KR960031425A - 다중불포화된 지방산 잔기를 갖는 아닐린 유도체 및 그의 용도 - Google Patents

다중불포화된 지방산 잔기를 갖는 아닐린 유도체 및 그의 용도 Download PDF

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KR960031425A
KR960031425A KR1019960002841A KR19960002841A KR960031425A KR 960031425 A KR960031425 A KR 960031425A KR 1019960002841 A KR1019960002841 A KR 1019960002841A KR 19960002841 A KR19960002841 A KR 19960002841A KR 960031425 A KR960031425 A KR 960031425A
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South Korea
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general formula
alkoxy
aniline derivative
carbon atoms
derivative according
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KR1019960002841A
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English (en)
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가주나가 야자와
가주오 와타나베
야스하루 이쥬인
마유미 시카노
야수지 소다
테추야 고사카
나오토 마추야마
코지 미주노
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시미주 마사미
니폰 쇼우지 가부시키가이샤
곤도 기요시
사카미 츄오우 카가쿠 켄큐소
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Publication of KR960031425A publication Critical patent/KR960031425A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/38—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/09—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • C07C233/15—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/27—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof

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  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 하기 일반식(Ⅰ)의 아닐린 유도체에 관한 것이다:
상기 식에서, R1은 아이코사펜타에노일 또는 도코사헥사에노일이며; R2및 R3은 각각 독립적으로 탄소수 1내지 6의 알킬 또는 알콕시, 또는 할로겐 원자를 나타내고; R4는 수소 원자, 탄소수 1 내지 6의 알킬 또는 알콕시, 또는 할로겐 원자를 나타내며; A는 단일결합, -C(=O)NH-(CH2)n-NH0(여기에서 n은 2 또는 3이다), 또는 다음 일반식의 2가 그룹을 나타내고,
여기에서 m 및 p는 각각 독립적으로 0 또는 1이다.
본 발명의 아닐린 유도체는 대식세포로부터 유도된 ACAT에 대한 좋은 억제활성 및 높은 선택성을 가지고 있으며, 동맥경화증의 예방 및 치료제로서 유용하다.

Description

다중불포화된 지방산 잔기를 갖는 아닐린 유도체 및 그 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(Ⅰ)의 아닐린 유도체:
    상기 식에서, R1은 아이코사펜타에노일 또는 도코사헥사에노일이며; R2및 R3은 각각 독립적으로 탄소수 1내지 6의 알킬 또는 알콕시, 또는 할로겐 원자를 나타내고; R4는 수소 원자, 탄소수 1 내지 6의 알킬 또는 알콕시, 또는 할로겐 원자를 나타내며; A는 단일결합, -C(=O)NH-(CH2)n-NH-(여기에서 n 2 또는 3이다), 또는 다음 일반식의 2가 그룹을 나타내고,
    여기에서 m 및 p는 각각 독립적으로 0 또는 1이다.
  2. 제1항에 있어서, 하기 일반식(Ⅰ)을 갖는 아닐린 유도체:
    상기 식에서, R1은 5,8,11,14,17-아이코사펜타에노일 또는 4,7,10,13,16,19-도코사헥사에노일이며; R2및 R3은 각각 독립적으로 메틴, 에틸, 이소프로필, 메톡시 또는 불소 원자를 나타내고; R4는 수소 원자, 메틸, 메톡시 또는 불소 원자를 나타내며; A는 단일결합, -C(=O)NH-(CH2)2-NH- 또는 다음 구조식의 2가 그룹을 나타낸다;
  3. 제1항에 따르는 아닐린 유도체 및 약제학적으로 허용되는 담체를 함유하는 약제학적 조성물.
  4. 활성성분으로서 제1항에 따르는 아닐린 유도체를 함유하는 ACAT 억제제.
  5. 활성성분으로서 제1항에 따르는 아닐린 유도체를 함유하는 동맥경화증 예방 및 치료제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960002841A 1995-02-08 1996-02-06 다중불포화된 지방산 잔기를 갖는 아닐린 유도체 및 그의 용도 KR960031425A (ko)

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JP2074195 1995-02-08
JP20741/1995 1995-02-28

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KR960031425A true KR960031425A (ko) 1996-09-17

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US (1) US5801178A (ko)
EP (1) EP0726247B1 (ko)
KR (1) KR960031425A (ko)
DE (1) DE69600396T2 (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5922767A (en) * 1996-10-30 1999-07-13 Ss Pharmaceutical Co., Ltd. Substituted benzylurea derivatives and medicine containing the same
WO2014080306A2 (en) * 2012-11-20 2014-05-30 Mahesh Kandula Compositions and methods for the treatment of cardiovascular diseases

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995059A (en) * 1966-10-04 1976-11-30 Sumitomo Chemical Company, Limited Pharmaceutical compositions containing fatty acid amide derivatives
US4053509A (en) * 1971-11-15 1977-10-11 Schering Corporation Substituted aryl and aralkyl amides
JPS57106638A (en) * 1980-12-24 1982-07-02 Eisai Co Ltd Conjugated polyprenylcarboxylic acid and its derivative
US4751026A (en) * 1986-03-24 1988-06-14 Warner-Lambert Company Substituted anilides of oleic, linoleic, or linolenic acid as inhibitors of acyl-coa:cholesterol acyltransferase
US4716175A (en) * 1987-02-24 1987-12-29 Warner-Lambert Company Saturated fatty acid amides as inhibitors of acyl-CoA:cholesterol acyltransferase
FR2673625B1 (fr) * 1991-03-08 1993-05-07 Adir Nouveaux derives d'acylaminophenol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.

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EP0726247B1 (en) 1998-07-08
DE69600396D1 (de) 1998-08-13
US5801178A (en) 1998-09-01
DE69600396T2 (de) 1998-10-29
EP0726247A1 (en) 1996-08-14

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