KR960000893A - Purification Method of Cephalosporin Salt - Google Patents

Purification Method of Cephalosporin Salt Download PDF

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Publication number
KR960000893A
KR960000893A KR1019950015338A KR19950015338A KR960000893A KR 960000893 A KR960000893 A KR 960000893A KR 1019950015338 A KR1019950015338 A KR 1019950015338A KR 19950015338 A KR19950015338 A KR 19950015338A KR 960000893 A KR960000893 A KR 960000893A
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KR
South Korea
Prior art keywords
isopropoxycarbonyloxy
carboxylic acid
hydroxyiminoacetamido
cepem
aminothiazol
Prior art date
Application number
KR1019950015338A
Other languages
Korean (ko)
Inventor
루데슈어 요하네르
푸커 라이너
볼프 지그프리트
Original Assignee
클리페 에스. 모리스. 한스 루돌프 하우스
바이오케미 게젤샤프트 엠.베.하.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 클리페 에스. 모리스. 한스 루돌프 하우스, 바이오케미 게젤샤프트 엠.베.하. filed Critical 클리페 에스. 모리스. 한스 루돌프 하우스
Publication of KR960000893A publication Critical patent/KR960000893A/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 구조식(I)의 7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 p-톨루엔설폰산 염, 다른 염의 제조에 있어서의 이의 용도 및 이를 함유하는 약제학적 조성물에 관한 것이다.The present invention provides 7- [2- (2-aminothiazol-4-yl) -2- (Z)-hydroxyiminoacetamido] -3-N, N-dimethylcarbamoyl of formula (I). P-toluenesulfonic acid salts of oxymethyl-3-cepem-4-carboxylic acid (isopropoxycarbonyloxy) ethylesters, their use in the preparation of other salts and pharmaceutical compositions containing them.

Description

세팔로스포린 염의 정제 방법Purification Method of Cephalosporin Salt

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (6)

7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 p-톨루엔설폰산 염.7- [2- (2-aminothiazol-4-yl) -2- (Z)-hydroxyiminoacetamido] -3-N, N-dimethylcarbamoyloxymethyl-3-cepem-4 P-toluenesulfonic acid salt of carboxylic acid (isopropoxycarbonyloxy) ethyl ester. 결정성인, 다음 구조식(I)의 7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 p-톨루엔설포네이트.7- [2- (2-aminothiazol-4-yl) -2- (Z) -hydroxyiminoacetamido] -3-N, N-dimethylcarba of crystalline structure (I) P-toluenesulfonate of moyloxymethyl-3-cepem-4-carboxylic acid (isopropoxycarbonyloxy) ethylester. 제2하엥 있어서, X-선 데이터 중에 28.247;9.473;5.014;4.942;3.994중 하낭 이상의 d-값(A)을 갖는 화합물.The compound of claim 2 having a d-value (A) of at least a lower bag in 28.247; 9.473; 5.014; 4.942; 3.994 in X-ray data. 7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 상이한 염을 제조하는 데 있어서의,7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 p-톨루엔설폰산 염의 용도.7- [2- (2-aminothiazol-4-yl) -2- (Z)-hydroxyiminoacetamido] -3-N, N-dimethylcarbamoyloxymethyl-3-cepem-4 7- [2- (2-aminothiazol-4-yl) -2- (Z) -hydroxyiminoa in preparing different salts of -carboxylic acid (isopropoxycarbonyloxy) ethyl ester Setamido] Use of p-toluenesulfonic acid salt of 3-N, N-dimethylcarbamoyloxymethyl-3-cepem-4-carboxylic acid (isopropoxycarbonyloxy) ethylester. 적절한 염 형성제를 사용하여 7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 p-톨루엔설폰산 염을 상이한 염으로 전환시킴을 포함하여,7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 염을 제조하는 방법.7- [2- (2-aminothiazol-4-yl) -2- (Z)-hydroxyiminoacetamido] -3-N, N-dimethylcarbamoyloxy using an appropriate salt former 7- [2- (2-aminothiazole-4-, including the conversion of the p-toluenesulfonic acid salt of methyl-3-cepem-4-carboxylic acid (isopropoxycarbonyloxy) ethylester to a different salt Yl) -2- (Z) -hydroxyiminoacetamido] -3-N, N-dimethylcarbamoyloxymethyl-3-cepem-4-carboxylic acid (isopropoxycarbonyloxy) ethyl ester salt How to prepare. 활성 성분으로서 7-[2-(2-아미노티아졸-4-일)-2-(Z)--하이드록시이미노아세트아미도]-3-N,N-디메틸카바모일옥시메틸-3-세펨-4-카복실산(이소프로폭시카보닐옥시)에틸에스테르의 p-톨루엔설폰산염을 함유하는 약제학적 조성물.7- [2- (2-aminothiazol-4-yl) -2- (Z)-hydroxyiminoacetamido] -3-N, N-dimethylcarbamoyloxymethyl-3- as active ingredient A pharmaceutical composition containing p-toluenesulfonate of cefem-4-carboxylic acid (isopropoxycarbonyloxy) ethylester. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019950015338A 1994-06-14 1995-06-12 Purification Method of Cephalosporin Salt KR960000893A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0118194A AT401651B (en) 1994-06-14 1994-06-14 7- (2- (2-AMINOTHIAZOL-4-YL) -2- (Z) - HYDROXIMINOACETAMIDO) -3-N, N- DIMETHYLCARBAMOYLOXYMETHYL-3-CEPHEM-4-
ATA1181/94 1994-06-14

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KR960000893A true KR960000893A (en) 1996-01-25

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US (2) US5659030A (en)
EP (1) EP0687676A1 (en)
JP (1) JP2936052B2 (en)
KR (1) KR960000893A (en)
AT (1) AT401651B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7527807B2 (en) * 2000-06-21 2009-05-05 Cubist Pharmaceuticals, Inc. Compositions and methods for increasing the oral absorption of antimicrobials
KR100463920B1 (en) * 2002-10-18 2004-12-30 제일약품주식회사 Cefditoren pivoxil mesitylene sulfonic acid salt and preparing method thereof
AU2006242535B2 (en) * 2005-04-29 2012-08-09 Merck Sharp & Dohme Corp. Therapeutic compositions
RU2495035C2 (en) * 2008-01-08 2013-10-10 Мерк Шарп Энд Домэ Лтд Pharmaceutically acceptable salts of 2-{4-[(3s)-piperidin-3-yl]phenyl}-2h-indazole-7-carboxamide
WO2011158931A1 (en) * 2010-06-17 2011-12-22 協和発酵キリン株式会社 Useful salts of indazole derivative
TWI574969B (en) * 2015-01-30 2017-03-21 美國禮來大藥廠 Tosylate salt

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* Cited by examiner, † Cited by third party
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DE3919259A1 (en) * 1989-06-13 1990-12-20 Hoechst Ag CRYSTALLINE CEPHEM ACID ADDITION SALTS AND METHOD FOR THE PRODUCTION THEREOF
IL113744A (en) * 1990-11-09 1998-06-15 Eisai Co Ltd 3-cephem derivatives and their preparation
YU48484B (en) * 1991-05-24 1998-09-18 Hoechst Aktiengesellschaft Crystal acid addition salts diastereometric pure 1-(-2,2-dimethylpropyonyloxy)-ethylesters 3-pephem-4-carbonic acid
JPH05230068A (en) * 1992-02-07 1993-09-07 Kyoto Yakuhin Kogyo Kk 3-di-substituted carbamoyloxymethylcephalosporin compound, its production and intermediate compound

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US5861508A (en) 1999-01-19
US5659030A (en) 1997-08-19
JP2936052B2 (en) 1999-08-23
JPH083170A (en) 1996-01-09
EP0687676A1 (en) 1995-12-20
AT401651B (en) 1996-11-25

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