KR950016763A - Hiv활성의 저해제 - Google Patents

Hiv활성의 저해제 Download PDF

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Publication number
KR950016763A
KR950016763A KR1019940007098A KR19940007098A KR950016763A KR 950016763 A KR950016763 A KR 950016763A KR 1019940007098 A KR1019940007098 A KR 1019940007098A KR 19940007098 A KR19940007098 A KR 19940007098A KR 950016763 A KR950016763 A KR 950016763A
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South Korea
Prior art keywords
solid medium
extract
enzyme
hiv activity
inhibitor
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KR1019940007098A
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English (en)
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KR0149477B1 (ko
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히토시 나가오카
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히토시 나가오카
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Publication of KR0149477B1 publication Critical patent/KR0149477B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/02—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Botany (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

바가스로 되어 있는 고체 배지에 표고버섯(Lentinus edodes)균류를 접종하고, 그런다음 증식된 균사체를 함유하는 고체 배지를 해속하고, 물 및 셀룰라아제, 프로테아제 및 글르코시다아제로 구성된 군으로부터 선택된 적어도 한 효소를, 고체 배지를 30 내지 50℃에 유지하면서, 해속이 된 고체 배지에 가하고, 효소의 존재하에 고체 배지를 분쇄 분말화하여 표고버섯 균사체 추출물을 얻고, 그런다음 추출물을 95℃보다 높지 않은 온도가지 가열하여 효소를 불활성화 하고 추출물을 살균하는 단계에 의해 얻어진 표고버섯 균사체추출물로 되어 있는 HIV활성의 저해제 이 HIV활성의 저해제는 HIV의 비루스 활성을 저해할 수 있고, 이 비루스의 증식을 억제할 수 있으며, 부작용의 우려가 적어 안전성이 탁월하다.

Description

HIV활성의 저해제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 HIV활성 저해제의 저해 활성을 보여주는 그래프이다.

Claims (3)

  1. 바가스로 되어 있는 고체 배지에 표고버섯(Lentinus edodes)균류를 접종하고, 그런다음 중식된 균사체를 함유하는 고체 배지를 해속하고, 물 및 셀룰라아제, 프로테아제 및 글르코시다아제로 구성된 군으로 부터 선택된 적어도 한 효소를, 고체 배지를 30 내지 50℃에 유지하면서, 해속된 고체 배지에 가하고, 효소의 존재하에 고체 배지를 분쇄, 분말화하여 표고버섯 균사체 추출물을 얻고, 그런다음 추출물을 95℃보다 높지 않은 온도가지 가열하여 효소를 불활성화 하고 추출물을 살균하는 단계에 의해 얻어진 표고버섯 균사체추출물로 되어 있는 HIV활성의 저해제.
  2. 제1항에 있어서, 효소가 셀룰라아제인 것을 특징으로 하는 HIV활성의 저해제.
  3. 제1항에 있어서, 고체배지가 바가스와 쌀겨로 되어 있는 것을 특징으로 하는 HIV 활성의 저해제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019940007098A 1993-12-17 1994-04-04 Hiv 활성의 저해제 KR0149477B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP93-317564 1993-12-17
JP5317564A JP3017630B2 (ja) 1993-12-17 1993-12-17 Ｈｉｖ型ウイルス活性阻害剤

Publications (2)

Publication Number Publication Date
KR950016763A true KR950016763A (ko) 1995-07-20
KR0149477B1 KR0149477B1 (ko) 1998-10-15

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Application Number Title Priority Date Filing Date
KR1019940007098A KR0149477B1 (ko) 1993-12-17 1994-04-04 Hiv 활성의 저해제

Country Status (5)

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US (1) US7494657B2 (ko)
JP (1) JP3017630B2 (ko)
KR (1) KR0149477B1 (ko)
CN (1) CN1062481C (ko)
TW (1) TW251238B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000159686A (ja) * 1998-11-27 2000-06-13 Kobayashi Pharmaceut Co Ltd シイタケ菌糸体抽出物由来のｌａｋ活性増強用製剤
JP2000159685A (ja) * 1998-11-27 2000-06-13 Kobayashi Pharmaceut Co Ltd シイタケ菌糸体抽出物由来のｌａｋ活性増強物質
CN1171630C (zh) 1998-11-27 2004-10-20 小林制药株式会社 从香菇菌丝体的提取物来源的lak活性增强剂和含有此提取物的lak活性增强配方
AU776783B2 (en) 1999-07-09 2004-09-23 Sun Farm Corporation Method of treating malignancies and viral infections and improving immune function with a dietary supplement
CN1124784C (zh) * 2000-04-20 2003-10-22 王先彬 香菇菌糠及柄蒂提取物制备生物农药及其工艺
NO20014256D0 (no) 2001-09-03 2001-09-03 Bjoern Kristiansen Fremstilling av immunstimulerende forbindelse
US7514085B2 (en) 2004-07-16 2009-04-07 Medimush A/S Immune modulating compounds from fungi
US8309072B2 (en) * 2004-11-12 2012-11-13 The Zhabilov Trust Irreversibly-inactivated pepsinogen fragments for modulating immune function
US8067531B2 (en) 2004-11-12 2011-11-29 The Zhabilov Trust Inactivated pepsin fragments for modulating immune system activity against human malignant tumor cells
US7479538B2 (en) * 2004-11-12 2009-01-20 The Zhabilov Trust Irreversibly-inactivated pepsinogen fragment and pharmaceutical compositions comprising the same for detecting, preventing, and treating HIV
US9072776B2 (en) 2005-06-15 2015-07-07 Glycanova As Anti-cancer combination treatment and kit-of-parts
CN102048974B (zh) * 2010-12-30 2012-08-08 北京中医药大学 甘蔗渣用于制备防治慢性阻塞性肺病的药物中的应用
CN106236787A (zh) * 2016-08-30 2016-12-21 青海民族大学 圆孢蘑菇抗hiv‑1病毒有效部位及制法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55157517A (en) * 1978-12-29 1980-12-08 Chiyokichi Iizuka Antiviral drug and its preparation
JPS58118519A (ja) * 1981-12-29 1983-07-14 Noda Shiyokukin Kogyo Kk 抗がん剤
JPS6023826A (ja) * 1983-07-19 1985-02-06 Seiko Instr & Electronics Ltd 表示装置
JPS60149528A (ja) 1984-01-14 1985-08-07 Hitoshi Nagaoka 霊芝菌糸体からの有効成分の抽出方法
JPS60149369A (ja) 1984-01-14 1985-08-06 Hitoshi Nagaoka 霊芝菌糸体エキスおよびその製造方法
JPH01312980A (ja) 1988-06-10 1989-12-18 Noda Shiyokukin Kogyo Kk 健康食品の製造方法
JPH046171A (ja) 1990-04-20 1992-01-10 Sumitomo Special Metals Co Ltd セラミックス接合用複合箔ろう材
JPH0435149A (ja) 1990-05-25 1992-02-05 Fujitsu Ltd 交換チケット格納，配布制御方式

Also Published As

Publication number Publication date
CN1106695A (zh) 1995-08-16
JPH07173070A (ja) 1995-07-11
KR0149477B1 (ko) 1998-10-15
TW251238B (ko) 1995-07-11
US20040038330A1 (en) 2004-02-26
JP3017630B2 (ja) 2000-03-13
CN1062481C (zh) 2001-02-28
US7494657B2 (en) 2009-02-24

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