ NZ286582A patent/NZ286582A/en unknown
- 1996-05-16 SK SK636-96A patent/SK283372B6/en unknown
- 1996-05-16 CZ CZ19961423A patent/CZ292373B6/en not_active IP Right Cessation
- 1996-05-16 CN CN96105030A patent/CN1063744C/en not_active Expired - Fee Related
- 1996-05-16 HU HU9601323A patent/HUP9601323A3/en unknown
- 1996-05-16 RU RU96109193/04A patent/RU2130015C1/en not_active IP Right Cessation
- 1996-05-17 KR KR1019960016609A patent/KR960041153A/en active IP Right Grant
- 1996-05-17 JP JP8148384A patent/JP2860778B2/en not_active Expired - Fee Related
-
1999
- 1999-10-29 GR GR990402774T patent/GR3031684T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK0743300T3 (en) | 2000-01-24 |
HU9601323D0 (en) | 1996-07-29 |
FR2734263A1 (en) | 1996-11-22 |
AU5208196A (en) | 1996-11-28 |
JPH0977733A (en) | 1997-03-25 |
JP2860778B2 (en) | 1999-02-24 |
ES2137634T3 (en) | 1999-12-16 |
CZ292373B6 (en) | 2003-09-17 |
HUP9601323A2 (en) | 1997-05-28 |
CA2176670A1 (en) | 1996-11-18 |
UA42798C2 (en) | 2001-11-15 |
RU2130015C1 (en) | 1999-05-10 |
FR2734263B1 (en) | 1997-06-20 |
ZA963775B (en) | 1996-11-25 |
NO961891L (en) | 1996-11-18 |
CN1143075A (en) | 1997-02-19 |
TW354782B (en) | 1999-03-21 |
CA2176670C (en) | 2002-03-26 |
AU694342B2 (en) | 1998-07-16 |
SK63696A3 (en) | 1996-12-04 |
NZ286582A (en) | 1998-07-28 |
ATE182882T1 (en) | 1999-08-15 |
US5733928A (en) | 1998-03-31 |
DE69603541D1 (en) | 1999-09-09 |
SK283372B6 (en) | 2003-06-03 |
HUP9601323A3 (en) | 1998-04-28 |
EP0743300B1 (en) | 1999-08-04 |
CZ142396A3 (en) | 1997-02-12 |
NO306397B1 (en) | 1999-11-01 |
CN1063744C (en) | 2001-03-28 |
GR3031684T3 (en) | 2000-02-29 |
EP0743300A1 (en) | 1996-11-20 |
NO961891D0 (en) | 1996-05-10 |
DE69603541T2 (en) | 2000-04-06 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
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NORF | Unpaid initial registration fee |