KR870002834A - 유제조성물의 제조방법 - Google Patents
유제조성물의 제조방법 Download PDFInfo
- Publication number
- KR870002834A KR870002834A KR1019860007580A KR860007580A KR870002834A KR 870002834 A KR870002834 A KR 870002834A KR 1019860007580 A KR1019860007580 A KR 1019860007580A KR 860007580 A KR860007580 A KR 860007580A KR 870002834 A KR870002834 A KR 870002834A
- Authority
- KR
- South Korea
- Prior art keywords
- ion
- hydrophobic drug
- drug
- pharmaceutically acceptable
- oil
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Colloid Chemistry (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 비스안트렌의 물에 대한 용해도를 나타낸 것이다.
제2도는 비스안트렌의 선택된 매체 및 생물학적 액체에 대한 용해도를 나타낸 것이다.
Claims (2)
- (a) 소수성 약물을 소수성 약물이 염기성인 경우 C6-C20포화 또는 불포화 지방족 또는 방향족 산으로 부터 선택된 그리고 소수성 약물이 산성인 경우 제약상 허용되는 지방족 또는 방향족 아민으로 부터 선택된 이온쌍 형성제와 반응시켜 이온-쌍을 형성하고:(b) 상기 이온-쌍을 물;(i) 천연산 식물유 및 (ii) 반합성모노, 디, 또는 트리글리세라이드로 부터 선택된 제약상 허용되는 유성 운반체 또는 오일 ; 계면활성제 또는 유화제 및 보조 계면활성제 또는 보조유화제와 혼합하여 수중유 유제를 형성시키는 단계들을 특징으로 하는 균질화된 약제 조성물의 제조방법.
- 제 1항에 있어서, 상기 유제를 8000~15000p.s.i. 압력하에서 균질화시켜 입자크기를 0.170~0.5미크론으로 감소시키는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/774,762 US4816247A (en) | 1985-09-11 | 1985-09-11 | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
US774,762 | 1985-09-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR870002834A true KR870002834A (ko) | 1987-04-13 |
KR900000211B1 KR900000211B1 (ko) | 1990-01-23 |
Family
ID=25102201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860007580A KR900000211B1 (ko) | 1985-09-11 | 1986-09-10 | 유제조성물 및 그의 제조방법 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4816247A (ko) |
EP (1) | EP0214501B1 (ko) |
JP (1) | JPS62111915A (ko) |
KR (1) | KR900000211B1 (ko) |
AT (1) | ATE80795T1 (ko) |
AU (1) | AU593014B2 (ko) |
CA (1) | CA1272685A (ko) |
DE (1) | DE3686797T2 (ko) |
DK (1) | DK432586A (ko) |
ES (1) | ES2001950A6 (ko) |
FI (1) | FI86142C (ko) |
GR (1) | GR862316B (ko) |
HU (1) | HU196700B (ko) |
IE (1) | IE59828B1 (ko) |
NO (1) | NO171145C (ko) |
NZ (1) | NZ217483A (ko) |
PH (1) | PH24313A (ko) |
ZA (1) | ZA866899B (ko) |
Families Citing this family (60)
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US4784845A (en) * | 1985-09-16 | 1988-11-15 | American Cyanamid Company | Emulsion compostions for the parenteral administration of sparingly water soluble ionizable hydrophobic drugs |
US6759057B1 (en) * | 1986-06-12 | 2004-07-06 | The Liposome Company, Inc. | Methods and compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
US5229422A (en) * | 1987-09-07 | 1993-07-20 | Teijin Limited | Extemporaneous preparation type kit of a pharmaceutical substance-containing fat emulsion |
US5244925A (en) * | 1987-12-18 | 1993-09-14 | Kabi Pharmacia Aktiebolag | Emulsion for parenteral administration |
JP2643217B2 (ja) * | 1988-01-22 | 1997-08-20 | エーザイ株式会社 | 脂溶性物質水性液 |
DE3902079A1 (de) * | 1988-04-15 | 1989-10-26 | Bayer Ag | I.m. injektionsformen von gyrase-inhibitoren |
GB2217596A (en) * | 1988-04-26 | 1989-11-01 | American Cyanamid Co | Anti-arthritic liposome composition |
ES2052016T3 (es) * | 1988-09-29 | 1994-07-01 | Shiseido Co Ltd | Composicion emulsionada. |
US4971788A (en) * | 1989-01-27 | 1990-11-20 | Medicontrol Corporation | Oral cavity and dental microemulsion products |
DE3908047A1 (de) * | 1989-03-13 | 1990-09-20 | Desitin Arzneimittel Gmbh | Hochdisperse pharmazeutische zusammensetzung |
US5364632A (en) * | 1989-04-05 | 1994-11-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Medicinal emulsions |
GB8919172D0 (en) * | 1989-08-23 | 1989-10-04 | Univ Nottingham | Useful composition |
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US5188837A (en) * | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
JPH0714872B2 (ja) * | 1990-02-06 | 1995-02-22 | 昭和薬品化工株式会社 | シロップ剤組成物 |
DE4015108A1 (de) * | 1990-05-11 | 1991-11-14 | Leopold Pharma Gmbh | Stabile emulsion zur applikation pharmakologisch aktiver wirkstoffe |
DE4124252A1 (de) * | 1991-07-22 | 1993-01-28 | Knoll Ag | Verfahren zur herstellung einer sterilfiltrierbaren wirkstoffloesung |
GB2260079B (en) * | 1991-10-01 | 1995-08-09 | American Cyanamid Co | Pharmaceutical composition containing felbinac |
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ATE521342T1 (de) * | 2002-05-22 | 2011-09-15 | Nihon Pharmaceutical Co Ltd | Peristolen-hemmer der glatten muskulatur |
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US9498454B2 (en) | 2003-02-24 | 2016-11-22 | Pharmaceutical Productions Inc. | Transmucosal drug delivery system |
US10172810B2 (en) | 2003-02-24 | 2019-01-08 | Pharmaceutical Productions, Inc. | Transmucosal ketamine delivery composition |
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-
1985
- 1985-09-11 US US06/774,762 patent/US4816247A/en not_active Expired - Fee Related
-
1986
- 1986-08-16 AT AT86111325T patent/ATE80795T1/de active
- 1986-08-16 DE DE8686111325T patent/DE3686797T2/de not_active Expired - Fee Related
- 1986-08-16 EP EP86111325A patent/EP0214501B1/en not_active Expired - Lifetime
- 1986-09-05 NZ NZ217483A patent/NZ217483A/xx unknown
- 1986-09-09 CA CA000517737A patent/CA1272685A/en not_active Expired - Fee Related
- 1986-09-10 KR KR1019860007580A patent/KR900000211B1/ko not_active IP Right Cessation
- 1986-09-10 FI FI863664A patent/FI86142C/fi not_active IP Right Cessation
- 1986-09-10 PH PH34241A patent/PH24313A/en unknown
- 1986-09-10 AU AU62538/86A patent/AU593014B2/en not_active Ceased
- 1986-09-10 GR GR862316A patent/GR862316B/el unknown
- 1986-09-10 ZA ZA866899A patent/ZA866899B/xx unknown
- 1986-09-10 NO NO863620A patent/NO171145C/no unknown
- 1986-09-10 DK DK432586A patent/DK432586A/da not_active Application Discontinuation
- 1986-09-10 ES ES8601758A patent/ES2001950A6/es not_active Expired
- 1986-09-10 HU HU863901A patent/HU196700B/hu not_active IP Right Cessation
- 1986-09-10 IE IE240886A patent/IE59828B1/en not_active IP Right Cessation
- 1986-09-11 JP JP61214969A patent/JPS62111915A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU593014B2 (en) | 1990-02-01 |
NZ217483A (en) | 1990-08-28 |
EP0214501B1 (en) | 1992-09-23 |
PH24313A (en) | 1990-05-29 |
DE3686797T2 (de) | 1993-03-25 |
NO171145B (no) | 1992-10-26 |
DK432586D0 (da) | 1986-09-10 |
ES2001950A6 (es) | 1988-07-01 |
DK432586A (da) | 1987-03-12 |
US4816247A (en) | 1989-03-28 |
HUT43948A (en) | 1988-01-28 |
EP0214501A2 (en) | 1987-03-18 |
CA1272685A (en) | 1990-08-14 |
IE862408L (en) | 1987-03-11 |
NO863620L (no) | 1987-03-12 |
NO171145C (no) | 1993-02-03 |
JPS62111915A (ja) | 1987-05-22 |
FI86142B (fi) | 1992-04-15 |
FI863664A (fi) | 1987-03-12 |
ATE80795T1 (de) | 1992-10-15 |
IE59828B1 (en) | 1994-04-06 |
NO863620D0 (no) | 1986-09-10 |
GR862316B (en) | 1987-01-13 |
EP0214501A3 (en) | 1987-09-09 |
FI863664A0 (fi) | 1986-09-10 |
AU6253886A (en) | 1987-03-12 |
HU196700B (en) | 1989-01-30 |
ZA866899B (en) | 1987-05-27 |
FI86142C (fi) | 1992-07-27 |
DE3686797D1 (de) | 1992-10-29 |
KR900000211B1 (ko) | 1990-01-23 |
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
G160 | Decision to publish patent application | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant | ||
FPAY | Annual fee payment |
Payment date: 19931229 Year of fee payment: 5 |
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LAPS | Lapse due to unpaid annual fee |