KR940005541A - 치환된 벤조에이트 유도체 - Google Patents

치환된 벤조에이트 유도체 Download PDF

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Publication number
KR940005541A
KR940005541A KR1019930013903A KR930013903A KR940005541A KR 940005541 A KR940005541 A KR 940005541A KR 1019930013903 A KR1019930013903 A KR 1019930013903A KR 930013903 A KR930013903 A KR 930013903A KR 940005541 A KR940005541 A KR 940005541A
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South Korea
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optionally substituted
substituted lower
pharmaceutically acceptable
lower alkyl
acceptable salt
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KR1019930013903A
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KR100273603B1 (ko
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시게루 마쓰다니
다다시 요시다
류지 사까자끼
야스히꼬 후지이
가즈시게 다나까
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시오노 요시히꼬
시오노기 세이야꾸 가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • C07C63/08—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 하기 일반식의 화합물 또는 그의 약학적으로 허용가능한 염에 관한 것이다.
상기식에서. R1,R2,R3,R4,R5,R6,R7및 R8은 독립적으로 수소, 임의로 치환된 저급 알킬, 임의로 치환된 저급 알콕시, 하이드록시, 아실옥시 또는 할로겐이고; R9는 수소, 하이드록시, 아실옥시, 임의로 치환된 저급 알킬, 임의로 치환된 저급 알콕시 또는 임의로 치환된 저급 알킬 아미노이고; E1은 수소 또는 에스테르 잔기이고 m은 1내지 4의 정수이다.
본 발명의 화합물은 포스포리파제 A2저해 활성을 나타내며, 염증 질환을 치료하는데 사용할 수 있다.

Description

치환된 벤조에이트 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 일반식의 화합물 또는 그의 약학적으로 허용가능한 염;
    상기식에서. R1,R2,R3,R4,R5,R6,R7및 R8은 독립적으로 수소, 임의로 치환된 저급 알킬, 임의로 치환된 저급 알콕시, 하이드록시, 아실옥시 또는 할로겐이고; R9는 수소, 하이드록시, 아실옥시, 임의로 치환된 저급 알킬, 임의로 치환된 저급 알콕시 또는 임의로 치환된 저급 알킬 아미노이고; E1은 수소 또는 에스테르 잔기이고 m은 1내지 4의 정수이다.
  2. 제1항에 있어서, R가 -NHCH2COOCH2Ph,-OCH2CH2--OCH2, -NHCH2COOEt, -OCH2CH2CH2CH3,(여기서, Ph는 임의로 치환된 페닐 그룹이다.)로 이루어진 그룹중에서 선택된 화합물 또는 그의 약학적으로 허용가능한 염.
  3. 제1항에 따른 화합물 또는 그의 약학적으로 허용가능한 염과 함께 하나 이상의 약학적으로 허용가능한 담체 또는 희석제를 포함하는 약학 조성물.
  4. 제3항에 있어서, 포스포리파제 A2를 억제하는데 사용하기 위한 약학 조성물.
  5. 포스포리파제 A2에 의해 발명된 질환을 앓거나 이 질환에 걸리기 쉬운 포유동물의 치료방법.
  6. 포스포리파제 A2에 의해 발명된 질환을 앓거나 이 질환에 걸리기 쉬운 포유동물의 치료하기 위한 제1항에 따른 화합물 또는 그의 약학적으로 허용가능한 염의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019930013903A 1992-07-23 1993-07-22 치환된 벤조에이트 유도체 KR100273603B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP19678992 1992-07-23
JP92-196789 1992-07-23

Publications (2)

Publication Number Publication Date
KR940005541A true KR940005541A (ko) 1994-03-21
KR100273603B1 KR100273603B1 (ko) 2000-12-15

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KR1019930013903A KR100273603B1 (ko) 1992-07-23 1993-07-22 치환된 벤조에이트 유도체

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Country Link
US (1) US5473096A (ko)
EP (1) EP0580378B1 (ko)
JP (1) JP3526889B2 (ko)
KR (1) KR100273603B1 (ko)
CN (1) CN1039317C (ko)
AT (1) ATE139764T1 (ko)
CA (1) CA2100640A1 (ko)
DE (1) DE69303333T2 (ko)
DK (1) DK0580378T3 (ko)
ES (1) ES2091558T3 (ko)
GR (1) GR3020336T3 (ko)
HU (1) HU218926B (ko)
TW (1) TW262462B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0763016B1 (en) * 1994-06-01 2000-01-26 Axys Pharmaceuticals, Inc. Compositions and methods for treating mast-cell mediated conditions
US5888721A (en) * 1996-07-03 1999-03-30 Millennium Pharmaceuticals, Inc. Antibacterial compounds
TW544310B (en) * 1998-04-02 2003-08-01 Ajinomoto Kk Amino acid derivatives and anti-inflammatory agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943102A (en) * 1972-12-26 1976-03-09 Ciba-Geigy Corporation Compositions stabilized with polyol esters of benzoyloxybenzoic acids
US3884960A (en) * 1972-12-26 1975-05-20 Ciba Geigy Corp Polyol esters of alkyl substituted hydroxy-benzoyloxybenzoic acids
JPS6459252A (en) * 1987-08-31 1989-03-06 Toshiba Corp Cooling device for electronic office equipment
JP2842613B2 (ja) * 1989-04-28 1999-01-06 塩野義製薬株式会社 フォスフォリパーゼａ▲下２▼阻害物質
JPH04159252A (ja) * 1990-10-22 1992-06-02 Shionogi & Co Ltd ホスホリパーゼａ↓２阻害物質
JP3403404B2 (ja) * 1991-07-03 2003-05-06 塩野義製薬株式会社 ホスホリパーゼａ▲２▼阻害物質

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Publication number Publication date
JPH0687790A (ja) 1994-03-29
HU9302141D0 (en) 1993-10-28
HUT64938A (en) 1994-03-28
KR100273603B1 (ko) 2000-12-15
DE69303333D1 (de) 1996-08-01
DK0580378T3 (da) 1996-07-29
DE69303333T2 (de) 1996-11-21
EP0580378A1 (en) 1994-01-26
US5473096A (en) 1995-12-05
ES2091558T3 (es) 1996-11-01
ATE139764T1 (de) 1996-07-15
CN1039317C (zh) 1998-07-29
HU218926B (hu) 2000-12-28
CN1088197A (zh) 1994-06-22
GR3020336T3 (en) 1996-09-30
JP3526889B2 (ja) 2004-05-17
TW262462B (ko) 1995-11-11
EP0580378B1 (en) 1996-06-26
CA2100640A1 (en) 1994-01-24

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