KR860007214A - 2-아미노-3-니트로-6-(4-플루오로벤질아미노)-피리딘 및 2-아미노-3-카브에톡시아미노-6-(4-플루오로-벤질아미노)- 피리딘의 제조방법 - Google Patents
2-아미노-3-니트로-6-(4-플루오로벤질아미노)-피리딘 및 2-아미노-3-카브에톡시아미노-6-(4-플루오로-벤질아미노)- 피리딘의 제조방법 Download PDFInfo
- Publication number
- KR860007214A KR860007214A KR1019860002142A KR860002142A KR860007214A KR 860007214 A KR860007214 A KR 860007214A KR 1019860002142 A KR1019860002142 A KR 1019860002142A KR 860002142 A KR860002142 A KR 860002142A KR 860007214 A KR860007214 A KR 860007214A
- Authority
- KR
- South Korea
- Prior art keywords
- amino
- pyridine
- nitro
- fluorobenzylamino
- carbethoxyamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 2-아미노-3-니트로-6-메톡시피리딘을 물중승온에서 4-플루오로벤질아민 또는 이의 염과 반응시키고, 임의로는 수득된 화합물중의 니트로그룹을 아미노그룹으로 환원시킨 다음, 이러한 3-위치의 아미노 그룹을 아실화하여 카브에톡시 그룹을 도입시키고, 임의로는 수득된 생성물을 이의 산 부가염으로 전환시킴을 특징으로 하여 2-아미노-3-니트로-6-(4-플루오로벤질아미노)-피리딘 또는 2-아미노-3-카브에톡시아미노-6-(4-플루오로벤질아미노)-피리딘을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3510623 | 1985-03-23 | ||
DEP3510623.9 | 1985-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR860007214A true KR860007214A (ko) | 1986-10-08 |
Family
ID=6266157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019860002142A KR860007214A (ko) | 1985-03-23 | 1986-03-22 | 2-아미노-3-니트로-6-(4-플루오로벤질아미노)-피리딘 및 2-아미노-3-카브에톡시아미노-6-(4-플루오로-벤질아미노)- 피리딘의 제조방법 |
Country Status (24)
Country | Link |
---|---|
US (1) | US4785110A (ko) |
EP (1) | EP0199951B1 (ko) |
JP (1) | JPS61221172A (ko) |
KR (1) | KR860007214A (ko) |
AT (1) | ATE60322T1 (ko) |
AU (1) | AU579922B2 (ko) |
BR (1) | BR8601283A (ko) |
CA (1) | CA1273343A (ko) |
CS (1) | CS259887B2 (ko) |
DD (1) | DD246761A5 (ko) |
DE (1) | DE3677042D1 (ko) |
DK (1) | DK162215C (ko) |
ES (1) | ES8702893A1 (ko) |
FI (1) | FI84819C (ko) |
GR (1) | GR860745B (ko) |
HU (1) | HU206679B (ko) |
IE (1) | IE58560B1 (ko) |
IL (1) | IL78218A (ko) |
NO (1) | NO860825L (ko) |
PL (1) | PL146631B1 (ko) |
PT (1) | PT82235B (ko) |
TR (1) | TR22924A (ko) |
YU (1) | YU45086A (ko) |
ZA (1) | ZA862138B (ko) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI855016A (fi) * | 1985-06-28 | 1986-12-29 | Degussa | Synergistisk kombination av flupirtin och 4-acetamido-fenol. |
DE4327516A1 (de) * | 1993-08-17 | 1995-02-23 | Asta Medica Ag | Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin |
JPWO2004069802A1 (ja) * | 2003-02-06 | 2006-05-25 | 塩野義製薬株式会社 | 2−アミノ−3−置換ピリジンの製造方法 |
US20080279930A1 (en) * | 2007-05-07 | 2008-11-13 | Bernd Terhaag | Controlled-Release Flupirtine Compositions, Compacts, Kits and Methods of Making and Use Thereof |
EP2206700A1 (en) | 2008-12-24 | 2010-07-14 | AWD.pharma GmbH & Co.KG | Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester) |
EP2206701A1 (en) | 2008-12-24 | 2010-07-14 | AWD.pharma GmbH & Co.KG | Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester) |
EP2206699A1 (en) | 2008-12-24 | 2010-07-14 | AWD.pharma GmbH & Co.KG | Crystalline form of flupirtine ((2-amino-6-(4-fluoro-benzylamino)-pyridin-3-yl)-carbamic acid ethyl ester) |
DE102009023162B4 (de) * | 2009-05-29 | 2011-07-07 | Corden PharmaChem GmbH, 68305 | Verfahren zur Herstellung von Flupirtin |
CN102140077A (zh) * | 2010-01-28 | 2011-08-03 | 范扶民 | 氟吡汀a晶型及其制备方法 |
WO2013080215A1 (en) | 2011-11-30 | 2013-06-06 | Arch Pharmalabs Limited | An improved process for the preparation of flupirtine and pharmaceutically acceptable salts thereof |
CN104083335B (zh) * | 2013-07-31 | 2015-11-11 | 成都苑东药业有限公司 | 一种马来酸氟吡汀胶囊组合物及其制备方法 |
DE102017007385A1 (de) | 2017-08-02 | 2019-02-07 | Christoph Hoock | Maleatfreie feste Arzneimittelformen |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1670522C3 (de) * | 1966-05-12 | 1978-08-31 | Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt | Neue Benzylaminopyridine |
BE764362R (en) * | 1966-05-12 | 1971-09-16 | Degussa | Subst amino pyridienes production |
US4481205A (en) * | 1980-09-13 | 1984-11-06 | Degussa Aktiengesellschaft | 2-Amino-3-carbethoxyamino-6-(p-fluoro-benzylamino)-pyridine-maleate |
EP0110091B1 (de) * | 1982-10-27 | 1987-01-21 | Degussa Aktiengesellschaft | 2-Amino-3-Acylamino-6-benzylamino-pyridin-Derivate mit anti-epileptischer Wirkung |
-
1986
- 1986-03-05 NO NO860825A patent/NO860825L/no unknown
- 1986-03-15 EP EP86103517A patent/EP0199951B1/de not_active Expired - Lifetime
- 1986-03-15 AT AT86103517T patent/ATE60322T1/de not_active IP Right Cessation
- 1986-03-15 DE DE8686103517T patent/DE3677042D1/de not_active Expired - Lifetime
- 1986-03-19 DK DK126886A patent/DK162215C/da not_active IP Right Cessation
- 1986-03-20 FI FI861183A patent/FI84819C/fi not_active IP Right Cessation
- 1986-03-20 GR GR860745A patent/GR860745B/el unknown
- 1986-03-21 ZA ZA862138A patent/ZA862138B/xx unknown
- 1986-03-21 IE IE74686A patent/IE58560B1/en not_active IP Right Cessation
- 1986-03-21 CS CS861986A patent/CS259887B2/cs unknown
- 1986-03-21 PL PL1986258543A patent/PL146631B1/pl unknown
- 1986-03-21 AU AU54997/86A patent/AU579922B2/en not_active Expired
- 1986-03-21 YU YU00450/86A patent/YU45086A/xx unknown
- 1986-03-21 BR BR8601283A patent/BR8601283A/pt not_active IP Right Cessation
- 1986-03-21 DD DD86288169A patent/DD246761A5/de unknown
- 1986-03-21 CA CA000504732A patent/CA1273343A/en not_active Expired - Lifetime
- 1986-03-21 ES ES553222A patent/ES8702893A1/es not_active Expired
- 1986-03-21 PT PT82235A patent/PT82235B/pt unknown
- 1986-03-21 IL IL78218A patent/IL78218A/xx unknown
- 1986-03-22 KR KR1019860002142A patent/KR860007214A/ko not_active Application Discontinuation
- 1986-03-22 TR TR163/86A patent/TR22924A/xx unknown
- 1986-03-24 US US06/843,253 patent/US4785110A/en not_active Expired - Lifetime
- 1986-03-24 HU HU861216A patent/HU206679B/hu unknown
- 1986-03-24 JP JP61064292A patent/JPS61221172A/ja active Granted
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR860007214A (ko) | 2-아미노-3-니트로-6-(4-플루오로벤질아미노)-피리딘 및 2-아미노-3-카브에톡시아미노-6-(4-플루오로-벤질아미노)- 피리딘의 제조방법 | |
KR850008678A (ko) | 2-아미노-3-에톡시카보닐아미노-6-cP-플루오로-벤질아미노)-피리딘 글루코노이트의 제조방법 | |
KR900007797A (ko) | (s)-α-에틸-2-옥소-1-피롤리딘 아세트아미드의 제법 | |
KR850001149A (ko) | 2-3차-부틸아미노-3'-클로로프로피오페논 말레에이트의 제조방법 | |
BR8600260A (pt) | Processo para a preparacao de triacetoxissilanas a partir de tris(amino)silanas | |
DK162095C (da) | Fremgangsmaade til fremstilling af thiotetronsyre | |
KR830006201A (ko) | N-(1-알릴-2-피롤리디닐-메틸) 2-메톡시-4-아미노-5-메틸설파모일 벤즈아미드의 제조방법 | |
YU46319B (sh) | Postupak za dobijanje 1-/3-merkapto-/2s/-metilpropionil/-pirolidin-/2s/-karboksilne kiseline | |
KR900701745A (ko) | 2-클로로-4-톨루엔술폰산의 제조방법 | |
SE8406578D0 (sv) | Process for the preparation of 3,4,5-trimethoxybenzonitrile | |
DK164050C (da) | 4-benzyloxy-3-pyrrolin-2-on samt anvendelse deraf til fremstilling af tetramsyre | |
KR890006561A (ko) | 디알킬 디클로로숙시네이트의 개선된 제조방법 | |
KR890000414A (ko) | 엘-시스틴의 제조방법 | |
KR850006182A (ko) | 시스-3,3,5-트리메틸사이클로헥실-D,L-α-(3-피리딘카복시)-페닐아세테이트의 제조방법 | |
KR970015746A (ko) | 고정화 효소를 이용한 7-아미노-3-크로로-3-세펨-4-카르복실산 제조법 | |
KR830010088A (ko) | 4-클로로-n-메틸벤조티아졸-2-온의 제조방법 | |
KR830006194A (ko) | 고순도톨릴티오 요소류의 제조방법 | |
KR840000572A (ko) | 유기 게르마늄 화합물의 제조방법 | |
KR890002047A (ko) | 오르트산 시프로헵타딘의 제조방법 | |
KR910000627A (ko) | 메틸렌디(페닐우레탄)의 제조방법 | |
DK0643041T3 (da) | Fremgangsmåde til fremstilling af isocyansyre ud fre cyanursyre | |
KR900004758A (ko) | 안트라 시클린 유도체 및 그의 제조 방법 | |
KR870004932A (ko) | 실리실산(salicylic acid)화합물 제조방법 | |
KR880006211A (ko) | 옥사졸 화합물의 제조방법 | |
KR830005244A (ko) | 세파피린의 아미노산염 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |