KR890008318A - 플라스모듐 팔시파룸의 재조합 히스티딘-고함유 단백질, 이의 제조방법 및 용도 - Google Patents
플라스모듐 팔시파룸의 재조합 히스티딘-고함유 단백질, 이의 제조방법 및 용도 Download PDFInfo
- Publication number
- KR890008318A KR890008318A KR1019880014351A KR880014351A KR890008318A KR 890008318 A KR890008318 A KR 890008318A KR 1019880014351 A KR1019880014351 A KR 1019880014351A KR 880014351 A KR880014351 A KR 880014351A KR 890008318 A KR890008318 A KR 890008318A
- Authority
- KR
- South Korea
- Prior art keywords
- antigen
- dna
- hrp
- protein
- rna
- Prior art date
Links
- 241000223960 Plasmodium falciparum Species 0.000 title 1
- 108010055837 phosphocarrier protein HPr Proteins 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 claims 9
- 102000036639 antigens Human genes 0.000 claims 9
- 108091007433 antigens Proteins 0.000 claims 9
- 108020004414 DNA Proteins 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 108020004635 Complementary DNA Proteins 0.000 claims 1
- 108020004394 Complementary RNA Proteins 0.000 claims 1
- 241000224016 Plasmodium Species 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 238000010804 cDNA synthesis Methods 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 239000003184 complementary RNA Substances 0.000 claims 1
- 230000001759 immunoprophylactic effect Effects 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
- C07K14/445—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
- C07K16/205—Plasmodium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/6893—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도 내지 제3도는 재조합 단백질31-1lrd(제1도) 및 HEPII-P(제2도)로 면역시킨 아오터스멍귀 및 면역시키지 않은 아오터스 멍키(대조군, 제3도)에서의 기생충혈중의 경과를 나타낸 플롯이다.(y-축은 감염된 적혈구의 %를 나타낸다.)
Claims (16)
- 표2에 나타낸 바와 같은 플라스코듐 팔시파룸 (Plasmodium folciporum) 스트레인 SGE 2의 HRP II항원 및 항원 활성을 갖는 이의 부분적 서열.
- 제1항에 있어서, λgt 10-41-3의 발현에 의해 수득된 HRP II항원.
- 제1항에 따른 항원을 함유하는 융합 단백질.
- 제1항에 따른 항원을 암호화하는 DNA 및 RNA.
- 제1항에 따른 항원 또는 제3항에 따른 융합 단백질을 암호하는 벡터 및 DNA구조물.
- 제4항에 따른 DNA 또는 제5항에 따른 벡터를 함유하는 숙주세포.
- 제6항에 따른 숙주세포에 의해 발현된 단백질.
- 제1항, 2항 또는 3항에 따른 단백질에 대한 폴리크로날 또는 모노클로날 항체.
- 피.팔시파룸의 HRP II항원 또는 이의 면역원 부분의 백신으로서의 용도.
- HRP II항원 또는 이의 면역원 부분을 함유하는 백신.
- 제1항,2항 또는 3항에 따른 항원 하나 이상을 함유하는 백신.
- 제8항에 따른 항체를 함유하는 면역 예방용 제제.
- 제4항에 따른 DNA 또는 RNA,또는 이의 상보적 DNA 또는 RNA를 함유하는 진단용 보조제.
- 제8항에 따른 항체를 함유하는 진단용 보조제.
- 제1항, 2항 또는 3항에 따른 항원을 함유하는 진단용 보조제.
- 제8항에 따른 항체를 사용하여 분리되는 단백질.※ 참고사항: 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873737238 DE3737238A1 (de) | 1987-11-03 | 1987-11-03 | Rekombinantes histidinreiches protein (37 kd antigen) von plasmodium falciparum, seine herstellung und verwendung |
DEP3737238.6 | 1987-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR890008318A true KR890008318A (ko) | 1989-07-10 |
KR970009346B1 KR970009346B1 (en) | 1997-06-10 |
Family
ID=6339664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR88014351A KR970009346B1 (en) | 1987-11-03 | 1988-11-02 | Recombinant histidine - rich protein of plasmodium falciparum, its preparation and use |
Country Status (12)
Country | Link |
---|---|
US (1) | US5393523A (ko) |
EP (1) | EP0315085B1 (ko) |
JP (1) | JPH01165398A (ko) |
KR (1) | KR970009346B1 (ko) |
AT (1) | ATE83928T1 (ko) |
AU (1) | AU618030B2 (ko) |
DE (2) | DE3737238A1 (ko) |
DK (1) | DK610588A (ko) |
ES (1) | ES2037795T3 (ko) |
FI (1) | FI97479C (ko) |
GR (1) | GR3007476T3 (ko) |
PT (1) | PT88915B (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0474891A1 (en) * | 1990-09-08 | 1992-03-18 | BEHRINGWERKE Aktiengesellschaft | Vectors for expression of malarial antigens on the surface of Salmonella vaccine strains |
DE4041836A1 (de) * | 1990-12-24 | 1992-06-25 | Behringwerke Ag | Protektive plasmodium falciparum hybridproteine, die teilsequenzen der malaria-antigene hrpii und serp enthalten, ihre herstellung und verwendung |
AU670108B2 (en) * | 1992-09-11 | 1996-07-04 | Becton Dickinson & Company | Improved antibodies to plasmodium falciparum |
EP1754717A1 (en) | 2005-08-19 | 2007-02-21 | Université de Lausanne | Antigenic peptides and their use |
US8556843B2 (en) * | 2008-02-02 | 2013-10-15 | AccelDx | Blood purification method and apparatus for the treatment of malaria |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2154592A (en) * | 1984-02-22 | 1985-09-11 | Wellcome Found | Cloning of a malarial gene |
AU5603786A (en) * | 1985-04-11 | 1986-10-16 | Walter And Eliza Hall Institute Of Medical Research, The | Highly repetitive antigens - sharp-arp-mesa-plasmodium falciparum |
US5130416A (en) * | 1986-08-13 | 1992-07-14 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA clone containing a genomic fragment of PfHRP-II gene from plasmodium falciparum |
US4721617A (en) * | 1986-08-14 | 1988-01-26 | Regents Of The University Of Minnesota | Vaccine against lyme disease |
-
1987
- 1987-11-03 DE DE19873737238 patent/DE3737238A1/de not_active Withdrawn
-
1988
- 1988-10-29 EP EP88118043A patent/EP0315085B1/de not_active Expired - Lifetime
- 1988-10-29 ES ES198888118043T patent/ES2037795T3/es not_active Expired - Lifetime
- 1988-10-29 AT AT88118043T patent/ATE83928T1/de not_active IP Right Cessation
- 1988-10-29 DE DE8888118043T patent/DE3877136D1/de not_active Expired - Fee Related
- 1988-11-01 FI FI885023A patent/FI97479C/fi not_active IP Right Cessation
- 1988-11-02 JP JP63278533A patent/JPH01165398A/ja active Pending
- 1988-11-02 DK DK610588A patent/DK610588A/da not_active Application Discontinuation
- 1988-11-02 PT PT88915A patent/PT88915B/pt not_active IP Right Cessation
- 1988-11-02 KR KR88014351A patent/KR970009346B1/ko not_active IP Right Cessation
- 1988-11-02 AU AU24590/88A patent/AU618030B2/en not_active Ceased
-
1993
- 1993-03-26 GR GR930400203T patent/GR3007476T3/el unknown
- 1993-08-20 US US08/109,478 patent/US5393523A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
FI885023A (fi) | 1989-05-04 |
KR970009346B1 (en) | 1997-06-10 |
FI97479B (fi) | 1996-09-13 |
AU2459088A (en) | 1989-05-25 |
PT88915A (pt) | 1988-12-01 |
DE3877136D1 (de) | 1993-02-11 |
US5393523A (en) | 1995-02-28 |
DE3737238A1 (de) | 1989-05-18 |
GR3007476T3 (ko) | 1993-07-30 |
AU618030B2 (en) | 1991-12-12 |
DK610588D0 (da) | 1988-11-02 |
FI885023A0 (fi) | 1988-11-01 |
JPH01165398A (ja) | 1989-06-29 |
ATE83928T1 (de) | 1993-01-15 |
ES2037795T3 (es) | 1993-07-01 |
EP0315085A2 (de) | 1989-05-10 |
DK610588A (da) | 1989-05-04 |
EP0315085A3 (en) | 1990-05-02 |
PT88915B (pt) | 1993-01-29 |
FI97479C (fi) | 1996-12-27 |
EP0315085B1 (de) | 1992-12-30 |
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E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
LAPS | Lapse due to unpaid annual fee |