KR870004940A - 신규 화합물의 제조 방법 - Google Patents

신규 화합물의 제조 방법 Download PDF

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KR870004940A
KR870004940A KR860009805A KR860009805A KR870004940A KR 870004940 A KR870004940 A KR 870004940A KR 860009805 A KR860009805 A KR 860009805A KR 860009805 A KR860009805 A KR 860009805A KR 870004940 A KR870004940 A KR 870004940A
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South Korea
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ethyl
hydroxyphenyl
benzenediol
hexylamino
ethylamino
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KR860009805A
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English (en)
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인스 프란시스
스프링토르프 브라이안
딕슨 존
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에프. 머피
피존스 피엘시
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Priority claimed from GB858528605A external-priority patent/GB8528605D0/en
Priority claimed from GB868616793A external-priority patent/GB8616793D0/en
Priority claimed from GB868616794A external-priority patent/GB8616794D0/en
Priority claimed from GB868616792A external-priority patent/GB8616792D0/en
Application filed by 에프. 머피, 피존스 피엘시 filed Critical 에프. 머피
Publication of KR870004940A publication Critical patent/KR870004940A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Luminescent Compositions (AREA)

Abstract

내용 없음

Description

신규 화합물의 제조 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 하기의 일반식 I,
    [식중, X는 이중결합 또는 S(O)n(여기에서, n은 0,1 또는 2임)에 의해 임의로 단속된 C2-8알킬렌사슬이고, Y는 O 또는 NH이고, 1 및 m은 각각 독립적으로 2,3 또는 4이고, R10은 1개 이상의 서로 동일하거나 상이한 치환체 R23에 의해 치환된 페닐기이거나, 또는 피리딜기, 포화 카르보시클릭기, C1-6알킬기 또는 수소이고, R15는 수소, 또는 R23과 함께 (CH2)P(여기에서, P는 0,1 또는 2일) 사슬을 형성하고, R20,R21,R22및 R23은 서로 동일하거나 상이한 것으로서, 독립적으로 수소, C1-6알킬기, NHR25(여기에서, R25는 수소, C1-6알킬기, C1-6알카노일기 또는 SO1C1-6알킬기 임), SH, NO2, 할로겐 CF3, SO2R30(여기에서, R30은 C1-6알킬기 또는 NH2기임), CH2OH 또는 OH기이되, 단, X가 단속되지 않은 C4알킬렌사슬이고, Y가 NH이고, m 및 1이 각각 2이고, R10이 페닐기이고, R15가 수소이고, R21,R22및 R23이 수소일 경우, R20은 수소 또는 4-OH가 될 수 없음]으로 표시되는 화합물, 약리적으로 허용되는 그의 염류 및 용매화물류의 제조방법에 있어서, 하기 일반식 Ⅱ
    [식중, Ya는 O 또는 NR4a이고, X,R15,m 및 1은 상기 정의한 바와 같고, R1a,R2a,R3a 및 R4a는 서로 동일하거나, 상이한 것으로서, 수소 또는 보호기이고, R10a는 상기 R10과 동일한 의미를 가지되, 예외로 R10a가 페닐기일 경우, 이것은 1개 이상의 치환체 R23a에 의해 치환될 수 있으며, R20a,R21a,R22a 및 R23a는 각각 상기 R20,R21,R22및 R23과 동일한 의미를 갖되, 예외로 추가해서 이들이 NR25, R26a, SR27a, CH2OR28a 또는 OR29a(여기에서, R26a,R27a,R28a 및 R29a는 서로 동일하거나 상이한 것으로서, 각각 보호기를 나타내고, R25는 상기 정의한 바와 같음)를 나타낼 수 있으되, 단 일반식(n)의 화합물은 적어도 1개의 보호기를 갖음]으로 표시되는 화합물로부터 보호기를 제거하고, 필요에 따라서 생성된 일반식(I)의 화합물을 제약상 허용되는 그의 염류 또는 그의 용매화물로 또는 그 역으로 전환시킴을 특징으로 하는 방법.
  2. 제1항에 있어서, R10이 서로 동일하거나 상이한 1개 이상의 치환체 R23에 의하여 치환된 페닐기인 방법.
  3. 제1항 또는 제2항에 있어서, R23이 독립적으로 1개 이상의 수소, 할로겐, 히드록시기, NH2,NHSO2C1-6알킬기, NO2또는 C1-6알킬기인 방법.
  4. 상기 항 중 어느 하나의 항에 있어서, R20,R21및 R22가 독립적으로 수소, 히드록시기, C1-6알킬기, 할로겐 또는 트리플루오로메틸기인 방법.
  5. 상기 항중 어느 하나의 항에 있어서, R20,R21또 R22중에서 1개가 3-OH기인 방법.
  6. 상기 항중 어느 하나의 항에 있어서, Y가 NH기인 방법.
  7. 제1항에 있어서, 일반식 I의 화합물이 3-[2-[3-히드록시페닐]에틸]-4-[2-[6-[2-페닐에틸아미노]헥실 아미노]에틸]-1,2-벤젠디올 또는 제약상 허용되는 그의 염 또는 용매화물인 방법.
  8. 제1항에 있어서, 일반식 I의 화합물이 하기의 화합물 3-[2-[3-히드록시페닐]에틸]-4-[2-[4-[2-페닐-에틸 아미노]부틸 아미노]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[8-[2-페닐에틸아미노]옥틸아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-시클로헥실에틸아미노]헥실아미노]에틸]-3-[2-[3-히드록시페닐]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[6-[2-[4-메틸페닐]에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[6-[2-[3-히드록시페닐]에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-헥실에틸아미노]헥실아마노]에틸]-3-[2-[3-히드록시페닐]에틸]-1,2-벤젠디올, 4-[2-[6-2-[4-클로로페닐]에틸아미노]헥실아미노]에틸]-3-[2-[3-히드록시페닐]에틸]-1,2-벤젠디올,4-[2-[6-[2,3-디히드로-1H-인덴-2-일아미노]헥실아미노]에틸]-3-[3-[3-히드록시페닐]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[6-[2-[4-피리딜]에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[6-[2-페닐에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[6-[2-[4-히드록시페닐]-에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[3-[2-[2-페닐에틸아미노]에틸티오]프로필아미노]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[3-[2-[2-페닐에틸아미노]에탈술포닐]프로파널아미노]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸-4-[2-[6-[2-[4-니트로페닐]에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-[4-아미노페닐]에틸아미노]헥실아미노]에틸]-3-[2-[3-히드록시페닐]에틸]-1,2-벤젠디올,4-[2-[6-[2-[3,4-디히드록시-2-[2-[3-히드록시페닐]에틸]페닐]에틸아미노]헥실아미노]에틸]-3-플루루오로-1,2-벤젠디올, 4-[2-[6-[3-플루오로-4-히드록시페닐]에틸아미노]헥실아미노]에틸]-3-[2-[3-히드록시페닐]에틸]-1,2-벤젠디올,3-[2-[3-메틸페닐]에틸]-4-[2-[6-[2-페닐에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-[4-히드록시페닐]에틸아미노]헥실아미노]에틸]-3-[2-[3-메틸페닐]에틸]-1,2-벤젠디올, 3-[2-[3-히드록시페닐]에틸]-4-[2-[8-[2-[4-히드록시페닐]에틸아미노]옥틸아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-페닐에틸아미노]헥실아미노]에틸]-3-[2-[3-[트리플루오로메틸]페닐]에틸]-1,2-벤젠디올, 3-[2-[3,5-디히드록시페닐]에틸]-4-[2-[6-[2-페닐에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-[3,4-디히드록시페닐]에틸아미노]헥실아미노]에틸]-3-[2-[3-히드록시페닐]에틸]-1,2-벤젠디올, 3-[3-[3-히드록시페닐]프로필]-4-[2-[6-[2-페닐에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 3-[3-[3-히드록시페닐]프로필]-4-[2-[6-[2-[4-히드록시페닐]에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-[2,3-디히드록시페닐]에틸아미노]헥실아미노]에틸]-3-[3-[3-히드록시페닐]에틸]-1,2-벤젠디올, 3-[2-[3-클로로페닐]에틸]-4-[2-[6-[2-페닐에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 3-[2-[3-클로로페닐]에틸]-4-[2-[6-[2-[4-히드록시페닐]에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 4-[2-[6-[2-시클로헥실에틸아미노]헥실아미노]에틸]-3-[2-[4-히드록시페닐]에틸]-1,2-벤젠디올, 3-[2-[4-히드록시페닐]에틸]-4-[2-[6-[2-[4-히드록시페닐]에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, 3-[4-[3-히드록시페닐]부틸]-4-[2-[6-[2-페닐에틸아미노]헥실아미노]에틸]-1,2-벤젠디올, E-3-[2-[3-히드록시페닐]에틸]4-[2-[6-[2-페닐에틸아미노]-3-헥실아미노]에틸]-1,2-벤젠디올, N-[4-[2-[6-[2-[3,4-디히드록시-2-[2-[3-히드록시페닐]에틸]페닐]에틸아미노]헥실아미노]에틸]페닐]메탄술폰아미드, 4-[2-[6-[2-페닐에톡시)]헥실아미노)에틸-3-[2-[3-히드록시페닐]에틸]-1,2-벤젠디올, 또는 제약상 허용되는 그의 염 또는 용매화물인 방법.
  9. 제1항에서 정의된 일반식 I의 화합물 또는 그의 염 또는 용매화물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR860009805A 1985-11-20 1986-11-20 신규 화합물의 제조 방법 KR870004940A (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB858528605A GB8528605D0 (en) 1985-11-20 1985-11-20 Aromatic compound
GB85/28605 1985-11-20
GB868616793A GB8616793D0 (en) 1986-07-10 1986-07-10 Aromatic compounds
GB86/16794 1986-07-10
GB86/16793 1986-07-10
GB868616794A GB8616794D0 (en) 1986-07-10 1986-07-10 Aromatic compounds
GB868616792A GB8616792D0 (en) 1986-07-10 1986-07-10 Aromatic compounds
GB86/16792 1986-07-10

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KR870004940A true KR870004940A (ko) 1987-06-02

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KR (1) KR870004940A (ko)
AT (1) ATE64369T1 (ko)
AU (1) AU599934B2 (ko)
CA (1) CA1275103A (ko)
DE (1) DE3679784D1 (ko)
DK (1) DK553486A (ko)
FI (1) FI864680A (ko)
IL (1) IL80682A0 (ko)
NO (1) NO165236C (ko)
NZ (1) NZ218333A (ko)
PT (1) PT83772B (ko)

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EP0314725A1 (en) * 1987-05-19 1989-05-10 FISONS plc 2-(3,4-dihydroxyphenyl)ethylamines, their preparation and use as pharmaceutical

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US3789072A (en) * 1970-04-22 1974-01-29 Squibb & Sons Inc Carboxamides
JPS5059339A (ko) * 1973-09-28 1975-05-22
DE3263531D1 (en) * 1981-08-05 1985-06-20 Fisons Plc Amine derivatives, processes for their production and pharmaceutical compositions containing them
EP0375668A3 (en) * 1983-10-25 1990-10-17 FISONS plc Phenylethylamines, process for their preparation and compositions containing them
US4720586A (en) * 1983-12-06 1988-01-19 Fisons, Plc Substituted 3,4-dihydroxy-phenylethylamino compounds
NZ214823A (en) * 1985-01-15 1989-08-29 Glaxo Group Ltd 2-substituted-3,4-dihydroxyphenethylamino derivatives

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PT83772A (en) 1986-12-01
FI864680A (fi) 1987-05-21
ATE64369T1 (de) 1991-06-15
AU599934B2 (en) 1990-08-02
EP0223598A3 (en) 1988-11-17
EP0223598B1 (en) 1991-06-12
NO165236C (no) 1991-01-16
DK553486D0 (da) 1986-11-19
DE3679784D1 (de) 1991-07-18
NO864616L (no) 1987-05-21
AU6539186A (en) 1987-05-28
DK553486A (da) 1987-05-21
US4883804A (en) 1989-11-28
NO165236B (no) 1990-10-08
PT83772B (pt) 1989-06-30
NZ218333A (en) 1990-07-26
NO864616D0 (no) 1986-11-19
FI864680A0 (fi) 1986-11-18
CA1275103A (en) 1990-10-09
EP0223598A2 (en) 1987-05-27
IL80682A0 (en) 1987-02-27

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