KR920004403A - 3'-alkyl or arylsilyloxybenzoxoxazinolipamycin derivatives - Google Patents

3'-alkyl or arylsilyloxybenzoxoxazinolipamycin derivatives Download PDF

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KR920004403A
KR920004403A KR1019910013459A KR910013459A KR920004403A KR 920004403 A KR920004403 A KR 920004403A KR 1019910013459 A KR1019910013459 A KR 1019910013459A KR 910013459 A KR910013459 A KR 910013459A KR 920004403 A KR920004403 A KR 920004403A
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alkyl
general formula
group
carbon atoms
atom
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KR1019910013459A
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KR100203729B1 (en
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가쯔지 야마시따
다께히꼬 야마네
고가데루요시
다꾸지 하시즈메
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다찌 다다스
가네가후찌 가가꾸 고오교가부시끼가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

내용 없음No content

Description

3'-알킬 또는 아릴실릴옥시벤즈옥사지노리파마이신 유도체3'-alkyl or arylsilyloxybenzoxoxazinolipamycin derivatives

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is a trivial issue, I did not include the contents of the text.

Claims (9)

하기 일반식(I)의 3-알킬 또는 아릴실릴옥시-2-아미노페놀 :3-alkyl or arylsilyloxy-2-aminophenols of the general formula (I) 상기식에서, R1,R2및 R3는 동일하거나 상이하며, 각각 독립적으로 탄소수 1내지 6의 알킬기, 아릴기 또는 아르알킬기를 나타낸다.In the above formula, R 1 , R 2 and R 3 are the same or different and each independently represents an alkyl group, an aryl group or an aralkyl group having 1 to 6 carbon atoms. 2-아미노-3-3급-부틸디메틸실릴옥시페놀.2-Amino-3-tert-butyldimethylsilyloxyphenol. 2-아미노레조르시놀과 하기 일반식(Ⅳ)의 화합물을 반응시키는 것을 특징으로 하는, 제1항에 따른 3-알킬 또는 아릴실릴옥시-2-아미노페놀의 제조방법:Method for preparing 3-alkyl or arylsilyloxy-2-aminophenols according to claim 1, characterized in that 2-aminoresorcinol is reacted with a compound of formula (IV) 상기식에서, R1,R2및 R3는 동일하거나 상이하며, 각각 독립적으로 탄소수 1내지 6의 알킬기, 아릴기 또는 아르알킬기를 나타내고, X는 불소원자, 염소원자, 요오드원자, 브롬원자, 요오드원자, OC103또는 OSO2CF3를 나타낸다.Wherein R 1 , R 2 and R 3 are the same or different and each independently represents an alkyl group, an aryl group or an aralkyl group having 1 to 6 carbon atoms, X represents a fluorine atom, a chlorine atom, an iodine atom, a bromine atom, It represents an atom, OC10 3 or OSO 2 CF 3. 제3항에 있어서, 염기존재하에 반응시키는 것을 특징으로 하는, 3-알킬 또는 아릴실릴옥시-2-아미노페놀의 제조방법.4. A process for the preparation of 3-alkyl or arylsilyloxy-2-aminophenols according to claim 3, characterized in that the reaction is carried out in the presence of a base. 제4항에 있어서, 염기가 트리에틸아민, 이미다졸 및 피페라진으로 이루어진 군으로 부터 선택됨을 특징으로 하는 3-알킬 또는 아릴실릴옥시-2-아미노페놀의 제조방법.5. The process according to claim 4, wherein the base is selected from the group consisting of triethylamine, imidazole and piperazine. 하기 일반식(Ⅱ)의 3'-알킬 또는 아릴실릴옥시벤즈옥사지노리파마이신 :3'-alkyl or arylsilyloxybenzoxazinoripamycin of the general formula (II) 상기식에서, R1,R2및 R3는 동일하거나 상이하며, 각각 독립적으로 탄소수 1내지 6의 알킬기, 아릴기 또는 아르알킬기를 나타낸다.In the above formula, R 1 , R 2 and R 3 are the same or different and each independently represents an alkyl group, an aryl group or an aralkyl group having 1 to 6 carbon atoms. 리파마이신 S와 제1항에 정의된 일반식(I)의 3-알킬 또는 아릴실리옥시-2-아미노페놀을 반응시키는 것을 특징으로 하는, 제6항에 따른 3'-알킬 또는 아릴실릴옥시벤즈옥사지노리파마이신의 제조방법.Characterized in that 3-alkyl or arylsilyloxy-2-aminophenols of the general formula (I) as defined in claim 1 are reacted with 3-alkyl or arylsilyloxybenzamides according to claim 6, A process for preparing oxazinoripamycin. 제6항에 정의된 일반식(Ⅱ)의 3'-알킬 또는 아릴실릴옥시벤즈옥사지노리파마이신과 일반식(Ⅴ)의 아민을 반응시키는 것을 특징으로 하는, 일반식(Ⅲ)의 3'-히드록시-5'-치환된 아미노벤즈옥사지노리파마이신의 제조방법.A 3'-alkyl or aryl silyloxybenzoxazinoriphamycin of general formula (II) as defined in claim 6 is reacted with an amine of general formula (V) Hydroxy-5'-substituted aminobenzoxazinoripamycin. 상기식에서, a는또는이고,Wherein a is or ego, R4및 R5는 동일하거나 상이하며, 각각 독립적으로 수소 원자 또는 탄소수 1내지 3의 알킬기를 나타내며, R6은 탄소수 1내지 6의 알킬기를 나타내고, n은 3내지 7의 정수이다.R 4 and R 5 are the same or different and each independently represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R 6 represents an alkyl group having 1 to 6 carbon atoms, and n is an integer of 3 to 7. 제8항에 있어서, 산화제의 일반식(Ⅱ)의 3'-알킬 또는 아릴실릴옥시벤즈옥사지노리파마이신과 일반식(Ⅴ)의 아민을 반응시키는 것을 특징으로 하는 3'-히드록시-5'-치환된 아미노벤즈옥사지노리파마이신의 제조방법.The method according to claim 8, wherein 3'-alkyl or arylsilyloxybenzoxazinoriphamycin of the general formula (II) of the oxidizing agent is reacted with an amine of the general formula (V) - < / RTI > substituted aminobenzoxazinoripamycin. ※ 참고사항 : 최초출원 내용에 의하여 공개되는 것임.※ Note: It is disclosed by the contents of the first application.
KR1019910013459A 1990-08-20 1991-08-03 3'-alkyl or aryl silicaneoxybenzoxazinorifamycin KR100203729B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019980051900A KR100203615B1 (en) 1990-08-20 1998-11-30 3'-alkyl or aryl silicaneoxybenzoxazinorifamycin

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JP2219519A JP2620399B2 (en) 1990-08-20 1990-08-20 3'-alkyl or arylsilyloxybenzoxazinolifamycin derivatives
JP90-219519 1990-08-20

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KR920004403A true KR920004403A (en) 1992-03-27
KR100203729B1 KR100203729B1 (en) 1999-06-15

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JP4851724B2 (en) * 2005-03-11 2012-01-11 日本曹達株式会社 Method for producing silyl compound
JP5337852B2 (en) * 2011-09-08 2013-11-06 日本曹達株式会社 Method for producing silyl compound
CN117659042A (en) * 2023-12-05 2024-03-08 北京大学第三医院（北京大学第三临床医学院） Rifamycin derivative and preparation method and application thereof

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JPS63183587A (en) * 1985-02-05 1988-07-28 Kanegafuchi Chem Ind Co Ltd Benzoxazino-rifamycin derivative
JPS6377884A (en) * 1986-09-20 1988-04-08 Kanegafuchi Chem Ind Co Ltd Benzoxazino or benzothiazinorifamycin having introduced aromatic amine
JP2862912B2 (en) * 1989-09-14 1999-03-03 鐘淵化学工業株式会社 5 '-(4-propyl or 4-isopropylpiperazinyl) benzoxazinolifamycin derivative

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JPH04103589A (en) 1992-04-06
CN1059145A (en) 1992-03-04
TW198725B (en) 1993-01-21
JP2620399B2 (en) 1997-06-11
CN1037607C (en) 1998-03-04
KR100203729B1 (en) 1999-06-15
KR100203615B1 (en) 1999-06-15

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