KR910007858A - 초기-촉진 및 향상된 진통제로서의 s(+)-이부프로펜-l-아미노산 및 s(+)-이부프로펜-d-아미노산 - Google Patents

초기-촉진 및 향상된 진통제로서의 s(+)-이부프로펜-l-아미노산 및 s(+)-이부프로펜-d-아미노산 Download PDF

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KR910007858A
KR910007858A KR1019900016429A KR900016429A KR910007858A KR 910007858 A KR910007858 A KR 910007858A KR 1019900016429 A KR1019900016429 A KR 1019900016429A KR 900016429 A KR900016429 A KR 900016429A KR 910007858 A KR910007858 A KR 910007858A
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South Korea
Prior art keywords
amino acid
ibuprofen
lysine
compound
amino acids
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KR1019900016429A
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킹츄관
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제임스 에프. 너턴
머크 앤드 캄파니. 인코포레이티드
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Publication of KR910007858A publication Critical patent/KR910007858A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

초기-촉진 및 향상된 진통제로서의 S(+)-이부프로펜-L-아미노산 및 S(+)-이부프로펜-D-아미노산
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 다른 이부프로펜-아미노산 입체이성체를 실질적으로 함유하지 않는 S(+)-이부프로펜-L-아미노산 또는 S(+)-이부프로펜-D-아미노산 화합물.
  2. 제1항에 있어서, L-아미노산이 L-리신, L-아르기닌 또는 L=히스티딘으로부터 선택되고, D-아미노산이 D-리신, D-아르기닌 또는 D-히스티딘으로부터 선택된 화합물.
  3. 제2항에 있어서, L-아미노산이 L-리신이고 D-아미노산이 D-리신인 화합물.
  4. 제3항에 있어서, S(+)-이부프로펜-L-리신인 화합물.
  5. 제2항에 있어서, L-아미노산이 L-아르기닌이고 D-아미노산이 D-아르기닌인 화합물.
  6. 제1항에 있어서, S(+)-이부프로펜-L-아미노산 또는 S(+)-이부프로펜-D-아미노산 대 이 염의 다른 입체이성체의 중량비가 95:5 이상인 화합물.
  7. 제6항에 있어서, S(+)-이부프로펜-L-아미노산 또는 S(+)-이부프로펜-D-아미노산 대 이 염의 다른 입체이성체의 중량비가 99:1 이상인 화합물.
  8. 치료를 필요로 하는 인간 유기체에게 초기-촉진되고 향상된 진통성 반응을 유도해 내기 위한 초기-촉진 및 향상된 진통성의 S(+)-이부프로펜-L-아미노산 또는 S(+)-이부프로펜-D-아미노산, 및 비독성 약제학적 허용가능한 담체를 함유하는 약제학적 조성물.
  9. 제8항에 있어서, L-아미노산이 L-리신이고, D-아미노산이 D-리신인 조성물.
  10. 치료를 필요로 하는 환자에게 초기-촉진되고 향상된 진통성을 갖는,다른 이부프로펜 아미노산 입체이성체를 함유하지 않는 S(+)-이부프로펜-L-아미노산 또는 S(+)-이부프로펜-D-아미노산 유효량을 투여함을 특징으로 하는 통증 및 염증의 치료방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900016429A 1989-10-17 1990-10-16 초기-촉진 및 향상된 진통제로서의 s(+)-이부프로펜-l-아미노산 및 s(+)-이부프로펜-d-아미노산 KR910007858A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US42246689A 1989-10-17 1989-10-17
US422466 1989-10-17

Publications (1)

Publication Number Publication Date
KR910007858A true KR910007858A (ko) 1991-05-30

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ID=23675012

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Application Number Title Priority Date Filing Date
KR1019900016429A KR910007858A (ko) 1989-10-17 1990-10-16 초기-촉진 및 향상된 진통제로서의 s(+)-이부프로펜-l-아미노산 및 s(+)-이부프로펜-d-아미노산

Country Status (10)

Country Link
EP (1) EP0424028B1 (ko)
JP (1) JPH03206064A (ko)
KR (1) KR910007858A (ko)
AT (1) ATE128452T1 (ko)
AU (1) AU635074B2 (ko)
CA (1) CA2027624A1 (ko)
DE (1) DE69022678T2 (ko)
DK (1) DK0424028T3 (ko)
IE (1) IE68508B1 (ko)
PT (1) PT95564B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100523242B1 (ko) * 2000-05-18 2005-10-24 한미약품 주식회사 이부프로펜을 함유하는 정제 조성물

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HUT59653A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing complexes containing s/+/-phenyl-alcanoic acids and alpha-hydroxy-alcanoic acids and pharmaceutical compositions containing them as active components
HUT59656A (en) * 1990-11-15 1992-06-29 Puetter Medice Chem Pharm Process for producing s/+/-phenyl-alkanoic acids and alpha-amino-acids containing complexes and pharmaceutical compositions containing them as active components
US5552160A (en) * 1991-01-25 1996-09-03 Nanosystems L.L.C. Surface modified NSAID nanoparticles
GB9200114D0 (en) * 1992-01-04 1992-02-26 Scras Dual inhibitors of no synthase and cyclooxygenase
FR2687673B1 (fr) * 1992-01-13 1995-07-07 Jung Jean Sels amines d'acides arylcarboxyliques, sterilisables, solubles dans l'eau, utilises en ophtalmologie et/ou dans la sphere otorhinolaryngologique.
US5599969A (en) * 1992-12-02 1997-02-04 The Boots Company Plc Process of resolving phenylpropionic acids using α-methylbenzylamine
IT1264855B1 (it) * 1993-06-21 1996-10-17 Zambon Spa Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici
IT1264856B1 (it) * 1993-06-21 1996-10-17 Zambon Spa Composizione farmaceutica ad attivita' analgesica
IT1266583B1 (it) * 1993-07-30 1997-01-09 Zambon Spa Processo per la preparazione di sali dell'acido 2-(4-isobutilfenil)- propionico
EP0740935A4 (en) * 1994-02-24 1999-06-16 Otsuka Pharma Co Ltd STIMULATOR OF ANALGESIC ACTIVITY
ES2105948B1 (es) * 1994-10-31 1998-07-01 Zambon Spa Procedimiento para la preparacion de sales de acido 2-(4-isobutilfenil) propionico.
EP2158907B1 (en) * 1997-09-17 2015-08-05 Strategic Science & Technologies, LLC Topical administration of arginine for pain treatment
US7914814B2 (en) 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
US9226909B2 (en) 2004-04-19 2016-01-05 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
CA2563678A1 (en) 2004-04-19 2005-11-03 Strategic Science & Technologies, Llc Beneficial effects of increasing local blood flow
ES2303468B1 (es) * 2007-01-22 2009-06-08 Masterfarm, S.L "una composicion farmaceutica pulverulenta que comprende ibuprofeno".
US11684624B2 (en) 2009-06-24 2023-06-27 Strategic Science & Technologies, Llc Treatment of erectile dysfunction and other indications
MX337166B (es) 2009-06-24 2016-02-15 Composicion topica que contiene ibuoprofeno.
WO2010151241A1 (en) 2009-06-24 2010-12-29 Strategic Science & Technologies, Llc Topical composition containing naproxen
CN101978955A (zh) * 2010-11-05 2011-02-23 航天中心医院 右旋布洛芬氨基酸盐片剂及其制备方法
CN105920603B (zh) 2010-12-29 2022-02-11 战略科学与技术有限责任公司 ***功能障碍和其它适应症的治疗
US9289495B2 (en) 2010-12-29 2016-03-22 Strategic Science & Technologies, Llc Systems and methods for treatment of allergies and other indications

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CH377368A (de) * 1960-04-07 1964-05-15 Inventa Ag Verfahren zur Reinigung von 1(+)-Lysin
IT1059677B (it) * 1974-03-22 1982-06-21 Neopharmed Spa Sale di lisina ad azione terapeutica
DE3669103D1 (de) * 1986-11-14 1990-04-05 Puetter Medice Chem Pharm Ibuprofen enthaltendes arzneimittel.
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
KR100523242B1 (ko) * 2000-05-18 2005-10-24 한미약품 주식회사 이부프로펜을 함유하는 정제 조성물

Also Published As

Publication number Publication date
JPH03206064A (ja) 1991-09-09
EP0424028A2 (en) 1991-04-24
CA2027624A1 (en) 1991-04-18
PT95564A (pt) 1991-08-14
DK0424028T3 (da) 1996-01-29
IE68508B1 (en) 1996-06-26
EP0424028B1 (en) 1995-09-27
DE69022678T2 (de) 1996-03-21
ATE128452T1 (de) 1995-10-15
PT95564B (pt) 1997-11-28
AU635074B2 (en) 1993-03-11
AU6469290A (en) 1991-04-26
DE69022678D1 (de) 1995-11-02
EP0424028A3 (en) 1992-06-10
IE903717A1 (en) 1991-04-24

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