KR920000313A - 제어성 약학 제제 - Google Patents

제어성 약학 제제 Download PDF

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Publication number
KR920000313A
KR920000313A KR1019910010955A KR910010955A KR920000313A KR 920000313 A KR920000313 A KR 920000313A KR 1019910010955 A KR1019910010955 A KR 1019910010955A KR 910010955 A KR910010955 A KR 910010955A KR 920000313 A KR920000313 A KR 920000313A
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KR
South Korea
Prior art keywords
water
coating layer
acrylic polymer
salt
insoluble
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Application number
KR1019910010955A
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English (en)
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KR0133511B1 (ko
Inventor
가즈오 노다
마사오 고바야시
다까시 오오사와
시게유끼 이시까와
Original Assignee
지바따 이찌로
다나베세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26494375&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR920000313(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 지바따 이찌로, 다나베세이야꾸 가부시끼가이샤 filed Critical 지바따 이찌로
Publication of KR920000313A publication Critical patent/KR920000313A/ko
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Publication of KR0133511B1 publication Critical patent/KR0133511B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Surgical Instruments (AREA)
  • Stringed Musical Instruments (AREA)
  • Pens And Brushes (AREA)

Abstract

내용 없음

Description

제어성 약학 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 시험 실시예 1에서 얻은, 코팅층의 양이 서로 다른 여러 제어성 과립(a)~(e)에 대한 물과의 용해도 시험결과를 나타낸 그래프이다.
제2도는 시험 실시예 1에서 얻은 제어성 과립(d)에 대한 물, 제1차 유체 및 제2차 유체와의 용해도 시험결과를 나타낸 그래프이다.

Claims (4)

  1. 의약품 화합물을 포함하는 코어 및 방수포제염과 트리메틸 암모늄에틸기를 갖는 비수용성이고 약간 수 - 침투성인 아크릴 중합체를 포함하는 코팅층으로 이루어진 제어성 약학적 제제.
  2. 제1항에 있어서, 코팅층의 방수포제염 1중량부당 아크릴 중합체 0.5~5중량부를 포함하는 약학적 제제.
  3. 제1항에 있어서, 아크릴 중합체가 비수용성이고 약간 수-침투성인 에틸아크릴레이트, 메틸 메타크릴레이트 및 β - 아크릴로일옥시 에틸트리메틸암모늄 클로라이드의 공중합체 이고, 방수포제 염은 알칼리 토금속 스테아레이트인 약학적 제제.
  4. 제1항에 있어서, 에틸 셀룰로스, 히드록시프로필셀룰로스와 의약품 화합물로 구성되는 군에서 선택되는 적어도 1개 재료료 만들어지는 또 다른 코팅층이 방수 포제염과 트리메틸모늄에틸기를 갖는 비수용성이고 약간 수 - 침투성인 아크릴 중합체를 포함하는 코팅층 주위에 제공되는 약학적 제제.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910010955A 1990-06-28 1991-06-28 방출 제어성 약학 제제 KR0133511B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP90-171762 1990-06-28
JP171762/90 1990-06-28
JP17176290 1990-06-28
SG4995A SG4995G (en) 1990-06-28 1995-01-13 Controlled release pharmaceutical preparation

Publications (2)

Publication Number Publication Date
KR920000313A true KR920000313A (ko) 1992-01-29
KR0133511B1 KR0133511B1 (ko) 1998-04-23

Family

ID=26494375

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910010955A KR0133511B1 (ko) 1990-06-28 1991-06-28 방출 제어성 약학 제제

Country Status (17)

Country Link
US (1) US5137733A (ko)
EP (1) EP0463877B2 (ko)
JP (1) JP2558396B2 (ko)
KR (1) KR0133511B1 (ko)
CN (1) CN1040061C (ko)
AT (1) ATE106241T1 (ko)
CA (1) CA2045358C (ko)
DE (1) DE69102211T3 (ko)
DK (1) DK0463877T3 (ko)
ES (1) ES2055962T5 (ko)
FI (1) FI103476B (ko)
GR (1) GR3024471T3 (ko)
HK (1) HK33895A (ko)
HU (1) HU214590B (ko)
IE (1) IE64629B1 (ko)
IL (1) IL98611A (ko)
SG (1) SG4995G (ko)

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Also Published As

Publication number Publication date
HUT59321A (en) 1992-05-28
DE69102211T3 (de) 1997-08-28
IE64629B1 (en) 1995-08-23
FI103476B1 (fi) 1999-07-15
IE912166A1 (en) 1992-01-01
EP0463877B2 (en) 1997-07-02
SG4995G (en) 1995-06-16
IL98611A0 (en) 1992-07-15
DK0463877T3 (da) 1994-06-27
CN1040061C (zh) 1998-10-07
AU7924391A (en) 1992-01-02
ATE106241T1 (de) 1994-06-15
US5137733A (en) 1992-08-11
FI103476B (fi) 1999-07-15
GR3024471T3 (en) 1997-11-28
IL98611A (en) 1998-10-30
ES2055962T5 (es) 1997-09-16
HU912170D0 (en) 1991-12-30
JP2558396B2 (ja) 1996-11-27
DE69102211D1 (de) 1994-07-07
ES2055962T3 (es) 1994-09-01
JPH04235123A (ja) 1992-08-24
AU634400B2 (en) 1993-02-18
CA2045358A1 (en) 1991-12-29
HU214590B (hu) 1998-04-28
FI912952A0 (fi) 1991-06-18
DE69102211T2 (de) 1994-09-15
CA2045358C (en) 1998-04-28
HK33895A (en) 1995-03-17
KR0133511B1 (ko) 1998-04-23
FI912952A (fi) 1991-12-29
EP0463877A1 (en) 1992-01-02
EP0463877B1 (en) 1994-06-01
CN1058533A (zh) 1992-02-12

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