KR870003991A - 치환된 벤젠 유도체의 제조방법 - Google Patents

치환된 벤젠 유도체의 제조방법 Download PDF

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Publication number
KR870003991A
KR870003991A KR1019860008270A KR860008270A KR870003991A KR 870003991 A KR870003991 A KR 870003991A KR 1019860008270 A KR1019860008270 A KR 1019860008270A KR 860008270 A KR860008270 A KR 860008270A KR 870003991 A KR870003991 A KR 870003991A
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KR
South Korea
Prior art keywords
quinoline
methyl
compound
halo
formula
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Application number
KR1019860008270A
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English (en)
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KR890004129B1 (ko
Inventor
프랭크 크레프트 3세 안토니
루이스 키스 케네드
헨리 뮤서 존
제이콥 빅슬러 제임스
피. 하우세 위니프레드
Original Assignee
조오지 드모르
아메리칸 홈 프로덕츠 코포레이션
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Publication of KR870003991A publication Critical patent/KR870003991A/ko
Application granted granted Critical
Publication of KR890004129B1 publication Critical patent/KR890004129B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

치환된 벤젠 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(Ⅰ)의 화합물 또는 약제학적으로 허용 가능한 이의 산 부가염.
    상기 식에서, X 는 n이 1인 경우에 CR 또는 N이거나, n이 0인 경우에 O,S,NR 또는 CR이고(여기서, R은 수소 또는 저급알킬이다);
    Y는 -CH2-, --S-, -O- 또는이며;
    (여기서, Z는 CH 또는 N 이고: R1은 할로 또는 트리플루오로메부이며; R2는수소 또는 할로이고; R3는 수소 또는 할로이다)이고; 단, A는 나프틸이고, Y가 -O-이며, n이 0인 경우, X는 S가 아니다.
  2. 제1항에 있어서, X가 CH이고, n이 1인 화합물.
  3. 제1항에 있어서, X가 S이고, n이 1인 화합물.
  4. 제1항에 있어서, 2-[3-브로모페녹시)메부]퀴놀린; 2-[(2-플루오로페녹시)메틸]퀴놀린; 2-[(3-클로로페녹시)메틸]퀴놀린; 2-[(4-클로로페녹시)메틸]퀴놀린;2-[(3-플루오로페녹시)메틸]퀴놀린;2-[(4-브로모페녹시)메틸]퀴놀린; 2-[(3, 4-디클로로페녹시)메틸]퀴놀린; 2-[(3-플루오로페녹시)메틸]퀴놀린;2-[(2-나프탈레닐옥시)메틸]퀴놀린; 2-(1-나프탈레닐옥시)메틸]퀴놀린 ; 2-[1-브로모-2-나프탈레닐옥시)메틸]퀴놀린 ; 2-[6-브로모-2-나프탈레닐옥시)메틸]퀴놀린; 2-[(4-브로모페닐)티에메틸]벤조티아졸; 2-[(3-브로모페닐)티오메틸)벤조티아졸; 2-[(8-퀴놀리닐옥시)메틸[퀴놀린 또는 2-[[3-(트리플루오로메틸)페녹시]메틸]퀴놀린.
  5. 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 유도체와 축합시키거나; 일반식(Ⅵ)의 화합물로 부터 음이온 안정화 그룹을 제거하거나; 일반식(Ⅶ)의 화합물을 방향족화하고, 경우에 따라서는 일반식(Ⅰ)의 유리염기를 약제학적으로 허용 가능한 산 부가염으로 전환시킴을 특징으로 하여 일반식(Ⅰ)의 화합물 또는 약제학적으로 허용 가능한 이의 산 부가염을 제조하는 방법
    상기 식에서, X 는 n이 1인 경우에 CR 또는 N이거나, n이 0인 경우에 O,S,NR 또는 CR이고(여기서, R은 수소 또는 저급알킬이다);
    Y는 -CH2-, -S-, -O- 또는이며;
    (여기서, Z는 CH또는 N이고; R1은 할로 또는 트리플루오로메틸이며; R2는 수소 또는 할로이고; R3는 수소 또는 할로이다)이고; 단, A가 나프틸이고, Y가 -O-이며, n이 0인 계우, X 는 S가 아니며; hal은 할로라디칼이고; R4및 R5는 음이온 안정화 그룹이며;
    이다(여기서, Z,R1, R2, R3및 R4는 상기한 바와 같다).
  6. 제1항 내지 제4항 중 어느 한 항에 청구된 화합물과 약제학적으로 허용가능한 담체로 이루어지는 약제학적 조성물.
  7. 제1항 내지 제4항중 어느 한 항에 청구된 화합물의 의약으로서의 용도.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860008270A 1985-10-03 1986-10-02 치환된 벤젠 유도체의 제조방법 KR890004129B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78414385A 1985-10-03 1985-10-03
US784,143 1985-10-03
US784143 1985-10-03
US905,619 1986-09-12
US06/905,619 US4732978A (en) 1985-10-03 1986-09-12 Novel substituted naphthyloxymethyl quinoline derivatives as anti-inflammatory and antiallergy agents
US905619 1986-09-12

Publications (2)

Publication Number Publication Date
KR870003991A true KR870003991A (ko) 1987-05-06
KR890004129B1 KR890004129B1 (ko) 1989-10-21

Family

ID=27120230

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860008270A KR890004129B1 (ko) 1985-10-03 1986-10-02 치환된 벤젠 유도체의 제조방법

Country Status (13)

Country Link
US (1) US4732978A (ko)
EP (1) EP0223368B1 (ko)
KR (1) KR890004129B1 (ko)
AU (1) AU583153B2 (ko)
CA (1) CA1267146A (ko)
DE (1) DE3667786D1 (ko)
DK (1) DK167614B1 (ko)
ES (1) ES2012451B3 (ko)
GB (1) GB2181135B (ko)
GR (1) GR3000343T3 (ko)
HU (1) HU196592B (ko)
IE (1) IE58801B1 (ko)
PT (1) PT83451B (ko)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4904786A (en) * 1986-01-27 1990-02-27 American Home Products Corporation Quinoline compounds as antiallergic and antiinflammatory agents
DE3632329A1 (de) * 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
DK196688A (da) * 1987-04-28 1988-10-29 Fujisawa Pharmaceutical Co Bicykliske forbindelser og fremgangsmaade til fremstilling deraf
US4960892A (en) * 1988-06-10 1990-10-02 American Home Products Corporation Naphthalenepropionic acid derivatives as anti-inflammatory/anti-allergic agents
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US5104882A (en) * 1987-11-25 1992-04-14 Merck Frosst Canada, Inc. Diarylstrylquinoline diacids and pharmaceutical compositions thereof
US5204358A (en) * 1987-11-25 1993-04-20 Merck Frosst Canada, Inc. Hetaryl styryl quinolines as leukotriene inhibitors
NZ233752A (en) * 1989-05-24 1993-05-26 Merck Frosst Canada Inc Substituted quinoline derivatives, preparation and pharmaceutical compositions thereof
JPH03173874A (ja) * 1989-09-29 1991-07-29 Mitsubishi Kasei Corp 新規複素環化合物
DE3935139A1 (de) * 1989-10-21 1991-04-25 Bayer Ag Substituierte (chinolin-2-yl-methoxy)phenyl-thioharnstoffe
ES2061406B1 (es) * 1993-05-07 1995-06-01 Uriach & Cia Sa J Nuevos derivados de la 2-(quinolina) con actividad farmacologica.
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
DE69531623T2 (de) * 1994-10-12 2004-06-17 Euroceltique S.A. Neue benzoxazole
US6372770B1 (en) 1994-10-12 2002-04-16 Euro-Celtique, S.A. Benzoxazoles
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
JPH10508032A (ja) * 1994-12-13 1998-08-04 ユーロ−セルティーク，エス．エイ． アリールチオキサンチン類
AU4527996A (en) * 1994-12-13 1996-07-03 Euro-Celtique S.A. Trisubstituted thioxanthines
EP0725063A1 (de) * 1995-02-01 1996-08-07 Ciba-Geigy Ag Chinolin-Derivate
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity

Family Cites Families (7)

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US31624A (en) * 1861-03-05 Tatting-frame
GB800713A (en) * 1955-04-27 1958-09-03 Boots Pure Drug Co Ltd Sulphur-containing benzoxazole derivatives and compositions containing them
USRE31624E (en) 1979-11-26 1984-07-03 Forsyth Dental Infirmary For Children Method of treating inflammation
US4563526A (en) * 1980-09-19 1986-01-07 Forsyth Dental Infirmary For Children Substituted 2-(arylmethoxy) phenol compounds for the treatment of inflammation
NZ213986A (en) * 1984-10-30 1989-07-27 Usv Pharma Corp Heterocyclic or aromatic compounds, and pharmaceutical compositions containing such
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4661499A (en) * 1985-06-18 1987-04-28 Merck Frosst Canada, Inc. 2-[(substituted)-phenoxymethyl]quinolines

Also Published As

Publication number Publication date
EP0223368A1 (en) 1987-05-27
IE58801B1 (en) 1993-11-17
GB8623616D0 (en) 1986-11-05
HUT42447A (en) 1987-07-28
HU196592B (en) 1988-12-28
DK462986A (da) 1987-04-04
US4732978A (en) 1988-03-22
GB2181135A (en) 1987-04-15
DE3667786D1 (de) 1990-02-01
CA1267146A (en) 1990-03-27
PT83451A (pt) 1986-10-01
AU6341486A (en) 1987-04-09
IE862616L (en) 1987-04-04
KR890004129B1 (ko) 1989-10-21
GR3000343T3 (en) 1991-06-07
ES2012451B3 (es) 1990-04-01
EP0223368B1 (en) 1989-12-27
DK462986D0 (da) 1986-09-29
PT83451B (pt) 1988-07-29
AU583153B2 (en) 1989-04-20
GB2181135B (en) 1989-09-13
DK167614B1 (da) 1993-11-29

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