KR890005273A - 2중 실관 반응기에 의한 구연산의 연속 생산방법 - Google Patents

2중 실관 반응기에 의한 구연산의 연속 생산방법 Download PDF

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Publication number
KR890005273A
KR890005273A KR870009944A KR870009944A KR890005273A KR 890005273 A KR890005273 A KR 890005273A KR 870009944 A KR870009944 A KR 870009944A KR 870009944 A KR870009944 A KR 870009944A KR 890005273 A KR890005273 A KR 890005273A
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South Korea
Prior art keywords
production method
citric acid
continuous production
chamber
reactor
Prior art date
Application number
KR870009944A
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English (en)
Inventor
장호남
정봉현
Original Assignee
이정오
한국과학기술원
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Filing date
Publication date
Application filed by 이정오, 한국과학기술원 filed Critical 이정오
Priority to KR870009944A priority Critical patent/KR890005273A/ko
Priority to JP62282943A priority patent/JPS6471494A/ja
Priority to US07/226,718 priority patent/US4910139A/en
Publication of KR890005273A publication Critical patent/KR890005273A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/48—Tricarboxylic acids, e.g. citric acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/66—Aspergillus
    • C12R2001/685—Aspergillus niger
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/913—Aspergillus
    • Y10S435/917—Aspergillus niger

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

내용 없음

Description

2중 실관 반응기에 의한 구연산의 연속 생산방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 2중 실관 한개의 단면도.
제2도는 본 발명에 이용되는 2중 실관 반응기의 횡단면도.
제3도는 세포 배양전과 배양후의 2중 실관 단면의 입체 현미경 사진.

Claims (2)

  1. 2중 실관 반응기의 실관과 외관 사이에 아스퍼질러스 나이저 B 60을 접종한 후 실관 내부로 액체 배지를 주입하고 외관 외부로 산소를 공급하여 아스퍼질러스 나이저 B 60을 고농도로 배양하고 이어서 외관 외부로 산소를 공급하면서 실관 내부로 NH4NO3가 결핍된 상기 액체 배지를 공급하는 2중 실관 반응기에 의한 구연산의 연속생산방법.
  2. 제1항에 있어서, 삼방밸브에 의하여 액체 배지의 공급 방향을 교대로 변경하여 반응기내 아스퍼질러스 나이저 B 60의 고농도를 균일하게 하는 2중 실관 반응기에 의한 구연산의 연속생산방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870009944A 1987-09-09 1987-09-09 2중 실관 반응기에 의한 구연산의 연속 생산방법 KR890005273A (ko)

Priority Applications (3)

Application Number Priority Date Filing Date Title
KR870009944A KR890005273A (ko) 1987-09-09 1987-09-09 2중 실관 반응기에 의한 구연산의 연속 생산방법
JP62282943A JPS6471494A (en) 1987-09-09 1987-11-09 Method for continuously manufacturing citric acid by reactor of double capillaries
US07/226,718 US4910139A (en) 1987-09-09 1988-08-01 Method for continuously producing citric acid by dual hollow fiber membrane bioreactor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR870009944A KR890005273A (ko) 1987-09-09 1987-09-09 2중 실관 반응기에 의한 구연산의 연속 생산방법

Publications (1)

Publication Number Publication Date
KR890005273A true KR890005273A (ko) 1989-05-13

Family

ID=19264327

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870009944A KR890005273A (ko) 1987-09-09 1987-09-09 2중 실관 반응기에 의한 구연산의 연속 생산방법

Country Status (3)

Country Link
US (1) US4910139A (ko)
JP (1) JPS6471494A (ko)
KR (1) KR890005273A (ko)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164081A (en) * 1989-03-24 1992-11-17 The Standard Oil Company Apparatus for separation and for treatment of fluid feedstreams, wafers for use therein and related methods
US5174900A (en) * 1989-03-24 1992-12-29 The Standard Oil Company Apparatus for separation and for treatment of fluid feedstreams, wafers for use therein and related methods
JPH02255079A (ja) * 1989-03-29 1990-10-15 Shimadzu Corp 細胞培養装置
JPH02276565A (ja) * 1989-04-18 1990-11-13 Japanese Res & Dev Assoc Bio Reactor Syst Food Ind 連続酵素反応装置
US5045459A (en) * 1990-10-05 1991-09-03 Haarmann & Reimer Corp. Method for the production of granular citric acid
US5104799A (en) * 1990-10-05 1992-04-14 Haarmann & Reimer Method for the production of granular citric acid and salts thereof
US5149643A (en) * 1990-10-05 1992-09-22 Haarmann & Beimer Method for the production of granular citric acid and salts thereof
US20070122904A1 (en) * 2000-09-29 2007-05-31 Unisearch Limited Method and apparatus for culturing cells
WO2002083890A2 (en) * 2000-11-22 2002-10-24 University Of Maryland, Baltimore Use of clya hemolysin for excretion of fusion proteins
US20060293261A1 (en) * 2005-06-24 2006-12-28 Taisho Pharmaceutical Co., Ltd. Clarithromycin or a salt thereof for the treatment or prevention of pulmonary disorders caused by the destruction of pulmonary alveoli
EP1907542B1 (en) * 2005-06-30 2012-08-29 Synexa Life Sciences (Proprietary) Limited Production of secondary metabolites using capillary membranes
CA2726293C (en) 2008-06-03 2017-02-28 University Of Maryland, Baltimore Non-hemolytic clya for excretion of proteins
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
JP6830059B2 (ja) 2014-09-26 2021-02-17 テルモ ビーシーティー、インコーポレーテッド スケジュール化された細胞フィーディング
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
CN117247899A (zh) 2017-03-31 2023-12-19 泰尔茂比司特公司 细胞扩增

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU907072A1 (ru) * 1980-06-30 1982-02-23 Ленинградский межотраслевой научно-исследовательский институт пищевой промышленности Способ получени лимонной кислоты
FR2507500A1 (fr) * 1981-06-12 1982-12-17 Dumont Engineering Et Cie Sa Dispositif pour agiter et aerer un liquide

Also Published As

Publication number Publication date
JPH0535B2 (ko) 1993-01-05
JPS6471494A (en) 1989-03-16
US4910139A (en) 1990-03-20

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