KR880003957A - 세팔로스포린 유도체의 제조방법 - Google Patents

세팔로스포린 유도체의 제조방법 Download PDF

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Publication number
KR880003957A
KR880003957A KR1019860008168A KR860008168A KR880003957A KR 880003957 A KR880003957 A KR 880003957A KR 1019860008168 A KR1019860008168 A KR 1019860008168A KR 860008168 A KR860008168 A KR 860008168A KR 880003957 A KR880003957 A KR 880003957A
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KR
South Korea
Prior art keywords
group
formula
compound
methyl
aminothiazol
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Application number
KR1019860008168A
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English (en)
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KR890001285B1 (ko
Inventor
고문규
신재무
김동수
김덕희
Original Assignee
우대규
한일약품공업 주식회사
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Priority to KR1019860008168A priority Critical patent/KR890001285B1/ko
Publication of KR880003957A publication Critical patent/KR880003957A/ko
Application granted granted Critical
Publication of KR890001285B1 publication Critical patent/KR890001285B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

내용 없음

Description

세팔로스포린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 다음 일반식(Ⅱ)의 유기산과 다음 일반식(Ⅲ)의 화합물을 반응시켜 다음 일반식(Ⅳ)의 화합물을 제조한 다음 이를 다음 일반식(Ⅴ)의 화합물과 반응시킴을 특징으로 하는 다음 일반식(Ⅰ)의 화합물의 제조방법.
    [상기 일반식에서 R1은 2-(2-아미노티아졸-4-일)-2-신-메톡시이미노아세틸기, 2-(2-아미노티아졸-4-일)-2-신-(2-카르복시프로프-2-옥시이미노아세틸기, 또는 2-(2-아미노티아졸-4-일)-2-신-(2-t-부톡시카르보닐프로프-2-옥시이미노)아세틸기와 D-(-)--(4-히드록시-6-메틸피리딘-3-카르복스아미도)--(4-히드록시페닐)아세틸기를 나타내고, R2는 아세톡시메틸기, (2,5-디히드로-6-히드록시-2-메틸-5-옥소-1,2,4-트리아진)-3-일]티오메틸기, (1-메틸피롤리딘이 오메틸기, (1-피리딘이움)메틸기와[(1-메틸-1H-테트라졸)-5-일]티오메틸기를 나타내고, M은 수소나 나트륨원자를 나타내고, X,Y는 각각 염소원자 또는 수소원자를 나타낸다.
  2. 제1항에서 일반식(Ⅳ)의 활성에스테르를 한용기내의 반응으로 제조함을 특징으로 하는 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008168A 1986-09-29 1986-09-29 세팔로스포린 유도체의 제조방법 KR890001285B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019860008168A KR890001285B1 (ko) 1986-09-29 1986-09-29 세팔로스포린 유도체의 제조방법

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019860008168A KR890001285B1 (ko) 1986-09-29 1986-09-29 세팔로스포린 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR880003957A true KR880003957A (ko) 1988-05-31
KR890001285B1 KR890001285B1 (ko) 1989-04-28

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ID=19252553

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860008168A KR890001285B1 (ko) 1986-09-29 1986-09-29 세팔로스포린 유도체의 제조방법

Country Status (1)

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KR (1) KR890001285B1 (ko)

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Publication number Publication date
KR890001285B1 (ko) 1989-04-28

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