KR950700288A - 5-에이취티4 길항제로서의 벤조피란, 벤조티오피란 및 벤조푸란 유도체(Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists) - Google Patents
5-에이취티4 길항제로서의 벤조피란, 벤조티오피란 및 벤조푸란 유도체(Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists)Info
- Publication number
- KR950700288A KR950700288A KR1019940702728A KR19940702728A KR950700288A KR 950700288 A KR950700288 A KR 950700288A KR 1019940702728 A KR1019940702728 A KR 1019940702728A KR 19940702728 A KR19940702728 A KR 19940702728A KR 950700288 A KR950700288 A KR 950700288A
- Authority
- KR
- South Korea
- Prior art keywords
- benzothiopyran
- benzopyran
- antagonists
- benzofuran derivatives
- benzofuran
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929202510A GB9202510D0 (en) | 1992-02-06 | 1992-02-06 | Pharmaceuticals |
| GB929215499A GB9215499D0 (en) | 1992-07-21 | 1992-07-21 | Pharmaceuticals |
| GB929221446A GB9221446D0 (en) | 1992-10-13 | 1992-10-13 | Pharmaceuticals |
| GB929225788A GB9225788D0 (en) | 1992-12-10 | 1992-12-10 | Pharmaceuticals |
| PCT/GB1993/000214 WO1993016072A1 (en) | 1992-02-06 | 1993-02-01 | Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950700288A true KR950700288A (ko) | 1995-01-16 |
Family
ID=27450819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019940702728A KR950700288A (ko) | 1992-02-06 | 1994-08-05 | 5-에이취티4 길항제로서의 벤조피란, 벤조티오피란 및 벤조푸란 유도체(Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists) |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0625149A1 (es) |
| JP (1) | JPH07503480A (es) |
| KR (1) | KR950700288A (es) |
| AU (1) | AU667874B2 (es) |
| CA (1) | CA2129112A1 (es) |
| MX (1) | MX9300616A (es) |
| NZ (1) | NZ246915A (es) |
| WO (1) | WO1993016072A1 (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5852014A (en) * | 1992-03-12 | 1998-12-22 | Smithkline Beecham P.L.C. | Condensed indole derivatives as 5HT4 -receptor antagonists |
| US5998409A (en) * | 1992-03-12 | 1999-12-07 | Smithkline Beecham Plc | Condensed indole derivatives as 5HT4 -receptor antagonists |
| AU4081393A (en) * | 1992-05-23 | 1993-12-30 | Smithkline Beecham Plc | Medicaments for the treatment of anxiety |
| AU4350493A (en) * | 1992-06-27 | 1994-01-24 | Smithkline Beecham Plc | Medicaments containing 5-ht4 receptor antagonists |
| GB9219163D0 (en) * | 1992-09-10 | 1992-10-28 | Smithkline Beecham Plc | Pharmaceuticals |
| MX9305947A (es) * | 1992-09-29 | 1994-06-30 | Smithkline Beecham Plc | Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
| JPH08502273A (ja) * | 1992-10-13 | 1996-03-12 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | ５−ｈｔ▲下４▼レセプターアンタゴニスト用複素環式エステルまたはアミド |
| MX9306311A (es) * | 1992-10-13 | 1994-04-29 | Smithkline Beecham Plc | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
| EP0664794A1 (en) * | 1992-10-16 | 1995-08-02 | Smithkline Beecham Plc | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists |
| GB9303340D0 (en) * | 1993-02-19 | 1993-04-07 | Smithkline Beecham Plc | Pharmaceuticals |
| GB9507882D0 (en) * | 1995-04-18 | 1995-05-31 | Pharmacia Spa | Substituted dihydrobenzofuran derivatives as 5-ht4 agonists |
| RU2167160C2 (ru) * | 1995-11-09 | 2001-05-20 | Санофи-Синтелябо | Производные 5-фенил-3-(пиперидин-4-ил)-1,3,4-оксадиазол-2(3н)-она, способ их получения, фармацевтическая композиция на их основе и лекарственное средство |
| FR2745574B1 (fr) * | 1996-03-04 | 1998-04-03 | Synthelabo | Derives de 5-phenyl-3-(piperidin-4-yl)-1, 3, 4-oxadiazol-2 (3h)-one, leur preparation et leur application en therapeutique |
| TW445263B (en) | 1996-02-29 | 2001-07-11 | Janssen Pharmaceutica Nv | Novel esters of 1,4-disubstituted piperidine derivatives |
| FR2762316B1 (fr) * | 1997-04-18 | 1999-12-17 | Sanofi Synthelabo | Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique |
| FR2763068B1 (fr) * | 1997-05-06 | 1999-06-04 | Synthelabo | Derives de 3-(pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique |
| TW402591B (en) | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
| KR100413150B1 (ko) * | 1998-09-10 | 2003-12-31 | 에프. 호프만-라 로슈 아게 | 5-에이치티4 수용체 길항제로서의 디하이드로벤조디옥신 카복스아미드 및 케톤 유도체 |
| TW570920B (en) | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
| DE602004009069T2 (de) * | 2003-06-19 | 2008-06-19 | Janssen Pharmaceutica N.V. | 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59186969A (ja) * | 1983-04-08 | 1984-10-23 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフラン−およびベンゾピランカルボキサミド誘導体 |
| CA1297877C (en) * | 1983-12-22 | 1992-03-24 | Daniel Lednicer | Benzofurancarboxamides useful as antiemetic or antipsychotic agents |
| US4888353A (en) * | 1986-02-28 | 1989-12-19 | Erbamont, Inc. | Carboxamides useful as antiemetic or antipsychotic agents |
| US5122528A (en) * | 1983-12-22 | 1992-06-16 | Erbamont, Inc. | Analgesic use of benzobicyclic carboxamides |
| SE8503055D0 (sv) * | 1985-06-19 | 1985-06-19 | Astra Laekemedel Ab | Piperonylcarboxamido derivatives |
| FR2593504B1 (fr) * | 1986-01-30 | 1988-12-09 | Ile De France | Nouveaux derives de dihydrobenzofuranne - et de chromane - carboxamides, leurs procedes de preparation et leur utilisation comme neuroleptiques |
| JPS62234083A (ja) * | 1986-02-28 | 1987-10-14 | アーバモント インク ディビーエイ アドリヤ ラボラトリーズ | 鎮吐薬または精神病治療薬として有用なカルボキサミド類 |
| EP0314483A1 (en) * | 1987-10-29 | 1989-05-03 | Erbamont, Inc. | Preparation of benzamides |
| US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
| US5122361A (en) * | 1989-04-17 | 1992-06-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and imaging agents |
| GB9005014D0 (en) * | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| JPH04225954A (ja) * | 1990-05-02 | 1992-08-14 | Yoshitomi Pharmaceut Ind Ltd | アミド化合物、その医薬用途および新規１−置換ピロリジンメチルアミン類 |
| GB9028105D0 (en) * | 1990-12-27 | 1991-02-13 | Erba Carlo Spa | Process for the preparation of substituted benzofuran derivatives |
| US5114947A (en) * | 1990-12-27 | 1992-05-19 | Erbamont Inc. | Method for alleviating anxiety using benzobicyclic carboxamides |
| JPH05163270A (ja) * | 1991-05-13 | 1993-06-29 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフランカルボキサミド化合物 |
| JPH04364181A (ja) * | 1991-06-04 | 1992-12-16 | Yoshitomi Pharmaceut Ind Ltd | ベンゾフランカルボキサミド化合物 |
-
1993
- 1993-02-01 CA CA002129112A patent/CA2129112A1/en not_active Abandoned
- 1993-02-01 WO PCT/GB1993/000214 patent/WO1993016072A1/en not_active Application Discontinuation
- 1993-02-01 NZ NZ246915A patent/NZ246915A/en unknown
- 1993-02-01 EP EP93917412A patent/EP0625149A1/en not_active Withdrawn
- 1993-02-01 JP JP5513865A patent/JPH07503480A/ja active Pending
- 1993-02-01 AU AU34572/93A patent/AU667874B2/en not_active Ceased
- 1993-02-04 MX MX9300616A patent/MX9300616A/es unknown
-
1994
- 1994-08-05 KR KR1019940702728A patent/KR950700288A/ko not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU667874B2 (en) | 1996-04-18 |
| JPH07503480A (ja) | 1995-04-13 |
| WO1993016072A1 (en) | 1993-08-19 |
| AU3457293A (en) | 1993-09-03 |
| EP0625149A1 (en) | 1994-11-23 |
| NZ246915A (en) | 1996-05-28 |
| CA2129112A1 (en) | 1993-08-19 |
| MX9300616A (es) | 1993-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E601 | Decision to refuse application |