KR910007532A - 항트롬보 활성을 지닌 설페이트화 글리코 사미노글리큐로난 - Google Patents

항트롬보 활성을 지닌 설페이트화 글리코 사미노글리큐로난 Download PDF

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KR910007532A
KR910007532A KR1019900015875A KR900015875A KR910007532A KR 910007532 A KR910007532 A KR 910007532A KR 1019900015875 A KR1019900015875 A KR 1019900015875A KR 900015875 A KR900015875 A KR 900015875A KR 910007532 A KR910007532 A KR 910007532A
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content
activity
sulfate
salt solution
sulfated
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KR1019900015875A
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KR0184260B1 (ko
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웰렘 칼렐 반 데뎀 기스버트
에버트 아브라함 반 하우덴호벤 프란코이스
게리트 뮤레만 더크
코넬리스 테우스 뮐커 휴버트
담베르터스 마리아 산더스 아드리아너스
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에프. 지. 엠 헤르만스ㆍ에이. 지. 제이 베르미렌
악조 엔. 브이
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

내용 없음

Description

항트롬보 활성을 지닌 설페이트화 글리코 사미노글리큐로난
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. a) 평균 분자량이 4,000 내지 8,000달톤이고, b) 질소 함량이 2,4 내지 3.0%이고, c) 황 함량이 7.5 내지 9.5%이고, d) 나트륨 함량이 9 내지 11%이고, e) 데르마탄 설페이트 함량이 5 내지 25%이고, f) 콘드로이틴 설페이트 함량이 9%이하이고, g) 항-Xa활성이 11 내지 20μ/㎎이고, h)항 트롬빈 Ⅲ의존 항 트롬빈 활성이 1μ/㎎이하인 것을 특징으로 하는 데르마탄 설페이트, 콘드리인 설페이트 및 헤파린 설페이트 염으로 구성되는 것을 특징으로 하는 항 트롬보 활성을 지닌 설페이트 글리코사미노 클리큐로난.
  2. 포유동물의 조직을 염 용액으로 용출시킨 음이온 교환기로 처리된 자기 분해 또는 단백질 분해 효소 작용에 처리시킨뒤, 용출액을 염용액으로 여과하고, 수득한 생성물을 이온 교환기에 결합시키고, 염용액 및 유기 용매로 용출한 뒤, 뉴클레인산으로 부터 추가의 정제가 필요하다면, 임의로 과망간산 칼륨 용액으로 처리하는 것을 특징으로 하는 제1항에 따른 설페이트화 글리코 사미노클리뉴로난의 제조방법.
  3. 제2항에 있어서, 돼지 장 점막이 단백질 분해 효소에 의해 소화되며, 염 용액이 염화 나트륨 용액이며, 여과는 약 5500달톤의 상대 분자질량을 지닌 공칭 컷 오프를 갖는 장치중에서 실행되며, 침전은 물중에서 점차적으로 증가하는 메탄올 함량으로 실시되는 것을 특징으로 하는 방법.
  4. 제1항에 따른 약학적 허용 부가물 및 설페이트화 글리코사미노 클로큐로난으로 구성되는 약학 조성물.
  5. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900015875A 1989-10-04 1990-09-29 항트롬보 활성을 지닌 황산화 글리코스아미노글리큐로난 KR0184260B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL89.202494.4 1989-10-04
EP892024944 1989-10-04
EP89202494 1989-10-04

Publications (2)

Publication Number Publication Date
KR910007532A true KR910007532A (ko) 1991-05-30
KR0184260B1 KR0184260B1 (ko) 1999-05-01

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KR1019900015875A KR0184260B1 (ko) 1989-10-04 1990-09-29 항트롬보 활성을 지닌 황산화 글리코스아미노글리큐로난

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Country Link
US (1) US5164377A (ko)
EP (1) EP0421508B1 (ko)
JP (1) JP2655746B2 (ko)
KR (1) KR0184260B1 (ko)
AT (1) ATE98656T1 (ko)
AU (1) AU637143B2 (ko)
CA (1) CA2026036C (ko)
DE (1) DE69005251T2 (ko)
DK (1) DK0421508T3 (ko)
ES (1) ES2062307T3 (ko)
FI (1) FI101152B (ko)
IE (1) IE64121B1 (ko)
MX (1) MX9203786A (ko)
NZ (1) NZ235440A (ko)
PT (1) PT95511B (ko)
ZA (1) ZA907495B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8826448D0 (en) * 1988-11-11 1988-12-14 Thrombosis Res Inst Improvements in/relating to organic compounds
JP3813169B2 (ja) * 1993-09-30 2006-08-23 生化学工業株式会社 抗血栓剤
CA2294780C (en) * 1997-07-16 2008-03-04 Akzo Nobel Nv Process for the production of heparin
JP4915888B2 (ja) * 2001-08-01 2012-04-11 株式会社ジャパンエコロジーシンキング 豚皮抽出物よりのデルマタン硫酸の製造方法
FR2847256B1 (fr) * 2002-11-15 2005-04-08 Biochimie Appliquee Soc Nouveau procede d'obtention d'acide chondroitine sulfurique et ses utilisations
KR100786174B1 (ko) * 2005-07-06 2007-12-17 건양대학교산학협력단 돈족유래의 글리코스아미노글리칸을 포함하는 식품 조성물 및 이의 추출방법
US20110036133A1 (en) * 2008-04-18 2011-02-17 N. V. Organon Purification of protein hydrolysate and the result and products
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
EP3997238A1 (en) 2019-07-09 2022-05-18 Optimvia, LLC Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE136572C (ko) * 1902-12-05
CH460248A (fr) * 1963-02-21 1968-07-31 Joseph Malgouzou Guy Louis Procédé de traitement de tissus animaux, en vue de la séparation de polysaccharides acides contenus dans ces tissus
US3887703A (en) * 1967-03-24 1975-06-03 Oreal Mucopolysaccharides, their preparation and use in cosmetic and pharmaceutical compositions
DE2426586A1 (de) * 1973-06-14 1975-01-09 Opocrin Srl Verfahren zur herstellung von glukuronil-glukosamin-glykan-sulfaten mit antilipaemischer wirkung
JPS5151509A (ko) * 1974-10-28 1976-05-07 Seikagaku Kogyo Co Ltd
IT1075117B (it) * 1977-02-14 1985-04-22 Fedeli Gianfranco Complesso polisaccaridico arterioso,processo per la sua preparazione e suo impiego in terapia umana
IT1158896B (it) * 1977-08-10 1987-02-25 Hepar Chimie Sa Esuronil esosaminoglicano solfato naturale, procedimento per la sua preparazione e impieghi terapeutici relativi
SE7811306L (sv) * 1978-11-01 1980-05-02 Rothman Gunnvor Antikoagulationsmedel samt sett for dess framstellning
EP0066908B1 (en) * 1981-05-21 1985-08-28 Akzo N.V. New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
DE3244214A1 (de) * 1982-11-30 1984-05-30 B. Braun Melsungen Ag, 3508 Melsungen Verfahren zur reinigung und fraktionierung von heparin
FR2538404B1 (ko) * 1982-12-28 1985-08-23 Anic Spa
US4745098A (en) * 1984-02-24 1988-05-17 The Regents Of The University Of California Compositions and method for improving wound healing
FR2572080B1 (fr) * 1984-10-18 1987-06-26 Dropic Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments
IT1208509B (it) * 1985-03-13 1989-07-10 Mediolanum Farmaceutici Srl Processo per la produzione di eparan solfato e dermatan solfato naturali sostanzialmente puri eloro impiego farmaceutico.
EP0209924A1 (en) * 1985-07-12 1987-01-28 Akzo N.V. New anti-trombosis agent based on glycosaminoglycan, process for its preparation, and pharmaceutical compositions
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
WO1988001280A1 (en) * 1986-08-21 1988-02-25 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
IT1217458B (it) * 1988-05-02 1990-03-22 Crinos Ind Farmacoriologica S Sulfoamino derivati di condroitin solfati,del dermatan solfato e dell' acido ialuronico e loro proprieta' farmacologiche

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Publication number Publication date
FI904828A0 (fi) 1990-10-01
AU6323890A (en) 1991-04-11
NZ235440A (en) 1992-07-28
DE69005251D1 (de) 1994-01-27
JPH03167127A (ja) 1991-07-19
US5164377A (en) 1992-11-17
IE64121B1 (en) 1995-07-12
CA2026036A1 (en) 1991-04-05
ZA907495B (en) 1991-07-31
CA2026036C (en) 2000-08-01
EP0421508B1 (en) 1993-12-15
DE69005251T2 (de) 1994-05-05
PT95511B (pt) 1997-07-31
EP0421508A3 (en) 1991-07-24
JP2655746B2 (ja) 1997-09-24
AU637143B2 (en) 1993-05-20
IE903366A1 (en) 1991-04-10
KR0184260B1 (ko) 1999-05-01
PT95511A (pt) 1991-08-14
ATE98656T1 (de) 1994-01-15
DK0421508T3 (da) 1994-04-11
EP0421508A2 (en) 1991-04-10
FI101152B (fi) 1998-04-30
MX9203786A (es) 1992-07-01
ES2062307T3 (es) 1994-12-16

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