KR880007434A - 치환 아미노메틸-5,6,7,8-테트라히드로나프틸옥시아세트산, 신규 중간체 생성물, 그의 제조 방법 및 의약품에 있어서 그의 용도 - Google Patents

치환 아미노메틸-5,6,7,8-테트라히드로나프틸옥시아세트산, 신규 중간체 생성물, 그의 제조 방법 및 의약품에 있어서 그의 용도 Download PDF

Info

Publication number
KR880007434A
KR880007434A KR870014011A KR870014011A KR880007434A KR 880007434 A KR880007434 A KR 880007434A KR 870014011 A KR870014011 A KR 870014011A KR 870014011 A KR870014011 A KR 870014011A KR 880007434 A KR880007434 A KR 880007434A
Authority
KR
South Korea
Prior art keywords
formula
compound
acid
general formula
alkyl
Prior art date
Application number
KR870014011A
Other languages
English (en)
Inventor
니뵈너 울리히
회버 프란쯔-페터
리브 폴커
로젠트레터 울리히
페르쯔보른 엘리자베트
피들러 폴커-베른트
조이터 프리델
Original Assignee
에리히 데브리쯔 루디 마이어
바이엘 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 에리히 데브리쯔 루디 마이어, 바이엘 악티엔게젤샤프트 filed Critical 에리히 데브리쯔 루디 마이어
Publication of KR880007434A publication Critical patent/KR880007434A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음.

Description

치환 아미노메틸-5,6,7,8-테트라히드로나프틸옥시아세트산, 신규 중간체 생성물, 그의 제조방법 및 의약품에 있어서 그의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 하기 일반식(I)의 아미노메틸-5,6,7,8-테트라히드로나프틸-옥시아세트산 및 일원자가 양이온 또는 이원자가 양이온을 갖는 그의 생리학적으로 허용되는 염.
    상기식중, R1은 SO2R3(여기서, R3은 아릴 또는 치환 아릴임)이며, R3은 히드록실, 알콕시, 페녹시, 벤즈옥시 또는 NR4R5(여기서, R4및 R5는 서로 동일하거나 또는 상이한 것으로서, 각각 수소 또는 알킬이거나, 또는 기 R4또는 R5중의 하나는 벤질임)이다.
  2. 제1항에 있어서, R1이 SO2R3(여기서, R3은 할로겐, 시아노, 트리플루오로에틸 및 1 내지 4개의 탄소원자를 갖는 알킬과 같은 1,2 또는 3개의 동일하거나 또는 상이한 치환체를 임의로 함유하는 페닐 또는 나프틸임)이여 R3이 히드록실, 페녹시, 벤즈옥시 또는 1 내지 4개의 탄소원자를 갖는 알콕시이거나 또는 기 NR4R5(여기서 R4및 R5는 서로 동일하거나 또는 상이한 것으로서, 각각 수소이거나 또는 1 내지 4개의 탄소원자를 갖는 알킬이거나, 또는 기 R4또는 R5중의 하나는 벤질임)인 일반식(1)의 화합물 및 일원자가 양이온 또는 이원자가 양이온을 갖는 그의 생리학적으로 허용되는 염.
  3. 제1항에 있어서, R3이 불소 또는 염소에 의해 치환된 메틸인 일반식(I)의 화합물.
  4. 하기 일반식(II) 아민을 일반식 R3SO3H의 산 또는 그의 활성화 유도체(예, 산염화물 또는 무수물 또는 활성화 에스테르)와 반응시키고, 필요에 따라서, R2=OH인 경우 유리 카르복실산으로의 가수분해를 행함을 특징으로 하는 일반식(I)의 아미노에틸-5,6,7,8-테트라히드로나프틸-옥사아세트산의 제조 방법.
    상기 식들중, R1은 SO2R3(여기서, R3은 아릴 또는 치환 아릴임)이며, R3은 히드록실, 알콕시, 페녹시, 벤즈옥시 또는 NR4R5(여기서, R4및 R5는 서로 동일하거나 또는 상이한 것으로서, 각각 수소 또는 알킬이거나, 또는 기 R4또는 R5중의 하나는 벤질임)이다.
  5. 제4항에 있어서, 하기 일반식(III)의 α,β-불포화 니틀릴을 증압하에서, 암모니아 존재하에 접촉수소 첨가 반응에 의해 화원시킴을 특징으로 하는 일반식(II)의 아민의 제조 방법.
    상기 식중, R2는 상기 정의한 바와 같다.
  6. 하기 일반식(IV)의 테트랄론을 먼저 시안화 트리에틸실릴을 사용하여 실릴화 시아노히드린으로 전환시키고, 이어서 이것을 알코올성 할로겐화 수소 용액으로 처리하여 α,β-불포화니트릴(III)로 전환시킴을 특징으로 하는 α,β-불포화니트릴(III)의 제조 방법.
    상기 식중 R3은 상기 정의한 바와 같다.
  7. 하기 일반식(II)의 화합물,
    상기 식중, R2는 제1항에서 정의한 바와 같다.
  8. 제1항에 의한 일반식(I)의 화합물의 제조에 있어서, 제6항에 의한 일반식(II)의 화합물의 용도.
  9. 제1항에 의한 일반식(I)의 화합물을 함유하는 의약품.
  10. 제1항에 의한 일반식(I)의 화합물을 필요에 따라서 불활성 보조제 및 부형제를 사용하여 적합한 투여 형태로 전환시킴을 특징으로 하는 의약품의 제조 방법.
  11. 질병 치료에 있어서 제1항에 의한 일반식(I)의 화합물의 용도.
  12. 혈전성, 색전증, 허혈성 질환 및 동맥경화증 치료용 의약품의 제조에 있어서, 제1항에 의한 일반식(l)의 화합물의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870014011A 1986-12-10 1987-12-09 치환 아미노메틸-5,6,7,8-테트라히드로나프틸옥시아세트산, 신규 중간체 생성물, 그의 제조 방법 및 의약품에 있어서 그의 용도 KR880007434A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3642105.7 1986-12-10
DE19863642105 DE3642105A1 (de) 1986-12-10 1986-12-10 Substituierte aminomethyl-5,6,7,8-tetrahydronaphtyl-oxyessigsaeuren, neue zwischenprodukte, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln

Publications (1)

Publication Number Publication Date
KR880007434A true KR880007434A (ko) 1988-08-27

Family

ID=6315835

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870014011A KR880007434A (ko) 1986-12-10 1987-12-09 치환 아미노메틸-5,6,7,8-테트라히드로나프틸옥시아세트산, 신규 중간체 생성물, 그의 제조 방법 및 의약품에 있어서 그의 용도

Country Status (15)

Country Link
US (2) US4868332A (ko)
EP (1) EP0270929A3 (ko)
JP (1) JPS63165362A (ko)
KR (1) KR880007434A (ko)
CN (1) CN87107427A (ko)
AU (1) AU601787B2 (ko)
DE (1) DE3642105A1 (ko)
DK (1) DK646387A (ko)
FI (1) FI875397A (ko)
HU (1) HU197723B (ko)
IL (1) IL84724A0 (ko)
NO (1) NO166177C (ko)
NZ (1) NZ222820A (ko)
PH (1) PH24509A (ko)
ZA (1) ZA879253B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3718317A1 (de) * 1986-12-10 1988-06-16 Bayer Ag Substituierte basische 2-aminotetraline
DE3829455A1 (de) * 1988-08-31 1990-03-15 Boehringer Mannheim Gmbh Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US5264458A (en) * 1989-11-02 1993-11-23 Bayer Aktiengesellschaft Antithrombotic iso- and heterocyclic phenylsulphonamides
GB8924755D0 (en) * 1989-11-02 1989-12-20 Bayer Ag Iso-and heterocyclic phenylsulphonylamides
US5206428A (en) * 1989-11-16 1993-04-27 Tanabe Seiyaku Co., Ltd. Tetrahydronaphthalene derivatives and preparation thereof
JPH04334358A (ja) * 1991-05-02 1992-11-20 Ono Pharmaceut Co Ltd 縮合ベンゼンオキシ酢酸誘導体
US5177106A (en) * 1991-06-21 1993-01-05 Warner-Lambert Company 4-amino substituted phenoxyalkyl carboxylic acid, ester, and alcohol derivatives as antihypercholesterolemic and antiatherosclerotic agents
US5344836A (en) * 1991-11-11 1994-09-06 Ono Pharmaceutical Co., Ltd. Fused benzeneoxyacetic acid derivatives
ES2118333T3 (es) * 1993-12-09 1998-09-16 Ono Pharmaceutical Co Derivados del acido naftilacetico como agonistas y antagonistas de pgez.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL285498A (ko) * 1961-11-14
JPS561305B2 (ko) * 1972-12-18 1981-01-13
DE2809377A1 (de) * 1978-03-04 1979-09-13 Boehringer Mannheim Gmbh Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
DE3207086A1 (de) * 1981-03-02 1982-11-04 Abbott Laboratories, 60064 North Chicago, Ill. Aminoalkylsubstituierte 1,2,3,4-tetrahydronaphthaline und diese enthaltende zusammensetzungen
GB8528398D0 (en) * 1985-11-19 1985-12-24 Glaxo Group Ltd Chemical compounds
DE3623941A1 (de) * 1986-07-16 1988-01-28 Bayer Ag Substituierte amino-5,6,7,8-tetrahydronaphthyl-oxyessigsaeuren, verfahren zu deren herstellung sowie die verwendung als arzneimittel
IL83230A (en) * 1986-08-06 1992-06-21 Tanabe Seiyaku Co Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
CN87107427A (zh) 1988-06-22
AU601787B2 (en) 1990-09-20
AU8241687A (en) 1988-06-16
FI875397A0 (fi) 1987-12-08
DK646387D0 (da) 1987-12-09
FI875397A (fi) 1988-06-11
DK646387A (da) 1988-06-11
HUT45972A (en) 1988-09-28
PH24509A (en) 1990-07-18
DE3642105A1 (de) 1988-06-16
NO166177C (no) 1991-06-12
US4886898A (en) 1989-12-12
NO166177B (no) 1991-03-04
IL84724A0 (en) 1988-05-31
NO874888L (no) 1988-06-13
HU197723B (en) 1989-05-29
NO874888D0 (no) 1987-11-24
ZA879253B (en) 1988-06-09
US4868332A (en) 1989-09-19
NZ222820A (en) 1990-11-27
JPS63165362A (ja) 1988-07-08
EP0270929A2 (de) 1988-06-15
EP0270929A3 (de) 1990-04-25

Similar Documents

Publication Publication Date Title
FR2453148A1 (fr) Nouveaux derives arylsulfinyle d'acide acetohydroxamique, leur procede de preparation et leur application en therapeutique
KR890001951A (ko) 치환 아미노-5,6,7,8- 테트라히드로 나프틸-옥시아세트산, 이들의 제조 방법 및 의약품으로서의 용도
KR880007434A (ko) 치환 아미노메틸-5,6,7,8-테트라히드로나프틸옥시아세트산, 신규 중간체 생성물, 그의 제조 방법 및 의약품에 있어서 그의 용도
FR2386502A1 (fr) Procede pour conferer a un produit en vermiculite de la stabilite a l'egard de l'eau
TNSN92017A1 (fr) Procede de preparation, d'un derive de benzothiazole, et d'une composition pharmaceutique le contenant et procede de traitement en comportant application
ATE82569T1 (de) Herstellung von chinolincarbonsaeuren.
KR890008097A (ko) 신규 플루오로메톡시페닐 디히드로피리딘, 그의 제조 방법 및 의약품으로서의 용도
HUT54113A (en) Process for producing butenecarboxylic acid derivatives and pharmaceutical compositions comprising such compounds
US3632636A (en) N-aryl-omega-aminoacids
FR2398047A1 (fr) Procede de preparation d'a-cetocarbonamides n-substitues et produits obtenus par ce procede
RU94026084A (ru) Применение n-(пиридинил) - 1н- индол-1-аминов для получения медикамента для лечения обсессивно-компульсивных расстройств
SU618036A3 (ru) Способ получени аминов или их солей
FR2581641B1 (fr) Procede de preparation d'acides 6-alkoxy(inferieur)-1-naphtoiques et des esters correspondants et utilisation de ce procede pour la preparation d'acides 6-alkoxy(inferieur)-5-halo-1-naphtoiques et des esters correspondants
PT74864B (fr) Procede pour la production de produits de salification des acides coliques en particulier de l'acide quenodioxicolique et ursodeoxicolique
FR2430426A1 (fr) Derives d'acides biliaires marques, utilisables pour le diagnostic medical
ATE118773T1 (de) Verfahren zur herstellung von 2-(3-pyridyl)- tetrahydrothiopyran-2-carbonsäurethioamid-1- (1r,2r)oxyden, die so erhaltenen 2-(3-pyridyl)- tetrahydrothiopyran-2-carbothioamid-1- (1r,2r)oxyde und diese enthaltende pharmazeutische zusammenstellungen.
EP0371837A3 (fr) Procédé de synthèse spécifique de nouveaux esters d'acides dithiocarbamiques par substitution de sites hydroxylés sur des molécules mono- ou polyhydroxylées produits obtenus for ce procédé et leurs applications
JPS5645498A (en) Manufacture of 66aminoo66desoxyy2*33oo isopropylideneealphaall sorbofuranose derivative and novel intermediate product
KR950700246A (ko) E형 프로스타글라딘류의 제조방법
FR2434814A1 (fr) Bromo-2 ergosinine et ses sels d'addition d'acides utiles comme medicaments et un procede de leur preparation
JPH0322875B2 (ko)
FR2357542A1 (fr) Procede de preparation de la prostaglandine a2 et de certains de ses derives
US3829576A (en) Method of treating neisseria gonorrhoeae with dihydroampicillin
Britt et al. Hydride-fluoride conversions in organosiloxane chains. 3-Fluoroheptamethyltrisiloxane
SU1089085A1 (ru) Способ получени аллиламина

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid