KR890015995A - 프로판아민 유도체 - Google Patents
프로판아민 유도체Info
- Publication number
- KR890015995A KR890015995A KR1019890004579A KR890004579A KR890015995A KR 890015995 A KR890015995 A KR 890015995A KR 1019890004579 A KR1019890004579 A KR 1019890004579A KR 890004579 A KR890004579 A KR 890004579A KR 890015995 A KR890015995 A KR 890015995A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- formula
- pharmaceutically acceptable
- methyl
- hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/24—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (8)
- 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 산부가염.상기식에서, R1은(C1-C2알킬) -S(O)p-, CF3S-, CF3O-, H2NOC-, H2NSO2-, 또는 CH3SO2NH-이고, R2는 수소 또는 메틸이며, p는 0,1 또는 2이다.
- 제 1 항에 있어서, R2가 수소인 화합물.
- 제 1 항에 있어서, R2가 메틸인 화합물.
- N-메틸-γ-[4-(메틸티오)페녹시]벤젠프로판아민 또는 이의 약제학적으로 허용되는 산부가염.
- N,N-디메틸-γ-[4-(메틸티오)페녹시]-벤젠프로판아민 또는 이의 약제학적으로 허용되는 산부가염.
- 제 1 항 내지 5항중 어느 한항에서 청구된 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염을 하나 이상의 약제학적으로 허용되는 담체. 희석제 또는 부형제와 함께 함유함을 특징으로 하는 약제학적 제제.
- (a) 일반식(Ⅱ)의 페닐프로필아민을 일반식(Ⅲ)의 벤젠 유도체와 반응시키거나 ; (b) R2가 메틸인 일반식(Ⅰ)의 화합물을 탈메틸화시켜 R2가 수소인 일반식(Ⅰ)의 화합물을 수득하거나 ; (c) R1이 H2N-인 일반식(Ⅰ)의 아미노 화합물을 메탄설포닐 클로라이드로 처리하여, R1이 CH3SO2NH-인 일반식(Ⅰ)의 화합물을 수득하거나 ; (d) R2가 (C1-C2알킬)-S(O)p-이고, p가 0 또는 1인 일반식(Ⅰ)의 화합물을 산화시켜 p가 1 또는 2인 화합물을 수득하고 ; (e)임의로 수득된 생성물을 약제학적으로 허용되는 염으로 전환시킴을 특징으로 하여 제 1 항 내지 5항중 어느 한항에서 청구된 일반식(Ⅰ)의 화합물 또는 이의 약제학적으로 허용되는 염을 제조하는 방법.상기식에서 R1및 R2는 제 1 항에서 정의한 바와 같고, X 및 Y중 하나는 하이드록시이며 다른 하나는 우수이탈 그룹이다.
- 제 7 항에 따른 방법으로 제조된 제 1 항 내지 5항중 어느 한 항에서 정의된 일반식(Ⅰ)의 화합물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17936888A | 1988-04-08 | 1988-04-08 | |
US07/179368 | 1988-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890015995A true KR890015995A (ko) | 1989-11-27 |
Family
ID=22656301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890004579A KR890015995A (ko) | 1988-04-08 | 1989-04-07 | 프로판아민 유도체 |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0336753B1 (ko) |
JP (1) | JPH0285236A (ko) |
KR (1) | KR890015995A (ko) |
CN (1) | CN1036562A (ko) |
AT (1) | ATE78029T1 (ko) |
AU (1) | AU611794B2 (ko) |
CA (1) | CA1337128C (ko) |
DE (1) | DE68901994T2 (ko) |
DK (1) | DK165489A (ko) |
ES (1) | ES2033525T3 (ko) |
GR (1) | GR3005662T3 (ko) |
HU (1) | HU205344B (ko) |
IE (1) | IE891122L (ko) |
IL (1) | IL89854A (ko) |
NZ (1) | NZ228636A (ko) |
PH (1) | PH27144A (ko) |
PT (1) | PT90212B (ko) |
SU (1) | SU1750421A3 (ko) |
ZA (1) | ZA892517B (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK630987D0 (da) * | 1987-12-01 | 1987-12-01 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
FI912280A (fi) * | 1990-05-17 | 1991-11-18 | Lilly Co Eli | Kiral syntes av 1-aryl-3-aminopropan-1 -oler. |
EP0537915B1 (en) * | 1991-09-27 | 1995-07-12 | Eli Lilly And Company | N-alkyl-3-phenyl-3-(2-alkylthiophenoxy)propylamines as norepinephrine inhibitors |
US5281624A (en) * | 1991-09-27 | 1994-01-25 | Eli Lilly And Company | N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof |
EP0576766A1 (en) * | 1992-06-29 | 1994-01-05 | Novo Nordisk A/S | Propanolamine derivatives, their preparation and use |
IL110857A0 (en) * | 1993-09-09 | 1994-11-28 | Lilly Co Eli | Cessation of tobacco use |
US5936124A (en) * | 1998-06-22 | 1999-08-10 | Sepacor Inc. | Fluoxetine process from benzoylpropionic acid |
US6025517A (en) * | 1998-08-03 | 2000-02-15 | Sepracor Inc. | Fluoxetine process from benzoylacetonitrile |
ITMI20061987A1 (it) * | 2006-10-16 | 2008-04-17 | Archimica Srl | Processo per la sintesi di arilossipropilammine ed eteroarilossipropilammine. |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4314081A (en) * | 1974-01-10 | 1982-02-02 | Eli Lilly And Company | Arloxyphenylpropylamines |
DE2732750A1 (de) * | 1977-07-20 | 1979-02-08 | Merck Patent Gmbh | Basische thioaether und verfahren zu ihrer herstellung |
US4243681A (en) * | 1977-10-11 | 1981-01-06 | Mead Johnson & Company | Alkylthiophenoxypropanolamines and pharmaceutical compositions and uses thereof |
US4147805A (en) * | 1978-07-28 | 1979-04-03 | Mead Johnson & Company | Alkylthiophenoxyalkylamines and the pharmaceutical use thereof |
GB2060622B (en) * | 1979-09-14 | 1983-05-25 | Wyeth John & Brother Ltd | 3-aryl-3-aryloxyalkylamines |
US4569801A (en) * | 1984-10-15 | 1986-02-11 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamines |
-
1989
- 1989-04-05 ZA ZA892517A patent/ZA892517B/xx unknown
- 1989-04-05 CA CA000595702A patent/CA1337128C/en not_active Expired - Fee Related
- 1989-04-05 IL IL8985489A patent/IL89854A/en unknown
- 1989-04-06 ES ES198989303401T patent/ES2033525T3/es not_active Expired - Lifetime
- 1989-04-06 DE DE8989303401T patent/DE68901994T2/de not_active Expired - Fee Related
- 1989-04-06 DK DK165489A patent/DK165489A/da not_active IP Right Cessation
- 1989-04-06 AU AU32528/89A patent/AU611794B2/en not_active Ceased
- 1989-04-06 AT AT89303401T patent/ATE78029T1/de not_active IP Right Cessation
- 1989-04-06 PH PH38452A patent/PH27144A/en unknown
- 1989-04-06 NZ NZ228636A patent/NZ228636A/en unknown
- 1989-04-06 EP EP89303401A patent/EP0336753B1/en not_active Expired - Lifetime
- 1989-04-06 PT PT90212A patent/PT90212B/pt not_active IP Right Cessation
- 1989-04-07 KR KR1019890004579A patent/KR890015995A/ko not_active Application Discontinuation
- 1989-04-07 IE IE891122A patent/IE891122L/xx unknown
- 1989-04-07 JP JP1089534A patent/JPH0285236A/ja active Pending
- 1989-04-07 CN CN89101789A patent/CN1036562A/zh active Pending
- 1989-04-07 SU SU894613806A patent/SU1750421A3/ru active
- 1989-04-07 HU HU891693A patent/HU205344B/hu not_active IP Right Cessation
-
1992
- 1992-09-10 GR GR920401985T patent/GR3005662T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NZ228636A (en) | 1990-12-21 |
HUT54976A (en) | 1991-04-29 |
GR3005662T3 (ko) | 1993-06-07 |
HU205344B (en) | 1992-04-28 |
ATE78029T1 (de) | 1992-07-15 |
DE68901994D1 (de) | 1992-08-13 |
DK165489A (da) | 1989-10-09 |
ES2033525T3 (es) | 1993-03-16 |
CN1036562A (zh) | 1989-10-25 |
EP0336753B1 (en) | 1992-07-08 |
DK165489D0 (da) | 1989-04-06 |
PT90212B (pt) | 1994-06-30 |
CA1337128C (en) | 1995-09-26 |
JPH0285236A (ja) | 1990-03-26 |
SU1750421A3 (ru) | 1992-07-23 |
PH27144A (en) | 1993-04-02 |
EP0336753A1 (en) | 1989-10-11 |
ZA892517B (en) | 1990-12-28 |
PT90212A (pt) | 1989-11-10 |
IE891122L (en) | 1989-10-08 |
AU3252889A (en) | 1989-10-12 |
AU611794B2 (en) | 1991-06-20 |
IL89854A (en) | 1994-02-27 |
DE68901994T2 (de) | 1993-02-25 |
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Legal Events
Date | Code | Title | Description |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |