KR870007094A - Method for preparing benzoylacetic acid ester derivative - Google Patents

Method for preparing benzoylacetic acid ester derivative Download PDF

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Publication number
KR870007094A
KR870007094A KR870000410A KR870000410A KR870007094A KR 870007094 A KR870007094 A KR 870007094A KR 870000410 A KR870000410 A KR 870000410A KR 870000410 A KR870000410 A KR 870000410A KR 870007094 A KR870007094 A KR 870007094A
Authority
KR
South Korea
Prior art keywords
acid ester
ester derivative
preparing
benzoylacetic acid
formula
Prior art date
Application number
KR870000410A
Other languages
Korean (ko)
Other versions
KR950004041B1 (en
Inventor
쭈또무 이리꾸라
세이고 수주에
사또시 무라야마
게이지 히라이
다까요시 이시자끼
Original Assignee
하기하라 히데
교오린 세이야꾸 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 하기하라 히데, 교오린 세이야꾸 가부시끼 가이샤 filed Critical 하기하라 히데
Publication of KR870007094A publication Critical patent/KR870007094A/en
Application granted granted Critical
Publication of KR950004041B1 publication Critical patent/KR950004041B1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/22—Unsaturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C07C67/32—Decarboxylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

내용 없음No content

Description

벤조일아세트 산 에스테르 유도체의 제조방법Method for preparing benzoylacetic acid ester derivative

본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음Since this is an open matter, no full text was included.

Claims (1)

하기 일반식(Ⅱ)의 화합물을 말론 산 에스테르와 축합시켜 하기 일반식(Ⅲ)의 벤조일말론 산 에스테르유도체를 수득하고 이 에스테르(Ⅲ)을 탈카복실화시켜 목적하는 화합물을 수득함을 특징으로 하여 하기 일반식(Ⅰ)의 벤조일아세트 산 에스테르 유도체를 제조하는 방법.By condensing the compound of formula (II) with malonic acid ester to obtain the benzoyl malonic acid ester derivative of formula (III) and decarboxylating the ester (III) A process for producing the benzoylacetic acid ester derivative of the general formula (I) below. 상기식에서, R은 저급 알킬 그룹이고, X는 할로겐원자이며, Y는 염소 또는 브롬원자이고, R'는 독립적으로 저급 알킬 그룹이다.Wherein R is a lower alkyl group, X is a halogen atom, Y is a chlorine or bromine atom, and R 'is independently a lower alkyl group. ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.※ Note: The disclosure is based on the initial application.
KR1019870000410A 1986-01-20 1987-01-20 Benzoylacetic acid ester derivatives and process for their preparation KR950004041B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP9649/86 1986-01-20
JP9649 1986-01-20
JP964986 1986-01-20
JP61286524A JPS62246541A (en) 1986-01-20 1986-12-01 Benzoylacetic acid ester derivative and production thereof
JP286524 1986-12-01
JP286524/86 1986-12-01

Publications (2)

Publication Number Publication Date
KR870007094A true KR870007094A (en) 1987-08-14
KR950004041B1 KR950004041B1 (en) 1995-04-22

Family

ID=11726061

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870000410A KR950004041B1 (en) 1986-01-20 1987-01-20 Benzoylacetic acid ester derivatives and process for their preparation

Country Status (2)

Country Link
JP (1) JPS62246541A (en)
KR (1) KR950004041B1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0342849A3 (en) * 1988-05-19 1990-03-14 Pfizer Inc. Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
KR100372563B1 (en) * 1996-12-16 2003-11-20 주식회사 엘지생명과학 Method for manufacturing beta-ketoester derivative as intermediate of quinolone based antibiotics

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3142854A1 (en) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-CYCLOPROPYL-6-FLUOR-1,4-DIHYDRO-4-OXO-7-PIPERAZINO-CHINOLINE-3-CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS
DE3308908A1 (en) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen BACTERICIDAL AGENTS
US4533663A (en) * 1984-04-26 1985-08-06 Abbott Laboratories Quino-benzothiazine antibacterial compounds
DE3420743A1 (en) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-AMINO-1-CYCLOPROPYL-6,8-DIHALOGEN-1,4-DIHYDRO-4-OXO-3-CHINOLINE CARBONIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING ANTIBACTERIAL AGENTS

Also Published As

Publication number Publication date
KR950004041B1 (en) 1995-04-22
JPS62246541A (en) 1987-10-27

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