KR930703331A - Bicyclopolyazamacrocyclocarboxylic acid complex, conjugates thereof, methods for its preparation and use thereof as radioactive agents - Google Patents

Bicyclopolyazamacrocyclocarboxylic acid complex, conjugates thereof, methods for its preparation and use thereof as radioactive agents

Info

Publication number
KR930703331A
KR930703331A KR1019930702370A KR930702370A KR930703331A KR 930703331 A KR930703331 A KR 930703331A KR 1019930702370 A KR1019930702370 A KR 1019930702370A KR 930702370 A KR930702370 A KR 930702370A KR 930703331 A KR930703331 A KR 930703331A
Authority
KR
South Korea
Prior art keywords
conjugates
preparation
methods
acid complex
radioactive agents
Prior art date
Application number
KR1019930702370A
Other languages
Korean (ko)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR930703331A publication Critical patent/KR930703331A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019930702370A 1991-12-10 1993-08-09 Bicyclopolyazamacrocyclocarboxylic acid complex, conjugates thereof, methods for its preparation and use thereof as radioactive agents KR930703331A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80539291A 1991-12-10 1991-12-10
PCT/US1992/010663 WO1993012112A1 (en) 1991-12-10 1992-12-10 Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates processes for their preparation, and use as radiopharmaceuticals

Publications (1)

Publication Number Publication Date
KR930703331A true KR930703331A (en) 1993-11-29

Family

ID=25191443

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930702370A KR930703331A (en) 1991-12-10 1993-08-09 Bicyclopolyazamacrocyclocarboxylic acid complex, conjugates thereof, methods for its preparation and use thereof as radioactive agents

Country Status (10)

Country Link
EP (1) EP0575583A4 (en)
KR (1) KR930703331A (en)
AU (1) AU3275293A (en)
CA (1) CA2103553A1 (en)
FI (1) FI933508A (en)
HU (1) HU9302308D0 (en)
IL (1) IL104062A0 (en)
MX (1) MX9207165A (en)
WO (1) WO1993012112A1 (en)
ZA (1) ZA929578B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
BRPI0911652A2 (en) 2008-04-11 2015-08-04 Merrimack Pharmaceuticals Inc Human serum albumin binders and their conjugates
RU2505499C1 (en) * 2012-10-08 2014-01-27 Юлия Алексеевна Щепочкина Raw material mixture for natural stone imitation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8502573D0 (en) * 1985-05-23 1985-05-23 Jouko Kanakre FLUORESCENT LANTHANIDE CHELATES USEFUL AS LABELS OF PHYSIOLOGICALLY ACTIVE MATERIALS
DE4001655A1 (en) * 1990-01-18 1991-07-25 Schering Ag 6-RING MACROCYCLIC TETRAAZA COMPOUNDS, METHOD FOR PRODUCING THE SAME AND PHARMACEUTICAL PRODUCTS CONTAINING THEM
DE3825040A1 (en) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- OR 6-RING MACROCYCLIC POLYAZA COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US4940796A (en) * 1989-03-17 1990-07-10 The University Of Southern Mississippi 2,6-substituted-4-aminopyridines and their corresponding intermediates
FR2644785B1 (en) * 1989-03-24 1991-07-05 Guerbet Sa NOVEL NITROGEN MACROCYCLIC LIGANDS, PROCESS FOR THEIR PREPARATION, METAL COMPLEXES FORMED BY SUCH LIGANDS AND DIAGNOSTIC COMPOSITION CONTAINING THEM

Also Published As

Publication number Publication date
IL104062A0 (en) 1993-05-13
MX9207165A (en) 1993-06-01
FI933508A0 (en) 1993-08-09
EP0575583A4 (en) 1995-02-15
FI933508A (en) 1993-08-31
HU9302308D0 (en) 1993-12-28
EP0575583A1 (en) 1993-12-29
AU3275293A (en) 1993-07-19
ZA929578B (en) 1994-06-10
CA2103553A1 (en) 1993-06-11
WO1993012112A1 (en) 1993-06-24

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Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid